1,875 research outputs found
Gyromagnetic remanence acquired by greigite (Fe3S4) during static three-axis alternating field demagnetization
A magnetic study was carried out on lacustrine sediments from the Zoigebasin, Tibetan Plateau, in order to obtain a better understanding ofpalaeoclimatic changes there. Gyromagnetic remanence (GRM) acquisitionis unexpectedly observed during static three-axis alternating field (AF)demagnetization in about 20 per cent of a large number of samples. X-raydiffraction (XRD) analysis on a magnetic extract clearly shows thatgreigite is the dominant magnetic mineral carrier. Scanning electronmicroscopy (SEM) reveals that the greigite particles are in the grainsize range of 200-300 nm, possibly in the single-domain state. Greigiteclumps of about 3 mu m size are sealed by silicates. Fitting of XRDpeaks yields a crystalline coherence length of about 15 nm, indicatingthat the particles seen in the SEM are polycrystalline.GRM intensities of most samples are of the same order as the NRM, whileothers show much stronger GRM although their magnetic properties aresimilar. Variation of the demagnetization sequence confirms that GRM ismainly produced perpendicular to the AF direction. The anisotropydirection can be derived from GRM, but more systematic studies areneeded for detailed conclusions. An attempt to correct for GRM faileddue to high GRM intensities and because smaller GRM acquisition was alsofound along the demagnetization axis. Behaviours of acquisition and AFdemagnetization of GRM are comparable with those of NRM, ARM, IRM,indicating fine grain sizes of remanence carriers
Sensitivity of the UK clinical practice research datalink to detect neurodevelopmental effects of medicine exposure in utero:comparative analysis of an antiepileptic drug-exposed cohort
Introduction: Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data on neurodevelopmental outcomes and its comparability with data generated through other methodologies is unknown. Objectives: The objectives of this study were to determine whether data from the UK Clinical Practice Research Datalink (CPRD) produces similar risk estimates to a prospective cohort study in relation to the risk of neurodevelopmental disorders (NDDs) following prenatal antiepileptic drug (AED) exposure. Methods: A cohort of mother–child pairs of women with epilepsy (WWE) was identified in the CPRD and matched to a cohort without epilepsy. The study period ran from 1 January 2000 to 31 March 2007 and children were required to be in the CPRD at age 6 years. AED exposure during pregnancy was determined from prescription data and children with an NDD diagnosis by 6 years were identified from Read clinical codes. The prevalence and risk of NDDs was calculated for mother–child pairs in WWE stratified by AED regimen and for those without epilepsy. Comparisons were made with the results of the prospective Liverpool and Manchester Neurodevelopment Group study which completed assessment on 201 WWE and 214 without epilepsy at age 6 years. Results: In the CPRD, 1018 mother–child pairs to WWE and 6048 to women without epilepsy were identified. The CPRD identified a lower prevalence of NDDs than the prospective study. In both studies, NDDs were more frequently reported in children of WWE than women without epilepsy, although the CPRD risk estimate was lower (2.16 vs. 0.96%, p < 0.001 and 7.46 vs. 1.87%, p = 0.0128). NDD prevalence differed across AED regimens but the CPRD data did not replicate the significantly higher risk of NDDs following in utero monotherapy valproate exposure (adjusted odds ratio [ORadj] 2.02, 95% confidence interval [CI] 0.52–7.86) observed in the prospective study (ORadj 6.05, 95% CI 1.65–24.53). Conclusion: It was possible to identify NDDs in the CPRD; however, the CPRD appears to under-record these outcomes. Larger studies are required to investigate further
Reducing the Social Gradient in Uptake of the NHS Colorectal Cancer Screening Programme Using a Narrative-Based Information Leaflet: A Cluster-Randomised Trial
Objective: To test the effectiveness of adding a narrative leaflet to the current information material delivered by the NHS English colorectal cancer (CRC) screening programme on reducing socioeconomic inequalities in uptake. / Participants: 150,417 adults (59-74 years) routinely invited to complete the guaiac Faecal Occult Blood test (gFOBt) in March 2013. / Design: A cluster randomised controlled trial (ISRCTN74121020) to compare uptake between two arms. The control arm received the standard NHS CRC screening information material (SI) and the intervention arm received the standard information plus a supplementary narrative leaflet, which had previously been shown to increase screening intentions (SI+N). Between group comparisons were made for uptake overall and across socioeconomic status (SES). Results: Uptake was 57.7% and did not differ significantly between the two trial arms (SI: 58.5%; SI+N: 56.7%; Odds Ratio = 0.93, 95% confidence interval: 0.81-1.06, p = 0.27). There was no interaction between group and SES quintile (p = 0.44). / Conclusions: Adding a narrative leaflet to existing information materials does not reduce the SES gradient in uptake. Despite the benefits of using a pragmatic trial design, the need to add to, rather than replace existing information may have limited the true value of an evidence-based intervention on behaviour
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Faecal immunochemical tests (FIT) versus colonoscopy for surveillance after screening and polypectomy: a diagnostic accuracy and cost-effectiveness study.
OBJECTIVE: The English Bowel Cancer Screening Programme (BCSP) recommends 3 yearly colonoscopy surveillance for patients at intermediate risk of colorectal cancer (CRC) postpolypectomy (those with three to four small adenomas or one ≥10 mm). We investigated whether faecal immunochemical tests (FITs) could reduce surveillance burden on patients and endoscopy services. DESIGN: Intermediate-risk patients (60-72 years) recommended 3 yearly surveillance were recruited within the BCSP (January 2012-December 2013). FITs were offered at 1, 2 and 3 years postpolypectomy. Invitees consenting and returning a year 1 FIT were included. Participants testing positive (haemoglobin ≥40 µg/g) at years one or two were offered colonoscopy early; all others were offered colonoscopy at 3 years. Diagnostic accuracy for CRC and advanced adenomas (AAs) was estimated considering multiple tests and thresholds. We calculated incremental costs per additional AA and CRC detected by colonoscopy versus FIT surveillance. RESULTS: 74% (5938/8009) of invitees were included in our study having participated at year 1. Of these, 97% returned FITs at years 2 and 3. Three-year cumulative positivity was 13% at the 40 µg/g haemoglobin threshold and 29% at 10 µg/g. 29 participants were diagnosed with CRC and 446 with AAs. Three-year programme sensitivities for CRC and AAs were, respectively, 59% and 33% at 40 µg/g, and 72% and 57% at 10 µg/g. Incremental costs per additional AA and CRC detected by colonoscopy versus FIT (40 µg/g) surveillance were £7354 and £180 778, respectively. CONCLUSIONS: Replacing 3 yearly colonoscopy surveillance in intermediate-risk patients with annual FIT could reduce colonoscopies by 71%, significantly cut costs but could miss 30%-40% of CRCs and 40%-70% of AAs. TRIAL REGISTRATION NUMBER: ISRCTN18040196; Results
Effects of evidence-based strategies to reduce the socioeconomic gradient of uptake in the English NHS Bowel Cancer Screening Programme (ASCEND): four cluster-randomised controlled trials
This study is funded by the National Institute for Health Research (NIHR) Programme Grants for Applied Research Programme ( RP-PG-0609-10106 ) and partly supported by the NIHR Collaboration for Leadership in Applied Health Research and Care (CLAHRC) North Thames (MCT and RR
Breaking into the conversation: cultural value and the role of the South African National Arts Festival from apartheid to democracy
The paper examines the value of the South African National Arts Festival (NAF) in the transition to democracy using theories of cultural capital. NAF history from 1974 to 2004 is used to argue that the Festival provided an important arena for the expression of political resistance in the 1980s and, to some degree, continues to do so today. It is concluded that an important part of the value of the arts is their ability to provide a forum for debating the goals and values of society and that individualistic utility theory is not always successful in measuring such social value
Nuclear dependence of the transverse single-spin asymmetry in the production of charged hadrons at forward rapidity in polarized , Al, and Au collisions at GeV
We report on the nuclear dependence of transverse single-spin asymmetries
(TSSAs) in the production of positively-charged hadrons in polarized
, Al and Au collisions at
GeV. The measurements have been performed at forward
rapidity () over the range of GeV and
. We observed a positive asymmetry for
positively-charged hadrons in \polpp collisions, and a significantly reduced
asymmetry in + collisions. These results reveal a nuclear
dependence of charged hadron in a regime where perturbative techniques
are relevant. These results provide new opportunities to use \polpA collisions
as a tool to investigate the rich phenomena behind TSSAs in hadronic collisions
and to use TSSA as a new handle in studying small-system collisions.Comment: 303 authors from 66 institutions, 9 pages, 2 figures, 1 table. v1 is
version accepted for publication in Physical Review Letters. Plain text data
tables for the points plotted in figures for this and previous PHENIX
publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Nuclear dependence of the transverse-single-spin asymmetry for forward neutron production in polarized collisions at GeV
During 2015 the Relativistic Heavy Ion Collider (RHIC) provided collisions of
transversely polarized protons with Au and Al nuclei for the first time,
enabling the exploration of transverse-single-spin asymmetries with heavy
nuclei. Large single-spin asymmetries in very forward neutron production have
been previously observed in transversely polarized collisions at
RHIC, and the existing theoretical framework that was successful in describing
the single-spin asymmetry in collisions predicts only a moderate
atomic-mass-number () dependence. In contrast, the asymmetries observed at
RHIC in collisions showed a surprisingly strong dependence in
inclusive forward neutron production. The observed asymmetry in Al
collisions is much smaller, while the asymmetry in Au collisions is a
factor of three larger in absolute value and of opposite sign. The interplay of
different neutron production mechanisms is discussed as a possible explanation
of the observed dependence.Comment: 315 authors, 8 pages, 4 figures, 1 table. v2 is version accepted for
publication in Phys. Rev. Lett. Plain text data tables for the points plotted
in figures for this and previous PHENIX publications are (or will be)
publicly available at http://www.phenix.bnl.gov/papers.htm
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