Test-bed of a real time detection system for L/H and H/L transitions implemented with the ITMS platform

A basic requirement of the data acquisition systems used in long pulse fusion experiments is to detect events of interest in the acquired signals in real time. Developing such applications is usually a complex task, so it is necessary to develop a set of hardware and software tools that simplify their implementation. An example of these tools is the Intelligent Test and Measurement System (ITMS), which offers distributed data acquisition, distribution and real time processing capabilities with advanced, but easy to use, software tools that simplify application development and system setup. This paper presents the application of the ITMS platform to solve the problem of detecting L/H and H/L transitions in real time based on the use of efficient pattern recognition algorithms

Census of HII regions in NGC 6754 derived with MUSE: Constraints on the metal mixing scale

We present a study of the HII regions in the galaxy NGC 6754 from a two pointing mosaic comprising 197,637 individual spectra, using Integral Field Spectrocopy (IFS) recently acquired with the MUSE instrument during its Science Verification program. The data cover the entire galaxy out to ~2 effective radii (re ), sampling its morphological structures with unprecedented spatial resolution for a wide-field IFU. A complete census of the H ii regions limited by the atmospheric seeing conditions was derived, comprising 396 individual ionized sources. This is one of the largest and most complete catalogue of H ii regions with spectroscopic information in a single galaxy. We use this catalogue to derive the radial abundance gradient in this SBb galaxy, finding a negative gradient with a slope consistent with the characteristic value for disk galaxies recently reported. The large number of H ii regions allow us to estimate the typical mixing scale-length (rmix ~0.4 re ), which sets strong constraints on the proposed mechanisms for metal mixing in disk galaxies, like radial movements associated with bars and spiral arms, when comparing with simulations. We found evidence for an azimuthal variation of the oxygen abundance, that may be related with the radial migration. These results illustrate the unique capabilities of MUSE for the study of the enrichment mechanisms in Local Universe galaxies.Comment: 13 pages, 7 Figurs, accepted for publishing in A&

Integrated phased array transducer for on-board structural health monitoring

Permanently bonded onto a structure, an integrated Phased Array (PhA II) transducer that can provide reliable electromechanical connection with corresponding sophisticated miniaturized ?all in one? SHM electronic device installed directly above it, without need for any interface cabling, during all aerospace structure lifecycle phases and for a huge variety of real harsh service environments of structures to be monitored is presented. This integrated PhA II transducer [1], as a key component of the PAMELA SHM? (Phased Array Monitoring for Enhanced Life Assessment) system, has two principal tasks at the same time, reliably transceive elastic waves in real aerospace service environments and serves as a reliable sole carrier or support for associated integrated on-board SHM electronic device attached above. The PhA II transducer successfully accomplished both required task throughout extensive test campaigns which included low to high temperature tests, temperature cycling, mechanical loading, combined thermo- mechanical loading and vibration resistance, etc. both with and without SHM device attached above due to RTCA DO-160F

Citrato de cafeína: ¿por qué usarlo en los recién nacidos?

ResumenEl citrato de cafeína, es uno de los medicamentos más comúnmente usado en cualquier unidad de cuidados intensivos neonatales; es una metilxantina e inhibidor de los receptores de adenosina. Desde hace más de 30 años es bien conocida su eficacia en el tratamiento de la apnea del prematuro, actualmente se le reconocen otros beneficios como disminución en la incidencia de displasia broncopulmonar, disminución de la falla a la extubación y ser un factor de neuroprotección entre otros. El objetivo del presente artículo fue realizará una revisión sobre las propiedades farmacológicas, mecanismos de acción, dosis adecuadas, niveles séricos y efectos terapéuticos de la cafeína en los recién nacidos.AbstractCaffeine, a methylxantine and nonspecific inhibitor of adenosine receptors, is commonly prescribed in the Neonatal Intensive Care Units. The efficacy of caffeine in an episode of apnea of prematurity has been known for over thirty years, but now it has been found that caffeine have others beneficial actions, such as reduction in the incidence of bronchopulmonary dysplasia, less extubation failure, the need for patent ductus arteriosus treatment, and neuroprotective role. The objective is this review was to update the current knowledge of pharmacologic properties, the mechanisms of action, caffeine dosing and therapeutic effects, in the neonatal population

SDSS-IV MANGA: Spatially Resolved Star Formation Main Sequence and LI(N)ER Sequence

We present our study on the spatially resolved H_alpha and M_star relation for 536 star-forming and 424 quiescent galaxies taken from the MaNGA survey. We show that the star formation rate surface density (Sigma_SFR), derived based on the H_alpha emissions, is strongly correlated with the M_star surface density (Sigma_star) on kpc scales for star- forming galaxies and can be directly connected to the global star-forming sequence. This suggests that the global main sequence may be a consequence of a more fundamental relation on small scales. On the other hand, our result suggests that about 20% of quiescent galaxies in our sample still have star formation activities in the outer region with lower SSFR than typical star-forming galaxies. Meanwhile, we also find a tight correlation between Sigma_H_alpha and Sigma_star for LI(N)ER regions, named the resolved "LI(N)ER" sequence, in quiescent galaxies, which is consistent with the scenario that LI(N)ER emissions are primarily powered by the hot, evolved stars as suggested in the literature.Comment: 6 pages, 4 figures. ApJ Letter accepte

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

Traducción de: Moher D, Shamseer L, Clarke M, Ghersi D, LiberatI A, Petticrew M, Shekelle P, Stewart LA, PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews. 2015; 4(1): 1 - 9. doi: 10.1186/2046-4053-4-1. Traducción con permiso de los/las autores/as. Los autores originales no han revisado ni verificado la traducción del manuscrito al español, y no necesariamente están de acuerdo con su contenido.Las revisiones sistemáticas deben establecerse sobre la base de un protocolo que describa la justificación, la hipótesis y los métodos planificados de la revisión, antes de su realización o publicación; sin embargo pocas revisiones publicadas informan sobre la existencia previa de un protocolo. Disponer de un protocolo detallado y bien escrito puede facilitar la comprensión y valoración de la metodología de la revisión, así como la detección de modificaciones en la metodología o la publicación selectiva en revisiones completadas. El presente trabajo describe el desarrollo de unas directrices de presentación de la información, Preferred Reporting Items for Systematic reviews and Meta-analyses for Protocols 2015 (PRISMA-P 2015). Las directrices PRISMA-P se componen de una lista de verificación de 17 elementos que pretenden facilitar la preparación y presentación de un protocolo sólido para la revisión sistemática. Las instituciones financiadoras y quienes encargan las revisiones podrían considerar la posibilidad de exigir la lista de verificación, a fin de facilitar la presentación de la información relevante del protocolo, para solicitar financiación. De forma similar, los revisores por pares y editores pueden utilizar las directrices para determinar la integridad y transparencia de un protocolo de revisión sistemática presentado a una revista u otro medio para su publicación.Systematic reviews should build on a protocol that describes the rationale, hypothesis, and planned methods of the review; few reviews report whether a protocol exists. Detailed, well-described protocols can facilitate the understanding and appraisal of the review methods, as well as the detection of modifications to methods and selective reporting in completed reviews. We describe the development of a reporting guideline, the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015). PRISMA-P consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review. Funders and those commissioning reviews might consider mandating the use of the checklist to facilitate the submission of relevant protocol information in funding applications. Similarly, peer reviewers and editors can use the guidance to gauge the completeness and transparency of a systematic review protocol submitted for publication in a journal or other medium

Desarrollo de la Red Aerobiológica de Castilla y León (RACYL)

XV lnternational A.P.L.E. Symposium of Palynolog

First survey of Wolf-Rayet star populations over the full extension of nearby galaxies observed with CALIFA

The search of extragalactic regions with conspicuous presence of Wolf-Rayet (WR) stars outside the Local Group is challenging task due to the difficulties in detecting their faint spectral features. In this exploratory work, we develop a methodology to perform an automated search of WR signatures through a pixel-by-pixel analysis of integral field spectroscopy (IFS) data belonging to the Calar Alto Legacy Integral Field Area survey, CALIFA. This technique allowed us to build the first catalogue of Wolf-Rayet rich regions with spatially-resolved information, allowing to study the properties of these complexes in a 2D context. The detection technique is based on the identification of the blue WR bump (around He II 4686 {\AA}, mainly associated to nitrogen-rich WR stars, WN) and the red WR bump (around C IV 5808 {\AA} and associated to carbon-rich WR stars, WC) using a pixel-by-pixel analysis. We identified 44 WR-rich regions with blue bumps distributed in 25 galaxies of a total of 558. The red WR bump was identified only in 5 of those regions. We found that the majority of the galaxies hosting WR populations in our sample are involved in some kind of interaction process. Half of the host galaxies share some properties with gamma-ray burst (GRB) hosts where WR stars, as potential candidates to being the progenitors of GRBs, are found. We also compared the WR properties derived from the CALIFA data with stellar population synthesis models, and confirm that simple star models are generally not able to reproduce the observations. We conclude that other effects, such as the binary star channel (which could extend the WR phase up to 10 Myr), fast rotation or other physical processes that causes the loss of observed Lyman continuum photons, are very likely affecting the derived WR properties, and hence should be considered when modelling the evolution of massive stars.Comment: 33 pages, accepted for publication in A&

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge

This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.[Background]: There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices in the areas of sequence data generation, analysis, interpretation and reporting. The CLARITY Challenge was designed to spur convergence in methods for diagnosing genetic disease starting from clinical case history and genome sequencing data. DNA samples were obtained from three families with heritable genetic disorders and genomic sequence data were donated by sequencing platform vendors. The challenge was to analyze and interpret these data with the goals of identifying disease-causing variants and reporting the findings in a clinically useful format. Participating contestant groups were solicited broadly, and an independent panel of judges evaluated their performance. [Results]: A total of 30 international groups were engaged. The entries reveal a general convergence of practices on most elements of the analysis and interpretation process. However, even given this commonality of approach, only two groups identified the consensus candidate variants in all disease cases, demonstrating a need for consistent fine-tuning of the generally accepted methods. There was greater diversity of the final clinical report content and in the patient consenting process, demonstrating that these areas require additional exploration and standardization. [Conclusions]: The CLARITY Challenge provides a comprehensive assessment of current practices for using genome sequencing to diagnose and report genetic diseases. There is remarkable convergence in bioinformatic techniques, but medical interpretation and reporting are areas that require further development by many groups.This work was supported by funds provided through the Gene Partnership and the Manton Center for Orphan Disease Research at Boston Children’s Hospital and the Center for Biomedical Informatics at Harvard Medical School and by generous donations in-kind of genomic sequencing services by Life Technologies (Carlsbad, CA, USA) and Complete Genomics (Mountain View, CA, USA).Peer Reviewe