951 research outputs found

    Letter from the Consistory of Rijssen to Rev. A. C. Van Raalte

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    A letter from the consistory in Rijsen to Rev. Albertus C. Van Raalte releasing Van Raalte from his service to the Rijssen congregation. Apparently V.R. assisted this congregation in becoming established while he was serving the Ommen congregation.https://digitalcommons.hope.edu/vrp_1840s/1001/thumbnail.jp

    Dietary pattern adherence in association with changes in body composition and adiposity measurements in the UK Biobank study

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    Background Unhealthy dietary patterns (DP) have been frequently linked to avoidable ill-health, mediated in part through higher body mass index. However it is unclear how these patterns relate to specific components of body composition or fat distribution, and whether this may explain reported gender differences in the relationship between diet and health. Methods Data from 101,046 UK Biobank participants with baseline bioimpedance analysis and anthropometric measures and dietary information on two or more occasions were used, of which 21,387 participants had repeated measures at follow up. Multivariable linear regressions estimated the associations between DP adherence (categorised in quintiles Q1–Q5) and body composition measures adjusted for a range of demographic and lifestyle confounders. Results After 8.1 years of follow-up, individuals with high adherence (Q5) to the DP showed significantly positive changes in fat mass (mean, 95 % CI): 1.26 (1.12–1.39) kg in men, 1.11 (0.88–1.35) kg in women vs low adherence (Q1) − 0.09 (− 0.28 to 0.10) kg in men and − 0.26 (− 0.42 to − 0.11) kg in women; as well as in waist circumference (Q5): 0.93 (0.63–1.22) cm in men and 1.94 (1.63, 2.25) cm in women vs Q1 − 1.06 (− 1.34 to − 0.78) cm in men and 0.27 (− 0.02 to 0.57) cm in women. Conclusion Adherence to an unhealthy DP is positively associated with increased adiposity, especially in the abdominal region, which may help explain the observed associations with adverse health outcomes.Ramon y Cajal Fellowship RYC2020-028818-I (Ministry of Science and Innovation, Spain)Oxford NIHR Biomedical Research CentreNIHR Oxford and Thames Valley Applied Research Collaboration and NIHR Biomedical Research CentreCancer Research UK Population Research Fellowship (C60192/A28516)World Cancer Research Fund (WCRF UK),Word Cancer Research Fund International Grant Programme (2019/1953)CTSU (Clinical Trial Service Unit)Council and the British Heart Foundation (CH/ 1996001/9454)UK Biobank was established by the Wellcome Trust, Medical Research CouncilDepartment of Health, Scottish government,Northwest Regional Development AgencyWelsh assembly government and the British Heart FoundationDepartment of Health and Social Car

    Direct evidence of an efficient energy transfer pathway from jellyfish carcasses to a commercially important deep-water species

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    Here we provide empirical evidence of the presence of an energetic pathway between jellyfish and a commercially important invertebrate species. Evidence of scavenging on jellyfish carcasses by the Norway lobster (Nephrops norvegicus) was captured during two deployments of an underwater camera system to 250–287 m depth in Sognefjorden, western Norway. The camera system was baited with two Periphylla periphylla (Scyphozoa) carcasses to simulate the transport of jellyfish detritus to the seafloor, hereby known as jelly-falls. N. norveigus rapidly located and consumed a large proportion (>50%) of the bait. We estimate that the energy input from jelly-falls may represent a significant contribution to N. norvegicus energy demand (0.21 to 10.7 times the energy required for the population of N. norvegicus in Sognefjorden). This potentially high energetic contribution from jelly-falls highlights a possible role of gelatinous material in the support of commercial fisheries. Such an energetic pathway between jelly-falls and N. norvegicus could become more important with increases in jellyfish blooms in some regions

    MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis

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    Commitment of progenitors in the dermomyotome to myoblast fate is the first step in establishing the body musculature. Pax3 is a crucial transcription factor, important for skeletal muscle development and expressed in myogenic progenitors in the dermomyotome of developing somites and in migratory muscle progenitors that populate the limb buds. Down-regulation of Pax3 is essential to ignite the myogenic program, including up-regulation of myogenic regulators, Myf-5 and MyoD. MicroRNAs (miRNAs) confer robustness to developmental timing by posttranscriptional repression of genetic programs that are related to previous developmental stages or to alternative cell fates. Here we demonstrate that the muscle-specific miRNAs miR-1 and miR-206 directly target Pax3. Antagomir-mediated inhibition of miR-1/miR-206 led to delayed myogenic differentiation in developing somites, as shown by transient loss of myogenin expression. This correlated with increased Pax3 and was phenocopied using Pax3-specific target protectors. Loss of myogenin after antagomir injection was rescued by Pax3 knockdown using a splice morpholino, suggesting that miR-1/miR-206 control somite myogenesis primarily through interactions with Pax3. Our studies reveal an important role for miR-1/miR-206 in providing precision to the timing of somite myogenesis. We propose that posttranscriptional control of Pax3 downstream of miR-1/miR-206 is required to stabilize myoblast commitment and subsequent differentiation. Given that mutually exclusive expression of miRNAs and their targets is a prevailing theme in development, our findings suggest that miRNA may provide a general mechanism for the unequivocal commitment underlying stem cell differentiation

    Has phytodetritus processing by an abyssal soft-sediment community recovered 26 years after an experimental disturbance?

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    The potential harvest of polymetallic nodules will heavily impact the abyssal, soft sediment ecosystem by removing sediment, hard substrate, and associated fauna inside mined areas. It is therefore important to know whether the ecosystem can recover from this disturbance and if so at which rate. The first objective of this study was to measure recovery of phytodetritus processing by the benthic food web from a sediment disturbance experiment in 1989. The second objective was to determine the role of holothurians in the uptake of fresh phytodetritus by the benthic food web. To meet both objectives, large benthic incubation chambers (CUBEs; 50 × 50 × 50 cm) were deployed inside plow tracks (with and without holothurian presence) and at a reference site (holothurian presence, only) at 4100 m water depth. Shortly after deployment, <sup>13</sup>C- and <sup>15</sup>N-labeled phytodetritus was injected in the incubation chambers and during the subsequent 3-day incubation period, water samples were taken five times to measure the production of <sup>13</sup>C-dissolved inorganic carbon over time. At the end of the incubation, holothurians and sediment samples were taken to determine biomass, densities and incorporation of <sup>13</sup>C and <sup>15</sup>N into bacteria, nematodes, macrofauna, and holothurians. For the first objective, the results showed that biomass of bacteria, nematodes and macrofauna did not differ between reference sites and plow track sites when holothurians were present. Additionally, meiofauna and macrofauna taxonomic composition was not significantly different between the sites. In contrast, total <sup>13</sup>C uptake by bacteria, nematodes and holothurians was significantly lower at plow track sites compared to reference sites, though the number of replicates was low. This result suggests that important ecosystem functions such as organic matter processing have not fully recovered from the disturbance that occurred 26 years prior to our study. For the second objective, the analysis indicated that holothurians incorporated 2.16 × 10<sup>−3</sup> mmol labile phytodetritus C m<sup>−2</sup> d<sup>−1</sup> into their biomass, which is one order of magnitude less as compared to bacteria, but 1.3 times higher than macrofauna and one order of magnitude higher than nematodes. Additionally, holothurians incorporated more phytodetritus carbon per unit biomass than macrofauna and meiofauna, suggesting a size-dependence in phytodetritus carbon uptake

    Invertebrate communities on historical shipwrecks in the western Atlantic : relation to islands

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    Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution. The definitive version was published in Marine Ecology Progress Series 566 (2017): 17-29, doi:10.3354/meps12058.Shipwrecks can be considered island-like habitats on the seafloor. We investigated the fauna of eight historical shipwrecks off the east coast of the U.S. to assess whether species distribution patterns on the shipwrecks fit models from classical island theory. Invertebrates on the shipwrecks included both sessile (sponges, anemones, hydroids) and motile (crustaceans, echinoderms) species. Invertebrate communities were significantly different among wrecks. The size and distance between wrecks influenced the biotic communities, much like on terrestrial islands. However, while wreck size influenced species richness (alpha diversity), distance to the nearest wreck influenced community composition (beta diversity). Alpha and beta diversity on the shipwrecks were thus influenced by different abiotic factors. We found no evidence of either nested patterns or non-random co-occurrence of morphotypes, suggesting that the taxa on a given shipwreck were randomly selected from the available taxon pool. Species present on the shipwrecks generally had one of two reproductive modes: most motile or solitary sessile species had long-duration planktotrophic larvae, while most encrusting or colonial sessile species had short-duration lecithotrophic larvae and underwent asexual reproduction by budding as adults. Short-duration larvae may recruit to their natal shipwreck, allowing them to build up dense populations and dominate the wreck surfaces. A high degree of dominance was indeed observed on the wrecks, with up to 80% of the fauna being accounted for by the most common species alone. By comparing the shipwreck communities to known patterns of succession in shallow water, we hypothesize that the shipwrecks are in a stage of mid-succession.This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-0829517. Funding for this project was supplied by the Bureau of Ocean Energy Management (BOEM), under contract to CSA Ocean Sciences, Inc. (contract M10PC00100) in partnership with the National Oceanographic 377 Partnership Program

    Rapid scavenging of jellyfish carcasses reveals the importance of gelatinous material to deep-sea food webs

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    Jellyfish blooms are common in many oceans, and anthropogenic changes appear to have increased their magnitude in some regions. Although mass falls of jellyfish carcasses have been observed recently at the deep seafloor, the dense necrophage aggregations and rapid consumption rates typical for vertebrate carrion have not been documented. This has led to a paradigm of limited energy transfer to higher trophic levels at jelly falls relative to vertebrate organic falls. We show from baited camera deployments in the Norwegian deep sea that dense aggregations of deep-sea scavengers (more than 1000 animals at peak densities) can rapidly form at jellyfish baits and consume entire jellyfish carcasses in 2.5 h. We also show that scavenging rates on jellyfish are not significantly different from fish carrion of similar mass, and reveal that scavenging communities typical for the NE Atlantic bathyal zone, including the Atlantic hagfish, galatheid crabs, decapod shrimp and lyssianasid amphipods, consume both types of carcasses. These rapid jellyfish carrion consumption rates suggest that the contribution of gelatinous material to organic fluxes may be seriously underestimated in some regions, because jelly falls may disappear much more rapidly than previously thought. Our results also demonstrate that the energy contained in gelatinous carrion can be efficiently incorporated into large numbers of deep-sea scavengers and food webs, lessening the expected impacts (e.g. smothering of the seafloor) of enhanced jellyfish production on deep-sea ecosystems and pelagic–benthic coupling

    Introduction: Feminist values in research

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