Staging Social and Political Spaces: Living Theatre in Joyce’s “The Dead”

In his study of the modernist short story, Dominic Head argues that: “The problem facing short story critics is to find a way of escaping their own reductive formulae” (21). The critical framework that the subject of “theatricality in the short story” sets is one of several means to escape reductive formulae in short story criticism. Above all, such a critical framework enables the envisioning of a more productively malleable definition of the genre of the short story in relation to other genres. The required definition would potentially reflect the need for flexibility which seems to be recurrently emphasized but rarely satisfied in discussions of the genre of the short story. One example of these discussions is an essay entitled “Destabilizing Frames for Story” in which Ian Reid touches upon the adaptation of the story “Monsieur Seguin’s Goat” in Alphonse Daudet’s Letters from My Windmill into a play entitled L’Arlésienne (The Girl from Arles). Through this discussion, Reid shows that the text of Daudet’s story “signals its status as a meetingplace for various generic tendencies”

Staging Social and Political Spaces: Living Theatre in Joyce’s “The Dead”

In his study of the modernist short story, Dominic Head argues that: “The problem facing short story critics is to find a way of escaping their own reductive formulae” (21). The critical framework that the subject of “theatricality in the short story” sets is one of several means to escape reductive formulae in short story criticism. Above all, such a critical framework enables the envisioning of a more productively malleable definition of the genre of the short story in relation to other genres. The required definition would potentially reflect the need for flexibility which seems to be recurrently emphasized but rarely satisfied in discussions of the genre of the short story. One example of these discussions is an essay entitled “Destabilizing Frames for Story” in which Ian Reid touches upon the adaptation of the story “Monsieur Seguin’s Goat” in Alphonse Daudet’s Letters from My Windmill into a play entitled L’Arlésienne (The Girl from Arles). Through this discussion, Reid shows that the text of Daudet’s story “signals its status as a meetingplace for various generic tendencies”

Silicone migration to the contralateral axillary lymph nodes and breast after highly cohesive silicone gel implant failure: a case report

Highly cohesive silicone gel implants are advertised for aesthetic and safety advantages. Our case is the fourth report describing early implant rupture and contralateral migration of siliconoma. Despite the greater degree of gel cohesiveness, a continued vigilance for signs and symptoms of migration is highly recommended

Lobular Carcinomas In Situ Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma

Purpose:; Lobular carcinoma; in situ; (LCIS) is a preinvasive lesion of the breast. We sought to define its genomic landscape, whether intralesion genetic heterogeneity is present in LCIS, and the clonal relatedness between LCIS and invasive breast cancers.; Experimental Design:; We reanalyzed whole-exome sequencing (WES) data and performed a targeted amplicon sequencing validation of mutations identified in 43 LCIS and 27 synchronous more clinically advanced lesions from 24 patients [9 ductal carcinomas; in situ; (DCIS), 13 invasive lobular carcinomas (ILC), and 5 invasive ductal carcinomas (IDC)]. Somatic genetic alterations, mutational signatures, clonal composition, and phylogenetic trees were defined using validated computational methods.; Results:; WES of 43 LCIS lesions revealed a genomic profile similar to that previously reported for ILCs, with; CDH1; mutations present in 81% of the lesions. Forty-two percent (18/43) of LCIS were found to be clonally related to synchronous DCIS and/or ILCs, with clonal evolutionary patterns indicative of clonal selection and/or parallel/branched progression. Intralesion genetic heterogeneity was higher among LCIS clonally related to DCIS/ILC than in those nonclonally related to DCIS/ILC. A shift from aging to APOBEC-related mutational processes was observed in the progression from LCIS to DCIS and/or ILC in a subset of cases.; Conclusions:; Our findings support the contention that LCIS has a repertoire of somatic genetic alterations similar to that of ILCs, and likely constitutes a nonobligate precursor of breast cancer. Intralesion genetic heterogeneity is observed in LCIS and should be considered in studies aiming to develop biomarkers of progression from LCIS to more advanced lesions

Common breast cancer susceptibility alleles are associated with tumor subtypes in BRCA1 and BRCA2 mutation carriers : results from the Consortium of Investigators of Modifiers of BRCA1/2.

Abstract Introduction Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour. Methods We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach. Results The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 × 10-6). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. Conclusions The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers

Imagining mid-nineteenth-century Beirut as a ‘City of the World’: Public intellectuals, photography, cartography and historical literature

This study explores the process of constructing mid-nineteenth-century (1858–76) Beirut as a city of the world not merely through its gradual material instantiation in mechanisms of technological modernization and in the built environment but also, more emphatically and enduringly, as a product of the cultural imagination. The article engages the ethico-political parameters of a ‘crisis of representation’ in the context of both the selected historical period that is one of geopolitical crisis, specifically the 1860 civil conflict in Mount Lebanon and Damascus that brought refugees, military and diplomatic intervention into Beirut, and our ongoing era of intensive contestation and critical attention to Beirut’s urban heritage. This contrapuntal framework of geocreativity invites an examination of the output of mid-nineteenth-century Beiruti intellectuals and missionaries (including newspapers, public lectures, the encyclopaedia and the memoir), alongside mid-nineteenth-century photography and cartography by military and civilian visitors to Beirut, and twenty-first-century Lebanese historical literature, particularly Rabī‘ Jabir’s Bayrūt trilogy (2003–07), that recreates mid-nineteenth-century Beirut as a city of the world from the perspectives of the archive and the consciousness of the city’s post-war transformations

Staging Social and Political Spaces: Living Theatre in Joyce’s “The Dead”

In his study of the modernist short story, Dominic Head argues that: “The problem facing short story critics is to find a way of escaping their own reductive formulae” (21). The critical framework that the subject of “theatricality in the short story” sets is one of several means to escape reductive formulae in short story criticism. Above all, such a critical framework enables the envisioning of a more productively malleable definition of the genre of the short story in relation to other genres. The required definition would potentially reflect the need for flexibility which seems to be recurrently emphasized but rarely satisfied in discussions of the genre of the short story. One example of these discussions is an essay entitled “Destabilizing Frames for Story” in which Ian Reid touches upon the adaptation of the story “Monsieur Seguin’s Goat” in Alphonse Daudet’s Letters from My Windmill into a play entitled L’Arlésienne (The Girl from Arles). Through this discussion, Reid shows that the text of Daudet’s story “signals its status as a meetingplace for various generic tendencies”

Imaginative migrations: An interview with the Lebanese-Canadian writer Rawi Hage

The history of mankind is full of wars, divisions, the flow of blood, the flight of refugees and misery. I long for the day when an African child will be able to roam the world as if it is rightly his; I long for the day when Palestinian, Guatemalan, Iraqi and Afghan children will have homes to keep and build upon. I long for the day when we humans realize that we are all gatherers and wanderers, ever bound to cross each other’s paths, and that these paths belong to us all. (From Hage’s Acceptance Speech at the 2008 International IMPAC Dublin Literary Award ceremony