Closure of complicated palatal fistula with facial artery musculomucosal flap

Background: Palatal fistulas occur most commonly as a complication of cleft palate surgery. Treatment of these fistulas, especially when they are wide and scarred, is a challenge for both patients and plastic surgeons, with a high rate of recurrence. Methods: The authors have operated on 22 cases of wide, scarred, recurrent palatal fistula with the use of the facial artery musculomucosal flap, first introduced by Pribaz et al. in 1992. The patients were operated on from March of 2001 to December of 2002 and ranged in age from 2 to 21 years. This flap is axial, centered over the facial artery, and can be raised inferiorly based or superiorly based. All of these patients with cleft palate had been operated on before. In one case, because of a very wide fistula, a bilateral facial artery musculomucosal flap was used. Results: There were two cases of partial necrosis and one case of complete failure, probably caused by twisting of the whole pedicle. The nasal lining was made using turndown flaps of the fistula margin. Because of hanging the base of the flap (inferiorly based) and producing bite block during mastication, the pedicle had to be divided and the flap inset secondarily 1 month later. Conclusions: The facial artery musculomucosal flap is an alternative for closing the scarred, wide, recurrent fistula, and is associated with a high rate of success. The flap should be included among the techniques of any plastic surgeon who performs palatal surgery

The comparison of psychological and social adaptation below elbow amputation men using a mechanical and myoelectric prosthesis by using of TAPES questionnaire

Design and manufacturing of the Myoelecterical prosthesis in compared to Mechanical prosthesis must also effectively, smart, light, strong and permanence. It is time consuming and expensive that ultimately leads to significant increases in the price of Myoelecterical prosthesis. Therefore, considering the high cost of these prostheses, hence, assessment of psychological and social adaptation between two groups must be clear and explicit. In this regards, present study was conducted on this topic. In this descriptive cross-sectional analytical study, two groups compared to each other from quality of life, participants was two groups of 20 below elbow amputation veterans that use from Mechanical or Myoelectrical prosthesis that refer to central technical orthopedic Kosar. For gathering the data we use TPEAS questionnaire. This questionnaire evaluates participants from 3 items: psychosocial adaptation, functional limitation and satisfaction of life. For data analysis use to t independent and ANOVA test. This research showed that there are significant differentiations in psychosocial adaptation between two groups. The findings identified that Myoelecterical group higher psychosocial and social adaptation in compare to Mechanical group. So that the hypothesis of this research in terms of higher psychological and social adaptation in the Myoelecterical group was accepted. Keyvani Hafshejani mA, Javanshir M, Kamali M., Ghasemi MS, Emami M, Esmaeeli SA, Langari A., Sattari Naeini M. The comparison of psychological and social adaptation below elbow amputation men using a mechanical and myoelectric prosthesis by using of TAPES questionnaire. Life Sci J 2012;9(4):5583-5587] (ISSN: 1097-8135). http://www.lifesciencesite.com. 82

The effect of Coriander cream on healing of superficial second degree burn wound

Background: Coriander with the binominal name of Corianda Sativum, is one of the oldest medicinal plants ever known to man. Anti-inflammatory, anti-microbial, and anti-fungal effects of its oil has been mentioned in numerous studies. This study examines the impact of coriander cream on wound healing of the second-degree singe burn. Methods: In this experimental study which was performed in the animal lab of the Hazrat Fatemeh Hospital in Tehran, 48 adult male rats with an approximate weight of 250- 300 grams, with deep burns of 2 cm 4�2 dimensions were prepared and divided into 4 groups of 12. We used silver sulfadiazine cream, alpha ointment, coriander cream and vaseline gauze (control group) dressings in burn wound of the groups 1 to 4 respectively. At the end of the study (30 days), rats were euthanized with a high dose of thiopental and the wounds were evaluated on days 10 and 17 with a punch biopsy. Samples were fixed with 10 formalin on histopathology slide using haematoxylin and eosin (H&E) staining (to assess and determine the presence of inflammatory cells). The amount of fibrin and collagen at the site were evaluated using a software program ImageJ, version 1.45 (National Institutes of Health, Bethesda, Maryland, USA). Results: The mean of wound surface area in the first photography was no significant (P= 0. 135). The rate of wound healing in alpha ointment and coriander cream had better outcomes than either of the other two groups (P= 0.000). The healing of the wound in silver sulfadiazine group was significantly less than other groups. Pathology results showed a statistically significant difference between the four groups (coriander, alpha, SSD and control), based on the Kruskal-Wallis test. These relate to (1) polymorphonuclear in the first (P= 0.032) and the second series (P= 0.003), (2) Angiogenesis in the second series (P= 0.004). (3) Fibrosis in the first series (P= 0.024) and the second series (P= 0.000). Conclusion: The results of this study showed that wound healing improvement in coriander cream group was better than the control group and silver sulfadiazine group; and similar to alpha ointment group. © 2015, Tehran University of Medical Sciences. All rights reserved

Cardiac metastases

We report a case of esophageal cancer with symptomatic metastases to the heart; the patient was treated with short-course radiotherapy with good symptomatic relief. We reviewed the current literature regarding the epidemiology, clinical presentation, diagnostic tools, treatment modalities, and the prognosis of cardiac metastases. In this report we summarize the most recent autopsy studies (published between 1975 and 2007), in which we found an autopsy incidence of cardiac metastases of 2.3% among the general population, while the incidence among autopsies of cancer patients was 7.1%. Therefore, we share the opinion with others that there has been an increase in the incidence of cardiac metastases among cancer patients diagnosed after 1970, in comparison with the reported incidences in older series before 1970 (7.1% vs 3.8%; Kruskal-Wallis rank test; P = 0.039). Special attention was given to the role of radiotherapy in the management of cardiac metastases

Interoperable and scalable data analysis with microservices: applications in metabolomics.

Developing a robust and performant data analysis workflow that integrates all necessary components whilst still being able to scale over multiple compute nodes is a challenging task. We introduce a generic method based on the microservice architecture, where software tools are encapsulated as Docker containers that can be connected into scientific workflows and executed using the Kubernetes container orchestrator. We developed a Virtual Research Environment (VRE) which facilitates rapid integration of new tools and developing scalable and interoperable workflows for performing metabolomics data analysis. The environment can be launched on-demand on cloud resources and desktop computers. IT-expertise requirements on the user side are kept to a minimum, and workflows can be re-used effortlessly by any novice user. We validate our method in the field of metabolomics on two mass spectrometry, one nuclear magnetic resonance spectroscopy and one fluxomics study. We showed that the method scales dynamically with increasing availability of computational resources. We demonstrated that the method facilitates interoperability using integration of the major software suites resulting in a turn-key workflow encompassing all steps for mass-spectrometry-based metabolomics including preprocessing, statistics and identification. Microservices is a generic methodology that can serve any scientific discipline and opens up for new types of large-scale integrative science. The PhenoMeNal consortium maintains a web portal (https://portal.phenomenal-h2020.eu) providing a GUI for launching the Virtual Research Environment. The GitHub repository https://github.com/phnmnl/ hosts the source code of all projects. Supplementary data are available at Bioinformatics online

First sagittarius A* Event Horizon Telescope results. VI. Testing the black hole metric

Galaxie

Resolving the inner parsec of the blazar J1924-2914 with the event horizon telescope

Galaxie