Tecnologias digitais para formação em empresas e entidades da economia social

The digital transformation is one of the challenges that all institutions –public and private– are facing in this post-pandemic situation to offer adequate services to citizens, thus favoring productivity and improving the performance of workers. With this study it has been intended to know with empirical data the reality of the digital transformation of entities of the Social Economy and more specifically in the context of training in companies. A quantitative approach has been chosen for an exploratory study supported by the survey technique. Two questionnaires created ad hoc have been designed: one for workers (participant sample: 200) and another for management positions of companies and entities of the Social Economy (participant sample: 115). Among the main results is that workers consider that they have adequate training to face the digitalization of their companies, although some data show that they lack certain skills necessary for the digital world (multimedia design, use of the cloud or strategies to share digital information). Companies and entities of the Social Economy prioritize the technological endowment and the protection of digital data with respect to the training on digital competence of their workers. It is also revealed that companies provide more technology for management to employees than to the management team. Finally, it is highlighted that despite the provision of technological infrastructure, the quality of this is usually improvable.La transformación digital es uno de los retos que todas las instituciones -públicas y privadas- están afrontando en esta situación postpandemia para ofrecer servicios adecuados a los ciudadanos, favoreciendo así la productividad y mejorando el rendimiento de los trabajadores. Con este estudio se ha pretendido conocer con datos empíricos la realidad de la transformación digital de entidades de la Economía Social y más específicamente en el contexto de la formación en empresas. Se ha optado por un enfoque cuantitativo para un estudio exploratorio apoyado en la técnica de encuesta. Se han diseñado dos cuestionarios creados ad hoc: uno para trabajadores (muestra participante: 200) y otro para cargos directivos de empresas y entidades de la Economía Social (muestra participante: 115). Entre los principales resultados se destaca que los trabajadores consideran que poseen una formación adecuada para enfrentarse a la digitalización de sus empresas, pese a que algunos datos ponen de manifiesto que carecen de ciertas competencias necesarias para el mundo digital (diseño de multimedia, uso de la nube o estrategias para compartir información digital). Empresas y entidades de la Economía Social priorizan la dotación tecnológica y la protección de datos digitales respecto a la formación sobre competencia digital de sus trabajadores. También se revela que las empresas dotan de mayor tecnología para la gestión a los empleados que al equipo directivo. Por último, se destaca que a pesar de la dotación de infraestructura tecnológica, la calidad de esta suele ser mejorable.A transformação digital é um dos desafios que todas as instituições –públicas e privadas– enfrentam nesta situação pós-pandemia para oferecerem serviços adequados aos cidadãos, favorecendo assim a produtividade e melhorando o desempenho dos trabalhadores. Com este estudo pretende-se conhecer com dados empíricos a realidade da transformação digital das entidades da Economia Social e, mais especificamente, no contexto da formação nas empresas. Foi escolhida uma abordagem quantitativa para um estudo exploratório apoiado pela técnica de pesquisa. Foram concebidos dois questionários criados ad hoc: um para trabalhadores (amostra de participante: 200) e outro para cargos de gestão de empresas e entidades da Economia Social (amostra de participantes: 115). Entre os principais resultados está o facto de os trabalhadores considerarem que têm formação adequada para fazer face à digitalização das suas empresas, embora alguns dados mostrem que carecem de certas competências necessárias para o mundo digital (design multimédia, utilização da nuvem ou estratégias para partilhar informação digital). As empresas e entidades da Economia Social priorizam a dotação tecnológica e a proteção dos dados digitais no que diz respeito à formação em competência digital dos seus trabalhadores. Revela-se ainda que as empresas fornecem mais tecnologia para a gestão aos colaboradores do que para a equipa de gestão. Por último, salienta-se que, apesar da disponibilização de infraestruturas tecnológicas, a qualidade desta situação é geralmente viável

Innovation, Creativity and Entreprenaeurship Learning Outcomes in Higher Education

A major trend in higher education is the current shift towards improving students’ creativity and individual thinking. The aim of this shift is to bring students closer to the real world and the complex problems they will encounter outside formal education. Competencies describe what training participants should be able to do at the end of such training. This paper defines the learning outcomes associated with the innovation, creativity and entrepreneurship competency. This proposal draws on a review of the innovation and competencies literature and the expertise of selected staff. According to the literature review and the following analysis by the authors, the main indicators (key aspects) associated with the competency are as follows: seek opportunities, generate ideas, execute plans and add value. These indicators vary by educational level to reflect increasing complexity and difficulty in the learning outcomes at each stage of university education. This paper proposes learning outcomes and indicators associated with the competencies of innovation, creativity and entrepreneurship. It corresponds to the first essential step associated with the definition of a competency assessment.This research has been partially supported by: Project for educational improvement B019/14. Integrating teamwork and leadership in class, funded by School of Higher Technical Studies in Engineering and Design and the Vice-Rector of Studies, Quality and Accreditation. Project for educational improvement (PIME/2014/A09). Students' perceptions and motivations in the development and assessment of competencies at the UPV, funded by the Escuela Técnica Superior de Ingeniería Industrial, Escuela Técnica Superior de Ingeniería Informática and the Vice-Rector of Studies, Quality and Accreditation. European Union [FINCODA 554493-EPP-1-2014-1-FI-EPPKA2-KA] and Universitat Politècnica de València [PIME/2014/A/013/A - Barómetro INCODE: Evaluación de Competencias de lnnovación en la Empresa y en la Universidad]. (The European Commission’s support for this publication does not constitute an endorsement of its contents, which reflect the views of the authors only. The European Commission cannot be held responsible for any use of the information contained herein). Project for educational improvement (PIME/2013/A/016/B) RECICRE - Rubric for evaluating competence of innovation and Tempus IDEA Inter Disciplinary Education Agenda.Cuenca, L.; Bonet Espinosa, MP.; Boza García, A.; Fuentes-Durá, P.; Lajara-Camilleri, N.; Marín García, JA.; Peris-Ortiz, M.... (2015). Innovation, Creativity and Entreprenaeurship Learning Outcomes in Higher Education. IATED, International Association of Technology, Education and Development. http://hdl.handle.net/10251/7284

Formación del Profesorado de Primaria para promover la igualdad de género

La formación del profesorado sobre igualdad y tratamiento de la violencia de género en las aulas es una necesidad cada vez más demandada en nuestras escuelas. Para responder a esta demanda y a la importancia de trabajar en las aulas este tema surge el Proyecto Europeo GEM (Gender Equality Matters) con la finalidad de diseñar materiales y estrategias de formación para que el profesorado de Enseñanza Primaria pueda trabajar en el aula la igualdad de género. En este artículo presentamos la fase de formación del profesorado llevada a cabo en el marco del proyecto y los resultados principales de la evaluación de la misma. Tras la evaluación, encontramos un elevado nivel de satisfacción entre el profesorado participante y un alto nivel de concienciación entre los mismos sobre la importancia de formarse en estas temáticas.Teacher training on equality and treatment of gender violence in classrooms is an increasingly demanded need in our schools. To respond to this demand and the importance of working in the classroom on this subject, the European GEM Project (Gender Equality Matters) arises with the purpose of training primary teachers on how to address the attitudes and behaviors that undermine the equality of gender. In this article, we present the teacher training carried out within the framework of the project and the main results of its evaluation. After the evaluation, we found a high level of satisfaction among the participating teachers and a high level of awareness among them about the importance of training on these topics

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression

Background PTOV1 is an adaptor protein with functions in diverse processes, including gene transcription and protein translation, whose overexpression is associated with a higher proliferation index and tumor grade in prostate cancer (PC) and other neoplasms. Here we report its interaction with the Notch pathway and its involvement in PC progression. Methods Stable PTOV1 knockdown or overexpression were performed by lentiviral transduction. Protein interactions were analyzed by co-immunoprecipitation, pull-down and/or immunofluorescence. Endogenous gene expression was analyzed by real time RT-PCR and/or Western blotting. Exogenous promoter activities were studied by luciferase assays. Gene promoter interactions were analyzed by chromatin immunoprecipitation assays (ChIP). In vivo studies were performed in the Drosophila melanogaster wing, the SCID-Beige mouse model, and human prostate cancer tissues and metastasis. The Excel package was used for statistical analysis [...]

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

We report a medium-throughput drug-screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metastasis, we identified several vulnerabilities. Among them, a blood-brain barrier permeable HSP90 inhibitor showed high potency against mouse and human brain metastases at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery. Furthermore, in situ proteomic analysis applied to metastases treated with the chaperone inhibitor uncovered a novel molecular program in brain metastasis, which includes biomarkers of poor prognosis and actionable mechanisms of resistance. Our work validates METPlatform as a potent resource for metastasis research integrating drug-screening and unbiased omic approaches that is compatible with human samples. Thus, this clinically relevant strategy is aimed to personalize the management of metastatic disease in the brain and elsewhere.Acknowledgments: This work was supported by MINECO (SAF2017-89643-R, SAF2014-57243-R, SAF2015-62547-ERC) (M.V.), Fundacion FERO (IX FERO Grant for Research in Oncology) (M.V.), Fundacio La Marato de TV3 (141) (M.V.), Melanoma Research Alliance (Bristol-Myers Squibb-Melanoma Research Alliance Young Investigator Award 2017 (https://doi.org/10.48050/pc.gr.75716)) (M.V.), Beug Foundation (Prize for Metastasis Research 2017) (M.V.), Fundacion Ramon Areces (CIVP19S8163) (M.V.) and CIVP20S10662 (E.O.P.), Worldwide Cancer Research (19-0177) (M.V.), H2020-FETOPEN (828972) (M.V.), Cancer Research Institute (Clinic and Laboratory Integration Program CRI Award 2018 (54545)) (M.V.), AECC (Coordinated Translational Groups 2017 (GCTRA16015SEOA) (M.V.), LAB AECC 2019 (LABAE19002-VALI) (M.V.), ERC CoG (864759) (M.V.), Sophien-Stiftung zur Förderung der klinischen Krebsforschung (T.W.), Promedica Stiftung (T.W.), Stiftung f€ur angewandte Krebsforschung (T.W.), Forschungskredit of the University of Zurich (FK-18-054) (T.W.), Betty and David Koetser Foundation for Brain Research (T.W.), Foundation for Applied Cancer Research in Zurich (T.W., M.W.), Comunidad de Madrid (S2017/BMD-3867 RENIM-CM and Y2018/NMT-4949 NanoLiver-CM) and European structural and investment funds (M.D.), ISCIII (PT20/00044) co-funded by FEDER “A way of making Europe” (M.D.), Ministero dell’Istruzione, dell’Universita e della Ricerca-MIUR, “Dipartimenti di Eccellenza 2018-2022”, (D15D18000410001) (L.B. and P.C.), Science Foundation Ireland Frontiers for the Future Award (19/FFP/6443) (L.Y.), Science Foundation Ireland Strategic Partnership Programme, Precision Oncology Ireland (18/SPP/3522) (L.Y.), Breast Cancer Now Fellowship Award/ with the generous support of Walk the Walk (2019AugSF1310) (D.V.), La Caixa-Severo Ochoa International PhD Program Fellowship (LCF/BQ/SO16/52270014) (L.Z.), La Caixa International PhD Program Fellowship-Marie Sklodowska-Curie (LCF/BQ/DI17/11620028) (P.G-G), MINECO-Severo Ochoa PhD Fellowship (BES-2017-081995) (L.A-E.), AECC Postdoctoral Fellowship (POSTD19016PRIE) (N.P.), Boehringer Ingelheim Fonds MD fellowship (L.M.). The contribution of the Experimental Therapeutics Programme was supported by core funding from the Spanish National Cancer Research Center (CNIO). CNIO is supported by the ISCIII, the Ministerio de Ciencia e Innovacion, and is a Severo Ochoa Center of Excellence (SEV-2015-0510). The CNIC is supported by the ISCIII, the Ministerio de Ciencia e Innovacion and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). M.V. was named Ramon y Cajal Investigator (RYC-2013-13365) and is member of EMBO YIP (4053)

Vulnerabilidad territorial ante la expansión urbana

En México según el INEGI para el 2010 la población urbana fue del 77.8%, lo que significa que un porcentaje importante de la población vive en localidades mayores a los 2500 habitantes. Las cuales tienen sus propios ritmos de crecimiento, funciones, especialización, cambios de usos del suelo y problemáticas específicas. Las ciudades principales se han expandido, en las últimas décadas, con escasa acción planificadora y bajos resultados en el ordenamiento territorial. Ello ha configurado crecimientos físicos dispersos y fragmentados con importantes efectos ambientales. En México, la dispersión urbana genera ocupación del territorio en riesgos, situaciones de vulnerabilidad con inexistencia de acciones públicas, porque se encuentra en pendientes abruptas, lugares que se inundan, en áreas naturales protegidas, entre otras formas, genera tejido construido en áreas no óptimas para el desarrollo urbano, todo ello impacta negativamente al medio ambiente y la calidad de vida de la población. El crecimiento urbano continuará porque en las ciudades se genera la riqueza del país, en ellas se encuentran las oportunidades y soluciones. La urbanización es el modelo para conseguir el desarrollo de la sociedad. En dicho desarrollo se aspira el crecimiento sustentable y armonioso con el ambiente. Se espera cambios regulatorios para revertir los efectos negativos generados durante décadas con la expansión urbana consumidora de recursos naturales, energía y recursos financieros. En este marco problemático se integra el libro “Vulnerabilidad territorial ante la expansión urbana”, es producto de las actividades científicas –foro y congreso realizados en 2015- de la Red internacional de territorios, sustentabilidad y gobernanza en México y Polonia (RETESYG) de la Facultad de Geografía, Facultad de Planeación Urbana y Regional de la Universidad Autónoma del Estado de México (UAEM), así como de la Facultad de Geografía y Estudios Regionales de la Universidad de Varsovia (UV) y la Facultad de Geografía y Biología de la Universidad Pedagógica “Comisión de Educación Nacional” de Cracovia. El libro tiene una visión integral de la vulnerabilidad territorial ante la expansión urbana, considera los enfoques de la geografía, de la planeación y del ordenamiento territorial para abordar las problemáticas ambiental y social. Presenta una visión amplia y de síntesis sobre vulnerabilidad del territorio y de las ciudades, en él se integran los saberes de la Geografía y de la Planeación Territorial. Destaca la necesidad de controlar el crecimiento anárquico y desordenado, las desigualdades sociales, los riesgos, los problemas ambientales, la falta de bases de datos geoespaciales dinámicas, entre otros. Los resultados de las investigaciones apuntan hacia el desarrollo territorial sustentable. El libro se conforma de dos partes, la primera presenta aspectos teóricos conceptuales y metodológicos de la vulnerabilidad territorial, estructural, física, ambiental y socioeconómica, los riesgos geomorfológicos, la sustentabilidad y manejo de recursos naturales, áreas naturales protegidas, metodologías para la evaluación de los impactos de la expansión metropolitana y gobernanza territorial. La segunda parte, desarrolla estudios de caso, a distintas escalas: desde huertos familiares, subcuentas, ciudad, municipio, zonas metropolitanas, megalópolis, regiones y país. En cada capítulo del libro se presenta bibliografía extensa, diversificada y actualizada que aportan al lector sobre el estado del arte de la vulnerabilidad territorial

Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease

Altres ajuts: acord transformatiu CRUE-CSICBackground and purpose: Reduced facial expression of emotions is a very frequent symptom of Parkinson's disease (PD) and has been considered part of the motor features of the disease. However, the neural correlates of hypomimia and the relationship between hypomimia and other non-motor symptoms of PD are poorly understood. Methods: The clinical and structural brain correlates of hypomimia were studied. For this purpose, cross-sectional data from the COPPADIS study database were used. Age, disease duration, levodopa equivalent daily dose, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), severity of apathy and depression and global cognitive status were collected. At the imaging level, analyses based on gray matter volume and cortical thickness were used. Results: After controlling for multiple confounding variables such as age or disease duration, the severity of hypomimia was shown to be indissociable from the UPDRS-III speech and bradykinesia items and was significantly related to the severity of apathy (β = 0.595; p < 0.0001). At the level of neural correlates, hypomimia was related to motor regions brodmann area 8 (BA 8) and to multiple fronto-temporo-parietal regions involved in the decoding, recognition and production of facial expression of emotions. Conclusion: Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge

DIA-DB : a database and web server for the prediction of diabetes drugs

The DIA-DB is a web server for the prediction of diabetes drugs that uses two different and complementary approaches: (a) comparison by shape similarity against a curated database of approved antidiabetic drugs and experimental small molecules and (b) inverse virtual screening of the input molecules chosen by the users against a set of therapeutic protein targets identified as key elements in diabetes. As a proof of concept DIA-DB was successfully applied in an integral workflow for the identification of the antidiabetic chemical profile in a complex crude plant extract. To this end, we conducted the extraction and LC-MS based chemical profile analysis of Sclerocarya birrea and subsequently utilized this data as input for our server. The server is open to all users, registration is not necessary, and a detailed report with the results of the prediction is sent to the user by email once calculations are completed. This is a novel public domain database and web server specific for diabetes drugs and can be accessed online through http://bio-hpc.eu/software/dia-db/.http://pubs.acs.org/journal/jcics1/about.htmlhj2021BiochemistryGeneticsMicrobiology and Plant Patholog

Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype

The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8.5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. The aim of this study was to find the optimized cognitive composites (CCs) domain scores most related to neuroimaging biomarkers within Pr-aMCI-storage subtype patients. The Fundació ACE (ACE) study with 20 Pr-aMCI-storage subtype subjects (MCI) were analyzed. All subjects underwent a neuropsychological assessment, a structural MRI, FDG-PET, and PIB-PET. The adjusted hippocampal volume (aHV) on MRI, the standard uptake value ratio (SUVR) on FDG-PET and PIB-PET SUVR measures were analyzed. The construction of the CCs domain scores, and the aHV on MRI and FDG-PET SUVR measures, were replicated in the parental AB255 study database (n = 133 MCI). Partial correlations adjusted by age, gender, and education were calculated with the associated p -value among every CC domain score and the neuroimaging biomarkers. The results were replicated in the "MCI due to AD" with memory storage impairments from ADNI. Delayed Recall CC domain score was significantly correlated with PIB-PET SUVR (β= -0.61, p = 0.003) in the ACE study and also with aHV on MRI (β= 0.27, p = 0.01) and FDG-PET SUVR (β= 0.27, p = 0.01) in the AB255 study. After a median survival time of 20.6 months, 85% from the ACE MCI converted to AD. The replication of our results in the ADNI dataset also confirmed our findings. Delayed Recall is the CC domain score best correlated with neuroimaging biomarkers associated with prodromal AD diagnosis

Mutational spectrum of GNAL, THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review

[Objective] We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature.[Methods] A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls) from southern and central Spain was included. The genes TOR1A, THAP1 and GNAL were screened using a combination of high-resolution melting analysis and direct DNA resequencing. In addition, an extensive literature search to identify original articles (published before 10 August 2020) reporting mutations in TOR1A, THAP1 or GNAL associated to dystonia was performed.[Results] Pathogenic or likely pathogenic variants in TOR1A, THAP1 and GNAL were identified in 0.48%, 0.57% and 0.29% of our patients, respectively. Five patients carried the variation p.Glu303del in TOR1A. A very rare variant in GNAL (p.Ser238Asn) was found as a putative risk factor for dystonia. In the literature, variations in TOR1A, THAP1 and GNAL accounted for about 6%, 1.8% and 1.1% of published dystonia patients, respectively.[Conclusions] There is a different genetic contribution to dystonia of these three genes in our patients (about 1.3% of patients) and in the literature (about 3.6% of patients), probably due the high proportion of adult-onset cases in our cohort. As regards age at onset, site of dystonia onset, and final distribution, in our population there is a clear differentiation between DYT-TOR1A and DYT-GNAL, with DYT-THAP1 likely to be an intermediate phenotype.This work was supported by the Carlos III Health Institute-European Regional Development Fund (ISCIII-FEDER) [PI14/01823, PI16/01575, PI18/01898, PI19/01576], the Andalusian Regional Ministry of Economics, Innovation, Science and Employment [CVI-02526, CTS-7685], the Andalusian Regional Ministry of Health and Welfare [PI-0741-2010, PI-0471-2013, PE-0210-2018, PI-0459-2018, PE-0186-2019], and the Alicia Koplowitz and Mutua Madrileña Foundations. Pilar Gómez-Garre was supported by the "Miguel Servet" program [MSII14/00018] (from ISCIII-FEDER) and “Nicolás Monardes” program [C-0048-2017] (from the Andalusian Regional Ministry of Health). Silvia Jesús was supported by the "Juan Rodés" program [B-0007-2019] and Daniel Macías-García by the “Río Hortega” program [CM18/00142] (both from ISCIII-FEDER). María Teresa Periñán was supported by the Spanish Ministry of Education [FPU16/05061]. Cristina Tejera was supported by VPPI-US from the University of Seville.Peer reviewe