Estimating the impact of Critical Habitat designation on the values of undeveloped and developed parcels

We use differences-in-differences (DID) estimators to measure the impact that Critical Habitat (CH) establishment had on undeveloped and developed parcel prices throughout the US between 2000 and 2019. In a national-level analysis we found that CH “treatment” had a positive impact on developed and undeveloped parcel sale prices relative to sale price trends in nearby but “untreated” control parcels. The finding that CH treatment had a positive impact on undeveloped parcel prices was surprising as we had hypothesized that the impact of CH on undeveloped parcel prices would be negative due to the additional regulatory costs and development uncertainty the CH regulation imposes on land developers. However, when we used relevant subsets of CH areas to measure CH’s effects we often found results that were inconsistent with the national-level trends. Therefore, the impact of CH on land prices cannot be reduced to a simple, consistent narrative

PROMOTING EXPORT OF ICT BASED SERVICES THROUGH THE IMPLEMENTATION OF EXPORT POLICY IN BANGLADESH

ICT has been identified as one of the major sub-sectors in the service sector in Bangladesh. Export policy of Bangladesh, designed for 2015-2018, has included 12 highest priority sectors considering their special export potentials, where software and ICT enabled service is one of them. The policy has some certain goals for promoting export of ICT based services. The broad objective of the study is to analyze export policy of Bangladesh related with ICT based service and the overall situation of policy implementation and under this broad objective specific objectives are (1) to evaluate the role of export policy of Bangladesh in promoting ICT based service export and (2) to find if there is gap between Bangladesh export policy for ICT based service and implementation of the policy. Both qualitative and quantitative methods have been used to conduct this research. The study found that the policy lacks some very important issues needed to be addressed for capitalizing high potentials ICT based service export sector. But there is no policy statement for supporting ICT entrepreneurs to have better access to national and international arena. Among the variables that affect policy implementation, political will and support have been appreciated by the ICT entrepreneurs. The goals which are not being implemented are probably being hampered by lack of required amount of financial allocation, lack of technical skill and knowledge of the implementers, and lack of related policies complementing this policy. Increased participation of entrepreneurs in this sector will be helpful to harvest the benefit from policy implementation.  Article visualizations

A model of motivational and technological factors influencing massive open online courses’ continuous intention to use

Massive open online courses have been regarded as effective technological innovations that improve educational systems in the era of digitalisation. However, only 10% of the registered students complete their courses. This study aims to examine the motivational and technological factors and contextual features on students’ continuous intention to use. A questionnaire was gathered from 315 of students in the UAE and revealed that social motivational and technological factors driven by the technology acceptance model and technology task fit theory significantly influenced the students’ continuance intention to use. This study also revealed that contextual features including language use and course accreditation are important indicators determining students’ behaviours toward the use. Hence, this study proposed an integrative model to explain ways to improve continuance intention to use. This study contributes to the sustainable use of massive open online courses in developing countries through an integrative model

Entrepreneurial motivation, competency and micro-enterprise sustainability performance: evidence from an emerging economy

Small to medium-sized enterprises suffer from loss of competitive advantage, low productivity, and poor performance because of inadequate competencies. Therefore, the primary objective of this study was to examine the effect of selected motivational dimensions (i.e., self-improvement, self-confidence, openness to change, pull factors, and the need for achievement) on entrepreneurial competency among micro-entrepreneurs. We used a cross-sectional design and collected quantitative data from 403 micro-entrepreneurs in Malaysia using random sampling. SEM-PLS was used for data analysis. The findings revealed that self-confidence, openness to change, and pull factors positively influenced entrepreneurial competencies. Moreover, there was a positive effect of self-confidence, pull factors, need for achievement, and entrepreneurial competency on enterprise sustainability performance. Furthermore, entrepreneurial competencies significantly mediated the effect of self-confidence, openness to change, and pull factors on enterprise sustainability performance. Apart from extending the lens of a resource-based view, this study enriches enterprise sustainability literature from emerging nations’ perspective. Policymakers can strengthen their programs and policies to improve the entrepreneurial competencies of micro-entrepreneurs and their business sustainability

Entrepreneurial motivation, competency and micro-enterprise sustainability performance: evidence from an emerging economy

Small to medium-sized enterprises suffer from loss of competitive advantage, low productivity, and poor performance because of inadequate competencies. Therefore, the primary objective of this study was to examine the effect of selected motivational dimensions (i.e., self-improvement, self-confidence, openness to change, pull factors, and the need for achievement) on entrepreneurial competency among micro-entrepreneurs. We used a cross-sectional design and collected quantitative data from 403 micro-entrepreneurs in Malaysia using random sampling. SEM-PLS was used for data analysis. The findings revealed that self-confidence, openness to change, and pull factors positively influenced entrepreneurial competencies. Moreover, there was a positive effect of self-confidence, pull factors, need for achievement, and entrepreneurial competency on enterprise sustainability performance. Furthermore, entrepreneurial competencies significantly mediated the effect of self-confidence, openness to change, and pull factors on enterprise sustainability performance. Apart from extending the lens of a resource-based view, this study enriches enterprise sustainability literature from emerging nations’ perspective. Policymakers can strengthen their programs and policies to improve the entrepreneurial competencies of micro-entrepreneurs and their business sustainability

Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation

Ionizing radiation (IR) produces direct two-ended DNA double-strand breaks (DSBs) primarily repaired by non-homologous end joining (NHEJ). It is, however, well established that homologous recombination (HR) is induced and required for repair of a subset of DSBs formed following IR. Here, we find that HR induced by IR is drastically reduced when post-DNA damage replication is inhibited in mammalian cells. Both IR-induced RAD51 foci and HR events in the hprt gene are reduced in the presence of replication polymerase inhibitor aphidicolin (APH). Interestingly, we also detect reduced IR-induced toxicity in HR deficient cells when inhibiting post-DNA damage replication. When studying DSB formation following IR exposure, we find that apart from the direct DSBs the treatment also triggers formation of secondary DSBs peaking at 7–9 h after exposure. These secondary DSBs are restricted to newly replicated DNA and abolished by inhibiting post-DNA damage replication. Further, we find that IR-induced RAD51 foci are decreased by APH only in cells replicating at the time of IR exposure, suggesting distinct differences between IR-induced HR in S- and G2-phases of the cell cycle. Altogether, our data indicate that secondary replication-associated DSBs formed following exposure to IR are major substrates for IR-induced HR repair

Abdominal cystic echinococcosis in Bangladesh: a hospital-based study

Introduction: Cystic echinococcosis (CE) is reported from nearly all geographic areas of Bangladesh, but little information is available on its epidemiologic and clinical features. The aim of this study was to describe the clinical manifestations of hepatic and abdominal CE cases presenting to tertiary referral hospitals in Dhaka, Bangladesh. Methodology: A retrospective study was conducted via chart reviews of hepatic and abdominal CE patients under care at tertiary referral hospitals in Dhaka, Bangladesh, between 2002 and 2011. Age, sex, education level, occupation, urban versus rural residence, drinking water source, history of dog ownership, cyst type and location, and clinical manifestations were recorded for all patients. Results: Of the 130 patients enrolled, 92 (70.8%) were female and 38 (29.2%) were male. The majority of patients were from rural (76.2%) rather than urban (23.8%) areas. All cases were from the northern part of the country, with no cases reported from the south or southeast. Most patients were between 21 and 40 years of age. A total of 119 patients (91.5%) had cysts only in the liver, with the remaining 8.5% having cysts in both the liver and lungs or in the abdominal cavity. Seventy-six (58.5%) of the hepatic cysts were stage CE1, indicating recent infection. Conclusions: Active transmission of Echinococcus granulosus appears to be occurring in Bangladesh, as indicated by the high number of CE1 hepatic cysts seen at tertiary care hospitals. Community ultrasound screening studies are warranted to better define the distribution of cases and risk factors for parasite transmission

Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years : an analysis of the Global Burden of Disease Study 2017

Background Many countries have shown marked declines in diarrhoea! disease mortality among children younger than 5 years. With this analysis, we provide updated results on diarrhoeal disease mortality among children younger than 5 years from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) and use the study's comparative risk assessment to quantify trends and effects of risk factors, interventions, and broader sociodemographic development on mortality changes in 195 countries and territories from 1990 to 2017. Methods This analysis for GBD 2017 had three main components. Diarrhoea mortality was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive, Bayesian, ensemble modelling tool; and the attribution of risk factors and interventions for diarrhoea were modelled in a counterfactual framework that combines modelled population-level prevalence of the exposure to each risk or intervention with the relative risk of diarrhoea given exposure to that factor. We assessed the relative and absolute change in diarrhoea mortality rate between 1990 and 2017, and used the change in risk factor exposure and sociodemographic status to explain differences in the trends of diarrhoea mortality among children younger than 5 years. Findings Diarrhoea was responsible for an estimated 533 768 deaths (95% uncertainty interval 477 162-593 145) among children younger than 5 years globally in 2017, a rate of 78.4 deaths (70.1-87.1) per 100 000 children. The diarrhoea mortality rate ranged between countries by over 685 deaths per 100 000 children. Diarrhoea mortality per 100 000 globally decreased by 69.6% (63.1-74.6) between 1990 and 2017. Among the risk factors considered in this study, those responsible for the largest declines in the diarrhoea mortality rate were reduction in exposure to unsafe sanitation (13.3% decrease, 11.2-15.5), childhood wasting (9.9% decrease, 9.6-10.2), and low use of oral rehydration solution (6.9% decrease, 4-8-8-4). Interpretation Diarrhoea mortality has declined substantially since 1990, although there are variations by country. Improvements in sociodemographic indicators might explain some of these trends, but changes in exposure to risk factors-particularly unsafe sanitation, childhood growth failure, and low use of oral rehydration solution-appear to be related to the relative and absolute rates of decline in diarrhoea mortality. Although the most effective interventions might vary by country or region, identifying and scaling up the interventions aimed at preventing and protecting against diarrhoea that have already reduced diarrhoea mortality could further avert many thousands of deaths due to this illness

Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years : an analysis for the Global Burden of Disease Study 2017

Background Despite large reductions in under-5 lower respiratory infection (LRI) mortality in many locations, the pace of progress for LRIs has generally lagged behind that of other childhood infectious diseases. To better inform programmes and policies focused on preventing and treating LRIs, we assessed the contributions and patterns of risk factor attribution, intervention coverage, and sociodemographic development in 195 countries and territories by drawing from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) LRI estimates. Methods We used four strategies to model LRI burden: the mortality due to LRIs was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive ensemble modelling tool; the incidence of LRIs was modelled using population representative surveys, health-care utilisation data, and scientific literature in a compartmental meta-regression tool; the attribution of risk factors for LRI mortality was modelled in a counterfactual framework; and trends in LRI mortality were analysed applying changes in exposure to risk factors over time. In GBD, infectious disease mortality, including that due to LRI, is among HIV-negative individuals. We categorised locations based on their burden in 1990 to make comparisons in the changing burden between 1990 and 2017 and evaluate the relative percent change in mortality rate, incidence, and risk factor exposure to explain differences in the health loss associated with LRIs among children younger than 5 years. Findings In 2017, LRIs caused 808 920 deaths (95% uncertainty interval 747 286-873 591) in children younger than 5 years. Since 1990, there has been a substantial decrease in the number of deaths (from 2 337 538 to 808 920 deaths; 65.4% decrease, 61.5-68.5) and in mortality rate (from 362.7 deaths [3304-392.0] per 100 000 children to 118.9 deaths [109.8-128.3] per 100 000 children; 67.2% decrease, 63.5-70.1). LRI incidence dedined globally (32.4% decrease, 27.2-37.5). The percent change in under-5 mortality rate and incidence has varied across locations. Among the risk factors assessed in this study, those responsible for the greatest decrease in under-5 LRI mortality between 1990 and 2017 were increased coverage of vaccination against Haemophilus influenza type b (11.4% decrease, 0.0-24.5), increased pneumococcal vaccine coverage (6.3% decrease, 6.1-6.3), and reductions in household air pollution (8.4%, 6 8-9.2). Interpretation Our findings show that there have been substantial but uneven declines in LRI mortality among countries between 1990 and 2017. Although improvements in indicators of sociodemographic development could explain some of these trends, changes in exposure to modifiable risk factors are related to the rates of decline in LRI mortality. No single intervention would universally accelerate reductions in health loss associated with LRIs in all settings, but emphasising the most dominant risk factors, particularly in countries with high case fatality, can contribute to the reduction of preventable deaths

Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years : an analysis of the Global Burden of Disease Study 2017

Background Many countries have shown marked declines in diarrhoea! disease mortality among children younger than 5 years. With this analysis, we provide updated results on diarrhoeal disease mortality among children younger than 5 years from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) and use the study's comparative risk assessment to quantify trends and effects of risk factors, interventions, and broader sociodemographic development on mortality changes in 195 countries and territories from 1990 to 2017. Methods This analysis for GBD 2017 had three main components. Diarrhoea mortality was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive, Bayesian, ensemble modelling tool; and the attribution of risk factors and interventions for diarrhoea were modelled in a counterfactual framework that combines modelled population-level prevalence of the exposure to each risk or intervention with the relative risk of diarrhoea given exposure to that factor. We assessed the relative and absolute change in diarrhoea mortality rate between 1990 and 2017, and used the change in risk factor exposure and sociodemographic status to explain differences in the trends of diarrhoea mortality among children younger than 5 years. Findings Diarrhoea was responsible for an estimated 533 768 deaths (95% uncertainty interval 477 162-593 145) among children younger than 5 years globally in 2017, a rate of 78.4 deaths (70.1-87.1) per 100 000 children. The diarrhoea mortality rate ranged between countries by over 685 deaths per 100 000 children. Diarrhoea mortality per 100 000 globally decreased by 69.6% (63.1-74.6) between 1990 and 2017. Among the risk factors considered in this study, those responsible for the largest declines in the diarrhoea mortality rate were reduction in exposure to unsafe sanitation (13.3% decrease, 11.2-15.5), childhood wasting (9.9% decrease, 9.6-10.2), and low use of oral rehydration solution (6.9% decrease, 4-8-8-4). Interpretation Diarrhoea mortality has declined substantially since 1990, although there are variations by country. Improvements in sociodemographic indicators might explain some of these trends, but changes in exposure to risk factors-particularly unsafe sanitation, childhood growth failure, and low use of oral rehydration solution-appear to be related to the relative and absolute rates of decline in diarrhoea mortality. Although the most effective interventions might vary by country or region, identifying and scaling up the interventions aimed at preventing and protecting against diarrhoea that have already reduced diarrhoea mortality could further avert many thousands of deaths due to this illness. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.Peer reviewe