267 research outputs found
Does Law School Still Make Economic Sense?: An Empirical Analysis of Big Law Firm Partnership Prospects and the Relationship to Law School Attended
Prospective law students and those in the legal community are often precluded from properly evaluating the potential likelihood that their choice of law school can measurably and tangibly impact their prospects for big law firm partnership 1 and its attendant, anticipated economic rewards. In an effort to answer the question of whether law school makes sense from an economic decision-making rationale - if one assumes (and we can certainly argue about this assumption) that one objective to attending law school is to become a partner in a large (and generally lucrative) law firm setting - this Study examines the characteristics of partners at large law firms across the country according to five main variable
Initial Sulfonylurea Use and Subsequent Insulin Therapy in Older Subjects with Type 2 Diabetes Mellitus
BACKGROUND: In type 2 diabetes mellitus (T2DM), progressive loss of beta cell function over time requires treatment intensification and eventually initiation of insulin for many patients. Relative to metformin, a greater rate of decline in beta cell function over time has been observed with sulfonylurea treatment. The present study examined the association between initial monotherapy with metformin or sulfonylurea and subsequent initiation of insulin in older subjects with T2DM. METHODS: In a retrospective cohort study using the GE electronic medical record database, eligible subjects with T2DM included those ≥65 years who received their first prescription of sulfonylurea or metformin as initial monotherapy between January 1, 2003 to December 31, 2008. The follow-up period lasted to the end of 2009 or the subject’s latest data available. Insulin initiation was determined by prescription records. Logistic regression analysis evaluated the likelihood of insulin addition. A Cox regression model estimated time to initiation of insulin. Differences in baseline characteristics were controlled for using propensity score matching. RESULTS: Overall, 12,036 subjects were included in the analysis. Mean age was 75 years and 50% were male. Subjects who initiated with sulfonylurea had a significantly (P < 0.001) higher incidence of insulin addition (2.8% vs. 1.4%) compared to those initiated with metformin within 1 year of follow-up. The likelihood of initiating insulin was higher in subjects initiated with sulfonylurea than with metformin (adjusted odds ratio 1.82, 95% confidence interval [CI] 1.40–2.38; P < 0.001). Sulfonylurea use was also significantly associated with a shorter time to insulin use compared to metformin (adjusted hazards ratio 2.10, 95% CI 1.83–2.39; P < 0.001). CONCLUSION: In a cohort of older subjects with T2DM initiating antihyperglycemic therapy, new users of sulfonylurea monotherapy were more likely to receive insulin therapy and received it earlier than those starting with metformin
Disease burden of urinary tract infections among type 2 diabetes mellitus patients in the U.S.
AbstractAimsType 2 diabetes is a reported risk factor for more frequent and severe urinary tract infections (UTI). We sought to quantify the annual healthcare cost burden of UTI in type 2 diabetic patients.MethodsAdult patients diagnosed with type 2 diabetes were identified in MarketScan administrative claims data. UTI occurrence and costs were assessed during a 1-year period. We examined UTI-related visit and antibiotic costs among patients diagnosed with UTI, comparing those with versus without a history of UTI in the previous year (prevalent vs. incident UTI cases). We estimated the total incremental cost of UTI by comparing all-cause healthcare costs in patients with versus without UTI, using propensity score-matched samples.ResultsWithin the year, 8.2% (6,014/73,151) of subjects had ≥1 UTI, of whom 33.8% had a history of UTI. UTI-related costs among prevalent versus incident cases were, respectively, 447 (p=0.033) for outpatient services, 1,819 (p=NS) for hospitalizations, and 35 (p<0.0001) for antibiotics. UTI was associated with a total all-cause incremental cost of $7,045 (95% CI: 4,130, 13,051) per patient with UTI per year.ConclusionsUTI is common and may impose a substantial direct medical cost burden among patients with type 2 diabetes
Determination of alphaS from Hadronic Event Shapes in e+e- Annihilation at 192 < sqrt(s) < 208 GeV
Results are presented from a study of the structure of high energy hadronic
events recorded by the L3 detector at sqrt(s)>192 GeV. The distributions of
several event shape variables are compared to resummed O(alphaS^2) QCD
calculations. We determine the strong coupling constant at three average
centre-of-mass energies: 194.4, 200.2 and 206.2 GeV. These measurements,
combined with previous L3 measurements at lower energies, demonstrate the
running of alphaS as expected in QCD and yield alphaS(mZ) = 0.1227 +- 0.0012 +-
0.0058, where the first uncertainty is experimental and the second is
theoretical
Neutral-Current Four-Fermion Production in e+e- Interactions at LEP
Neutral-current four-fermion production, e+e- -> ffff is studied in 0.7/fb of
data collected with the L3 detector at LEP at centre-of-mass energies
root(s)=183-209GeV. Four final states are considered: qqvv, qqll, llll and
llvv, where l denotes either an electron or a muon. Their cross sections are
measured and found to agree with the Standard Model predictions. In addition,
the e+e- -> Zgamma* -> ffff process is studied and its total cross section at
the average centre-of-mass energy 196.6GeV is found to be 0.29 +/- 0.05 +/-
0.03 pb, where the first uncertainty is statistical and the second systematic,
in agreement with the Standard Model prediction of 0.22 pb. Finally, the mass
spectra of the qqll final states are analysed to search for the possible
production of a new neutral heavy particle, for which no evidence is found
Study of the e+e- -> Ze+e- process at LEP
The cross section of the process e+e- -> Ze+e is measured with 0.7fb^-1 of
data collected with the L3 detector at LEP. Decays of the Z boson into quarks
and muons are considered at centre-of-mass energies ranging from 183GeV up to
209GeV. The measurements are found to agree with Standard Model predictions,
achieving a precision of about 10% for the hadronic channel
Inclusive Lambda Production in Two-Photon Collisions at LEP
The reactions e^+e^- -> e^+e^- Lambda X and e^+e^- -> e^+e^- Lambda X are
studied using data collected at LEP with the L3 detector at centre-of-mass
energies between 189 and 209 GeV. Inclusive differential cross sections are
measured as a function of the lambda transverse momentum, p_t, and
pseudo-rapidity, eta, in the ranges 0.4 GeV < p_t < 2.5 GeV and |\eta| < 1.2.
The data are compared to Monte Carlo predictions. The differential cross
section as a function of p_t is well described by an exponential of the form A
exp (- p_t / )$
Search for Charged Higgs Bosons at LEP
A search for pair-produced charged Higgs bosons is performed with the L3
detector at LEP using data collected at centre-of-mass energies between 189 and
209GeV, corresponding to an integrated luminosity of 629.4/pb. Decays into a
charm and a strange quark or into a tau lepton and its neutrino are considered.
No significant excess is observed and lower limits on the mass of the charged
Higgs boson are derived at the 95% confidence level. They vary from 76.5 to
82.7GeV, as a function of the H->tv branching ratio
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