Geoquímica del W en el área circundante al yacimiento de cheelita de Barruecopardo (Salamanca)

La microclinización, proceso ácido débil, implica una corrosión de plagioclasas y una transformación biotita-clorita, con paso del W de dicha biotita a la fase volátil, bajo forma compleja. El descenso de presión en las fisuras (filones) hace precipitar a los wolframatos. Este mecanismo explica el empobrecimiento en W en las inmediaciones del yacimiento, y justifica una explicación geoquímica y mineralógica expuesta precedentemente

Recurrence of the blue wing enhancements in the high ionization lines of SDSS 1004+4112 A

We present integral field spectroscopic observations of the quadruple-lensed QSO SDSS 1004+4112 taken with the fiber system INTEGRAL at the William Herschel Telescope on 2004 January 19. In May 2003 a blueward enhancement in the high ionization lines of SDSS 1004+4112A was detected and then faded. Our observations are the first to note a second event of similar characteristics less than one year after. Although initially attributed to microlensing, the resemblance among the spectra of both events and the absence of microlensing-induced changes in the continuum of component A are puzzling. The lack of a convincing explanation under the microlensing or intrinsic variability hypotheses makes the observed enhancements particularly relevant, calling for close monitoring of this object.Comment: 4 pages, 5 figure

Search for Tidal Dwarf Galaxies Candidates in a Sample of Ultraluminous Infrared Galaxies

(ABRIDGED) Star-forming small galaxies made out of collisional debris have been found in a variety of merging systems. So far only a few of them are known in ULIRGs although they show clear signs of interactions. Whether external star formation may take place in such objects is an open question. The aim of this paper is to identify and characterise the physical and kinematic properties of the external star forming regions in a sample of ULIRGs, including TDG candidates, using optical IFS and high angular resolution HST imaging. We have found that the presence of external star-forming regions is common with 12 objects being identified in 5 ULIRGs. These regions show a large range of dynamical mass up to 1x10^{10} M_sun, with average sizes of ~750 pc. In addition, the line ratios, metallicities and H\alpha equivalent widths are typical of young bursts of star formation (age ~ 5-8 Myr), and similar to those of other TDG candidates. Their extinction corrected H\alpha luminosities lead to masses for the young stellar component of ~2x10^6 - 7x10^8 M_sun. The likelihood of survival of these regions as TDGs is discussed based on their structural and kinematic properties. Most of these systems follow the relation between effective radius and velocity dispersion found for globular clusters and Ellipticals, which suggests they are stable against internal motions. The stability against forces from the parent galaxy have been studied and a comparison of the data with the predictions of dynamical evolutionary models is also performed. Five regions out of twelve show High-Medium or High likelihood of survival. Our best candidate, which satisfy all the utilized criteria, is located in the advanced merger IRAS15250+3609 and presents a velocity field decoupled from the relatively distant parent galaxy.Comment: 14 pages, 7 figures; A&A accepte

PINGS: the PPAK IFS Nearby Galaxies Survey

We present the PPAK Integral Field Spectroscopy (IFS) Nearby Galaxies Survey: PINGS, a 2-dimensional spectroscopic mosaicking of 17 nearby disk galaxies in the optical wavelength range. This project represents the first attempt to obtain continuous coverage spectra of the whole surface of a galaxy in the nearby universe. The final data set comprises more than 50000 individual spectra, covering in total an observed area of nearly 80 arcmin^2. In this paper we describe the main astrophysical issues to be addressed by the PINGS project, we present the galaxy sample and explain the observing strategy, the data reduction process and all uncertainties involved. Additionally, we give some scientific highlights extracted from the first analysis of the PINGS sample.Comment: Accepted for publication in MNRAS, 26 pages, 14 figures (some in low resolution), 3 table

Effects of Sex, Age and Height on Symphysis–Ischial Spine Distance Measured on a Pelvic CT

Objective: To examine the influence of age, sex and height on the symphysis–ischial spine distance (SID) measured on pelvic Computed tomography (CT)images in subjects of reproductive age, and to determine the interobserver reproducibility. This measurement (SID) is of great importance because the use of intrapartum ultrasound is based on the assumption of a specific value (30 mm) of such a measurement. Methods: This was a cross-sectional descriptive study in which SID was measured in subjects aged 20 to 44 years who had been scheduled for pelvic CT at our centre from January 2018 to May 2021 for different reasons. Radiographic measurements of the pelvis were obtained through the multiplanar reconstruction of the CT image. The images obtained from all of the participants were independently assessed by three senior radiologists, and the SID measurements made by each one were blinded from those of the remaining observers. Correlations between the SID and patient age, height and sex were analyzed by univariate and multivariate linear regression. Results: The mean SID for 87 of the enrolled participants (45 women, 42 men) was 28.2 ± 6.25 mm. Among the observers, the mean difference in this distance was 1 to 2 mm, and was scarcely related to measurement size, with agreement being greater than 70%. The mean SID was significantly related to sex and height (SID = −24.9 − 6.51 × sex (0 or 1) + 0.34 × height (cm); p = 0.01; sex equals 1 for a man and 0 for a woman), such that it was a mean of 2.5 mm greater in women than men (29.50 mm vs. 26.99 mm). Conclusion: Measurements of SID on CT images show good interobserver reproducibility, and are related to sex and height.Depto. de Salud Pública y Materno - InfantilFac. de MedicinaTRUEUnión EuropeaComunidad de MadridInstituto de Salud Carlos IIIHalekulani S.L.pu

Efficacy of Manual Therapy on Facilitatory Nociception and Endogenous Pain Modulation in Older Adults with Knee Osteoarthritis: A Case Series.

Background: manual therapy (MT) has been shown to have positive effects in patients with osteoarthritis (OA)-related pain, and its use in clinical settings is recommended. However, the mechanisms of action for how these positive effects occur are not yet well understood. The aim of the present study was to investigate the influence of MT treatment on facilitatory nociception and endogenous pain modulation in patients with knee OA related pain. Methods: Twenty-eight patients with knee OA were included in this study. Pain intensity using the numerical pain rating scale (NPRS), temporal summation (TS), conditioned pain modulation (CPM), and local (knee) and distant (elbow) hyperalgesia through the pressure pain threshold (PPT), were assessed to evaluate the pain modulatory system. Patients underwent four sessions of MT treatments within 3 weeks and were evaluated at the baseline, after the first session and after the fourth session. Results: the MT treatment reduced knee pain after the first session (p = 0.03) and after the fourth session (p = 0.04). TS decreased significantly after the fourth session of MT (p = 0.02), while a significant increase in the CPM assessment was detected after the fourth session (p = 0.05). No significant changes in the PPT over the knee and elbow were found in the follow-ups. Conclusions: The results from our study suggest that MT might be an effective and safe method for improving pain and for decreasing temporal summation.post-print502 K

Compact molecular gas emission in local LIRGs among low- and high-z galaxies

We present new CO(2–1) observations of a representative sample of 24 local (z < 0.02) luminous infrared galaxies (LIRGs) at high spatial resolution (< 100 pc) from the Atacama Large Millimeter/submillimeter Array (ALMA). Our LIRGs lie above the main sequence (MS), with typical stellar masses in the range 1010–1011 M⊙ and SFR ∼ 30 M⊙ yr−1. We derive the effective radii of the CO(2–1) and the 1.3 mm continuum emissions using the curve-of-growth method. LIRGs show an extremely compact cold molecular gas distribution (median RCO ∼ 0.7 kpc), which is a factor 2 smaller than the ionized gas (median RHα ∼ 1.4 kpc), and 3.5 times smaller than the stellar size (median Rstar ∼ 2.4 kpc). The molecular size of LIRGs is similar to that of early-type galaxies (ETGs; RCO ∼ 1 kpc) and about a factor of 6 more compact than local spiral galaxies of similar stellar mass. Only the CO emission in low-z ULIRGs is more compact than these local LIRGs by a factor of 2. Compared to high-z (1 < z < 6) systems, the stellar sizes and masses of local LIRGs are similar to those of high-z MS star-forming galaxies (SFGs) and about a factor of 2–3 lower than submillimeter (submm) galaxies (SMGs). The molecular sizes of high-z MS SFGs and SMGs are larger than those derived for LIRGs by a factor of ∼3 and ∼8, respectively. Contrary to high-z SFGs and SMGs, which have comparable molecular and stellar sizes (median Rstar/RCO = 1.8 and 1.2, respectively), local LIRGs show more centrally concentrated molecular gas distribution (median Rstar/RCO = 3.3). A fraction of the low-z LIRGs and high-z galaxies share a similar range in the size of the ionized gas distribution, from 1 to 4 kpc. However, no LIRGs with a very extended (above 4 kpc) radius are identified, while for high-z galaxies no compact (less than 1 kpc) emission is detected. These results indicate that while low-z LIRGs and high-z MS SFGs have similar stellar masses and sizes, the regions of current star formation (traced by the ionized gas) and of potential star formation (traced by the molecular gas) are substantially smaller in LIRGs, and constrained to the central kiloparsec (kpc) region. High-z galaxies represent a wider population but their star-forming regions are more extended, even covering the entire extent of the galaxy. High-z galaxies have larger fractions of gas than low-z LIRGs, and therefore the formation of stars could be induced by interactions and mergers in extended disks or filaments with sufficiently large molecular gas surface density involving physical mechanisms similar to those identified in the central kpc of LIRGs

A Non-Viral Plasmid DNA Delivery System Consisting on a Lysine-Derived Cationic Lipid Mixed with a Fusogenic Lipid

The insertion of biocompatible amino acid moieties in non-viral gene nanocarriers is an attractive approach that has been recently gaining interest. In this work, a cationic lipid, consisting of a lysine-derived moiety linked to a C12 chain (LYCl) was combined with a common fusogenic helper lipid (DOPE) and evaluated as a potential vehicle to transfect two plasmid DNAs (encoding green fluorescent protein GFP and luciferase) into COS-7 cells. A multidisciplinary approach has been followed: (i) biophysical characterization based on zeta potential, gel electrophoresis, small-angle X-ray scattering (SAXS), and cryo-transmission electronic microscopy (cryo-TEM); (ii) biological studies by fluorescence assisted cell sorting (FACS), luminometry, and cytotoxicity experiments; and (iii) a computational study of the formation of lipid bilayers and their subsequent stabilization with DNA. The results indicate that LYCl/DOPE nanocarriers are capable of compacting the pDNAs and protecting them efficiently against DNase I degradation, by forming Lα lyotropic liquid crystal phases, with an average size of ~200 nm and low polydispersity that facilitate the cellular uptake process. The computational results confirmed that the LYCl/DOPE lipid bilayers are stable and also capable of stabilizing DNA fragments via lipoplex formation, with dimensions consistent with experimental values. The optimum formulations (found at 20% of LYCl content) were able to complete the transfection process efficiently and with high cell viabilities, even improving the outcomes of the positive control Lipo2000*

Modelo CBCRisk para determinar el riesgo de cáncer de mama contralateral en el cáncer de mama esporádico

Introducción La mayoría de los cánceres de mama (CM) se diagnostican en mujeres sin antecedentes familiares y no portadoras de mutaciones de riesgo. En las últimas décadas se ha producido un aumento de mastectomías profilácticas contralaterales (MPC) en estas pacientes. El CBCRisk es un modelo que calcula el riesgo absoluto de cáncer de mama contralateral (CMC) y pretende servir para el asesoramiento de pacientes con CM esporádico sobre la MPC. Método Análisis observacional retrospectivo de pacientes con un cáncer de mama esporádico sometidas a MPC durante 2017-2019. Análisis descriptivo, comparativo y de regresión logística univariante para identificar factores predictivos de LMAR y/o CMC oculto. Evaluación del modelo CBCRisk publicado en 2017 y distintos valores límite para la recomendación de MPC. Resultados Se seleccionaron 42 pacientes. Incidencia de LMAR y cáncer oculto (CO) menor que la descrita en la literatura (9, 52% LMAR, 2, 38% CO). Ninguna de las variables evaluadas alcanzó significación estadística para la predicción de lesiones. El valor de CBCRisk a cinco años medio en pacientes con hallazgos patológicos fue de 2, 08 (DE 0, 97), superior al CBCRisk medio del conjunto (1, 87 ± 0, 91) y del subgrupo de MPC sin hallazgos patológicos (1, 84 ± 0, 91). Solo el CBCRisk = 3 resultó significativo (p = 0, 04) para la predicción de hallazgos patológicos. Conclusión Las pacientes con CM esporádico deben ser adecuadamente informadas de los riesgos y beneficios estimados de la MPC. El CBCRisk puede ser útil para el asesoramiento de estas pacientes, pero precisa validación en cohortes más amplias y prospectivas. Introduction The great majority of breast cancer (BC) cases are diagnosed in women who have no known family history of the disease and are not carriers of any risk mutation. During the past few decades an increase in the number of contralateral prophylactic mastectomy (CPM) has been produced in these patients. The CBCRisk model calculates the absolute risk of suffering from contralateral breast cancer (CBC); thus, it can be used to counselling patients with sporadic breast cancer. Method An observational, retrospective study including sporadic breast cancer patients treated with contralateral prophylactic mastectomy has been conducted between 2017 and 2019. A descriptive and comparative study with one variation of logistic regression has been carried out in order to identify predictive factors of occult tumors (OT) and medium/high risk damage (MHRD). Evaluation of the CBCRisk model published in 2017 and different limit values for the CPM recommendation. Results 42 patients were selected. Incidence of MHRD and OT was lower than that described in the literatura (9.52% MHRD, 2.38% OT). None of the evaluated variables reached statistical significance for predicting injuries. The average value of CBCRisk 5 years ahead found in patients with pathological findings was 2.08 (SD 0.97), higher than the average value of the whole group (1.87 ± 0.91) and the subgroup without pathological findings (1.84 ± 0.91). Only values = 3 for CBCRisk were considered statistically significant (p = 0.04) for the prediction of histological lesions. Conclusion Patients with sporadic breast cancer should be adequately informed about the estimated risks and benefits of undergoing a contralateral prophylactic mastectomy. The CBCRisk may be useful for the counseling of these patients, but it requires validation in larger and prospective cohorts