Brigatinib (BRG) vs crizotinib (CRZ) in the phase III ALTA-1L trial

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Painéis sanduíches de poliéster reforçado com fibras de rami para aplicação na Construção Civil

RESUMO Neste trabalho foram produzidos e caracterizados mecanicamente compósitos de resina de poliéster reforçada com tecido bidirecional de fios de rami, com diferentes teores de reforço. Estes compósitos foram testados experimentalmente e numericamente como faces de painéis sanduíches formados com núcleos de bucha vegetal impregnada com resina de poliéster e poliestireno expandido - EPS. A caracterização mecânica dos materiais em estudo foi realizada em laboratório a partir de ensaios de tração e flexão, e simulação numérica pelo Método de Elementos Finitos (MEF). A microestrutura do compósito foi analisada por Microscopia Eletrônica de Varredura (MEV). A partir das propriedades mecânicas obtidas para os compósitos reforçados com tecido bidirecional de fios de rami e núcleos de EPS e bucha vegetal, observou-se viável a confecção de painéis sanduíches para aplicação na Construção Civil. Os compósitos com 50% de volume de fios de rami apresentaram as melhores propriedades mecânicas e foram usados como faces nos protótipos dos painéis. Os núcleos em estudo apresentaram bons resultados, com destaque para a bucha vegetal impregnada de resina poliéster, que apresentou maior rigidez e opções de confecção de painéis com maiores dimensões e mais delgados. O presente trabalho evidenciou o potencial das fibras vegetais para uso como constituintes dos compósitos poliméricos e núcleo dos painéis sanduíches e, portanto, revela uma nova alternativa de aproveitamento dessas fibras para aplicação no setor da construção

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Algal Biodiversity of Polluted Waters of River Gomti - A Study

12-14A study on algal biodiversity at different polluted sites of river Gomti of Lucknow is reported. A total 23 algal forms have been observed, out of which sixteen are diatioms of Bacillariophyceae, four are green. Algae and the rest three are blue- green algae. It has been found that green algae, being pollution-sensiti ve form is not present at site- I of Gomti river, where the level of poll ution is low or nil. Sites II and III are polluted areas dominated by pollution indicators of diatoms. As a pollution resistant alga Oscillatoria has been found at polluted as well as unpolluted sites of the river Gomti

Physico-Chemical, Mechanical and Morphological Characterization of Furcraea Selloa K.Koch Plant Leaf Fibers-An Exploratory Investigation

The interest in developing bio-based composite materials had grown up with the context of maintaining ecological integrity by introducing new eco-friendly materials. The present study investigated the suitability of a novel Furcraea selloa K. Koch leaf fiber (FSLF) for composite reinforcement instead of existing synthetic harmful fiber materials. The identification for exploration of novel natural fibers with significant properties is a great challenge for researchers, due to their accessibility in polymer composites eco-friendliness and sustainability. Indeed, physicochemical, thermal, mechanical, and morphological features were established through this study, low density (810 kg/m3), high crystallinity (56.7%), high thermal stability (350°C), good tensile strength (650 ± 23 MPa) were the notable features of FSLF that facilitate its further use for composite reinforcement. Moreover, good surface roughness with fewer impurities and low microfibril angle also prove its sustainability in composite reinforcement. This study suggests that the potential properties of FSLF would be a suitable alternative to commercially important synthetic fiber, in the highest seeking-fibers as reinforcement

Studies on Ramie cellulose microfibrils reinforced cassava starch composite: influence of microfibrils loading

Composites were fabricated from Ramie cellulose microfibrils (RCMF) with cassava starch as matrix and glycerol as a plasticizer. Different composites were fabricated with microfibrils loadings of 0, 2, 4, 8, and 10 wt%. The Particle Size Analyzer results show the average size of RCMF as 1.573 μm. The addition of RCMF considerably influenced the physical, crystalline, thermal, and tensile properties of composites. The addition of RCMF enhanced the crystallinity index (CI) from 32% to 36.67%. Thermogravimetric analysis and tensile test results showed improvement in thermal stability and tensile strength of composite up to 6 wt% microfibrils addition