Ramón Pérez de Ayala y las novelas de 1902: ruptura modernista y renovación literaria

Se destacan las contribuciones que Pérez de Ayala realizó con respecto a la renovación novelística de inicios del siglo XX, y la deuda que toda la narrativa de su primera época creativa tiene con respecto al cambio de actitud modernista

Forms of Life and Subjectivity

"Forms of Life and Subjectivity: Rethinking Sartre’s Philosophy explores the fundamental question of why we act as we do. Informed by an ontological and phenomenological approach, and building mainly, but not exclusively, on the thought of Sartre, Daniel Rueda Garrido considers the concept of a ""form of life” as a term that bridges the gap between subjective identity and communities. This first systematic ontology of ""forms of life” seeks to understand why we act in certain ways, and why we cling to certain identities, such as nationalisms, social movements, cultural minorities, racism, or religion. The answer, as Rueda Garrido argues, depends on an understanding of ourselves as ""forms of life” that remains sensitive to the relationship between ontology and power, between what we want to be and what we ought to be. Structured in seven chapters, Rueda Garrido’s investigation yields illuminating and timely discussions of conversion, the constitution of subjectivity as an intersubjective self, the distinction between imitation and reproduction, the relationship between freedom and facticity, and the dialectical process by which two particular ways of being and acting enter into a situation of assimilation-resistance, as exemplified by capitalist and artistic forms of life. This ambitious and original work will be of great interest to scholars and students of philosophy, social sciences, cultural studies, psychology and anthropology. Its wide-ranging reflection on the human being and society will also appeal to the general reader of philosophy.

An approach to Spanish Krausism’s theory of knowledge

The Spanish Krausism based its theory of knowledge on the substantive relation between the subject and the object, being the latter present to the conscience as one. The Krausists developed the Spanish science by means of spreading from secondary school the importance of intuition for knowing the object ahead in its essence and truth, together with other relevant aspects like the analysis and synthesis of data in the consciousness

Structure of co-expression networks of Bifidobacterium species in response to human milk oligosaccharides

Biological systems respond to environmental perturbations and a large diversity of compounds through gene interactions, and these genetic factors comprise complex networks. Experimental information from transcriptomic studies has allowed the identification of gene networks that contribute to our understanding of microbial adaptations. In this study, we analyzed the gene co-expression networks of three Bifidobacterium species in response to different types of human milk oligosaccharides (HMO) using weighted gene co-expression analysis (WGCNA). RNA-seq data obtained from Geo Datasets were obtained for Bifidobacterium longum subsp. Infantis, Bifidobacterium bifidum and Bifidobacterium longum subsp. Longum. Between 10 and 20 co-expressing modules were obtained for each dataset. HMO-associated genes appeared in the modules with more genes for B. infantis and B. bifidum, in contrast with B. longum. Hub genes were identified in each module, and in general they participated in conserved essential processes. Certain modules were differentially enriched with LacI-like transcription factors, and others with certain metabolic pathways such as the biosynthesis of secondary metabolites. The three Bifidobacterium transcriptomes showed distinct regulation patterns for HMO utilization. HMO-associated genes in B. infantis co-expressed in two modules according to their participation in galactose or N-Acetylglucosamine utilization. Instead, B. bifidum showed a less structured co-expression of genes participating in HMO utilization. Finally, this category of genes in B. longum clustered in a small module, indicating a lack of co-expression with main cell processes and suggesting a recent acquisition. This study highlights distinct co-expression architectures in these bifidobacterial genomes during HMO consumption, and contributes to understanding gene regulation and co-expression in these species of the gut microbiome

¿CUÁN IMPORTANTES SON LOS BOSQUES SECOS PARA LAS URBANIZACIONES? EL CASO DE DAULE, ECUADOR

Global change and direct sun near the ecuador increase the temperature of cities whereas forests regulate such temperature. We therefore assessed the structure and above ground biomass of two forest remnants nearby a newly built urbanization in Daule, Ecuador (Daule 1-2). We made n=5 transects (25 m × 4 m) covering 0.05 ha/site, then measured all trees ≥2.5 cm dbh (1.3 m above ground level) and compared with other forests studied by Alwyn Gentry. Daule-1 and Daule-2 had 39 and 35 individuals, respectively whereas Gentry found 159 and 216 individuals at Capeira and Esmeraldas. The densities for our n=5 transects (average ± standard error) were smaller for (Daule-1=780±37.42 ind/ha) and (Daule-2=740±40.00 ind/ha) while Capeira and Esmeraldas (n=10 transects for each site) which had (2270±211.37 ind/ha) and (3540±265.50 ind/ha), respectively (ANOVA, P<0.001). The carbon captured was Daule-1=131.6 Mg/ha, Daule-2=111.7 Mg/ha, Daule-1+Daule-2=243.3 Mg/ha likewise Capeira 210.6 Mg / ha and Esmeraldas 181.5 Mg / ha. Such results suggest that forest remnants play an important role for people’s life quality by capturing carbon dioxide and producing oxygen; role they would play better if the forests would have more extensive.El calentamiento global y el sol directo cerca del ecuador aumentan la temperatura en las ciudades, mientras que los bosques son los encargados de regular dicha temperatura. Evaluamos la estructura y biomasa aérea de dos remanentes de bosques cerca de una urbanización en construcción en Daule, Ecuador (Daule 1-2). Se tomaron n=5 transectos (25 m x 4 m) cubriendo 0.05 ha/sitio, medimos todos los árboles ≥2,5 cm dap (1.3 m sobre el nivel del suelo) y comparamos con otros bosques estudiados por Alwyn Gentry. Daule-1 y Daule-2 tenían 39 y 35 individuos, respectivamente, mientras que Gentry encontró 159 y 216 individuos en Capeira y Esmeraldas. La densidad en los n=5 transectos (promedio ± error estándar) fueron menores para (Daule-1=780±37.42 ind/ha) y (Daule-2=740±40.00 ind/ha) en tanto que Capeira y Esmeraldas (n=10 transectos para cada sitio) tuvieron (2270±211.37 ind/ha) y (3540±265.50 ind/ha), respectivamente (ANOVA, P<0.001). El carbono capturado fueDaule-1=131.6 Mg/ha, Daule-2=111.7 Mg/ha, Daule-1+Daule-2=243.3Mg/ha así mismo Capeira 210.6 Mg/ha y Esmeraldas 181.5 Mg/ha. Tales resultados sugieren que los remanentes de bosques juegan un papel importante para la calidad de vida de las personas al capturar dióxido de carbono y producir oxígeno; papel que jugarían mejor si los bosques fueran más extensos. &nbsp

CSVS, a crowdsourcing database of the Spanish population genetic variability

The knowledge of the genetic variability of the local population is of utmost importance in personalized medicine and has been revealed as a critical factor for the discovery of new disease variants. Here, we present the Collaborative Spanish Variability Server (CSVS), which currently contains more than 2000 genomes and exomes of unrelated Spanish individuals. This database has been generated in a collaborative crowdsourcing effort collecting sequencing data produced by local genomic projects and for other purposes. Sequences have been grouped by ICD10 upper categories. A web interface allows querying the database removing one or more ICD10 categories. In this way, aggregated counts of allele frequencies of the pseudo-control Spanish population can be obtained for diseases belonging to the category removed. Interestingly, in addition to pseudo-control studies, some population studies can be made, as, for example, prevalence of pharmacogenomic variants, etc. In addition, this genomic data has been used to define the first Spanish Genome Reference Panel (SGRP1.0) for imputation. This is the first local repository of variability entirely produced by a crowdsourcing effort and constitutes an example for future initiatives to characterize local variabilityworldwide. CSVS is also part of the GA4GH Beacon network.Spanish Ministry of Economy and Competitiveness SAF2017-88908-R PT17/0009/0006 PI19/00321 CIBERER ACCI-06/07/0036 PI14-948 PI171659Regional Government of Madrid, RAREGenomicsCM B2017/BMD3721 B2017/BMD-3721European Union (EU)European Union (EU) 676559University Chair UAM-IIS-FJD of Genomic MedicineRamon Areces Foundatio

A crowdsourcing database for the copy-number variation of the Spanish population

Background: Despite being a very common type of genetic variation, the distribution of copy-number variations (CNVs) in the population is still poorly understood. The knowledge of the genetic variability, especially at the level of the local population, is a critical factor for distinguishing pathogenic from non-pathogenic variation in the discovery of new disease variants. Results: Here, we present the SPAnish Copy Number Alterations Collaborative Server (SPACNACS), which currently contains copy number variation profiles obtained from more than 400 genomes and exomes of unrelated Spanish individuals. By means of a collaborative crowdsourcing effort whole genome and whole exome sequencing data, produced by local genomic projects and for other purposes, is continuously collected. Once checked both, the Spanish ancestry and the lack of kinship with other individuals in the SPACNACS, the CNVs are inferred for these sequences and they are used to populate the database. A web interface allows querying the database with different filters that include ICD10 upper categories. This allows discarding samples from the disease under study and obtaining pseudo-control CNV profiles from the local population. We also show here additional studies on the local impact of CNVs in some phenotypes and on pharmacogenomic variants. SPACNACS can be accessed at: http://csvs.clinbioinfosspa.es/spacnacs/. Conclusion: SPACNACS facilitates disease gene discovery by providing detailed information of the local variability of the population and exemplifies how to reuse genomic data produced for other purposes to build a local reference database

Covid-19: la malinterpretación de los datos de la pandemia daña la confianza del público

Dos cartas publicadas en The Lancet y The Lancet Public Health en los últimos meses defienden la necesidad de evaluar de forma independiente la respuesta española ante la covid-19. Estamos de acuerdo, pero nos gustaría complementarlas con tres puntos que nos acercan a la ciencia abierta. Nos referimos a la confusión terminológica, la calidad de los datos y su disponibilidad