11 research outputs found
Carbonylation of Anthranilic Acid with Aryl and Heteroaryl Bromides to Synthesize Benzoxazinone Derivatives
A simple and efficient, PdCl2(PhCN)2/P(tBu)3⋅HBF4‐catalyzed carbonylative cyclization of anthranilic acid with aryl bromide was investigated for the synthesis of benzoxazinones under mild reaction conditions. The developed protocol has been extended for the synthesis of quinazolin‐4(3 H)‐ones. Furthermore, the tolerance of a wide range of functional groups on anthranilic acid as well as on aryl bromide demonstrates the practical utility of the protocol.Three in 1: A simple and efficient PdCl2(PhCN)2/P(tBu)3⋅HBF4‐catalyzed carbonylative cyclization of anthranilic acid with aryl bromide was investigated for the synthesis of benzoxazinones under mild reaction conditions.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137223/1/ajoc201600253.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137223/2/ajoc201600253-sup-0001-misc_information.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137223/3/ajoc201600253_am.pd
Acide lysergique et dérivés, aspects synthétique et applications
REIMS-BU Santé (514542104) / SudocSudocFranceF
Carbonylation of Anthranilic Acid with Aryl and Heteroaryl Bromides to Synthesize Benzoxazinone Derivatives
Crystal structure and biochemical characterization of a manganese superoxide dismutase from Chaetomium thermophilum
A manganese superoxide dismutase from the thermophilic fungus Chaetomium thermophilum (CtMnSOD) was expressed in Pichia pastoris and purified to homogeneity. Its optimal temperature was 60 °C with approximately 75% of its activity retained after incubation at 70 °C for 60 min. Recombinant yeast cells carrying C. thermophilum mnsod gene exhibited higher stress resistance to salt and oxidative stress-inducing agents than control yeast cells. In an effort to provide structural insights, CtMnSOD was crystallized and its structure was determined at 2.0 Å resolution. The overall architecture of CtMnSOD was found similar to other MnSODs with highest structural similarities obtained against a MnSOD from the thermotolerant fungus Aspergillus fumigatus. In order to explain its thermostability, structural and sequence analysis of CtMnSOD with other MnSODs was carried out. An increased number of charged residues and an increase in the number of intersubunit salt bridges and the Thr:Ser ratio were identified as potential reasons for the thermostability of CtMnSOD
Biointerface analysis on a molecular level: new tools for biosensor research
Tiefenauer L, Ros R. Biointerface analysis on a molecular level: new tools for biosensor research. Colloids and surfaces, B: Biointerfaces. 2002;23(2-3):95-114.In the last decade various techniques have been developed to investigate biointerfaces on a molecular level. Here, their impact for biointerface analysis is reviewed with emphasis on biosensor research. In order to demonstrate the power and limitations of local probe methods the imaging and force spectroscopy on single molecules are presented in details