111 research outputs found

    Chiral Symmetry restoration in the massive Thirring model at finite T and μ\mu: Dimensional reduction and the Coulomb gas

    Get PDF
    We show that in certain limits the (1+1)-dimensional massive Thirring model at finite temperature TT is equivalent to a one-dimensional Coulomb gas of charged particles at the same TT. This equivalence is then used to explore the phase structure of the massive Thirring model. For strong coupling and T>>mT>>m (the fermion mass) the system is shown to behave as a free gas of "molecules" (charge pairs in the Coulomb gas terminology) made of pairs of chiral condensates. This binding of chiral condensates is responsible for the restoration of chiral symmetry as TT\to\infty. In addition, when a fermion chemical potential μ0\mu\neq 0 is included, the analogy with a Coulomb gas still holds with μ\mu playing the role of a purely imaginary external electric field. For small TT and μ\mu we find a typical massive Fermi gas behaviour for the fermion density, whereas for large μ\mu it shows chiral restoration by means of a vanishing effective fermion mass. Some similarities with the chiral properties of low-energy QCD at finite TT and baryon chemical potential are discussed.Comment: 28 pages, 6 figures, better resolution figures are available upon reques

    Data curation during a pandemic and lessons learned from COVID-19

    Get PDF
    Detailed, accurate data related to a disease outbreak enable informed public health decision making. Given the variety of data types available across different regions, global data curation and standardization efforts are essential to guarantee rapid data integration and dissemination in times of a pandemic.Data availability The underlying dataset for Fig. 1a is available open access from the supplemental material in ref. 5, and datasets for Fig. 1b,c from the UNESCO World Heritage List 2021 in ref. 32.https://www.nature.com/natcomputscihj2023Computer Scienc

    Zinc status alters Alzheimer’s disease progression through NLRP3-dependent inflammation

    Get PDF
    Alzheimer’s disease is a devastating neurodegenerative disease with a dramatically increasing prevalence and no disease-modifying treatment. Inflammatory lifestyle factors increase the risk of developing Alzheimer’s disease. Zinc deficiency is the most prevalent malnutrition in the world and may be a risk factor for Alzheimer’s disease potentially through enhanced inflammation, although evidence for this is limited. Here we provide epidemiological evidence suggesting that zinc supplementation was associated with reduced risk and slower cognitive decline, in people with Alzheimer’s disease and mild cognitive impairment. Using the APP/PS1 mouse model of Alzheimer’s disease fed a control (35mg/kg zinc) or diet deficient in zinc (3mg/kg zinc), we determined that zinc deficiency accelerated Alzheimer’s-like memory deficits without modifying amyloid beta (β) plaque burden in the brains of male mice. The NLRP3-inflammasome complex is one of the most important regulators of inflammation and we show here that zinc deficiency in immune cells, including microglia, potentiated NLRP3 responses to inflammatory stimuli in vitro including amyloid oligomers, while zinc supplementation inhibited NLRP3 activation. APP/PS1 mice deficient in NLRP3 were protected against the accelerated cognitive decline with zinc deficiency. Collectively, this research suggests that zinc status is linked to inflammatory reactivity and may be modified in people to reduce the risk and slow the progression of Alzheimer’s disease

    Madagascar’s extraordinary biodiversity: Evolution, distribution, and use

    Get PDF
    Madagascar's biota is hyperdiverse and includes exceptional levels of endemicity. We review the current state of knowledge on Madagascar's past and current terrestrial and freshwater biodiversity by compiling and presenting comprehensive data on species diversity, endemism, and rates of species description and human uses, in addition to presenting an updated and simplified map of vegetation types. We report a substantial increase of records and species new to science in recent years; however, the diversity and evolution of many groups remain practically unknown (e.g., fungi and most invertebrates). Digitization efforts are increasing the resolution of species richness patterns and we highlight the crucial role of field- and collections-based research for advancing biodiversity knowledge and identifying gaps in our understanding, particularly as species richness corresponds closely to collection effort. Phylogenetic diversity patterns mirror that of species richness and endemism in most of the analyzed groups. We highlight humid forests as centers of diversity and endemism because of their role as refugia and centers of recent and rapid radiations. However, the distinct endemism of other areas, such as the grassland-woodland mosaic of the Central Highlands and the spiny forest of the southwest, is also biologically important despite lower species richness. The documented uses of Malagasy biodiversity are manifold, with much potential for the uncovering of new useful traits for food, medicine, and climate mitigation. The data presented here showcase Madagascar as a unique living laboratory for our understanding of evolution and the complex interactions between people and nature. The gathering and analysis of biodiversity data must continue and accelerate if we are to fully understand and safeguard this unique subset of Earth's biodiversity

    Madagascar’s extraordinary biodiversity: Threats and opportunities

    Get PDF
    Madagascar's unique biota is heavily affected by human activity and is under intense threat. Here, we review the current state of knowledge on the conservation status of Madagascar's terrestrial and freshwater biodiversity by presenting data and analyses on documented and predicted species-level conservation statuses, the most prevalent and relevant threats, ex situ collections and programs, and the coverage and comprehensiveness of protected areas. The existing terrestrial protected area network in Madagascar covers 10.4% of its land area and includes at least part of the range of the majority of described native species of vertebrates with known distributions (97.1% of freshwater fishes, amphibians, reptiles, birds, and mammals combined) and plants (67.7%). The overall figures are higher for threatened species (97.7% of threatened vertebrates and 79.6% of threatened plants occurring within at least one protected area). International Union for Conservation of Nature (IUCN) Red List assessments and Bayesian neural network analyses for plants identify overexploitation of biological resources and unsustainable agriculture as themost prominent threats to biodiversity. We highlight five opportunities for action at multiple levels to ensure that conservation and ecological restoration objectives, programs, and activities take account of complex underlying and interacting factors and produce tangible benefits for the biodiversity and people of Madagascar

    The role of Big Data in explaining disaster resilience in supply chains for sustainability

    Get PDF
    The purpose of this paper is to propose and test a theoretical framework to explain resilience in supply chain networks for sustainability using unstructured Big Data, based upon 36,422 items gathered in the form of tweets, news, Facebook, WordPress, Instagram, Google+, and YouTube, and structured data, via responses from 205 managers involved in disaster relief activities in the aftermath of Nepal earthquake in 2015. The paper uses Big Data analysis, followed by a survey which was analyzed using content analysis and confirmatory factor analysis (CFA). The results of the analysis suggest that swift trust, information sharing and public-private partnership are critical enablers of resilience in supply chain networks. The current study used crosssectional data. However the hypotheses of the study can be tested using longitudinal data to attempt to establish causality. The article advances the literature on resilience in disaster supply chain networks for sustainability in that (i) it suggests the use of Big Data analysis to propose and test particular frameworks in the context of resilient supply chains that enable sustainability; (ii) it argues that swift trust, public private partnerships, and quality information sharing link to resilience in supply chain networks; and (iii) it uses the context of Nepal, at the moment of the disaster relief activities to provide contemporaneous perceptions of the phenomenon as it takes place. Vol 142 (2) pp.1108-111
    corecore