Impact of dams and irrigation schemes in Anopheline (Diptera: Culicidae) bionomics and malaria epidemiology

Irrigation schemes and dams have posed a great concern on public health systems of several countries, mainly in the tropics. The focus of the present review is to elucidate the different ways how these human interventions may have an effect on population dynamics of anopheline mosquitoes and hence, how local malaria transmission patterns may be changed. We discuss different studies within the three main tropical and sub-tropical regions (namely Africa, Asia and the Pacific and the Americas). Factors such as pre-human impact malaria epidemiological patterns, control measures, demographic movements, human behaviour and local Anopheles bionomics would determine if the implementation of an irrigation scheme or a dam will have negative effects on human health. Some examples of successful implementation of control measures in such settings are presented. The use of Geographic Information System as a powerful tool to assist on the study and control of malaria in these scenarios is also highlighted.Intervenções humanas como projetos de irrigação e usinas hidrelétricas, tem se transformado em graves problemas de saúde em muitos países, especialmente naqueles localizados nos trópicos. No presente artigo discutimos os efeitos que essas intervenções causam a dinâmica populacional dos anofelinos e nos padrões de transmissão de malaria. Foram revisados estudos feitos nas três principais regiões geográficas dos trópicos e sub-trópicos (África, Ásia e o Pacífico e Américas). Constatamos que os padrões da transmissão da malária antes da introdução dos empreendimentos, as medidas de controle, os movimentos demográficos, os padrões comportamentais das comunidades humanas e a bionomia dos anofelinos locais determinarão se o estabelecimento de campos de irrigação e/ou usinas hidrelétricas podem influenciar negativamente na saúde das pessoas. São apresentados exemplos de medidas de controle bem sucedidas nesses cenários. A utilização de Sistemas de Informação Geográfico tem sido destacada como uma importante ferramenta para subsidiar o estudo e controle da malária em áreas sob impacto ambiental

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub

Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain structure and from complex mechanisms of regulation of its expression levels, activity, and localization within the cell, what allows the precise spatio-temporal shaping of GRK2 targets. A better understanding of the GRK2 interactome and its modulation mechanisms is helping to identify the GRK2-interacting proteins and its substrates involved in the participation of this kinase in different cellular processes and pathophysiological contexts.Our laboratories are supported by Ministerio de Ciencia, Innovación y Universidades (Grant SAF2017-84125-R to FM and SAF2017-82886-R to FSM), CIBERCV-Instituto de Salud Carlos III, Spain (Grant B16/11/00278 to F.M, co-funded with European FEDER contribution), Instituto de Salud Carlos III, Spain (Grant PI17-00576 to PP and grant PI18/01662 to CR), Fundacion Ramón Areces (to FM) and Programa de Actividades en Biomedicina de la Comunidad de Madrid-B2017/BMD-3671-INFLAMUNE to FM and FSM. We also acknowledge institutional support to the CBMSO from Fundación Ramón ArecesS

Effect of La3+/Sr2+ ordering on the magnetic properties of La2/3Sr1/3MnO3 by first principles calculations

In this work, using DFT + U formalism, we investigate the effect of order-disorder in the A-site occupation byLa3+and Sr2+on the stability of the ferromagnetic order in La2/3Sr1/3MnO3with−Rc3symmetry. To date, adetailed theoretical discussion of such phenomenon, using a combination of different representations of theelectronic structure, is still missing in the Literature. We employed structural models consisting of 120 atomsupercells constructed according to the precise stoichiometry of the compound. Two configurations, describingrandomized and ordered occupation of the La3+/Sr2+ions, were evaluated. We demonstrate that the ferro-magnetic arrangement of La2/3Sr1/3MnO3with randomly distributed La3+and Sr2+ions is more stable. In suchconfiguration wefind that the Mn3+and Mn4+ions are not distinguished, favoring the double-exchange me-chanism, enhanced by the higher degree of covalence in the MneO bonds near the Fermi level between thespin-upMn-egorbitals and the O-porbitals

Direct assessment of the sensitivity drift of SQM sensors installed outdoors

Long-term monitoring of the evolution of the artificial night sky brightness is a key tool for developing science-informed public policies and assessing the efficacy of light pollution mitigation measures. Detecting the underlying artificial brightness trend is a challenging task, since the typical night sky brightness signal shows a large variability with characteristic time scales ranging from seconds to years. In order to effectively isolate the weak signature of the effect of interest, determining the potential long term drifts of the radiance sensing systems is crucial. If these drifts can be adequately characterized, the raw measurements could be easily corrected for them and transformed to a consistent scale. In this short note we report on the progressive darkening of the signal recorded by SQM detectors belonging to several monitoring networks, permanently installed outdoors for periods ranging from several months to several years. The sensitivity drifts were estimated by means of parallel measurements made at the beginning and at the end of the evaluation periods using reference detectors of the same kind that were little or no exposed to weathering in the intervening time. Our preliminary results suggest that SQM detectors installed outdoors steadily increase their readings at an average rate of +0.034 magSQM/arcsec2 per MWh/m2 of exposure to solar horizontal global irradiation, that for our locations translates into approximately +0.05 to +0.06 magSQM/arcsec2 per year.This work was supported in part by Xunta de Galicia, grant ED431B 2020/29. J.Z. acknowledges the support from ACTION, a project funded by the European Union H2020-SwafS-2018-1-824603, RTI2018-096188-B-I00 and S2018/NMT-4291 (TEC2SPACE-CM). Part of this work was developed in the framework of the Spanish Network for Light Pollution Studies (REECL).Peer ReviewedPostprint (published version

Transformación digital y profesión contable: reflexiones desde el ejercicio profesional y la formación de contadores públicos

Desde el inicio del presente siglo hemos sido testigos de fuertes cambios en las sociedades producto de la digitalización. Esta revolución, también llamada “Revolución 4.0” caracterizada por la conectividad, informatización de la fabricación y tecnologías disruptivas como el blockchain, machine learning o big data, se ha visto potenciada en los últimos meses en este escenario denominado por muchos como “la nueva normalidad”. (Romero, 2020) Si bien todavía no es posible evaluar el impacto completo de la transformación digital en la profesión y sabiendo que el impacto no será igual para todos los profesionales coincidimos en que existe una alta probabilidad que los cambios resulten sustanciales. En este marco, el presente trabajo intenta reflexionar sobre cuáles podrían ser los desafíos que presenta la transformación digital a la profesión contable, desde el ejercicio profesional y desde la formación de los contadores públicos. A partir de la revisión de la literatura y de resultados de estudios anteriores concluimos que, si bien todavía no es posible evaluar el impacto completo de la transformación digital en la profesión y sabiendo que el impacto no será igual para todos los profesionales, existe una alta probabilidad que los cambios resulten sustanciales y dicha realidad presenta desafíos para los profesionales, las entidades que los nuclean y las universidades. Consideramos que la sociedad necesita de profesionales idóneos y capaces de asumir desafíos interdisciplinarios y de adaptar su accionar al constante cambio de normas y formas legales y este es el desafío principal en cuanto a formación de las universidades. Sin embargo, los profesionales, y los consejos, también deberían tomar decisiones que les permitan adecuar rápida y eficazmente sus perfiles a este contexto difícil y complejo.Eje temático: Tecnologías de la Información y BlockchainInstituto de Investigaciones y Estudios Contable

Biogeographic, Atmospheric, and Climatic Factors Influencing Tree Growth in Mediterranean Aleppo Pine Forests

There is a lack of knowledge on how tree species respond to climatic constraints like water shortages and related atmospheric patterns across broad spatial and temporal scales. These assessments are needed to project which populations will better tolerate or respond to global warming across the tree species distribution range. Warmer and drier conditions have been forecasted for the Mediterranean Basin, where Aleppo pine (Pinus halepensisMill.) is the most widely distributed conifer in dry sites. This species shows plastic growth responses to climate, being particularly sensitive to drought. We evaluated how 32 Aleppo pine forests responded to climate during the second half of the 20th century by using dendrochronology. Climatic constraints of radial growth were inferred by fitting the Vaganov-Shashkin (VS-Lite) growth model to ring-width data from our Aleppo pine forest network. Our findings reported that Aleppo pine growth decreased and showed the highest common coherence among trees in dry, continental sites located in southeastern and eastern inland Spain and Algeria. In contrast, growth increased in wetter sites located in northeastern Spain. Overall, across the Aleppo pine network tree growth was enhanced by prior wet winters and cool and wet springs, whilst warm summers were associated with less growth. The relationships between site ring-width chronologies were higher in nearby forests. This explains why Aleppo pine growth was distinctly linked to indices of atmospheric circulation patterns depending on the geographical location of the forests. The western forests were more influenced by moisture and temperature conditions driven by the Western Mediterranean Oscillation (WeMO) and the Northern Atlantic Oscillation (NAO), the southern forests by the East Atlantic (EA) and the august NAO, while the Balearic, Tunisian and northeastern sites by the Arctic Oscillation (AO) and the Scandinavian pattern (SCA). The climatic constraints for Aleppo pine tree growth and its biogeographical variability were well captured by the VS-Lite model. The model performed better in dry and continental sites, showing strong growth coherence between trees and climatic limitations of growth. Further research using similar broad-scale approaches to climate-growth relationships in drought-prone regions deserves more attention

Pequeñas firmas profesionales: riesgos, ética y compliance

El objetivo del trabajo es identificar el posicionamiento ético del contador público y explorar potenciales riesgos en la pequeña firma de servicios profesionales asociadas a su plan de integridad y que requieran, en una etapa posterior, un mapeo de riesgos. Se trata de un estudio es de carácter descriptivo aplicando la metodología cualitativa de tipo fenomenológica. Los datos recolectados surgen de una muestra de los profesionales matriculados del ámbito territorial de la Delegación Tandil del C.P.C.E.P.B.A. De los resultados presentados se pudieron identificar algunos potenciales riesgos inherentes al ejercicio profesional de los contadores participantes del estudio como el fraude laboral, la ciberseguridad, la dependencia de proveedores de TICs, la gestión del talento humano, los controles por parte de los organismos del estado, la competencia, la reputación del servicio, el modelo de negocio y el aspecto comunicacional. Adicionalmente se asociaron a cada tipo de riesgo potencial comentarios o acciones que podrían mitigarlo. En relación con el posicionamiento de los profesionales en relación con la ética, los entrevistados la consideran como un valor inherente a la persona, predominando las valoraciones negativas sobre la regulación profesional, marcando insistentemente la poca utilidad de un código de ética profesional.Instituto de Investigaciones y Estudios Contable

Environmentally driven transcriptomic and metabolic changes leading to color differences in “Golden Reinders” apples

Apple is characterized by its high adaptation to diverse growing environments. However, little is still known about how different environments can regulate at the metabolic or molecular level specific apple quality traits such as the yellow fruit peel color. In this study, changes in carotenoids and chlorophylls, antioxidants as well as differences in the transcriptome were investigated by comparing the peel of “Golden Reinders” apples grown at different valley and mountain orchards. Mountain environment favored the development of yellow color, which was not caused by an enhanced accumulation of carotenoids but rather by a decrease in the chlorophyll content. The yellow phenotype was also associated to higher expression of genes related to chloroplast functions and oxidative stress. Time-course analysis over the last stages of apple development and ripening, in fruit from both locations, further revealed that the environment differentially modulated isoprenoids and phenylpropanoid metabolism and pointed out a key role for H2O2 in triggering apple peel degreening. Overall, the results presented herein provide new insights into how different environmental conditions regulate pigment and antioxidant metabolism in apple leading to noticeable differences in the apple peel colorinfo:eu-repo/semantics/publishedVersio

49Cr: Towards full spectroscopy up to 4 MeV

The nucleus 49Cr has been studied analysing gamma-gamma coincidences in the reaction 46Ti(alpha,n)49Cr at the bombarding energy of 12 MeV. The level scheme has been greatly extended at low excitation energy and several new lifetimes have been determined by means of the Doppler Shift Attenuation Method. Shell model calculations in the full pf configuration space reproduce well negative-parity levels. Satisfactory agreement is obtained for positive parity levels by extending the configuration space to include a nucleon-hole either in the 1d3/2 or in the 2s1/2 orbitals. A nearly one-to-one correspondence is found between experimental and theoretical levels up to an excitation energy of 4 MeV. Experimental data and shell model calculations are interpreted in terms of the Nilsson diagram and the particle-rotor model, showing the strongly coupled nature of the bands in this prolate nucleus. Nine values of K(pi) are proposed for the levels observed in this experiment. As a by-result it is shown that the values of the experimental magnetic moments in 1f7/2 nuclei are well reproduced without quenching the nucleon g-factors.Comment: 13 pages, 8 figure

The HADES RV Programme with HARPS-N@TNG IV. Time resolved analysis of the Ca ii H&K and H{\alpha} chromospheric emission of low-activity early-type M dwarfs

M dwarfs are prime targets for planet search programs, particularly of those focused on the detection and characterization of rocky planets in the habitable zone. Understanding their magnetic activity is important because it affects our ability to detect small planets, and it plays a key role in the characterization of the stellar environment. We analyze observations of the Ca II H&K and H{\alpha} lines as diagnostics of chromospheric activity for low-activity early-type M dwarfs. We analyze the time series of spectra of 71 early-type M dwarfs collected for the HADES project for planet search purposes. The HARPS-N spectra provide simultaneously the H&K doublet and the H{\alpha} line. We develop a reduction scheme able to correct the HARPS-N spectra for instrumental and atmospheric effects, and to provide flux-calibrated spectra in units of flux at the stellar surface. The H&K and H{\alpha} fluxes are compared with each other, and their variability is analyzed. We find that the H and K flux excesses are strongly correlated with each other, while the H{\alpha} flux excess is generally less correlated with the H&K doublet. We also find that H{\alpha} emission does not increase monotonically with the H&K line flux, showing some absorption before being filled in by chromospheric emission when H&K activity increases. Analyzing the time variability of the emission fluxes, we derive a tentative estimate of the rotation period (of the order of a few tens of days) for some of the program stars, and the typical lifetime of chromospheric active regions (a few stellar rotations). Our results are in good agreement with previous studies. In particular, we find evidence that the chromospheres of early-type M dwarfs could be characterized by different filaments coverage, affecting the formation mechanism of the H{\alpha} line. We also show that chromospheric structure is likely related to spectral type