885 research outputs found
Letter from Sturges S. Sigler to Thomas S. Armstrong
Sturges Sigler writes to Thomas that his business is in such shape he needs to refrain from joining the volunteer infantry. He offers Thomas advice on attracting the attention of his superiors while enlisted.https://digitalcommons.owu.edu/harvey-letters/1051/thumbnail.jp
ReducingGroundwater Nitrate in the Judith River Watershed: A Participatory Approach to AchieveEffective Management for Improved Water Quality
Rising levels of nitrate in groundwater threaten human health and downstream ecosystems. In the Judith River Watershed, Montana, groundwater nitrate concentrations frequently exceed 10 mg L-Ââ1, and may be increasing due to agricultural practices on thin soils overlying shallow, unconfined aquifers with short groundwater residence :mes. Previous extension and research ac:vi:es in the watershed have provided key data and established working relationships with local stakeholders, but adoption rates of water quality best management practices (BMPs) have been low. With this project, we undertake a participatory approach that engages agricultural producers and stakeholders to
Potential for modulation of the hydrophobic effect inside chaperonins
Despite the spontaneity of some in vitro protein folding reactions, native
folding in vivo often requires the participation of barrel-shaped multimeric
complexes known as chaperonins. Although it has long been known that chaperonin
substrates fold upon sequestration inside the chaperonin barrel, the precise
mechanism by which confinement within this space facilitates folding remains
unknown. In this study, we examine the possibility that the chaperonin mediates
a favorable reorganization of the solvent for the folding reaction. We begin by
discussing the effect of electrostatic charge on solvent-mediated hydrophobic
forces in an aqueous environment. Based on these initial physical arguments, we
construct a simple, phenomenological theory for the thermodynamics of density
and hydrogen bond order fluctuations in liquid water. Within the framework of
this model, we investigate the effect of confinement within a chaperonin-like
cavity on the configurational free energy of water by calculating solvent free
energies for cavities corresponding to the different conformational states in
the ATP- driven catalytic cycle of the prokaryotic chaperonin GroEL. Our
findings suggest that one function of chaperonins may be to trap unfolded
proteins and subsequently expose them to a micro-environment in which the
hydrophobic effect, a crucial thermodynamic driving force for folding, is
enhanced
Logocrinus brandoni, A New Inadunate Crinoid from the Middle Devonian Silica Shale of Ohio
213-220http://deepblue.lib.umich.edu/bitstream/2027.42/48455/2/ID304.pd
Evolution of volatile and phenolic compounds during bottle storage of merlot wines vinified using pulsed electric fields-treated grapes
This study aimed to elucidate changes in volatile, phenolic, and oenological profiles of wines vinified from Pulsed Electric Fields (PEF)-treated and untreated Merlot grapes during bottle storage of up to 150, 90, and 56 days at 4 °C, 25 °C, and 45 °C, respectively, through chemometrics technique. Wines produced from untreated grapes and those PEF-treated at four different processing conditions (electric field strength 33.1 and 41.5 kV/cm and energy inputs between 16.5 and 49.4 kJ/kg) were used for the bottle storage study. Results showed that hydroxycinnamic and hydroxybenzoic acids in all stored wines, regardless vinified from untreated and PEF-treated grapes, increased as a function of time and temperature, while anthocyanins and selected esters (e.g., ethyl butanoate) decreased. Extreme storage temperature, at 45 °C particularly, resulted in a higher amount of linalool-3, 7-oxide in all stored wines. After prolonged storage, all wines produced from grapes PEF-treated with four different processing conditions were shown to favor high retention of phenolics after storage but induced faster reduction of anthocyanins when compared to wines produced from untreated grapes. Moreover, some volatiles in wines vinified using PEF-treated grapes, such as citronellol and 2-phenylethyl acetate, were found to be less susceptible towards degradation during prolonged storage. Production of furans was generally lower in most stored wines, particularly those produced from PEF-treated grapes at higher energy inputs (>47 kJ/kg). Overall, PEF pre-treatment on grapes may improve storage and temperature stability of the obtained wines
Cross-continental emergence of Nannizziopsis barbatae disease may threaten wild Australian lizards
Members of the genus Nannizziopsis are emerging fungal pathogens of reptiles that have been documented as the cause of fatal mycoses in a wide range of reptiles in captivity. Cases of severe, proliferative dermatitis, debility and death have been detected in multiple free-living lizard species from locations across Australia, including a substantial outbreak among Eastern water dragons (Intellagama lesueurii) in Brisbane, Queensland. We investigated this disease in a subset of severely affected lizards and identified a clinically consistent syndrome characterized by hyperkeratosis, epidermal hyperplasia, dermal inflammation, necrosis, ulceration, and emaciation. Using a novel fungal isolation method, histopathology, and molecular techniques, we identified the etiologic agent as Nannizziopsis barbatae, a species reported only once previously from captive lizards in Australia. Here we report severe dermatomycosis caused by N. barbatae in five species of Australian lizard, representing the first cases of Nannizziopsis infection among free-living reptiles, globally. Further, we evaluate key pathogen and host characteristics that indicate N. barbatae-associated dermatomycosis may pose a concerning threat to Australian lizards
Radiative Muon Capture on Hydrogen and the Induced Pseudoscalar Coupling
The first measurement of the elementary process is reported. A photon pair spectrometer was used to measure
the partial branching ratio ( for photons of k >
60 MeV. The value of the weak pseudoscalar coupling constant determined from
the partial branching ratio is , where the first error is the quadrature sum of statistical
and systematic uncertainties and the second error is due to the uncertainty in
, the decay rate of the ortho to para molecule. This
value of g_p is 1.5 times the prediction of PCAC and pion-pole dominance.Comment: 13 pages, RevTeX type, 3 figures (encapsulated postscript), submitted
to Phys. Rev. Let
Talking shit: is community-led total sanitation a radical and revolutionary approach to sanitation?
Abstract: Please refer to full text to view abstrac
50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens
New species of Emmonsia-like fungi, with phylogenetic and clinical similarities to Blastomyces and Histoplasma, have emerged as causes of systemic human mycoses worldwide. They differ from classical Emmonsia species by producing a thermally-dependent, yeast-like phase rather than adiaspores, and by causing disseminated infections, predominantly in immunocompromised patients and often with high case-fatality rates. Such differences will be important for clinicians to consider in diagnosis and patient management, and for microbiologists who may encounter these fungi with increasing frequency
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