Narraciones vulgares

Copia digital : Diputación de Málaga. Biblioteca Canovas del Castillo, 201

Environment and Space Rule, but Time also Matters for the Organization of Tropical Pond Metacommunities

Metacommunities are dynamic systems, but the influence of time independently of environmental change in their configuration has been rarely considered. In temporary ponds, strong temporal effects are expected to influence their metacommunity structure, even in relatively constant environments such as tropical habitats. We therefore expect that time as an independent factor could modulate tropical pond metacommunities, which would be also less affected by niche-related processes than by dispersal-related processes. In addition, good dispersers should be more environmentally structured than bad dispersers, which should be more spatially structured. Finally, the relevance of temporal effects should vary among organisms with different generation times. To test these hypotheses, we surveyed 30 temporary ponds along the dry tropical region of western Costa Rica and Nicaragua at three different moments of their hydroperiod: shortly after the infilling of the water bodies, at the middle of the hydroperiod and just before desiccation. We obtained data on 56 environmental variables and used geographic coordinates to build spatial variables (Moran Eigenvector Maps). We collected biological samples and estimated the specific abundance of phytoplankton, zooplankton and benthic invertebrates. To evaluate the relative role of environmental, spatial and temporal (sequential sampling season) effects for metacommunity organization, we used variation partitioning with distance-based redundancy analyses for each group of organisms. The inclusion of time in the analysis highlighted that pure temporal effects explained part of metacommunity variance in almost every group, being as important as spatial or even environmental effects for some groups of organisms. In contrast to the assumed low environmental constraints in tropical areas (i.e., high and stable temperatures), we found strong environmental effects. Passive dispersers were more influenced by environmental factors than active ones. We also found a positive relationship between the body size of the different groups of organisms and the magnitude of the temporal effects, interpreted as related to generation time. Finally, when analyzing each sampling period separately, we found differences in the relative role of environment and space at different sampling periods, showing that snapshot surveys may not be representative of highly dynamic metacommunities

Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma. ATG5 rs2245214 SNP was not associated with any location. Overall, our results indicate the importance of the autophagy pathway in the susceptibility of head and neck squamous cell carcinoma and demonstrate the heterogeneity between its locations encompassed under a single terminology

Current and prospective situation of municipal solid waste final disposal in Mexico: A spatio-temporal evaluation

Mexico, similarly to other developing countries, has planned landfilling as the central technology to manage municipal solid waste (MSW). In this research, the current and future situation of final disposal of MSW in Mexico was studied, focusing on the spatial and temporal evaluation of final disposal sites (FDS), landfill gas (LFG) emissions, and potential power generation in an 80-year horizon. Geographic information systems were applied for spatial evaluation. The Mexico LFG 2.0 model was used to estimate the LFG emissions in 1782 FDS in operation, considering statal MSW characteristics and local FDS features. The transition towards a MSW management system that is less dependent on final disposal was carried out via a sensitivity analysis of the reduction of FDS in LFG emissions, power generation, and greenhouse gases (GHG) emissions. The study estimated that Mexico had an LFG generation of 2298 Mm3 in 2020, where only 4.6% of FDS were suited for power generation, up to 2534 GWh y-1. This electricity can avoid the emission of 1.45 Mt CO2 , since fossil fuels are predominant in the Mexican power grid. The sensitivity analysis showed that suppressing MSW landfilling could reduce 1636 Mt CO2 eq over the period studied compared to the business-as-usual scenario. The power generation potential of LFG has been used scarcely (165 GWh y-1). Public policies may focus on proposing economic incentives and establishing conditions for a biogas market, increasing the number of SL that use LFG for energy purposes

Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population

Despite classical environmental risk factors like tobacco, alcohol or viral infection, not all individuals develop head and neck cancer. Therefore, identification of the genetic susceptibility produced by single nucleotide polymorphisms (SNPs) is an important task. A total of 296 human papillomavirus negative head and neck cancer (HNC) patients (126 laryngeal, 100 pharyngeal and 70 oral cavity) were included in the study, involving 29 candidate SNPs in genes within important carcinogenic pathways (oncogenesis and tumour suppression, DNA repair, inflammation, oxidation and apoptosis). Genotyping was performed using TaqMan probes or restriction fragment length assays in peripheral blood DNA. In addition, 259 paired controls were also evaluated with the same risk factors for each specific location. Nine SNPs in DNA repair (ERCC1 rs11615, ERCC2 rs13181), inflammatory (IL2 rs2069762, IL6 rs1800795), oxidative (NFE2L2 rs13035806 and rs2706110) and apoptotic genes (TP53 rs1042522, MDM2 rs2279744, BCL2 rs2279115) were differently associated with HNSCC susceptibility by location. Some of these SNPs were not described before in this tumour type. In conclusion, we describe several SNPs associated with HNC in a Spanish population

Cultivo de Ceratocystis (Ophiostoma) ulmi (Buism.) Moreau en medio líquido, e inoculación

The methodology to obtain yeastlike phase and to evaluate resistance to Ceratocystis (Ophiostoma) ulmi (Buism.) Moreau, was tested using aggressive and nonaggressive strains.En el presente trabajo se ensaya la técnica de inoculación de Ceratocystis (Ophiostoma) ulmi (Buism.) Moreau, en olmos procedentes de semilla y se observa la respuesta de las plantas a la enfermedad

Cultivo de Ceratocystis (Ophiostoma) ulmi (Buism.) Moreau en medio líquido, e inoculación

En el presente trabajo se ensaya la técnica de inoculación de Ceratocystis (Ophiostoma) ulmi (Buism.) Moreau, en olmos procedentes de semilla y se observa la respuesta de las plantas a la enfermedad.The methodology to obtain yeastlike phase and to evaluate resistance to Ceratocystis (Ophiostoma) ulmi (Buism.) Moreau, was tested using aggressive and nonaggressive strains

Stratification and therapeutic potential of PML in metastatic breast cancer.

Patient stratification has been instrumental for the success of targeted therapies in breast cancer. However, the molecular basis of metastatic breast cancer and its therapeutic vulnerabilities remain poorly understood. Here we show that PML is a novel target in aggressive breast cancer. The acquisition of aggressiveness and metastatic features in breast tumours is accompanied by the elevated PML expression and enhanced sensitivity to its inhibition. Interestingly, we find that STAT3 is responsible, at least in part, for the transcriptional upregulation of PML in breast cancer. Moreover, PML targeting hampers breast cancer initiation and metastatic seeding. Mechanistically, this biological activity relies on the regulation of the stem cell gene SOX9 through interaction of PML with its promoter region. Altogether, we identify a novel pathway sustaining breast cancer aggressiveness that can be therapeutically exploited in combination with PML-based stratification.The work of A.C. is supported by the Ramón y Cajal award, the Basque Department of Industry, Tourism and Trade (Etortek), Health (2012111086) and Education (PI2012-03), Marie Curie (277043), Movember Foundation (GAP1), ISCIII (PI10/01484, PI13/00031), FERO (VIII Fellowship) and ERC (336343). N.M.-M. and P.A. are supported by the Spanish Association Against Cancer (AECC), AECC JP Vizcaya and Guipuzcoa, respectively. J.U. and F.S. are Juan de la Cierva Researchers (MINECO). L.A., A.A.-A. and L.V.-J. are supported by the Basque Government of education. M.L.-M.C. acknowledges SAF2014-54658-R and Asociación Española contra el Cancer. R.B. acknowledges Spanish MINECO (BFU2014-52282-P, Consolider BFU2014-57703-REDC), the Departments of Education and Industry of the Basque Government (PI2012/42) and the Bizkaia County. M.S., V.S. and J.B. acknowledge Banco Bilbao Vizcaya Argentaria (BBVA) Foundation (Tumour Biomarker Research Program). M.S. and J.B. are supported by NIH grant P30 CA008748. M.dM.V. is supported by the Institute of Health Carlos III (PI11/02251, PI14/01328) and Basque Government, Health Department (2014111145). A.M. is supported by ISCIII (CP10/00539, PI13/02277) and Marie Curie CIG 2012/712404. V.S. is supported by the SCIII (PI13/01714, CP14/00228), the FERO Foundation and the Catalan Agency AGAUR (2014 SGR 1331). R.R.G. research support is provided by the Spanish Ministry of Science and Innovation grant SAF2013-46196, BBVA Foundation, the Generalitat de Catalunya (2014 SGR 535), Institució Catalana de Recerca i Estudis Avançats, the Spanish Ministerio de Economia y Competitividad (MINECO) and FEDER funds (SAF2013-46196).This is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/ncomms1259

Seminario de Economía Mexicana

Serie de ponencias referentes al Seminario de Economía Mexicana. Memorias del Seminario de Economía Mexicana de 199

INFORME CIENTÍFICO – TÉCNICO de la Campaña SUBVENT1

Memoria del Informe Cintífico-Técnico de la campaña oceanográfica SUBVENT-1.Anexos de operatividad y de las distintas técnicas utilizados a lo largo de la misma.La campaña SUBVENT1-0913 se ha realizado a lo largo del talud inferior del margen continental de las Islas Canarias, área que también es conocida en la literatura como Cuenca Canaria. Esta zona se caracteriza por la presencia de una serie de estructuras geológicas recientes, así se encuentran la parte distal de los depósitos de debris procedentes de las avalanchas volcánicas generadas desde las Islas Canarias, a favor de la pendiente y probablemente en relación con episodios eruptivos. En la parte meridional se encuentra además un conjunto de montes submarinos, de diversa entidad, de origen volcánico y, en general, aparece todo un conjunto de montículos con desniveles comprendidos entre 30 y 300 m que han constituido el principal objetivo de esta campaña. Así mismo, en este sector existen numerosos escarpes lineales de orientación subparalela a la del propio talud a los que se encuentran asociados en ocasiones los citados montículos. La adquisición de nuevos datos geofísicos y el muestreo llevado a cabo durante la campaña permitirá conocer mejor el origen de estos montículos y el proceso de emisión que los ha generado. Por otro lado, el conocimiento de las relaciones entre los sedimentos de debris y hemipelágicos junto con los asociados a las posibles emisiones de la zona permitirá conocer no sólo la evolución sedimentaria de este margen, sino establecer los episodios de emisión que generaron los montículos y conocer sus patrones de crecimiento. Así mismo, se podrá evaluar la tasa de sedimentación de la zona y el papel de la masa de agua de fondo antártica (AABW) en esta evolución.The SUBVENT1-0913 cruise has been carried out along the lower slope of the continental margin of the Canary Islands. This area is characterized by the presence of several recent geological structures. Among these are the distal parts of the volcano-clastics debris deposits originated by volcanic avalanches of the Canary Islands, transported by gravity along the slope and probably related in origin to eruptive episodes. In the southern part, numerous and different reliefs (seamounts, hills or mounds) of volcanic origin occur. The most frequents features display heights between 30 and 300 m and they have constituted one of the main aims of this survey. Moreover, in this sector there are several subparallel linear scarps with similar directions to the slope trend that could be associated with the aforementioned mounds. The acquisition of new geophysical data and samples during this campaign will allow a better understanding of the origin of these mounds and the emission processes that have generated them. On the other hand, the knowledge of the relationships between debris and hemipelagic sediments together with those associated with possible venting processes in the area, will reveal not only the sedimentary evolution of this margin, but also to establish emission episodes generating mounds and to know their growth patterns. Furthermore, it would be possible to evaluate the sedimentation rate in the area and the role played by the Antarctic Bottom Water (AABW) mass on this process.Plan Nacional de I+D, Ministerio de Economía y Competitividad. Investigación fundamental no Orientada. Proyecto de Investigación Coordinado SUBVENT “Emisiones submarinas de fluidos en los márgenes continentales de las Islas Canarias y del Golfo de Cádiz: Análisis comparativo de las construcciones asociadas” (CGL2012‐39524‐C02). Acción Complementaria EXARCAN “Trabajos científico-técnicos para la preparación, presentación y defensa de las propuestas de España ante Naciones Unidas para la Extensión de la Plataforma Continental de las Islas Canarias y Galicia” (CTM2010-09496-E)