560 research outputs found
Invariance and Symmetry in Evolutionary Dynamics
The concept of fitness is central to evolutionary biology. Models of evolutionary change typically use some quantity called “fitness” which measures an organism’s reproductive success. But what exactly does it mean that fitness is such a measure? In what follows, we look at the interplay between abstract evolutionary models and quantitative measures of fitness and develop a measurement-theoretic perspective on fitness in order to explore what makes certain measures of fitness significant
Exercise Degrades Bone in Caloric Restriction, Despite Suppression of Marrow Adipose Tissue (MAT)
Marrow adipose tissue (MAT) and its relevance to skeletal health during caloric restriction (CR) is unknown: It remains unclear whether exercise, which is anabolic to bone in a calorie-replete state, alters bone or MAT in CR. We hypothesized that response of bone and MAT to exercise in CR differs from the calorie-replete state. Ten-week-old female B6 mice fed a regular diet (RD) or 30% CR diet were allocated to sedentary (RD, CR, n = 10/group) or running exercise (RD-E, CR-E, n = 7/group). After 6 weeks, CR mice weighed 20% less than RD, p < 0.001; exercise did not affect weight. Femoral bone volume (BV) via 3D MRI was 20% lower in CR versus RD (p < 0.0001). CR was associated with decreased bone by μCT: Tb.Th was 16% less in CR versus RD, p < 0.003, Ct.Th was 5% less, p < 0.07. In CR-E, Tb.Th was 40% less than RD-E, p < 0.0001. Exercise increased Tb.Th in RD (+23% RD-E versus RD, p <; 0.003) but failed to do so in CR. Cortical porosity increased after exercise in CR (+28%, p = 0.04), suggesting exercise during CR is deleterious to bone. In terms of bone fat, metaphyseal MAT/ BV rose 159% in CR versus RD, p = 0.003 via 3D MRI. Exercise decreased MAT/BV by 52% in RD, p < 0.05, and also suppressed MAT in CR (−121%, p = 0.047). Histomorphometric analysis of adipocyte area correlated with MAT by MRI (R2 = 0.6233, p < 0.0001). With respect to bone, TRAP and Sost mRNA were reduced in CR. Intriguingly, the repressed Sost in CR rose with exercise and may underlie the failure of CR-bone quantity to increase in response to exercise. Notably, CD36, a marker of fatty acid uptake, rose 4088% in CR (p < 0.01 versus RD), suggesting that basal increases in MAT during calorie restriction serve to supply local energy needs and are depleted during exercise with a negative impact on bone
A high-flux source of polarization-entangled photons from a periodically-poled KTP parametric downconverter
We have demonstrated a high-flux source of polarization-entangled photons
using a type-II phase-matched periodically-poled KTP parametric downconverter
in a collinearly propagating configuration. We have observed quantum
interference between the single-beam downconverted photons with a visibility of
99% and a measured coincidence flux of 300/s/mW of pump. The
Clauser-Horne-Shimony-Holt version of Bell's inequality was violated with a
value of 2.711 +/- 0.017.Comment: 7 pages submitted to Physical Review
Reliability of the beamsplitter based Bell-state measurement
A linear 50/50 beamsplitter, together with a coincidence measurement, has
been widely used in quantum optical experiments, such as teleportation, dense
coding, etc., for interferometrically distinguishing, measuring, or projecting
onto one of the four two-photon polarization Bell-states . In
this paper, we demonstrate that the coincidence measurement at the output of a
beamsplitter cannot be used as an absolute identifier of the input state
nor as an indication that the input photons have projected to
the state.Comment: 4 pages, two-colum
The origin of aubrites: Evidence from lithophile trace element abundances and oxygen isotope compositions
We report the abundances of a selected set of “lithophile” trace elements (including lanthanides, actinides and high field strength elements) and high-precision oxygen isotope analyses of a comprehensive suite of aubrites. Two distinct groups of aubrites can be distinguished: (a) the main-group aubrites display flat or light-REE depleted REE patterns with variable Eu and Y anomalies; their pyroxenes are light-REE depleted and show marked negative Eu anomalies; (b) the Mount Egerton enstatites and the silicate fraction from Larned display distinctive light-REE enrichments, and high Th/Sm ratios; Mount Egerton pyroxenes have much less pronounced negative Eu anomalies than pyroxenes from the main-group aubrites.
Leaching experiments were undertaken to investigate the contribution of sulfides to the whole rock budget of the main-group aubrites. Sulfides contain in most cases at least 50% of the REEs and of the actinides. Among the elements we have analyzed, those displaying the strongest lithophile behaviors are Rb, Ba, Sr and Sc.
The homogeneity of the Δ17O values obtained for main-group aubrite falls [Δ17O = +0.009 ± 0.010‰ (2σ)] suggests that they originated from a single parent body whose differentiation involved an early phase of large-scale melting that may have led to the development of a magma ocean. This interpretation is at first glance in agreement with the limited variability of the shapes of the REE patterns of these aubrites. However, the trace element concentrations of their phases cannot be used to discuss this hypothesis, because their igneous trace-element signatures have been modified by subsolidus exchange. Finally, despite similar O isotopic compositions, the marked light-REE enrichments displayed by Mount Egerton and Larned suggest that they are unrelated to the main-group aubrites and probably originated from a distinct parent body
Interferometric Bell-state preparation using femtosecond-pulse-pumped Spontaneous Parametric Down-Conversion
We present theoretical and experimental study of preparing maximally
entangled two-photon polarization states, or Bell states, using femtosecond
pulse pumped spontaneous parametric down-conversion (SPDC). First, we show how
the inherent distinguishability in femtosecond pulse pumped type-II SPDC can be
removed by using an interferometric technique without spectral and amplitude
post-selection. We then analyze the recently introduced Bell state preparation
scheme using type-I SPDC. Theoretically, both methods offer the same results,
however, type-I SPDC provides experimentally superior methods of preparing Bell
states in femtosecond pulse pumped SPDC. Such a pulsed source of highly
entangled photon pairs is useful in quantum communications, quantum
cryptography, quantum teleportation, etc.Comment: 11 pages, two-column format, to appear in PR
Ranks of twists of elliptic curves and Hilbert's Tenth Problem
In this paper we investigate the 2-Selmer rank in families of quadratic
twists of elliptic curves over arbitrary number fields. We give sufficient
conditions on an elliptic curve so that it has twists of arbitrary 2-Selmer
rank, and we give lower bounds for the number of twists (with bounded
conductor) that have a given 2-Selmer rank. As a consequence, under appropriate
hypotheses we can find many twists with trivial Mordell-Weil group, and
(assuming the Shafarevich-Tate conjecture) many others with infinite cyclic
Mordell-Weil group. Using work of Poonen and Shlapentokh, it follows from our
results that if the Shafarevich-Tate conjecture holds, then Hilbert's Tenth
Problem has a negative answer over the ring of integers of every number field.Comment: Minor changes. To appear in Inventiones mathematica
Entangled-Photon Generation from Parametric Down-Conversion in Media with Inhomogeneous Nonlinearity
We develop and experimentally verify a theory of Type-II spontaneous
parametric down-conversion (SPDC) in media with inhomogeneous distributions of
second-order nonlinearity. As a special case, we explore interference effects
from SPDC generated in a cascade of two bulk crystals separated by an air gap.
The polarization quantum-interference pattern is found to vary strongly with
the spacing between the two crystals. This is found to be a cooperative effect
due to two mechanisms: the chromatic dispersion of the medium separating the
crystals and spatiotemporal effects which arise from the inclusion of
transverse wave vectors. These effects provide two concomitant avenues for
controlling the quantum state generated in SPDC. We expect these results to be
of interest for the development of quantum technologies and the generation of
SPDC in periodically varying nonlinear materials.Comment: submitted to Physical Review
Observers and Locality in Everett Quantum Field Theory
A model for measurement in collapse-free nonrelativistic fermionic quantum
field theory is presented. In addition to local propagation and
effectively-local interactions, the model incorporates explicit representations
of localized observers, thus extending an earlier model of entanglement
generation in Everett quantum field theory [M. A. Rubin, Found. Phys. 32,
1495-1523 (2002)]. Transformations of the field operators from the Heisenberg
picture to the Deutsch-Hayden picture, involving fictitious auxiliary fields,
establish the locality of the model. The model is applied to manifestly-local
calculations of the results of measurements, using a type of sudden
approximation and in the limit of massive systems in narrow-wavepacket states.
Detection of the presence of a spin-1/2 system in a given spin state by a
freely-moving two-state observer illustrates the features of the model and the
nonperturbative computational methodology. With the help of perturbation theory
the model is applied to a calculation of the quintessential "nonlocal" quantum
phenomenon, spin correlations in the Einstein-Podolsky-Rosen-Bohm experiment.Comment: Some changes to introduction and discussion sections, typos
corrected, conclusions unchanged. To appear in Foundations of Physic
Fusion of secretory vesicles isolated from rat liver
Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy. The number of fused vesicles increases with increasing Ca2+-concentrations and is half maximal around 10–6 m. Other divalent cations (Ba2+, Sr2+, and Mg2+) were ineffective. Mg2+ inhibits Ca2+-induced fusion. Therefore, the fusion of secretory vesiclesin vitro is Ca2+ specific and exhibits properties similar to the exocytotic process of various secretory cells.
Various substances affecting secretionin vivo (microtubular inhibitors, local anethetics, ionophores) were tested for their effect on membrane fusion in our system.
The fusion of isolated secretory vesicles from liver was found to differ from that of pure phospholipid membranes in its temperature dependence, in its much lower requirement for Ca2+, and in its Ca2+-specificity. Chemical and enzymatic modifications of the vesicle membrane indicate that glycoproteins may account for these differences
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