Innovation, generative relationships and scaffolding structures: implications of a complexity perspective to innovation for public and private interventions

The linear model of innovation has been superseded by a variety of theoretical models that view the innovation process as systemic, complex, multi-level, multi-temporal, involving a plurality of heterogeneous economic agents. Accordingly, the emphasis of the policy discourse has changed over time. The focus has shifted from the direct public funding of basic research as an engine of innovation, to the creation of markets for knowledge goods, to, eventually, the acknowledgement that knowledge transfer very often requires direct interactions among innovating actors. In most cases, policy interventions attempt to facilitate the match between “demand” and “supply” of the knowledge needed to innovate. A complexity perspective calls for a different framing, one focused on the fostering of processes characterized by multiple agency levels, multiple temporal scales, ontological uncertainty and emergent outcomes. This contribution explores what it means to design interventions in support of innovation processes inspired by a complex systems perspective. It does so by analyzing two examples of coordinated interventions: a public policy funding innovating networks (with SMEs, research centers and university), and a private initiative, promoted by a network of medium-sized mechanical engineering firms, that supports innovation by means of technology brokerage. Relying on two unique datasets recording the interactions of the organizations involved in these interventions, social network analysis and qualitative research are combined in order to investigate network dynamics and the roles of specific actors in fostering innovation processes. Then, some general implications for the design of coordinated interventions supporting innovation in a complexity perspective are drawn

Hypertemporal Imaging of NYC Grid Dynamics

Hypertemporal visible imaging of an urban lightscape can reveal the phase of the electrical grid granular to individual housing units. In contrast to in-situ monitoring or metering, this method offers broad, persistent, real-time, and non-permissive coverage through a single camera sited at an urban vantage point. Rapid changes in the phase of individual housing units signal changes in load (e.g., appliances turning on and off), while slower building- or neighborhood-level changes can indicate the health of distribution transformers. We demonstrate the concept by observing the 120 Hz flicker of lights across a NYC skyline. A liquid crystal shutter driven at 119.75 Hz down-converts the flicker to 0.25 Hz, which is imaged at a 4 Hz cadence by an inexpensive CCD camera; the grid phase of each source is determined by analysis of its sinusoidal light curve over an imaging "burst" of some 25 seconds. Analysis of bursts taken at ~15 minute cadence over several hours demonstrates both the stability and variation of phases of halogen, incandescent, and some fluorescent lights. Correlation of such results with ground-truth data will validate a method that could be applied to better monitor electricity consumption and distribution in both developed and developing cities.Comment: This paper uses astronomical techniques applied to the study of urban lights. This research is reproducible but the data access is restricted. A Github repository contains all code supporting this research as well as additional material: https://github.com/fedhere/detect12

Impact of the annealing temperature on Pt/g-C3N4 structure, activity and selectivity between photodegradation and water splitting

Acknowledgements: The authors would like to thank SABIC as well as EPSRC platform grant [EP/K015540/1] for financial support and the Royal Society of Chemistry for a Wolfson Merit Award. In order to protect intellectual property the data underpinning this publication are not made publicly available. All enquiries about the data should be addressed to [email protected] reviewedPostprin

Development and Initial Validation of a Questionnaire to Measure Health-Related Quality of Life of Adults with Common Variable Immune Deficiency: The CVID_QoL Questionnaire.

BACKGROUND: Generic health status quality of life (QoL) instruments have been used in patients with common variable immune deficiency (CVID). However, by their nature, these tools may over- or underestimate the impact of diseases on an individual's QoL. OBJECTIVE: The objective of this study was to develop and validate a questionnaire to measure specific-health-related QoL for adults with CVID (CVID_QoL). METHODS: The 32-item content of the CVID_QoL questionnaire was developed using focus groups and individual patient interviews. Validation studies included 118 adults with CVID who completed Short Form-36, Saint George Respiratory Questionnaire, General Health Questionnaire-12, and EuroQol-5D questionnaire in a single session. Principal component and factor analysis solutions identified 3 scores to be similar in number and content for each solution. Validation of 3 factor scores was performed by construct validity. Reproducibility, reliability, convergent validity, and discriminant validity were evaluated. Matrices consisting of correlations between the 32 items in the CVID_QOL were calculated. RESULTS: Factor analysis identified 3 dimensions: emotional functioning (EF), relational functioning (RF), and gastrointestinal and skin symptoms (GSS). The instrument had good internal consistency (Cronbach's alpha, min. 0.74 for GSS, max. 0.84 for RF, n = 118) and high reproducibility (intraclass correlation coefficient, min. 0.79 for RF, max 0.90 for EF, n = 27). EF and RF scores showed good convergent validity correlating with conceptually similar dimensions of other study scales. Acute and relapsing infections had a significant impact on EF and RF. CONCLUSIONS: This study provides evidence of the reliability and construct validity of the CVID_QoL to identify QoL issues in patients with CVID that may not be addressed by generic instruments

Biostratigraphy of larger foraminifera in the Eocene (upper Ypresianlower Bartonian) sequences of the Southern Slope of the Western Caucasus (Russia, NE Black Sea). Correlation with regional and standard planktonic foraminiferal zones

The biostratigraphic analysis of two Eocene (Upper Ypresian-Lower Bartonian) sections located on the Southern Slope of the Western Caucasus (Inal and Loo sections in the Tuapse and Sochi districts, respectively) was carried out using planktonic and larger foraminifera. The planktonic foraminiferal assemblages recorded in these southern sections were similar to those recorded in the North Caucasian region and enabled to recognize the lower Ypresian to lower Bartonian zones of the local Caucasian biostratigraphic scale. The turbiditic sedimentary processes recorded in these sections affected the composition of larger foraminiferal assemblages, which is mostly represented by nummulitids and orthophragmines. Although the larger foraminiferal assemblages are typical of the Peritethys and also resemble those reported in the Northern Caucasian region, the Tethyan SBZ zonal scheme could be applied and SBZ11 to 15/16 zones were identified (at least late Ypresian to middle Lutetian). This integrated study improves the correlation between the planktonic and benthonic local biostratigraphic scales in the Caucasus and allows their correlation with the standard and other biostratigraphic scales in neighbouring Tethyan regions

Century-scale trends and seasonality in pH and temperature for shallow zones of the Bering Sea

No records exist to evaluate long-term pH dynamics in high-latitude oceans, which have the greatest probability of rapid acidification from anthropogenic CO2 emissions. We reconstructed both seasonal variability and anthropogenic change in seawater pH and temperature by using laser ablation high-resolution 2D images of stable boron isotopes (δ11B) on a long-lived coralline alga that grew continuously through the 20th century. Analyses focused on four multiannual growth segments. We show a long-term decline of 0.08 ± 0.01 pH units between the end of the 19th and 20th century, which is consistent with atmospheric CO2 records. Additionally, a strong seasonal cycle (∼0.22 pH units) is observed and interpreted as episodic annual pH increases caused by the consumption of CO2 during strong algal (kelp) growth in spring and summer. The rate of acidification intensifies from –0.006 ± 0.007 pH units per decade (between 1920s and 1960s) to –0.019 ± 0.009 pH units per decade (between 1960s and 1990s), and the episodic pH increases show a continuous shift to earlier times of the year throughout the centennial record. This is indicative of ecosystem shifts in shallow water algal productivity in this high-latitude habitat resulting from warming and acidification

Local seismic response studies in the north-western portion of the August 24th, 2016 Mw 6.0 earthquake affected area. The case of Visso village (Central Apennines).

In this work, we investigate the possible causes of the differential damaging observed in Visso village (Central Apennines, about 28 km north from the August 24th, 2016 Mw 6.0 earthquake epicenter). Following insights from the available geological cartography at 1:10.000 scale, a preliminary geophysical survey has been performed in the damaged area in order to constrain geometries and extent of the subsoil lithotypes. Then, these results have been used to retrieve a Vs profile close to the most heavily damaged buildings. This latter has been used as input for a numerical analysis aimed at deriving the motion at the ground level in the study area. In particular, a linear equivalent simulation has been performed by means of EERA code and the waveform has been obtained convolving the time history recorded during the August 24th, 2016 mainshock at Spoleto Monteluco (SPM) site. Our preliminary results indicate a possible correlation of damaging to the thickness and shape of the geological units. Nevertheless, further analyses are necessary to highlight any 2D basin and / non- linear soil behaviour effects in order to compare them to the intrinsic buildings vulnerability, according to the EMS98 guidelines

Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells

In this work, we have exploited the unique properties of a chimeric archaeal-human ferritin to encapsulate, deliver and release cytochrome c and induce apoptosis in a myeloid leukemia cell line. The chimeric protein combines the versatility in 24-meric assembly and cargo incorporation capability of Archaeglobus fulgidus ferritin with specific binding of human H ferritin to CD71, the “heavy duty” carrier responsible for transferrin-iron uptake. Delivery of ferritin-encapsulated cytochrome C to the Acute Promyelocytic Leukemia (APL) NB4 cell line, highly resistant to transfection by conventional methods, was successfully achieved in vitro. The effective liberation of cytochrome C within the cytosolic environment, demonstrated by double fluorescent labelling, induced apoptosis in the cancer cells

Muon and Tau Neutrinos Spectra from Solar Flares

Solar neutrino flares and mixing are considered. Most power-full solar flare as the ones occurred on 23th February 1956, September 29th 1989, 28th October and on 2nd-4th November 2003 are sources of cosmic rays, X, gamma and neutrino bursts. These flares took place both on front or in the edge and in the hidden solar disk. The observed and estimated total flare energy should be a source of a prompt secondary neutrino burst originated, by proton-proton-pion production on the sun itself; a more delayed and spread neutrino flux signal arise by the solar charged flare particles reaching the terrestrial atmosphere. Our first estimates of neutrino signals in largest underground detectors hint for few events in correlation with, gamma,radio onser. Our approximated spectra for muons and taus from these rare solar eruption are shown over the most common background. The muon and tau signature is very peculiar and characteristic over electron and anti-electron neutrino fluxes. The rise of muon neutrinos will be detectable above the minimal muon threshold of 113 MeV. The rarest tau appearence will be possible only for hardest solar neutrino energies above 3.471 GeVComment: 14 pages, 4 figures, Vulcano Conference 200