Activity patterns and behavior of Myocastor coypus in a gated community in the metropolitan area of Buenos Aires (Argentina)

Anthropization processes confront local wildlife with a new set of conditions that may lead to local extinctions or allow the expansion of some species. This is what happens with the coypu (Myocastor coypus) in gated communities in the metropolitan area of Buenos Aires (Argentina), where its rapid population growth results in continuous conflicts with the local inhabitants. The aim of this study was to document the daily and seasonal activity patterns and behavior of the coypu in an urban landscape within their natural distribution range. To achieve this, we conducted a camera-trap survey within areas occupied by the species from February to November 2018. The coypu activity was mainly crepuscular and nocturnal with variations between seasons. We found that the seasons with the greatest activity patterns overlap were winter and autumn (84%), while the least overlap was observed between summer and winter (53%). During the active periods, time spent on foraging behavior was dominant. Time dedicated to vigilance was greater in summer than in winter. This result, alongside an increase in nocturnal activity during summer, shows that coypu in this urban landscape shift its behavior when exposed to an increasing human activity. This study brings up more ecological data of this species, which is key to find alternative control methods within gated communities to lead to a harmonic relationship between inhabitants and the species in its native distribution.Fil: Salas, Magdalena. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hernandez Hernandez, Julio C. Universidad Autónoma Metropolitana; MéxicoFil: Iglesias, Martín. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; ArgentinaFil: Corriale, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentin

Laser in surgical scar clearance: An update review.

AbstractScar formation is a consequence of wound healing that developed from damaged tissue either from physical injury or surgical incision. A hypertrophic scar develops due to an abnormal healing response to trauma. It might lead to serious functional and cosmetic disability. There are numerous methods mentioned in the literature to treat such scars but to date, no single method has been known to cure them. In this review, we focused on differences between various types of nonsurgical management of hypertrophic scar focusing on the indication, mechanism of action, and efficacy of the pulsed dye laser (PDL), fractional carbon dioxide laser (fCO2), Er‐YAG laser, and intense pulse light (IPL). The literature research included peer‐reviewed articles (clinical trials or scientific reviews) which were identified by searching electronic databases like PubMed till January 2021 and reference lists of respective articles. Only articles published in the English language were included

Further insights in trichothiodistrophy: a clinical, microscopic, and ultrastructural study of 20 cases and literature review

Background: Trichothiodistrophy (TTD) is a rare autosomal recessive condition that is characterized by a specific congenital hair shaft dysplasia caused by deficiency of sulfur associated with a wide spectrum of multisystem abnormalities. In this article, we study clinical, microscopic, and ultrastructural findings of 20 patients with TTD with the aim to add further insights regarding to this rare condition. Additionally, analyses of our results are compared with those extracted from the literature in order to enhance its comprehensibility. Materials and Methods: Twenty cases of TTD were included: 7 from Mexico and 14 from Spain. Clinical, microscopic, scanning electron microscopy (SEM) studies and X-ray microanalysis (XrMa) were carried out in all of them. Genetic studies were performed in all seven Mexican cases. Patients with xeroderma pigmentosum and xeroderma pigmentosum/TTD-complex were excluded. Results: Cuticular changes and longitudinal crests of the hair shaft were demonstrated. These crests were irregular, disorganized, following the hair longest axis. Hair shaft sulfur deficiency was disposed discontinuously and intermittently rather than uniformly. This severe decrease of sulfur contents was located close to the trichoschisis areas. Only five patients did not show related disturbances. Micro-dolichocephaly was observed in five cases and represented the most frequent facial dysmorphism found. It is also remarkable that all patients with urologic malformations also combined diverse neurologic disorders. Moreover, three Mexican sisters demonstrated the coexistence of scarce pubic vellus hair, developmental delay, onychodystrophy, and maxillar/mandibullar hypoplasia. Conclusions: TTD phenotype has greatly varied from very subtle forms to severe alterations such as neurologic abnormalities, blindness, lamellar ichthyosis and gonadal malformations. Herein, a multisystem study should be performed mandatorily in patients diagnosed with TTD

Influence of the pairs in the expression of bullying in high school students in Arequipa

El objetivo del presente estudio fue determinar el grado de influencia que ejerce la cercanía de los alumnos de secundaria con pares que transgreden normas, sobre el rol que asumen estos alumnos dentro del bullying (agresor, víctima o espectador) en el área metropolitana de la ciudad de Arequipa, teniendo en cuenta sexo y grado de instrucción. Se evaluó a 3979 estudiantes de educación secundaria de colegios estatales, privados y paraestatales de 19 distritos de la provincia de Arequipa, con  edades comprendidas entre 11 y 19 años. Se realizó un análisis descriptivo y de regresión lineal múltiple y logística binaria para modelar la asociación entre variables. Los resultados muestran una mayor tendencia de los varones hacia las conductas agresivas y a asumir roles de “bully”. La influencia de pares transgresores de normas favorece en mayor grado la práctica de roles de agresor o víctima. En cuanto a la frecuencia de bullying, existe una alta prevalencia de agresores y víctimas entre los encuestados, cercana a la mitad de la muestra, mientras que la otra parte corresponde a los espectadores ya sean estos reforzadores del bullying o prosociales.The aim of this study was to determine the degree of influence of the proximity of high school students with peers who break rules on the role assumed these students within the bullying (bully, victim or viewer) in the metropolitan area of the city Arequipa, considering sex and level of education. We evaluated 3979 high school students from state, private and parastatal schools in 19 districts in the province of Arequipa, aged between 11 and 19 years. A descriptive and binary logistic regression and multiple linear analysis was performed to model the association between variables. The results show a greater tendency of men to aggressive behavior and assume roles of "bully". The influence of offenders pairs of rules favors greater practical role of aggressor or victim. As for the frequency of bullying, there is a high prevalence of perpetrators and victims among respondents, nearly half of the sample, while the other part is for the spectators whether these enhancers bullying or prosocial

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https://www.ester.ee/record=b4538881*es

Diagnóstico de salud comunitaria de Alcanar

Introducción: El diagnóstico de salud es el resultado de un estudio epidemiológico de una comunidad, a partir de una descripción y análisis de las necesidades de salud. Es decir, es la medición del estado de salud de la población en un momento determinado mediante indicadores de salud. Objetivos: Generales: Analizar la situación de salud e identificar las necesidades poblacionales reconocidas. Secundarios: Identificar los elementos necesario que permitan la elaboración del diagnóstico de salud de Alcanar. Conocer los recursos que dispone el municipio para satisfacer las necesidades poblacionales. Material y métodos: Estudio descriptivo transversal. La recogida de datos se realizó en distintas instituciones de la población y de las bases de datos estadísticas de la Generalitat de Catalunya. Se realizó una revisión de la literatura con el fin de localizar la mayor evidencia relacionada con las actividades planteadas. Resultados: Los resultados en los indicadores de niveles de salud, de condiciones sanitarias, de recursos y actividades, indicadores económico-sociales, educativos y socio-económicos, de educación, del estado nutricional de la población, sobre saneamiento y urbanismo, son óptimos. Las enfermedades de más prevalencia son la HTA, obesidad, DMT2, seguidas del Alzheimer con 1.76%. Discusión: La necesidad pertinente de intervención fue la atención a los enfermos de Alzheimer, no por ser la enfermedad con más prevalencia, sino por no presentar un plan de intervención, porque afecta tanto al paciente como al cuidador y ha aumentado su incidencia. Las intervenciones van dirigidas a disminuir el deterioro cognitivo, físico y aliviar los problemas conductuales

Molecular and Morphological Phylogenetic Analyses of New World Cycad Beetles: What They Reveal about Cycad Evolution in the New World

Two major lineages of beetles inhabit cycad cones in the New World: weevils (Curculionoidea) in the subtribe Allocorynina, including the genera Notorhopalotria Tang and O’Brien, Parallocorynus Voss, Protocorynus O’Brien and Tang and Rhopalotria Chevrolat, and beetles in the family Erotylidae, including the genus Pharaxonotha Reitter. Analysis of the 16S ribosomal RNA (rRNA) mitochondrial gene as well as cladistic analysis of morphological characters of the weevils indicate four major radiations, with a probable origin on the cycad genus Dioon Lindl. and comparatively recent host shifts onto Zamia L. Analysis of the 16S rRNA gene for erotylid beetles indicates that an undescribed genus restricted to New World Ceratozamia Brongn. is the most early-diverging clade, and this lineage is sister to a large radiation of the genus Pharaxonotha onto Zamia, with apparent host shifts onto Dioon and Ceratozamia. Analysis of beetles are in accord with current models of continental drift in the Caribbean basin, support some proposed species groupings of cycads, but not others, and suggest that pollinator type may impact population genetic structure in their host cycads

Mutations in the Cholesterol Transporter Gene ABCA5 Are Associated with Excessive Hair Overgrowth

Inherited hypertrichoses are rare syndromes characterized by excessive hair growth that does not result from androgen stimulation, and are often associated with additional congenital abnormalities. In this study, we investigated the genetic defect in a case of autosomal recessive congenital generalized hypertrichosis terminalis (CGHT) (OMIM135400) using whole-exome sequencing. We identified a single base pair substitution in the 5′ donor splice site of intron 32 in the ABC lipid transporter gene ABCA5 that leads to aberrant splicing of the transcript and a decrease in protein levels throughout patient hair follicles. The homozygous recessive disruption of ABCA5 leads to reduced lysosome function, which results in an accumulation of autophagosomes, autophagosomal cargos as well as increased endolysosomal cholesterol in CGHT keratinocytes. In an unrelated sporadic case of CGHT, we identified a 1.3 Mb cryptic deletion of chr17q24.2-q24.3 encompassing ABCA5 and found that ABCA5 levels are dramatically reduced throughout patient hair follicles. Collectively, our findings support ABCA5 as a gene underlying the CGHT phenotype and suggest a novel, previously unrecognized role for this gene in regulating hair growth

Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation

Regenerative responses predispose tissues to tumor formation by largely unknown mechanisms. High-mobility group box 1 (HMGB1) is a danger-associated molecular pattern contributing to inflammatory pathologies. We show that HMGB1 derived from keratinocytes, but not myeloid cells, delays cutaneous wound healing and drives tumor formation. In wounds of mice lacking HMGB1 selectively in keratinocytes, a marked reduction in neutrophil extracellular trap (NET) formation is observed. Pharmacological targeting of HMGB1 or NETs prevents skin tumorigenesis and accelerates wound regeneration. HMGB1-dependent NET formation and skin tumorigenesis is orchestrated by tumor necrosis factor (TNF) and requires RIPK1 kinase activity. NETs are present in the microenvironment of keratinocyte-derived tumors in mice and lesional and tumor skin of patients suffering from recessive dystrophic epidermolysis bullosa, a disease in which skin blistering predisposes to tumorigenesis. We conclude that tumorigenicity of the wound microenvironment depends on epithelial-derived HMGB1 regulating NET formation, thereby establishing a mechanism linking reparative inflammation to tumor initiation