ANALISIS KINERJA PERSIMPANGAN JALAN M.H THAMRIN DAN JALAN MERDEKA

ABSTRAK   Persimpangan Jalan M.H Thamrin dan Jalan Merdeka merupakan simpang empat yang sering terjadi kemacetan dan kecelakaan. Banyaknya aktivitas di persimpangan jalan seperti aktivitas anak-anak yang tujuan ke sekolah dan pengunjung ke rumah makan serta parkiran pengunjung dan kendaraan umum yg memarkir kendaraan sembarangan sehingga sering terjadi kemacetan dan hampir menggunakan seluruh badan jalan. Hal ini menyebabkan terjadinya kemacetan lalu lintas yang mengakibatkan meningkatnya konflik yang timbul dan dapat menyebabkan menurunnya kecepatan arus lalu lintas serta tingkat keamanan dan kenyamanan bagi pengguna jalan. Penelitian ini bertujuan untuk mengetahui kinerja persimpangan Jalan M.H Thamrin dan Jalan Merdeka di Kota Gorontalo serta mengetahui tingkat pelayanan persimpangan jalan tersebut. Metode yang digunakan adalah metode MKJI 1997, dengan mengolah data primer dan data sekunder ke dalam perhitungan nilai kapasitas, nilai derajat kejenuhan, nilai tundaan simpang, nilai peluang antrian, dan tingkat pelayanan. Dari hasil analisis data diperoleh bahwa volume arus lalu lintas maksimum terjadi pada hari kamis pukul 08.00-09.00 sebesar 1852 kend/jam atau 1016 smp/jam. Nilai kapasitas adalah 1888 smp/jam lebih besar dari volume lalu lintas yang diperoleh dari hasil penelitian yaitu 1852 smp/jam sehingga kapasitas ruas jalan simpang empat Jln. MH. Thamrin dan Jln. Merdeka masih bisa menampung volume lalu lintas di jalan tersebut. Nilai derajat kejenuhan adalah 0.538 dengan tingkat pelayanan D dimana pada kondisi ini arus mendekati tidak stabil dengan volume lalu lintas tinggi dan kecepatan masih ditolerir namun sangat terpengaruh oleh perubahan kondisi arus, kepadatan lalu lintas sedang fluktuasi volume lalu lintas dan hambatan temporer dapat menyebabkan penurunan kecepatan yang besar, serta pengemudi memiliki kebebasan yang sangat terbatas dalam menjalankan kendaraan, kenyamanan rendah, tetapi kondisi ini masih dapat ditolerir untuk waktu yang singkat.   Kata Kunci : Persimpangan, Volume, Lalu Linta

Characterization of a de novo constitutional balanced translocation

Abstract Reciprocal balanced translocations associated with clinical features are very rare. This study reports cytogenetic and molecular cytogenetic findings in a 3-year-old patient with mild developmental retardation, slight hypotone with a de novo balanced 46, XX, t(2; 11) (q33; q23) translocation. G-banded chromosomes and FISH-Analysis were used to examine the patient's karyotype as well as her parents'. FISH-probes prepared with specific RP11-BAC clones mapped near 2q33 and 11q23 regions were used to characterize the location of the breakpoints. The FISH results revealed that one of the break points is located within the human NBEAL1-Gene locus on chromosome 2, suggesting a correlation between this gene disruption and the patient’s mild developmental retardation. 

Sosialisasi dan Pelatihan Pemasaran Berbasis Digital Dengan Menggunakan Media Sosial pada Kelompok Tani Desa Botumoputi Kecamatan Tibawa

ABSTRACTCorn is the most productive cereal crop in the world besides rice and wheat. Plants that can grow in high temperature areas, and cob maturation is determined by the accumulated heat obtained by the plant. Corn (Zea mays L.) is a single seed plant (monocotyledon) with rough stems ranging from 0.6 to 3 m and is a seasonal plant with an age of approximately 3 months. Botumoputi Village is one of the villages that has the largest corn producer in the Tibawa sub-district. There are 15 groups of corn farmers in the village and among them there are rice corn farmers. The results of the corn harvest are mostly sold directly without any processing into further products. Due to the lack of knowledge and knowledge they have, the harvest only flows in the market. Because marketing problems are so-so, there is a need for socialization and digital marketing training. The purpose of these activities is to provide insight and knowledge of skills and increase work creativity. Activities carried out in the hall of Botumoputi Village involved some members of the community, heads of farmer groups, PKK women and village officials. In its implementation using sustainable extension methods. The hope that can be achieved from this activity is that the people of Botumoputi Village can be more creative and can work to increase family economic income through internet networks. Keywords; marketing, corn, social medi

Outcome of Vaginal Progesterone as a Tocolytic Agent: Randomized Clinical Trial

Vaginal progesterone has a potential beneficial effect in postponing of preterm labor by suppression of prostaglandins cascades. Although different studies evaluated the use of progesterone for preterm birth, the exact effect of which on prolongation of pregnancy remains unclear. Seventy two women who underwent preterm labor were managed by magnesium sulfate. Then they were randomly assigned to continue pregnancy either by applying vaginal progesterone (400 mg) until delivery or without using any drug. Gestational age mean at the time of delivery (P = 0.039) and postponing delivery mean time (P = 0.048) were significantly higher in progesterone group. Comparison of neonatal outcomes between two groups of patients showed meaningful benefits of progesterone in increasing of neonatal weight, reduction of low birth weight babies, and lowing neonate admitted in NICU

25-Hydroxy Vitamin D Level and Its Correlation with Mean Platelet Volume in Preeclampsia

Background: Preeclampsia is one of the challenging complications of pregnancy, of which little is known about its etiology and pathogenesis. Many studies have shown higher mean platelet volume (MPV) in preeclamptic patients. Vitamin D deficiency is in association with larger-size platelets. Thus, we aimed to determine the correlation of vitamin D with MPV in preeclamptic patients. Methods: This prospective case–control study was conducted in two tertiary hospitals in Tehran, Iran. Overall, 85 preeclamptic pregnant women and 85 normotensive pregnant women were entered between 2017 and 2018. Serum vitamin D concentration (ng/ml) and MPV (femtoliter) were measured for all patients. Results: MPV was significantly higher in the cases compared to controls (10.59±1.08 vs 8.10±0.95, P=0.0001). In addition, serum vitamin D level in the preeclamptic group was significantly lower in compare to the control group (17.79±11.03 vs 30.24±12.49; P=0.0001). In multivariate logistic regression analysis, high age of mother (OR: 1.13; 95% CI: 1.01-1.27; P=0.03), low level of serum vitamin D (OR: 0.93; 95% CI: 0.87-0.99; P=0.02) and high MPV (OR: 8.83; 95% CI: 4.17-18.67; P=0.0001) were independent predictors of preeclampsia. Moreover, a correlation analysis revealed that vitamin D levels correlated negatively with MPV (r= -0.41, P<0.0001). Conclusion: Low levels of vitamin D in preeclamptic pregnancy are associated with higher platelet activity and thrombosis. In fact, the increment of MPV level might be a potential pathway for adverse outcomes of pregnancy including preeclampsia in the context of vitamin D deficiency.

Afghan migrants face more suboptimal care than natives: a maternal near-miss audit study at university hospitals in Tehran, Iran.

BACKGROUND: Women from low-income settings have higher risk of maternal near miss (MNM) and suboptimal care than natives in high-income countries. Iran is the second largest host country for Afghan refugees in the world. Our aim was to investigate whether care quality for MNM differed between Iranians and Afghans and identify potential preventable attributes of MNM. METHODS: An MNM audit study was conducted from 2012 to 2014 at three university hospitals in Tehran. Auditors evaluated the quality of care by reviewing the hospital records of 76 MNM cases (54 Iranians, 22 Afghans) and considering additional input from interviews with patients and professionals. Main outcomes were frequency of suboptimal care and the preventable attributes of MNM. Crude and adjusted odds ratios with confidence intervals for the independent predictors were examined. RESULTS: Afghan MNM faced suboptimal care more frequently than Iranians after adjusting for educational level, family income, and insurance status. Above two-thirds (71%, 54/76) of MNM cases were potentially avoidable. Preventable factors were mostly provider-related (85%, 46/54), but patient- (31%, 17/54) and health system-related factors (26%, 14/54) were also important. Delayed recognition, misdiagnosis, inappropriate care plan, delays in care-seeking, and costly care services were the main potentially preventable attributes of MNM. CONCLUSIONS: Afghan mothers faced inequality in obstetric care. Suboptimal care was provided in a majority of preventable near-miss events. Improving obstetric practice and targeting migrants' specific needs during pregnancy may avert near-miss outcomes

Performance and Predictive Value of First Trimester Screening Markers for Down Syndrome in Iranian Pregnancies

Objective: To investigate the performance of first trimester Down syndrome (DS) screening markers in Iranian pregnancies.Although sonographic and serum markers are currently recommended for the first trimester screening of Down syndrome, the screening performance of the markers depends on the race and ethnicity. Materials and methods: A retrospective case-control study using first trimester screening results recorded with the prenatal diagnostic multi-centers in Iran. A total of 6,384 pregnant women were examined from March 2012 to February 2017. Totally 100 Down syndrome cases and 266 matched controls were selected and the maternal characteristics, sonographic and biochemical screening data were collected. Statistical analysis was performed using logistic regression and descriptive statistics. A decision tree model was designed using the chi-squared automatic interaction detection method based on serum markers. Results: For screening of DS pregnancies, PAPP-A (cut-off 0.795 MoM) yielded the highest sensitivity (86%) and NB marker presented highest specificity (96.24%). combination of the biochemical markers PAPP-A and β-hCG (cut-off: 1.55 MoM) showed the highest sensitivity over other combined markers. The decision-tree model based on serum markers improved (91% DR For a 5% FPR) first trimester screening performance. Conclusion: The novel decision-tree model base on serum markers revealed a better predictive value to achieve high sensitivity and specificity of first trimester Down syndrome screening in Iranian population

Neonatal, infant, and under-5 mortality and morbidity burden in the Eastern Mediterranean region: findings from the Global Burden of Disease 2015 study

Objectives Although substantial reductions in under-5 mortality have been observed during the past 35 years, progress in the Eastern Mediterranean Region (EMR) has been uneven. This paper provides an overview of child mortality and morbidity in the EMR based on the Global Burden of Disease (GBD) study. Methods We used GBD 2015 study results to explore under-5 mortality and morbidity in EMR countries. Results In 2015, 755,844 (95% uncertainty interval (UI) 712,064–801,565) children under 5 died in the EMR. In the early neonatal category, deaths in the EMR decreased by 22.4%, compared to 42.4% globally. The rate of years of life lost per 100,000 population under 5 decreased 54.38% from 177,537 (173,812–181,463) in 1990 to 80,985 (76,308–85,876) in 2015; the rate of years lived with disability decreased by 0.57% in the EMR compared to 9.97% globally. Conclusions Our findings call for accelerated action to decrease child morbidity and mortality in the EMR. Governments and organizations should coordinate efforts to address this burden. Political commitment is needed to ensure that child health receives the resources needed to end preventable deaths