38 research outputs found
Leading order analysis of neutrino induced dimuon events in the CHORUS experiment
We present a leading order QCD analysis of a sample of neutrino induced
charged-current events with two muons in the final state originating in the
lead-scintillating fibre calorimeter of the CHORUS detector. The results are
based on a sample of 8910 neutrino and 430 antineutrino induced opposite-sign
dimuon events collected during the exposure of the detector to the CERN Wide
Band Neutrino Beam between 1995 and 1998. % with GeV
and GeV collected %between 1995 and 1998. The analysis yields a
value of the charm quark mass of \mc = (1.26\pm 0.16 \pm 0.09) \GeVcc and a
value of the ratio of the strange to non-strange sea in the nucleon of , improving the results obtained in similar analyses
by previous experiments.Comment: Submitted to Nuclear Physics
Associated Charm Production in Neutrino-Nucleus Interactions
In this paper a search for associated charm production both in neutral and
charged current -nucleus interactions is presented. The improvement of
automatic scanning systems in the {CHORUS} experiment allows an efficient
search to be performed in emulsion for short-lived particles. Hence a search
for rare processes, like the associated charm production, becomes possible
through the observation of the double charm-decay topology with a very low
background. About 130,000 interactions located in the emulsion target
have been analysed. Three events with two charm decays have been observed in
the neutral-current sample with an estimated background of 0.180.05. The
relative rate of the associated charm cross-section in deep inelastic
interactions, has been
measured. One event with two charm decays has been observed in charged-current
interactions with an estimated background of 0.180.06 and the
upper limit on associated charm production in charged-current interactions at
90% C.L. has been found to be .Comment: 10 pages, 4 figure
Charged-Particle Multiplicities in Charged-Current Neutrino-- and Anti-Neutrino--Nucleus Interactions
The CHORUS experiment, designed to search for
oscillations, consists of a nuclear emulsion target and electronic detectors.
In this paper, results on the production of charged particles in a small sample
of charged-current neutrino-- and anti-neutrino--nucleus interactions at high
energy are presented. For each event, the emission angle and the ionization
features of the charged particles produced in the interaction are recorded,
while the standard kinematic variables are reconstructed using the electronic
detectors. The average multiplicities for charged tracks, the pseudo-rapidity
distributions, the dispersion in the multiplicity of charged particles and the
KNO scaling are studied in different kinematical regions. A study of
quasi-elastic topologies performed for the first time in nuclear emulsions is
also reported. The results are presented in a form suitable for use in the
validation of Monte Carlo generators of neutrino--nucleus interactions.Comment: 17 pages, 5 figure
Redirected nuclear glutamate dehydrogenase supplies Tet3 with alpha-ketoglutarate in neurons
Tet3 is the main alpha -ketoglutarate (alpha KG)-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and further on to 5-formyl- and 5-carboxy-dC. Neurons possess high levels of 5-hydroxymethyl-dC that further increase during neural activity to establish transcriptional plasticity required for learning and memory functions. How alpha KG, which is mainly generated in mitochondria as an intermediate of the tricarboxylic acid cycle, is made available in the nucleus has remained an unresolved question in the connection between metabolism and epigenetics. We show that in neurons the mitochondrial enzyme glutamate dehydrogenase, which converts glutamate into alpha KG in an NAD(+)-dependent manner, is redirected to the nucleus by the alpha KG-consumer protein Tet3, suggesting on-site production of alpha KG. Further, glutamate dehydrogenase has a stimulatory effect on Tet3 demethylation activity in neurons, and neuronal activation increases the levels of alpha KG. Overall, the glutamate dehydrogenase-Tet3 interaction might have a role in epigenetic changes during neural plasticity. alpha -ketoglutarate (alpha KG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to alpha KG, is redirected from the mitochondria to the nucleus.Proteomic
Measurement of charm production in neutrino charged-current interactions
The nuclear emulsion target of the CHORUS detector was exposed to the
wide-band neutrino beam of the CERN SPS of 27 GeV average neutrino energy from
1994 to 1997. In total about 100000 charged-current neutrino interactions with
at least one identified muon were located in the emulsion target and fully
reconstructed, using newly developed automated scanning systems. Charmed
particles were searched for by a program recognizing particle decays. The
observation of the decay in nuclear emulsion makes it possible to select a
sample with very low background and minimal kinematical bias. 2013
charged-current interactions with a charmed hadron candidate in the final state
were selected and confirmed through visual inspection. The charm production
rate induced by neutrinos relative to the charged-current cross-section is
measured to be sigma(nu_mu N -> mu- C X)/sigma(CC) = (5.75 +-0.32 stat +-0.30
syst)%. The charm production cross-section as a function of the neutrino energy
is also obtained. The results are in good agreement with previous measurements.
The charm-quark hadronization produces the following charmed hadrons with
relative fractions (in %): f_Dzero = 43.7+-4.5, f_Lambda_c^plus = 19.2+-4.2,
f_Dplus = 25.3+-4.2, and f_D_splus = 11.8+-4.7.Comment: 16 pages, 5 figure
Evaluation of annexin V and Calcein-AM as markers of mononuclear cell apoptosis during human immunodeficiency virus infection
Evaluation of apoptosis by flow cytometry is generally accomplished by methods that use annexin V-FITC as vital dye, which access phosphatidylserine exposed on the external membrane at the beginning of this process. In addition, the concomitant use of propidium iodide makes possible to verify the characteristic nuclear alterations in the late stages of apoptosis, as a consequence of the increase in membrane permeability. On the other hand, the use of calcein-AM in association with ethidium homodimer (EthD-1) allows the evaluation of cell apoptosis through detection of esterase activity and cellular membrane physical and chemical alterations. The aim of this study was to compare the sensibility of calcein-AM and EthD-1 with annexin V-FITC and propidium iodide for early apoptosis evaluation in peripheral blood mononuclear cell culture, obtained from HIV-infected patients. Apoptosis and cellular viability were detected and quantified by flow cytometry after 24 and 48 hours incubation times. Our results showed that calcein-AM/EthD-1 was more sensitive for apoptotic cell quantification in both incubation times than annexin V-FITC/propidium iodide (mean of 46.95% ± 3.56, p < 0.0001, for 24 hours and mean of 37.67% ± 2.47, p < 0.0014 for 48 hours), besides allowing to clearly define viable, apoptotic and dead cell populations
Trigger and target transfusion strategy in patients with non-variceal acute upper gastrointestinal bleeding (NV-AUGIB) : A prospective multicentre observational stud
Charge-Particle Multiplicities in Charged-Current Neutrino and Anti-Neutrino-Nucleus Interactions.
Measurement of topological muonic branching ratios of charmed hadrons produced in neutrino-induced charged-current interactions.
From 1994 to 1997, the emulsion target of the CHORUS detector was exposed to the wideband neutrino beam of the CERN SPS. In total about 100 000 charged-current neutrino interactions were located in the nuclear emulsion target and fully reconstructed. From this sample of events based on the data acquired by new automatic scanning systems; 2013 charm-decay events were selected by a pattern recognition program. They were confirmed as decays through visual inspection. Based on these events, the effective branching ratio of charmed particles into muons was determined to be (B) over bar (mu) = [7.3 +/- 0.8(stat) +/- 0.2(syst)] x 10(-2). In addition, the muonic branching ratios are presented for dominating charm-decay topologies. Normalization of the muonic decays to charged-current interactions provides sigma(mu)-(mu)+/sigma(cc) = [3.16 +/- 0.34(stat) 0.09(syst)] x 10(-3). Selecting only events with visible energy greater than 30 GeV gives a value of (B) over bar (mu) that is less affected by the charm production threshold and quasi-elastic Delta(+)(c) production. Combining this value with the current average of B 12 of vertical bar V(cd)vertical bar(LO) = 0. 236 +/- 0.016. (c) 2005 Elsevier B.V. All rights reserved
Measurements of production and of decay branching fractions in neutrino nucleon scattering
During the years 1994-97, the emulsion target of the CHORUS detector was exposed to the wide-band neutrino beam of the CERN SPS of 27 GeV average neutrino energy. In total about 100 000 charged-current neutrino interactions were located in the nuclear emulsion target and fully reconstructed. From this sample of events which was based on the data acquired by new automatic scanning systems, 1048 charged-current interactions with a D^0 in the final state were selected by a pattern recognition program and confirmed as neutral-particle decays through visual inspection. The ratio of decay branching fractions of the D^0 into four-charged particles to two charged particles was measured to B(D^0 -> V4) / B(D^0 -> V2) = 0.207+- 0.004. The inclusive measurement of the observed production rate of the D^0 with a decay into four charged prongs in combination with external measurements of this topological branching ratio was used to determine the total D^0 production rate by neutrinos without additional assumption on the branching fractions. The value of this rate relative to the charged-current cross-section was found to be \sigma(D^0) / \sigma(CC) = 0.0269 +- 0.0018 +- 0.0013. In addition, the same normalization method was used to deduce the inclusive topological decay rate into final states with neutral particles only. A value of 0.218 +- 0.049 +- 0.036 was found for this branching fraction. From an observed number of three charged six-prongs events the branching ratio into six charged particles was determined to be (1.2^1.3_-0.9 +- 0.2) x 10^-3. A measurement of the energy dependence of the D^0 production by neutrinos relative to the total charged-current cross-section is also reported. This measurement was used to deduce for m_c, the effective charm-quark mass, a value of (1.42 +- 0.08) GeV/c^2