Cuerpo. Vestido. Paisaje

Clothing, as the first space of living, raises a deep consciousness on the relation between body and space. Itaims at the wonderful notion of mutual affectation and at the possibility of understanding this bond like an infinite continuity between landscape and life.El vestido como primer espacio del habitar plantea una profunda conciencia sobre la relación entre el cuerpo y el espacio. Apunta a la maravillosa noción de afectación mutua y desde allí a laposibilidad de entender este vínculo como una continuidad infinita entre el paisaje y la vida.O vestido como primeiro espaço do habitar propõe uma profunda consciência sobre a relação entre o corpo eo espaço. Aponta à maravilhosa noção de afetação mútua e desde ali à possibilidade de entender este vínculo como umacontinuidade infinita entre a paisagem e a vida

Museo, tramas, cuerpo y experiencia

 This text, in the form of an epistolary dialogue, approaches the imaginary of the Museum from three particular points of view that intertwine and complement each other. Este texto, en formato de diálogo epistolar, aborda el imaginario del Museo desde tres miradas particulares que se entraman y complementan.&nbsp

Biodegradable PEG-poly(ω-pentadecalactone- co - p -dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors

Intracranial delivery of therapeutic agents is limited by penetration beyond the blood-brain barrier (BBB) and rapid metabolism of the drugs that are delivered. Convection-enhanced delivery (CED) of drugloaded nanoparticles (NPs) provides for local administration, control of distribution, and sustained drug release. While some investigators have shown that repeated CED procedures are possible, longer periods of sustained release could eliminate the need for repeated infusions, which would enhance safety and translatability of the approach. Here, we demonstrate that nanoparticles formed from poly(ethylene glycol)-poly(u-pentadecalactone-co-p-dioxanone) block copolymers [PEG-poly(PDL-co- DO)] are highly efficient nanocarriers that provide long-term release: small nanoparticles (less than 100 nm in diameter) continuously released a radiosensitizer (VE822) over a period of several weeks in vitro, provided widespread intracranial drug distribution during CED, and yielded significant drug retention within the brain for over 1 week. One advantage of PEG-poly(PDL-co-DO) nanoparticles is that hydrophobicity can be tuned by adjusting the ratio of hydrophobic PDL to hydrophilic DO monomers, thus making it possible to achieve a wide range of drug release rates and drug distribution profiles. When administered by CED to rats with intracranial RG2 tumors, and combined with a 5-day course of fractionated radiation therapy, VE822-loaded PEG-poly(PDL-co-DO) NPs significantly prolonged survival when compared to free VE822. Thus, PEG-poly(PDL-co-DO) NPs represent a new type of versatile nanocarrier system with potential for sustained intracranial delivery of therapeutic agents to treat brain tumors

Synchronous volcanic eruptions and abrupt climate change ∼17.7 ka plausibly linked by stratospheric ozone depletion.

Glacial-state greenhouse gas concentrations and Southern Hemisphere climate conditions persisted until ∼17.7 ka, when a nearly synchronous acceleration in deglaciation was recorded in paleoclimate proxies in large parts of the Southern Hemisphere, with many changes ascribed to a sudden poleward shift in the Southern Hemisphere westerlies and subsequent climate impacts. We used high-resolution chemical measurements in the West Antarctic Ice Sheet Divide, Byrd, and other ice cores to document a unique, ∼192-y series of halogen-rich volcanic eruptions exactly at the start of accelerated deglaciation, with tephra identifying the nearby Mount Takahe volcano as the source. Extensive fallout from these massive eruptions has been found >2,800 km from Mount Takahe. Sulfur isotope anomalies and marked decreases in ice core bromine consistent with increased surface UV radiation indicate that the eruptions led to stratospheric ozone depletion. Rather than a highly improbable coincidence, circulation and climate changes extending from the Antarctic Peninsula to the subtropics-similar to those associated with modern stratospheric ozone depletion over Antarctica-plausibly link the Mount Takahe eruptions to the onset of accelerated Southern Hemisphere deglaciation ∼17.7 ka

Speciation analysis of iodine and bromine at picogram-per-gram levels in polar ice

Iodine and bromine species participate in key atmospheric reactions including the formation of cloud con- densation nuclei and ozone depletion. We present a novel method coupling a high-performance liquid chromatogra- phy with ion chromatography and inductively coupled plas- ma mass spectrometry, which allows the determination of iodine (I) and bromine (Br) species (IO3−, I−, Br−, BrO3−) at the picogram-per-gram levels presents in Antarctic ice. Chromatographic separation was achieved using an ION- PAC® AS16 Analytical Column with NaOH as eluent. Detection limits for I and Br species were 5 to 9 pg g−1 with an uncertainty of less than 2.5% for all considered species. Inorganic iodine and bromine species have been determined in Antarctic ice core samples, with concentrations close to the detection limits for iodine species, and approximately 150 pg g−1 for Br−. Although iodate (IO3−) is the most abundant iodine species in the atmosphere, only the much rarer iodide (I−) species was present in Antarctic Holocene ice. Bromine was found to be present in Antarctic ice as Br−

Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA, software that quantifies tumor content in cfDNA from 0.1× coverage whole-genome sequencing data without prior knowledge of tumor mutations. We apply ichorCNA to 1439 blood samples from 520 patients with metastatic prostate or breast cancers. In the earliest tested sample for each patient, 34% of patients have ≥10% tumor-derived cfDNA, sufficient for standard coverage whole-exome sequencing. Using whole-exome sequencing, we validate the concordance of clonal somatic mutations (88%), copy number alterations (80%), mutational signatures, and neoantigens between cfDNA and matched tumor biopsies from 41 patients with ≥10% cfDNA tumor content. In summary, we provide methods to identify patients eligible for comprehensive cfDNA profiling, revealing its applicability to many patients, and demonstrate high concordance of cfDNA and metastatic tumor whole-exome sequencing

Vínculos

In this article, the author intends to discuss the body as something that can be perceived as a cultural construction, which reveals the individuals’ life and sociability. If life refers to changes, so it is essential to establish again this basic situation formed by the world and us, fixing its focus on the link and the woof. We understand that we are a landscape, a context-body which represents a unity like na ocean wave. And this space is built between the relation. It is no more a universe of statical forms; it just transforms itself in a scenery of dynamic events and situations between thebody and the space. Surface, silhouette and links are elements that allow this analogy body-landscape.Neste artigo, pretende-se discutir que o corpo pode ser percebido como uma construção cultural que manifesta a vida e a sociabilidade dos indivíduos. Se a vida se refere à troca, então é indispensável voltar a restabelecer esta situação básica que é o laço entre nós e o mundo, estabelecer foco no vínculo, na trama. Entende-se que somos paisagem, um corpo-contexto que representa uma unidade como uma onda no mar. E este espaço se constrói na relação. Deixa de ser um universo de formas estáticas para se converter em cenário de acontecimentos e situações dinâmicas entre o corpo e o espaço. Superfície, silhueta e vínculos são todos elementos que nos permitem fazer esta analogia entre corpo e paisagem

Private Bar Delivery of Civil Legal Services to the Poor: A Design for a Combined Private Attorney and Staffed Office Delivery System

Since the advent of federally funded civil legal services to the poor, there has been a debate over which is the better delivery system for those services-the staffed office delivery system or the private attorney (judicare) delivery system. This Article does not join that debate, but rather proposes a hybrid delivery system that combines elements of both the staffed office and judicare systems. After an overview of the delivery system debate, the Article discusses the potential of a combined delivery system and presents a detailed design for such a system. The proposal includes a discussion of: type of panel; the scope of the private attorney component; the intake process, including eligibility determination, case approval, and case referral; payment of attorneys; and quality of service, including quality assurance and quality training techniques. The Article concludes that the implementation of such a combined delivery system could lead to the goal sought by both sides of the delivery system debate---effective and efficient civil legal services to the poor