Evaluación del rendimiento de la red 5G con diferentes implementaciones de sistemas de antenas distribuidas en mmW para zonas de alto tráfico en interiores

[ES] En la banda de mmW donde la cobertura es limitada, la implementación de cada transmisor exactamente donde se necesita se vuelve más crítica que nunca. Además, el número de dispositivos que se implementarán es mucho mayor que en frecuencias más bajas. En este marco, este trabajo final de grado tiene como objetivo evaluar cuáles son las mejores distribuciones de antenas de acuerdo con los requisitos de la red en banda mmW y considerando la simplicidad en la implementación práctica.[EN] In the mmW band where coverage is limited, deploying each transmitter exactly where it is needed becomes more critical than ever. In addition, the number of devices to be deployed is much higher than at lower frequencies. In this framework, this project aims to evaluate which are the best antenna distributions according to the requirements of the mmW network and considering the simplicity in practical deployment.Antón Ruiz, A. (2020). Evaluación del rendimiento de la red 5G con diferentes implementaciones de sistemas de antenas distribuidas en mmW para zonas de alto tráfico en interiores. http://hdl.handle.net/10251/152387TFG

Impact of Excitation and Weighting Errors on Performance of Compact OTA Testing Systems

This paper investigates the impact of complex excitation errors of the chamber array antenna on the accuracy of the test zone of a random line-of-sight over-the-air testing setup. First, several combinations of compact chamber arrays of lengths L and short distances D between the test zone and the chamber array, which emulate a plane wave impinging at the test zone are obtained. The chamber array is linear and uniform with 100 antenna elements, and a linear taper was applied to some of the elements to emulate a plane wave impinging at the test zone with more compact setups. A subset of L and D was chosen, providing compact over-the-air test setups that fulfilled the defined figures of merit, which assess the similarity of the obtained field distribution to that of a plane wave. The tolerance of the chosen setups to complex excitation errors of the chamber array was then investigated, concluding that these errors must be considered when defining appropriate L and D combinations. Moreover, the performance of the matched filter and zero-forcing algorithms is evaluated for errors of the device under test array weighting coefficients. A random line-of-sight over-the-air testing setup with two arrays was simulated, where one of the arrays emulated the desired signal and the other emulated the interference, observing that the errors were more significant at higher signal-to-noise ratios. Additionally, the zero-forcing algorithm was more sensitive to errors than the matched filter, which was expected since the accuracy of the former for interference suppression is critical.Comment: EuCAP2023 conferenc

Predicción del precio en el mercado de viviendas en la ciudad de Valencia mediante redes neuronales en el año 2020

[ES] Las redes neuronales artificiales permiten capturar las relaciones entre las variables decisivas para la fijación del valor del mercado de la vivienda. En este TFG se construye, a partir de la web idealista, una base de datos de precios de oferta y características (ubicación, superficie, habitaciones, planta y ascensor) de viviendas en la ciudad de Valencia, a partir de la cual se diseña, aplica y optimiza un modelo para la predicción del precio de oferta de una vivienda en base a sus características, basado en redes neuronales artificiales. A fin de valorar la precisión del modelo, se mide el error mediante el error absoluto medio, a partir de un esquema de validación cruzada empleando subconjuntos de entrenamiento, validación y test.[EN] Artificial neural networks are able to capture the relationships between the most relevant variables in market pricing of properties. In the present bachelor¿s thesis, a database containing offer prices and features (location, surface area, rooms, floor and elevator) of properties located in Valencia city is built, using idealista web as the source. With this database, an offer price predictive model using the properties¿ features as an input, and based in neural networks is designed, built, and optimized. In order to assess its performance, mean absolute error is measured within a cross-validation scheme, in which training, validation and test subsets are used.Antón Ruiz, A. (2020). Predicción del precio en el mercado de viviendas en la ciudad de Valencia mediante redes neuronales en el año 2020. http://hdl.handle.net/10251/152158TFG

Constrained FoV Radiated Power as a Figure of Merit of Phased Arrays

In this paper, we propose quantifying the radiated power of phased arrays or, in general, directive antennas, by the Constrained-View Radiated Power (CVRP). The constrained view shall be interpreted here as the Field-of-View (FoV) of an antenna that defines a region in space where focusing the radiated power is highly desired. In the limiting cases, we have that CVRP equals the Total Radiated Power (TRP) when the FoV covers the whole sphere, while, if the FoV reduces to a single point in space, the CVRP equals the Equivalent Isotropic Radiated Power (EIRP). We further present an analysis based on measured radiation patterns of a 16-element, linearly polarized, millimeter-Wave (mmWave), planar phased array antenna operating at 28 GHz. We compare the results to two ideal planar array antennas with the same number of Huygens and cosine elements. The evaluated figure of merit is computed for different scanning angles, as well as for different malfunctions of antenna elements, both for the real and simulated arrays. The results show that the introduced figure of merit could be potentially used for the detection of malfunctioning elements in antenna arrays as well as to characterize the impact of scan loss. Furthermore, CVRP is useful to straightforwardly and significantly characterize the performance of a directive antenna in terms of the power radiated towards a specific region in space

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes

Familial cold autoinflammatory syndrome, Muckle-Wells syndrome (MWS), and chronic, infantile, neurological, cutaneous and articular (CINCA) syndrome are dominantly inherited autoinflammatory diseases associated to gain-of-function NLRP3 mutations and included in the cryopyrin-associated periodic syndromes (CAPS). A variable degree of somatic NLRP3 mosaicism has been detected in ≈35% of patients with CINCA. However, no data are currently available regarding the relevance of this mechanism in other CAPS phenotypes. OBJECTIVE: To evaluate somatic NLRP3 mosaicism as the disease-causing mechanism in patients with clinical CAPS phenotypes other than CINCA and NLRP3 mutation-negative. METHODS: NLRP3 analyses were performed by Sanger sequencing and by massively parallel sequencing. Apoptosis-associated Speck-like protein containing a CARD (ASC)-dependent nuclear factor kappa-light chain-enhancer of activated B cells (NF-κB) activation and transfection-induced THP-1 cell death assays determined the functional consequences of the detected variants. RESULTS: A variable degree (5.5-34.9%) of somatic NLRP3 mosaicism was detected in 12.5% of enrolled patients, all of them with a MWS phenotype. Six different missense variants, three novel (p.D303A, p.K355T and p.L411F), were identified. Bioinformatics and functional analyses confirmed that they were disease-causing, gain-of-function NLRP3 mutations. All patients treated with anti-interleukin1 drugs showed long-lasting positive responses. CONCLUSIONS: We herein show somatic NLRP3 mosaicism underlying MWS, probably representing a shared genetic mechanism in CAPS not restricted to CINCA syndrome. The data here described allowed definitive diagnoses of these patients, which had serious implications for gaining access to anti-interleukin 1 treatments under legal indication and for genetic counselling. The detection of somatic mosaicism is difficult when using conventional methods. Potential candidates should benefit from the use of modern genetic tool

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

PhDAY 2020 -FOO (Facultad de Óptica y Optometría)

Por cuarto año consecutivo los doctorandos de la Facultad de Óptica y Optometría de la Universidad Complutense de Madrid cuentan con un congreso propio organizado por y para ellos, el 4º PhDAY- FOO. Se trata de un congreso gratuito abierto en la que estos jóvenes científicos podrán presentar sus investigaciones al resto de sus compañeros predoctorales y a toda la comunidad universitaria que quiera disfrutar de este evento. Apunta en tu agenda: el 15 de octubre de 2020. En esta ocasión será un Congreso On-line para evitar que la incertidumbre asociada a la pandemia Covid-19 pudiera condicionar su celebración