Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).

We report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia. GATA2 is a transcription factor that plays an essential role in gene regulation during vascular development and hematopoietic differentiation. Our findings indicate that haploinsufficiency of GATA2 underlies primary lymphedema and predisposes to acute myeloid leukemia in this syndrome

The Structure of Episodic Memory: Ganeri's ‘Mental Time Travel and Attention’

We offer a framework for assessing what the structure of episodic memory might be, if one accepts the Buddhist denial of persisting selves. This paper is a response to Jonardon Ganeri's paper "Mental time travel and attention", which explores Buddhaghosa's ideas about memory. (It will eventually be published with a reply by Ganeri)

Measurement of the neutrino component of an anti-neutrino beam observed by a non-magnetized detector

Two independent methods are employed to measure the neutrino flux of the anti-neutrino-mode beam observed by the MiniBooNE detector. The first method compares data to simulated event rates in a high purity \numu induced charged-current single \pip (CC1\pip) sample while the second exploits the difference between the angular distributions of muons created in \numu and \numub charged-current quasi-elastic (CCQE) interactions. The results from both analyses indicate the prediction of the neutrino flux component of the pre-dominately anti-neutrino beam is over-estimated - the CC1\pip analysis indicates the predicted \numu flux should be scaled by $0.76 \pm 0.11$, while the CCQE angular fit yields $0.65 \pm 0.23$. The energy spectrum of the flux prediction is checked by repeating the analyses in bins of reconstructed neutrino energy, and the results show that the spectral shape is well modeled. These analyses are a demonstration of techniques for measuring the neutrino contamination of anti-neutrino beams observed by future non-magnetized detectors.Comment: 15 pages, 7 figures, published in Physical Review D, latest version reflects changes from referee comment

A Search for Electron Antineutrino Appearance at the Δm2∼\Delta m^2 \sim 1 eV2\mathrm{eV}^{2} Scale

The MiniBooNE Collaboration reports initial results from a search for $\bar{\nu}_{\mu}\to\bar{\nu}_e$ oscillations. A signal-blind analysis was performed using a data sample corresponding to $3.39 \times 10^{20}$ protons on target. The data are consistent with background prediction across the full range of neutrino energy reconstructed assuming quasielastic scattering, $200 < E_{\nu}^{QE} < 3000$ MeV: 144 electron-like events have been observed in this energy range, compared to an expectation of $139.2 \pm 17.6$ events. No significant excess of events has been observed, both at low energy, 200-475 MeV, and at high energy, 475-1250 MeV. The data are inconclusive with respect to antineutrino oscillations suggested by data from the Liquid Scintillator Neutrino Detector at Los Alamos National Laboratory.Comment: 5 pages, 3 figures, 2 table

Search for Charged Current Coherent Pion Production on Carbon in a Few-GeV Neutrino Beam

The SciBooNE Collaboration has performed a search for charged current coherent pion production from muon neutrinos scattering on carbon, \nu_\mu ^{12}C \to \mu^- ^{12}C \pi^+, with two distinct data samples. No evidence for coherent pion production is observed. We set 90% confidence level upper limits on the cross section ratio of charged current coherent pion production to the total charged current cross section at 0.67\times 10^{-2} at mean neutrino energy 1.1 GeV and 1.36\times 10^{-2} at mean neutrino energy 2.2 GeV.Comment: 18 pages, 16 figures, Minor revisions to match version accepted for publication in Physical Review

Measurement of Muon Neutrino Quasi-Elastic Scattering on Carbon

The observation of neutrino oscillations is clear evidence for physics beyond the standard model. To make precise measurements of this phenomenon, neutrino oscillation experiments, including MiniBooNE, require an accurate description of neutrino charged current quasi-elastic (CCQE) cross sections to predict signal samples. Using a high-statistics sample of muon neutrino CCQE events, MiniBooNE finds that a simple Fermi gas model, with appropriate adjustments, accurately characterizes the CCQE events observed in a carbon-based detector. The extracted parameters include an effective axial mass, M_A^eff = 1.23+/-0.20 GeV, that describes the four-momentum dependence of the axial-vector form factor of the nucleon; and a Pauli-suppression parameter, kappa = 1.019+/-0.011. Such a modified Fermi gas model may also be used by future accelerator-based experiments measuring neutrino oscillations on nuclear targets.Comment: 5 pages, 3 figure

Measurement of the \nu_\mu charged current \pi^+ to quasi-elastic cross section ratio on mineral oil in a 0.8 GeV neutrino beam

Using high statistics samples of charged current $\nu_\mu$ interactions, MiniBooNE reports a measurement of the single charged pion production to quasi-elastic cross section ratio on mineral oil (CH$_2$), both with and without corrections for hadron re-interactions in the target nucleus. The result is provided as a function of neutrino energy in the range 0.4 GeV $< E_\nu <$ 2.4 GeV with 11% precision in the region of highest statistics. The results are consistent with previous measurements and the prediction from historical neutrino calculations.Comment: 4 pages, 2 figure

Measurement of inclusive charged current interactions on carbon in a few-GeV neutrino beam

The SciBooNE Collaboration reports a measurement of inclusive charged current interactions of muon neutrinos on carbon with an average energy of 0.8 GeV using the Fermilab Booster Neutrino Beam. We compare our measurement with two neutrino interaction simulations: NEUT and NUANCE. The charged current interaction rates (product of flux and cross section) are extracted by fitting the muon kinematics, with a precision of 6-15% for the energy dependent and 3% for the energy integrated analyses. We also extract CC inclusive interaction cross sections from the observed rates, with a precision of 10-30% for the energy dependent and 8% for the energy integrated analyses. This is the first measurement of the CC inclusive cross section on carbon around 1 GeV. These results can be used to convert previous SciBooNE cross section ratio measurements to absolute cross section values.Comment: 21 pages, 16 figures. Accepted by Phys. Rev. D. Minor revisions to match the accepted versio

A Proposal for a Three Detector Short-Baseline Neutrino Oscillation Program in the Fermilab Booster Neutrino Beam

A Short-Baseline Neutrino (SBN) physics program of three LAr-TPC detectors located along the Booster Neutrino Beam (BNB) at Fermilab is presented. This new SBN Program will deliver a rich and compelling physics opportunity, including the ability to resolve a class of experimental anomalies in neutrino physics and to perform the most sensitive search to date for sterile neutrinos at the eV mass-scale through both appearance and disappearance oscillation channels. Using data sets of 6.6e20 protons on target (P.O.T.) in the LAr1-ND and ICARUS T600 detectors plus 13.2e20 P.O.T. in the MicroBooNE detector, we estimate that a search for muon neutrino to electron neutrino appearance can be performed with ~5 sigma sensitivity for the LSND allowed (99% C.L.) parameter region. In this proposal for the SBN Program, we describe the physics analysis, the conceptual design of the LAr1-ND detector, the design and refurbishment of the T600 detector, the necessary infrastructure required to execute the program, and a possible reconfiguration of the BNB target and horn system to improve its performance for oscillation searches.Comment: 209 pages, 129 figure

The Ninth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-III Baryon Oscillation Spectroscopic Survey

The Sloan Digital Sky Survey III (SDSS-III) presents the first spectroscopic data from the Baryon Oscillation Spectroscopic Survey (BOSS). This ninth data release (DR9) of the SDSS project includes 535,995 new galaxy spectra (median z=0.52), 102,100 new quasar spectra (median z=2.32), and 90,897 new stellar spectra, along with the data presented in previous data releases. These spectra were obtained with the new BOSS spectrograph and were taken between 2009 December and 2011 July. In addition, the stellar parameters pipeline, which determines radial velocities, surface temperatures, surface gravities, and metallicities of stars, has been updated and refined with improvements in temperature estimates for stars with T_eff<5000 K and in metallicity estimates for stars with [Fe/H]>-0.5. DR9 includes new stellar parameters for all stars presented in DR8, including stars from SDSS-I and II, as well as those observed as part of the SDSS-III Sloan Extension for Galactic Understanding and Exploration-2 (SEGUE-2). The astrometry error introduced in the DR8 imaging catalogs has been corrected in the DR9 data products. The next data release for SDSS-III will be in Summer 2013, which will present the first data from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) along with another year of data from BOSS, followed by the final SDSS-III data release in December 2014.Comment: 9 figures; 2 tables. Submitted to ApJS. DR9 is available at http://www.sdss3.org/dr