Stratigraphy and Depositional Environment of the Elgin Sandstone (Pennsylvanian) in South-Central Kansas

The Elgin sandstone, a unit in the Kanwaka Shale (Virgilian, Upper Pennsylvanian), crops out in south-central Kansas. Distribution of the Elgin, which ranges from 0 to 180 feet in thickness, indicates that it was deposited in a shallow-marine to marginal-marine environment controlled by the distributary pattern of a large delta complex. Major source of the material for the clastic wedge was from the south in the Arbuckle-Ouachita Mountain area. Distribution of the Elgin Sandstone seemingly was not influenced by the algal limestone buildups f the underlying Plattsmouth Limestone Member of the Oread Limestone, although the basal shales of the Kanwaka reflect the presence of these buildups

Fixação de nitrogênio e crescimento de Alnus Rubra fertilização com uréia ou biosólidos

Nitrogen fertilization of forests using biosolids offers a potentially environmentally friendly means to accelerate tree growth. This field study was designed to analyze the effects of nitrogen fertilization on the symbiotic, nitrogen (N)-fixing relationship between Alnus rubra Bong. (red alder) and Frankia. Anaerobically digested, class B biosolids and synthetic urea (46% N) were applied at rates of 140, 280 and 560 kg ha-1 available N to a well-drained, sandy, glacial outwash soil in the Indianola series (mixed, mesic Dystric Xeropsamments). Plots were planted with A. rubra seedlings. At the end of each of two growing seasons trees were harvested and analyzed for the rate of N fixation (as acetylene reduction activity), biomass and foliar N. At year 1, there was no N fixation for trees grown with urea amendments, but control (17 µmol C2H4 g-1 hr-1) and biosolids (26-45 µmol C2H4 g-1 hr-1) trees were fixing N. At the end of year 2, all trees in all treatments were fixing N (7 µmol C2H4 g-1 hr-1, 4-16 µmol C2H4 g-1 hr-1, and 20-29 µmol C2H4 g-1 hr-1 for control, urea and biosolids respectively). Trees grown with biosolids amendments were larger overall (year 1 shoot biomass 10 g, 5 g, and 23 g for control, urea, and biosolids respectively, year 2 shoot biomass 50 g, 51 g, and 190 g for control, urea, and biosolids respectively) with higher concentrations of foliar N for both years of the study (year 1 foliar N 26 g kg-1, 27 g kg-1, and 40 g kg-1 for control, urea, and biosolids respectively, year 2 foliar N 17 g kg-1, 19 g kg-1, and 23 g kg-1 for control, urea, and biosolids respectively). Trees grown with urea amendments appeared to use the urea N over Frankia supplied N, whereas the biosolids trees appeared to be able to use both N in biosolids and N from Frankia. The results from this study indicated that the greater growth of A. rubra may have been responsible for the observed higher N demand. Biosolids may have supplied other nutrients to the trees to support this accelerated growth.A fertilização nitrogenada de florestas com biosólidos constitui um meio de aceleração do crescimento das plantas potencialmente não impactante ao meio. Os efeitos de fertilização de nitrogênio atmosférico na relação simbiôntica e de fixação de nitrogênio Alnus rubra Bong. (amieiro vermelho) e Frankia foram avaliados em um estudo de campo. Biosólidos classe B digeridos anaerobicamente e uréia sintética (46% N) foram aplicados a taxas de 140, 280 e 560 kg ha-1 de N disponível em um solo tipo Areia Quartzosa. Ao contrário das plantas do grupo controle (17 µmol C2H4 g-1 hr-1) ou fertilizadas com biosólidos (26-45 µmol C2H4 g-1 hr-1), plantas fertilizadas com uréia não apresentavam fixação de nitrogênio após um ano de cultivo. Ao final do segundo ano, todas as árvores em todos os tratamentos fixavam N (7 µmol C2H4 g-1 hr-1; 4-16 µmol C2H4 g-1 hr-1; e 20-29 µmol C2H4 g-1 hr-1 para controle, uréia e biosólidos, respectivamente). Plantas cultivadas sob remediação com biosólidos apresentaram maior biomassa na parte aérea ao final do ano 2 (50 g; 51 g; e 190 g para controle, uréia, e biosólidos, respectivamente), e também maiores concentrações de nitrogênio foliar em ambos os períodos analisados (N foliar no ano 1 26 g kg-1, 27 g kg-1, e 40 g kg-1; N foliar no ano 2 17 g kg-1, 19 g kg-1, and 23 g kg-1, respectivamente para controle, uréia e biosólidos). A maior taxa de crescimento de A. rubra pode ter resultado em maior exigência em N e os biosólidos supriram quantidades adicionais de nutrientes capazes de sustentar o crescimento acelerado

Crescimento e fixação de nitrogênio por Alnus rubra cultivado sob fertilização com biosólidos com altos e baixos teores de metais

Forest application of biosolids offers a potential environmentally friendly alternative to landfilling. This two-year investigation was designed to analyze the effects of elevated soil metal concentration resulting from the land application of biosolids on the symbiotic, nitrogen (N) fixing relationship between Alnus rubra Bong. (red alder) and Frankia. High metal biosolids and a modern-day composted biosolid applied at high loading rates of 250, 500, and 1000 Mg ha-1, were used to represent a worst-case scenario for metal contamination. The high metal biosolids were obtained before the current regulations were formulated and had been lagooned prior to use in this study. Total cadmium (Cd), lead (Pb) and zinc (Zn) in the high metal biosolids were 45, 958, and 2623 mg kg-1 respectively. These metal concentrations are above current regulatory limits in the US. The compost was made using biosolids that are currently produced and had Cd, Pb and Zn of 0.8, 20 and 160 mg kg-1 respectively. Trees were harvested and analyzed for rate of N fixation (as measured by acetylene reduction activity), biomass, and foliar metals. Soils were analyzed for available N, total carbon and N, pH and total Cd, Pb and Zn. Rates of N fixation were not affected by soil amendment. In year 2, shoot biomass of trees grown in both the compost and high metal amendments were higher than the control. Shoot biomass increased with increasing amount of compost amendments, but decreased with increasing amount of high metal amendments. There was no relationship between soil metal concentration and plant biomass. Foliar Cd and Pb were below detection for all trees and foliar Zn increased with increasing amount of both compost and high metal amendment, with concentrations of 249 mg kg-1 for trees grown in the compost amendment and 279 mg kg-1 for the high metal amendment. The results from this study indicate that the growth of A. rubra benefited from both types of biosolids used in the study and that the Alnus/Frankia relationship was not negatively impacted by metal concentrations resulting from the high metal biosolids amendments.A aplicação de biosólidos em florestas representa uma potencial alternativa ambientalmente correta para aterros sanitários. Os efeitos de fertilização de nitrogênio na relação simbiôntica e de fixação de nitrogênio Alnus rubra Bong. (amieiro vermelho) e Frankia foram avaliados em um estudo de campo conduzido por dois anos. Um biosólido com concentração de metais muito acima dos marcos regulatórios (45 mg kg-1 Cd; 958 mg kg-1 Pb; 2623 mg kg-1 Zn) produzido há mais de 25 anos e um biosólido composto recente foram aplicados nas doses de 250, 500 e 1000 Mg ha-1, representando um cenário pior possível de concentração de metais. Ao final do segundo ano, a biomassa da parte aérea das plantas cultivadas sob ambos os compostos era maior que a das plantas controle, mas não foi observada inter-relação entre a concentração de metais no solo e a biomassa das plantas. As concentrações de Cd e Pb foliares permaneceram abaixo do nível de detecção em todas as plantas, mas a concentração de Zn foliar aumentou proporcionalmente ao aumento da adição do bioremediador, atingindo concentrações de 249 mg kg-1 e 279 mg kg-1 para os tratamentos alto metal e composto, respectivamente. Embora não tenham sido registrados efeitos negativos do biosólido com altos teores de metais, outras rotas de exposição podem levar a possíveis impactos ecológicos

Mediterranean UNESCO World Heritage at risk from coastal flooding and erosion due to sea-level rise

UNESCO World Heritage sites (WHS) located in coastal areas are increasingly at risk from coastal hazards due to sea-level rise. In this study we assess Mediterranean cultural WHS at risk from coastal flooding and erosion under four sea-level rise scenarios until 2100. Based on the analysis of spatially explicit WHS data, we develop an index-based approach that allows for ranking WHS at risk from 15 both coastal hazards. Here we show that of 49 cultural WHS located in low-lying coastal areas of the Mediterranean, 37 are at risk from a 100-year flood and 42 from coastal erosion, already today. Until 2100, flood risk may increase by 50 % and erosion risk by 13 % across the region, with considerably higher increases at individual WHS. Our results provide a first-order assessment of where adaptation is most urgently needed and can support policymakers in steering local-scale research to devise suitable adaptation strategies for each WHS

Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [⁶⁸Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith

Contaminants in commercial preparations of ‘purified’ small leucine-rich proteoglycans may distort mechanistic studies

The authors are grateful to Genodisc (EC’s 7th Framework Programme (FP7, 2007-2013) under grant agreement no. HEALTH-F2-2008-201626) and the Orthopaedic Institute Ltd for funding.This paper reports the perplexing results that came about because of seriously impure commercially available reagents. Commercial reagents and chemicals are routinely ordered by scientists and are expected to have been rigorously assessed for their purity. Unfortunately, we found this assumption to be risky. Extensive work was carried out within our laboratory using commercially-sourced preparations of the small leucine-rich proteoglycans, decorin and biglycan, to investigate their influence on nerve cell growth. Unusual results compelled us to analyse the composition and purity of both preparations of these proteoglycans using both mass spectrometry and Western blotting, with and without various enzymatic deglycosylations. Commercial ‘decorin’ and ‘biglycan’ were found to contain a mixture of proteoglycans including not only both decorin and biglycan but also fibromodulin and aggrecan. The unexpected effects of ‘decorin’ and ‘biglycan’ on nerve cell growth could be explained by these impurities. Decorin and biglycan contain either chondroitin or dermatan sulphate glycosaminoglycan chains whilst fibromodulin only contains keratan sulphate and the large (>2,500 kDa), highly glycosylated aggrecan, contains both keratan and chondroitin sulphate. The different structure, molecular weights and composition of these impurities significantly affected our work and any conclusions that could be made. These findings beg the question as to whether scientists need to verify the purity of each commercially obtained reagent used in their experiments. The implications of these findings are vast, since the effects of these impurities may already have led to inaccurate conclusions and reports in the literature with concomitant loss of researchers’ funds and time.Publisher PDFPeer reviewe

Ursinus College Bulletin, Summer 1984

Business at Ursinus • California, here they come! • Ursinus who\u27s who of Olympic field hockey • Hopeful • Helpful • Marketing of Ursinus • What you can do to help • Commencement: Leaving the garden of Eden • Faculty: Of cowboys and cactuses • Upperclass confidence: It comes with age • Staying out of the kitchen: West Indies style • Like father, like son, for better profit • Sweet & Sour poems: The farm family; Safely home • Two professors retire • Social spring for five groups • Alumna leaves $370,000 • Parents\u27 Committee meets • Richter head of CICU • Press holds third contest • Penn program accepts student • Alumnus finds hope, survives in Beirut • Four named to positions on college staff • Meistersingers tour the east • Two elected to Board of Directors • Special games at Ursinus • Society taps thirteen from Ursinus • Cogger named • Parsons elected • Lacrosse team tops • Softball team wins • Basketball coach appointed • News notes • Marriages • Births • Deaths • The tree goes onhttps://digitalcommons.ursinus.edu/new_bulletin/1038/thumbnail.jp

Morphine and fentanyl exposure during therapeutic hypothermia does not impair neurodevelopment

Background Hypothermia-treated and intubated infants with moderate or severe hypoxic-ischemic encephalopathy (HIE) usually receive morphine for sedation and analgesia (SA) during therapeutic hypothermia (TH) and endotracheal ventilation. Altered drug pharmacokinetics in this population increases the risk of drug accumulation. Opioids are neurotoxic in preterm infants. In term infants undergoing TH, the long-term effects of morphine exposure are unknown. We examined the effect of opioid administration during TH on neurodevelopmental outcome and time to extubation after sedation ended. Methods In this prospectively collected population-based cohort of 282 infants with HIE treated with TH (2007–2017), the cumulative opioid dose of morphine and equipotent fentanyl (10–60 µg/kg/h) administered during the first week of life was calculated. Clinical outcomes and concomitant medications were also collected. Of 258 survivors, 229 underwent Bayley-3 neurodevelopmental assessments of cognition, language and motor function at 18–24 months. Multivariate stepwise linear regression analysis was used to examine the relation between cumulative opioid dose and Bayley-3 scores. Three severity-groups (mild-moderate-severe) were stratified by early (<6 h) amplitude-integrated electroencephalography (aEEG) patterns. Findings The cumulative dose of opioid administered as SA during TH was median (IQR) 2121 µg/kg (1343, 2741). Time to extubation was independent of SA dose (p > 0.2). There was no significant association between cumulative SA dose and any of the Bayley-3 domains when analysing the entire cohort or any of the aEEG severity groups. Interpretation Higher cumulative opioid doses in TH-treated infants with HIE was not associated with worse Bayley-3 scores at 18–24 months of age. Funding The Bristol cooling program was funded by the Children's Medical Research Charity SPARKS managing donations for our research from the UK and US, the UK Moulton Foundation, the Lærdal Foundation for Acute Medicine in Norway and the Norwegian Research Council (JKG)

A typology of responsibility for coastal flood risk adaptation

The management of coastal flood risk is adapting to meet the challenges and increased risks posed by population change as well as by climate change, especially sea level rise. Protection is being targeted to areas where the benefits are highest, while elsewhere there is a shift towards more localized “living with floods” and “resilience” approaches. Such decentralized approaches to flood risk management (FRM) require a diverse range of stakeholder groups to be engaged as “flood risk citizens”. Engagement of households in FRM is central to this process. Despite significant research on stakeholder engagement in coastal and flood risk management, there is less focus on the nature of responsibility in coastal adaptation. There is no framework by which to assess the different types of responsibility in hazard management and adaptation, and little research on the implications of expecting these responsibilities of stakeholder groups. In this paper, we identify five types of responsibility that are embedded throughout the disaster risk reduction cycle of managing coastal flooding. We build this ”typology of responsibility” on existing work on the evolution of stakeholder engagement and stakeholder responsibility relationships in risk management processes, and a dataset of institutional stakeholder interviews and households surveys conducted across three case studies in England, the United Kingdom, in 2018 and 2019. We analyze the interviews using thematic analysis to explore institutional stakeholder perceptions of responsibility in coastal FRM, and analyze the household survey through descriptive and inferential statistics. By developing the first disaster risk reduction focused typology of responsibility for coastal flooding, we provide researchers and decision-makers with a tool to guide their planning and allocation of responsibilities in risk management for floods and other climate-driven hazards

Global Ethics and Nanotechnology: A Comparison of the Nanoethics Environments of the EU and China

The following article offers a brief overview of current nanotechnology policy, regulation and ethics in Europe and The People’s Republic of China with the intent of noting (dis)similarities in approach, before focusing on the involvement of the public in science and technology policy (i.e. participatory Technology Assessment). The conclusions of this article are, that (a) in terms of nanosafety as expressed through policy and regulation, China PR and the EU have similar approaches towards, and concerns about, nanotoxicity—the official debate on benefits and risks is not markedly different in the two regions; (b) that there is a similar economic drive behind both regions’ approach to nanodevelopment, the difference being the degree of public concern admitted; and (c) participation in decision-making is fundamentally different in the two regions. Thus in China PR, the focus is on the responsibility of the scientist; in the EU, it is about government accountability to the public. The formulation of a Code of Conduct for scientists in both regions (China PR’s predicted for 2012) reveals both similarity and difference in approach to nanotechnology development. This may change, since individual responsibility alone cannot guide S&T development, and as public participation is increasingly seen globally as integral to governmental decision-making