Pancreatic phospholipase A2 activity in acute pancreatitis: A prognostic marker for early identification of patients at risk

Remarkably elevated levels of phospholipase A(2) (PLA(2)) are measurable in human blood samples in cases of acute pancreatitis. The source of the enzyme was first thought to be exclusively the pancreas, but now it is generally accepted that two isoenzymes the pancreatic PLA(2), group I, and the extrapancreatic PLA(2), group II contribute to the raised activity. In contrast to the group II-PLA(2), the pancreatic PLA(2) is heatresistant for 1 hour at 60 degreesC. The catalytically inactive proenzyme of the pancreatic PLA(2) can be activated by trypsin. The aim of our study was to evaluate the diagnostic value of PLA(2) isoenzyme activity measurements to identify patients with severe complications in acute pancreatitis. Blood samples from patients suffering from acute pancreatitis were analyzed for catalytically active pancreatic PLA(2) on day 1 and 2 of hospitalization with a modified radiometric Escherichia colibased PLA(2) assay. In 10 of 41 patients clearly elevated values of catalytically active, heatresistant pancreatic PLA(2) (7.2 to 81.2 U/l) were observed. This group of patients was characterized by severe complications (necrotizing pancreatitis, shock, sepsis, respiratory problems) of which two patients subsequently died. Patients with low or undetectable activity (<7 U/l) of pancreatic PLA(2) recovered rapidly. According to these results the presence of catalytically active pancreatic PLA(2) in serum is associated with severe complications of acute pancreatitis. In contrast to total serumPLA(2), the catalytic concentration of pancreatic PLA(2) can serve as a prognostic marker in acute pancreatitis

Assessing meaning in life on an international scale: Psychometric evidence for the Meaning in Life Questionnaire-Short Form among Chilean households

Several research projects have endeavored to articulate parsimonious and comprehensive accounts of wellbeing. A set of core concepts is seen to be emerging, including the psychological wellbeing module of the Oxford Poverty and Human Development Initiative’s international research on poverty. One of the core components of wellbeing according to this initiative and others is meaning in life. The present study focuses on a psychometric evaluation of a short measure of meaning in life to be used in international measurement of wellbeing, using data from a nationally-representative sample of households in Chile (N = 1,997). The factor structure of the Meaning in Life Questionnaire-Short Form (MLQ-SF) was confirmed, and shown to be invariant across gender and age. The items of the MLQ-SF formed a factor that was distinct from the items of other wellbeing measures that were assessed (psychological needs, life satisfaction, and domain satisfaction). Scores on the MLQ-SF were reliable in this sample, and correlated in the expected directions with other wellbeing indicators. We conclude that the MLQ-SF shows distinct promise as a measure of a core component of wellbeing—meaning in life—in international research.

Effect of weather condition on LoRa IoT communication technology in a tropical region: Malaysia

An experimental study on the effect of weather conditions such as solar radiation, humidity, temperature, and rain on the Long Range (LoRa) communication in a tropical region (Malaysia) via a campus environment has been carried out and analyzed. The weather parameters were obtained from an online meteorological weather station (Meteoblue) and the use of a local automatic weather station. A temperature sensor was attached to the LoRa node to measure the onboard temperature. We analyze the diurnal variation and the effects of the weather condition based on the LoRa link in a LoRaWAN setup. A regular pattern of RSSI was observed with stronger RSSI values having a positive correlation with the atmospheric temperature, onboard temperature, and solar radiation during the day but degrades in late evenings. The positive correlation and pattern observed can be attributed to the prevailing metrological conditions and opens room for further research needed for propagation modeling. The RSSI signals and relative humidity, on the other hand, showed no correlation. Furthermore, strong RSSI signals were obtained when the atmospheric temperature was between 30 - 40 °C, and the onboard temperature between 40 - 50 °C. No significant impact was observed on the RSSI signals when the rainfall rates vary from 12 mm/h to 180 mm/h. The study presents useful information to be considered on the effects of weather conditions in the propagation model and deployment of LoRa for IoT communication

A New Troodontid Theropod, Talos sampsoni gen. et sp. nov., from the Upper Cretaceous Western Interior Basin of North America

Troodontids are a predominantly small-bodied group of feathered theropod dinosaurs notable for their close evolutionary relationship with Avialae. Despite a diverse Asian representation with remarkable growth in recent years, the North American record of the clade remains poor, with only one controversial species--Troodon formosus--presently known from substantial skeletal remains.Here we report a gracile new troodontid theropod--Talos sampsoni gen. et sp. nov.--from the Upper Cretaceous Kaiparowits Formation, Utah, USA, representing one of the most complete troodontid skeletons described from North America to date. Histological assessment of the holotype specimen indicates that the adult body size of Talos was notably smaller than that of the contemporary genus Troodon. Phylogenetic analysis recovers Talos as a member of a derived, latest Cretaceous subclade, minimally containing Troodon, Saurornithoides, and Zanabazar. MicroCT scans reveal extreme pathological remodeling on pedal phalanx II-1 of the holotype specimen likely resulting from physical trauma and subsequent infectious processes.Talos sampsoni adds to the singularity of the Kaiparowits Formation dinosaur fauna, which is represented by at least 10 previously unrecognized species including the recently named ceratopsids Utahceratops and Kosmoceratops, the hadrosaurine Gryposaurus monumentensis, the tyrannosaurid Teratophoneus, and the oviraptorosaurian Hagryphus. The presence of a distinct troodontid taxon in the Kaiparowits Formation supports the hypothesis that late Campanian dinosaurs of the Western Interior Basin exhibited restricted geographic ranges and suggests that the taxonomic diversity of Late Cretaceous troodontids from North America is currently underestimated. An apparent traumatic injury to the foot of Talos with evidence of subsequent healing sheds new light on the paleobiology of deinonychosaurians by bolstering functional interpretations of prey grappling and/or intraspecific combat for the second pedal digit, and supporting trackway evidence indicating a minimal role in weight bearing

Subsequent Event Risk in Individuals with Established Coronary Heart Disease:Design and Rationale of the GENIUS-CHD Consortium

BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators

Development of two-dimensional chromatographic methods for the separation and characterization of polyesters of different degrees of branching

The demand for new and innovative products with new or improved properties leads to the synthesis of a large variety of new complex polymer structures. One way to synthesize structures with new or improved properties is the introduction of branches. The introduction of branches results however in an another type of heterogeneity besides the most commonly known according to molar mass, making the characterization of these complex structures more complicated. However, there is a need for the characterization of these complex structures, since the knowledge of the detailed topological characteristics and their effect on material properties will ultimately allow the design of new tailor made high-performance polymers. Thus, the necessity for new characterization methods grows. These methods should allow understanding the molecular structures of such polymer products in order to relate them to the observed macroscopic properties. The aim of the present thesis was to develop new liquid chromatographic methods for the characterization of the degree of branching (DB) and DB distribution of branched polyesters in order to gain a better understanding on how branching influences the structure-property relationship of polymeric materials. Present analytical techniques for the characterization of linear and branched polyesters do not exist or are limited to yield only average values on e.g. the DB of the whole sample. However, for a detailed characterization of branched polymers, more information than the average DB has to be obtained. Therefore, the focus on the method development within this PhD thesis was on conventional and multidimensional liquid chromatographic techniques, which allow a more detailed characterization of linear and branched polymers