La filière arachide de bouche : technologie post-récolte et valorisation des produits

L'obtention de graines décortiquées d'arachide de bouche suit le même processus que les semences prêtes à l'emploi, jusqu'avant le traitement fongicide. Le croissance du marché international ne pouvant être totalement couverte par les grands pays producteurs, l'Afrique bénéficie d'une nouvelle opportunité de prise de parts de marché. L'article décrit les normes générales de production et de collecte qui doivent être respectées par le producteur et par l'organisme ou le service responsable de la commercialisation. La production de gousses triées pour l'exportation est étudié

A molecular method to discriminate between mass-reared sterile and wild tsetse flies during eradication programmes that have a sterile insect technique component

Background The Government of Senegal has embarked several years ago on a project that aims to eradicate Glossina palpalis gambiensis from the Niayes area. The removal of the animal try-panosomosis would allow the development more efficient livestock production systems. The project was implemented using an area-wide integrated pest management strategy including a sterile insect technique (SIT) component. The released sterile male flies originated from a colony from Burkina Faso. Methodology/Principal Findings Monitoring the efficacy of the sterile male releases requires the discrimination between wild and sterile male G.p. gambiensis that are sampled in monitoring traps. Before being released, sterile male flies were marked with a fluorescent dye powder. The marking was however not infallible with some sterile flies only slightly marked or some wild flies contaminated with a few dye particles in the monitoring traps. Trapped flies can also be damaged due to predation by ants, making it difficult to discriminate between wild and sterile males using a fluorescence camera and / or a fluorescence microscope. We developed a molecular technique based on the determination of cytochrome oxidase haplotypes of G. p. gambiensis to discriminate between wild and sterile males. DNA was isolated from the head of flies and a portion of the 5' end of the mitochondrial gene cytochrome oxidase I was amplified to be finally sequenced. Our results indicated that all the sterile males from the Burkina Faso colony displayed the same haplotype and systematically differed from wild male flies trapped in Senegal and Burkina Faso. This allowed 100% discrimination between sterile and wild male G. p. gambiensis. Conclusions/Significance This tool might be useful for other tsetse control campaigns with a SIT component in the framework of the Pan-African Tsetse and Trypanosomosis Eradication Campaign (PATTEC) and, more generally, for other vector or insect pest control programs

Public–private partnership in higher education provision in Tanzania: implications for access to and quality of education

published_or_final_versio

Water-condition effects on rhizobia competition for cowpea nodule occupancy

Two indigenous bradyrhizobia strains displaying different natural behaviours towards water regime (strain ORS 3257, nodulating more frequently in favourable-water conditions and strain ORS 3260, in limited-water conditions) were studied for their competitivity for nodulation of cowpea (Mouridecultivar) under favourable and limited water conditions in non-sterile soil. The nodule occupancy was studied by PCR-RFLP analysis. Both strains showed good competition with other indigenous rhizobia populations under favourable- and limited-water conditions. Competition between the inoculatedstrains in the mixture varied between water regimes. In non-limited-water conditions, strain ORS 3257 was the best competitor, whereas in limited-water conditions, strain ORS 3260 was the best competitor. Results indicated that screening of strains according to their environmental origin could ensuresuccessful rhizobia inoculatio

Monitoring and Forecasting of Coastal Erosion in the Context of Climate Change in Saint Louis (Senegal)

Owing to its unique physical and socio-economic characteristics, the Saint Louis region stands out as one of the most susceptible areas in Senegal to the adverse impacts of coastal erosion. The dynamics of erosion in this region are significantly influenced by the Langue de Barbarie (LB), a sand spit formed at the mouth of the Senegal River. Initially, in 2003, a 4 m wide artificial breach was strategically introduced to mitigate flooding; however, sediment dynamics expanded it to 6 km by 2020, thereby affecting the entire region. This study delves into the coastline change of the LB, specifically divided into three zones (LB-1, LB-2, and LB-3), spanning the period from 1994 to 2042. Leveraging Geographic Information System (GIS) and remote sensing techniques, our investigation reveals that, prior to the breach’s creation, the average dynamic coastline rates in zones LB-1, LB-2, and LB-3 were estimated at 4.4, 5.9, and 4.4 m/year, respectively. Subsequent to the breach, these rates shifted to −1.2, 8.4, and −2.7 m/year, with the most significant erosion observed alongshore of LB-3 at −6.6 m/year during the period 2002–2012. Projecting into 2032, LB-1 and LB-3 are anticipated to experience erosion rates of −11.5 and −26.8 m/year, respectively, while the LB-2 records an estimated accretion rate of 8.41 m/year. Eroded areas are expected to total 571,458 m2, while accumulated areas are expected to total 67,191 m2. By 2042, zones LB-1, LB-2, and LB-3 are expected to experience erosion rates of −23 and −53.6 m/year, resulting in the erosion of 1,021,963 m2 and the accumulation of 94,930 m2 with a dynamic rate of 168.2 m/year in zone LB-3. These results have significant implications for solving the urgent issue of coastal erosion in LB. © 2024 by the authors

Etude de l’activité antifalcémiante d’extraits de racines de Leptadenia hastata Decne. (Asclepiadacae)

L’objectif de cette étude est d’évaluer l’activité antifalcémiante d’extraits de racines de Leptadenia hastata sur des hémoglobines falciformes et d’identifier les principes actifs à l’origine de cette activité. La méthode employée étudie la réversibilité des drépanocytes, en fonction du temps d’incubation des extraits par rapport aux témoins (eau physiologique, phénylalanine et arginine) sur des échantillons de sang de patients drépanocytaires homozygotes. Des concentrations de 0,05; 0,5; 5 et 10 mg/ml de quatre extraits (méthanol, hexane, acétate d’éthyle et méthanol résiduel) ont été mises en contact avec des drépanocytes de type SS après avoir provoqué leur falciformation avec une solution à 2% de métabisulfite de sodium. L’évaluation a été effectuée toutes les 30 minutes pendant 120 minutes. Les différents extraits ont montré une activité dosedépendante sur la réversibilité de la falciformation des globules rouges avec plus de 80% d’inversion en 120 minutes pour l’extrait méthanolique, le plus actif. Un screening phytochimique a permis de faire une corrélation entre les flavonoïdes et l’activité antifalcémiante des extraits de Leptadenia hastata.Mots clés : Drépanocytose, hémoglobine, activité antifalcémiante, Leptadenia hastata, flavonoïdes

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.

Leiomyosarcome retro-rectal : place de la voie d’abord périnéale

Introduction : les tumeurs rétro rectales se développent dans l’espace limité en avant par le rectum, en arrière par la pièce sacro coccygienne, en bas par les releveurs et les muscles anococcygiens, latéralement par les uretères et les vaisseaux iliaques .leur incidence est estimée à 1/40 000, leur nature histologique est très variable et 30 à 50 % d’entre elles sont malignes ou le deviennent au cours de l’évolution.Observation : nous rapportons le cas d’un leiomyosarcome  rétro- rectal  chez un patient de 40 ans qui se plaignait depuis 2 ans de douleurs pelviennes paroxystiques avec pesanteur et pollakiurie .le toucher rectal perçoit une masse latero-rectale gauche. La Tomodensitométrie été en faveur d’une collection abcédée, en montrant une formation hypodense, et c’est l’imagerie par résonance magnétique nucléaire qui a posé le diagnostic de processus tumoral latero-rectal gauche, arrivant au contact du plancher pelvien et autorisant la voie d’abord périnéale de cette tumeur dont l’exérèse était complète sans effraction capsulaire. L’examen anatomopathologique de la pièce de résection a conclu après immunohistochimie à un leiomyosarcome de bas grade de malignité .une radiothérapie complémentaire centrée sur le site opératoire a été indiquée pour prévenir une éventuelle récidive locorégionale. Conclusion : Le leiomyosarcome retrorectal est une tumeur rare qui pose des problèmes d’abord chirurgical. Le pronostic reste relativement réservé et il faut guetter une éventuelle récidive. Le traitement néo-adjuvent n’est pas encore codifi