Non-structural mitigation programs for sediment-related disasters after the Chichi Earthquake in Taiwan

Following the Chichi Earthquake (M(L)=7.3) in 1999, sediment-related disasters, such as landslides and debris flows, have become more frequent in Taiwan. Because engineering structures cannot be fully and rapidly emplaced, the government has initiated non-structural hazard mitigation programs. Initially, community debris flow evacuation drills were promoted in 2000. Typhoon Toraji caused numerous debris flow events in July 2001, and some communities evacuated according to the drills, significantly reducing the numbers of possible casualties. Based on that result, the government expanded the program for evacuation drills. Secondly, the early warning system created after the Chichi Earthquake will prevent many potential future casualties. Rainfall threshold values for debris flow warnings in different areas are determined from information received from local weather stations and modified for local geomorphologic situations. Realtime information is gradually being integrated to create a debris flow disaster warning system, the goal of which is to provide warnings to zones in which debris flows are likely. The warning system was launched in 2005 and has two levels of alarms: yellow and red. The final, red alarm triggers enforced evacuation. Overall, the decrease in casualties from debris flows during the decade after the Chichi Earthquake is not the result of a decrease in number or severity of sediment related disasters, but is more directly related to the gradually improved early warning and evacuation system. However, the compound hazards resulting from Typhoon Morakot in 2009 remind us of the ongoing need for improving the existing mitigation system

Adaptive Robust Self-Balancing and Steering of a Two-Wheeled Human Transportation Vehicle

This paper presents adaptive robust regulation methods for self-balancing and yaw motion of a two-wheeled human transportation vehicle (HTV) with varying payload and system uncertainties. The proposed regulators are aimed at providing consistent driving performance for the HTV with system uncertainties and parameter variations caused by different drivers. By decomposing the overall system into the yaw motion subsystems and the wheeled inverted pendulum, two proposed adaptive robust regulators are synthesized to achieve self-balancing and yaw motion control. Numerical simulations and experimental results on different terrains show that the proposed adaptive robust controllers are capable of achieving satisfactory control actions to steer the vehicle

Adaptive Polar-Space Motion Control for Embedded Omnidirectional Mobile Robots with Parameter Variations and Uncertainties

This paper presents an adaptive polar-space motion controller for trajectory tracking and stabilization of a three-wheeled, embedded omnidirectional mobile robot with parameter variations and uncertainties caused by friction, slip and payloads. With the derived dynamic model in polar coordinates, an adaptive motion controller is synthesized via the adaptive backstepping approach. This proposed polar-space robust adaptive motion controller was implemented into an embedded processor using a field-programmable gate array (FPGA) chip. Furthermore, the embedded adaptive motion controller works with a reusable user IP (Intellectual Property) core library and an embedded real-time operating system (RTOS) in the same chip to steer the mobile robot to track the desired trajectory by using hardware/software co-design technique and SoPC (system-on-a-programmable-chip) technology. Simulation results are conducted to show the merit of the proposed polar-space control method in comparison with a conventional proportional-integral (PI) feedback controller and a non-adaptive polar-space kinematic controller. Finally, the effectiveness and performance of the proposed embedded adaptive motion controller are exemplified by conducting several experiments on steering an embedded omnidirectional mobile robot

Surface loops in a single SH2 domain are capable of encoding the spectrum of specificity of the SH2 family

Src homology 2 (SH2) domains play an essential role in cellular signal transduction by binding to proteins phos-phorylated on Tyr residue. Although Tyr phosphorylation (pY) is a prerequisite for binding for essentially all SH2 domains characterized to date, different SH2 domains prefer specific sequence motifs C-terminal to the pY residue. Because all SH2 domains adopt the same structural fold, it is not well understood how different SH2 domains have acquired the ability to recognize distinct sequence motifs. We have shown previously that the EF and BG loops that connect the secondary structure elements on an SH2 domain dictate its specificity. In this study, we investigated if these surface loops could be engineered to encode diverse specificities. By characterizing a group of SH2 variants selected by different pY peptides from phage-displayed libraries, we show that the EF and BG loops of the Fyn SH2 domain can encode a wide spectrum of specificities, including all three major specificity classes (p 2, p 3 and p 4) of the SH2 domain family. Furthermore, we found that the specificity of a given variant correlates with the sequence feature of the bait peptide used for its isolation, suggesting that an SH2 domain may acquire specificity by co-evolving with its ligand. Intriguingly, we found that the SH2 variants can employ a variety of different mechanisms to confer the same specificity, suggesting the EF and BG loops are highly flexible and adaptable. Our work provides a plausible mechanism for the SH2 domain to acquire the wide spectrum of specificity observed in nature through loop variation with minimal disturbance to the SH2 fold. It is likely that similar mechanisms may have been employed by other modular interaction domains to generate diversity in specificity

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

Although interferon-λ [also known as type III interferon or interleukin-28 (IL-28)/IL-29] restricts infection by several viruses, its inhibitory mechanism has remained uncertain. We used recombinant interferon-λ and mice lacking the interferon-λ receptor (IFNLR1) to evaluate the effect of interferon-λ on infection with West Nile virus, an encephalitic flavivirus. Cell culture studies in mouse keratinocytes and dendritic cells showed no direct antiviral effect of exogenous interferon-λ, even though expression of interferon-stimulated genes was induced. We observed no differences in West Nile virus burden between wild-type and Ifnlr1-/- mice in the draining lymph nodes, spleen, or blood. We detected increased West Nile virus infection in the brain and spinal cord of Ifnlr1-/- mice, yet this was not associated with a direct antiviral effect in mouse neurons. Instead, we observed an increase in blood-brain barrier permeability in Ifnlr1-/- mice. Treatment of mice with pegylated interferon-λ2 resulted in decreased blood-brain barrier permeability, reduced West Nile virus infection in the brain without affecting viremia, and improved survival against lethal virus challenge. An in vitro model of the blood-brain barrier showed that interferon-λ signaling in mouse brain microvascular endothelial cells increased transendothelial electrical resistance, decreased virus movement across the barrier, and modulated tight junction protein localization in a protein synthesis- and signal transducer and activator of transcription 1 (STAT1)-independent manner. Our data establish an indirect antiviral function of interferon-λ in which noncanonical signaling through IFNLR1 tightens the blood-brain barrier and restricts viral neuroinvasion and pathogenesis

The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons

While the predominant function of all tendons is to transfer force from muscle to bone and position the limbs, some tendons additionally function as energy stores, reducing the cost of locomotion. Energy storing tendons experience extremely high strains and need to be able to recoil efficiently for maximum energy storage and return. In the equine forelimb, the energy storing superficial digital flexor tendon (SDFT) has much higher failure strains than the positional common digital extensor tendon (CDET). However, we have previously shown that this is not due to differences in the properties of the SDFT and CDET fascicles (the largest tendon subunits). Instead, there is a greater capacity for interfascicular sliding in the SDFT which facilitates the greater extensions in this particular tendon (Thorpe et al., 2012). In the current study, we exposed fascicles and interfascicular matrix (IFM) from the SDFT and CDET to cyclic loading followed by a test to failure. The results show that IFM mechanical behaviour is not a result of irreversible deformation, but the IFM is able to withstand cyclic loading, and is more elastic in the SDFT than in the CDET. We also assessed the effect of ageing on IFM properties, demonstrating that the IFM is less able to resist repetitive loading as it ages, becoming stiffer with increasing age in the SDFT. These results provide further indications that the IFM is important for efficient function in energy storing tendons, and age-related alterations to the IFM may compromise function and predispose older tendons to injury

Ordering of the lamellar phase under a shear flow

The dynamics of a system quenched into a state with lamellar order and subject to an uniform shear flow is solved in the large-N limit. The description is based on the Brazovskii free-energy and the evolution follows a convection-diffusion equation. Lamellae order preferentially with the normal along the vorticity direction. Typical lengths grow as $\gamma t^{5/4}$ (with logarithmic corrections) in the flow direction and logarithmically in the shear direction. Dynamical scaling holds in the two-dimensional case while it is violated in D=3

Manifestation of photonic band structure in small clusters of spherical particles

We study the formation of the photonic band structure in small clusters of dielectric spheres. The first signs of the band structure, an attribute of an infinite crystal, can appear for clusters of 5 particles. Density of resonant states of a cluster of 32 spheres may exhibit a well defined structure similar to the density of electromagnetic states of the infinite photonic crystal. The resonant mode structure of finite-size aggregates is shown to be insensitive to random displacements of particles off the perfect lattice positions as large as half-radius of the particle. The results were obtained by an efficient numerical method, which relates the density of resonant states to the the scattering coefficients of the electromagnetic scattering problem. Generalized multisphere Mie (GMM) solution was used to obtain scattering matrix elements. These results are important to miniature photonic crystal design as well as understanding of light localization in dense random media.Comment: 4 pages, 2 figure

Universal flow diagram for the magnetoconductance in disordered GaAs layers

The temperature driven flow lines of the diagonal and Hall magnetoconductance data (G_{xx},G_{xy}) are studied in heavily Si-doped, disordered GaAs layers with different thicknesses. The flow lines are quantitatively well described by a recent universal scaling theory developed for the case of duality symmetry. The separatrix G_{xy}=1 (in units e^2/h) separates an insulating state from a spin-degenerate quantum Hall effect (QHE) state. The merging into the insulator or the QHE state at low temperatures happens along a semicircle separatrix G_{xx}^2+(G_{xy}-1)^2=1 which is divided by an unstable fixed point at (G_{xx},G_{xy})=(1,1).Comment: 10 pages, 5 figures, submitted to Phys. Rev. Let