121 research outputs found
Prospects of Scintillating Crystal Detector in Low-Energy Low-Background Experiments
Scintillating crystal detector offers potential advantages in low-energy
(keV-MeV range) low-background experiments for particle physics and
astrophysics. The merits are discussed using CsI(Tl) crystal as illustrations.
The various physics topics which can be pursued with this detector technology
are summarized. A conceptual design for a generic detector is presented.Comment: 20 pages, 1 tables, 7 figures, submitted to Astroparticle Physic
A CsI(Tl) Scintillating Crystal Detector for the Studies of Low Energy Neutrino Interactions
Scintillating crystal detector may offer some potential advantages in the
low-energy, low-background experiments. A 500 kg CsI(Tl) detector to be placed
near the core of Nuclear Power Station II in Taiwan is being constructed for
the studies of electron-neutrino scatterings and other keV-MeV range neutrino
interactions. The motivations of this detector approach, the physics to be
addressed, the basic experimental design, and the characteristic performance of
prototype modules are described. The expected background channels and their
experimental handles are discussed.Comment: 34 pages, 11 figures, submitted to Nucl. Instrum. Method
Parity Violating Measurements of Neutron Densities
Parity violating electron nucleus scattering is a clean and powerful tool for
measuring the spatial distributions of neutrons in nuclei with unprecedented
accuracy. Parity violation arises from the interference of electromagnetic and
weak neutral amplitudes, and the of the Standard Model couples primarily
to neutrons at low . The data can be interpreted with as much confidence
as electromagnetic scattering. After briefly reviewing the present theoretical
and experimental knowledge of neutron densities, we discuss possible parity
violation measurements, their theoretical interpretation, and applications. The
experiments are feasible at existing facilities. We show that theoretical
corrections are either small or well understood, which makes the interpretation
clean. The quantitative relationship to atomic parity nonconservation
observables is examined, and we show that the electron scattering asymmetries
can be directly applied to atomic PNC because the observables have
approximately the same dependence on nuclear shape.Comment: 38 pages, 7 ps figures, very minor changes, submitted to Phys. Rev.
The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue
BACKGROUND: Lung cancer is a leading cause of cancer morbidity and mortality worldwide. Several studies have suggested that Human papillomavirus (HPV) infection is an important risk factor in the development of lung cancer. In this study, we aim to address the role of HPV in the development of lung cancer mechanistically by examining the induction of inflammation and epithelial-mesenchymal transition (EMT) by this virus. METHODS: In this case-control study, tissue samples were collected from 102 cases with lung cancer and 48 controls. We examined the presence of HPV DNA and also the viral genotype in positive samples. We also examined the expression of viral genes (E2, E6 and E7), anti-carcinogenic genes (p53, retinoblastoma (RB)), and inflammatory cytokines in HPV positive cases. RESULTS: HPV DNA was detected in 52.9 (54/102) of the case samples and in 25 (12/48) of controls. A significant association was observed between a HPV positive status and lung cancer (OR�=�3.37, 95 C.I�=�1.58-7.22, P�=�0.001). The most prevalent virus genotype in the patients was type 16 (38.8). The expression of p53 and RB were decreased while and inflammatory cytokines were increased in HPV-positive lung cancer and HPV-positive control tissues compared to HPV-negative lung cancer and HPV-negative control tissues. Also, the expression level of E-cad and PTPN-13 genes were decreased in HPV- positive samples while the expression level of SLUG, TWIST and N-cad was increased in HPV-positive samples compared to negative samples. CONCLUSION: Our study suggests that HPV infection drives the induction of inflammation and EMT which may promote in the development of lung cancer
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel
A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-wide association studies (GWAS). Here we develop a method to estimate haplotypes from low-coverage sequencing data that can take advantage of single-nucleotide polymorphism (SNP) microarray genotypes on the same samples. First the SNP array data are phased to build a backbone (or 'scaffold') of haplotypes across each chromosome. We then phase the sequence data 'onto' this haplotype scaffold. This approach can take advantage of relatedness between sequenced and non-sequenced samples to improve accuracy. We use this method to create a new 1000GP haplotype reference set for use by the human genetic community. Using a set of validation genotypes at SNP and bi-allelic indels we show that these haplotypes have lower genotype discordance and improved imputation performance into downstream GWAS samples, especially at low-frequency variants. © 2014 Macmillan Publishers Limited. All rights reserved
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