The value of countryside elements in the conservation of a threatened arboreal marsupial Petaurus norfolcensis in agricultural landscapes of South-Eastern Australia—the disproportional value of scattered trees

Human activities, particularly agriculture, have transformed much of the world's terrestrial environment. Within these anthropogenic landscapes, a variety of relictual and semi-natural habitats exist, which we term countryside elements. The habitat value of countryside elements (hereafter termed 'elements') is increasingly recognised. We quantify the relative value of four kinds of such 'elements' (linear roadside remnants, native vegetation patches, scattered trees and tree plantings) used by a threatened Australian arboreal marsupial, the squirrel glider (Petaurus norfolcensis). We examined relationships between home range size and the availability of each 'element' and whether the usage was relative to predicted levels of use. The use of 'elements' by gliders was largely explained by their availability, but there was a preference for native vegetation patches and scattered trees. We found home range size was significantly smaller with increasing area of scattered trees and a contrasting effect with increasing area of linear roadside remnants or native vegetation patches. Our work showed that each 'element' was used and as such had a role in the conservation of the squirrel glider, but their relative value varied. We illustrate the need to assess the conservation value of countryside elements so they can be incorporated into the holistic management of agricultural landscapes. This work demonstrates the disproportional value of scattered trees, underscoring the need to specifically incorporate and/or enhance the protection and recruitment of scattered trees in biodiversity conservation policy and management

Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors

Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (Cx36KO) mice using a pentylenetetrazol (PTZ) model

Childhood abuse and the content of delusions

Original article can be found at: http://www.sciencedirect.com/science/journal/01452134 Copyright Elsevier Ltd.We aimed to investigate possible associations between histories of childhood abuse and the content of delusions for individuals with psychotic disorders. 39 participants with a psychotic disorder including one or more delusional beliefs successfully completed structured interviews about childhood trauma, delusional beliefs and associated anomalous perceptual experiences including hallucinations. The presence of hallucinations was predicted by greater physical abuse. Greater abuse in general was associated with delusions involving ‘special abilities’ (grandiosity) and, at trend levels, with those involving ‘defective self’. Though preliminary, these results suggest that further investigation is warranted. The presence and nature of abuse may be relevant to delusional presentations and should form an essential part of clinical assessment of psychotic disorder.Peer reviewe

An introduction to crowdsourcing for language and multimedia technology research

Language and multimedia technology research often relies on large manually constructed datasets for training or evaluation of algorithms and systems. Constructing these datasets is often expensive with significant challenges in terms of recruitment of personnel to carry out the work. Crowdsourcing methods using scalable pools of workers available on-demand offers a flexible means of rapid low-cost construction of many of these datasets to support existing research requirements and potentially promote new research initiatives that would otherwise not be possible

An integrated statistical model of Emergency Department length of stay informed by Resilient Health Care principles

Background Hospital Emergency Departments (EDs) face variable demand and capacity issues affecting timely discharge of patients. This is due in part to a lack of integration of routine monitoring data, affecting anticipation and response. Methods Patient flow was modelled (four hour target breaches; time to decision-to-admit; subsequent time to admit-to-hospital) in a busy ED. Patient and organisational data were collated, screened and conceptualised using Resilient Health Care (RHC) theory. Data were collected for all patients presenting during a 24-month period (May 2014–April 2016; n = 232,920) and analysed via multivariable logistic regression for four hour target breaches, and ordinary least squares regression for time. A measure of effect size was calculated for each independent variable. Overall model fit was assessed using percent concordant. Results Length of stay is related to demand, capacity and process indicators including: number of patients; night shift; first location being resuscitation or major injury area(s); urgent or very urgent triage patients; patients readmitting from up to 7 days previous; bed capacity; recent ambulance arrivals; and patients where the primary presenting complaint (PPC) is related to mental health or difficult to ascertain. Conclusions Understanding variation in performance through RHC theory can support staff and organisations in monitoring, anticipating and responding. A set of reliable core predictors has been identified to help design future ways to facilitate resilient performance through early indicators of pressure

Dynamic Power Convertor Development for Radioisotope Power Systems at NASA Glenn Research Center

The Thermal Energy Conversion Branch at NASA Glenn Research Center (GRC) is supporting the development of high-efficiency power convertors for use in Radioisotope Power Systems (RPS). Significant progress was made towards such a system that utilized Stirling conversion during the 2001 to 2015 timeframe. Flight development of the Advanced Stirling Radioisotope Generator (ASRG) was cancelled in 2013 by the Department of Energy (DOE) and NASA Headquarters primarily due to budget constraints, and the Advanced Stirling Convertor (ASC) technology contract was subsequently concluded in 2015. A new chapter of technology development has recently been initiated by the NASA RPS Program. This effort is considering all dynamic power convertor options, such as Stirling and Brayton cycles. Four convertor development contracts supporting this effort were awarded in 2017. The awarded contracts include two free-piston Stirling, one thermoacoustic Stirling, and one turbo-Brayton designs. The technology development contracts each consist of up to three phases: Design, Fabricate, and Test. As of May 2018, all contracts have completed the Design Phase, and each underwent a design review with an independent review board. Three of the contracts are planned to execute the Phase 2 option for fabrication. Convertors manifesting from these development efforts will then undergo independent validation and verification at NASA facilities, which will consist of convertor performance and RPS viability demonstrations. Example tests include launch vibration simulation, performance mapping over the environmental temperature range, and static acceleration exposure. In parallel with this renewed development effort, NASA GRC is still demonstrating free-piston Stirling convertor technology using assets from previous projects. The Stirling Research Laboratory (SRL) is still operating several convertors from previous development projects which have similarities and relevance to current contract designs. Four of which are flexure-bearing based, and another six are gas-bearing based. One of the flexure-bearing convertors has accumulated over 110,000 hours of operation, and holds the current record for maintenance-free heat-engine run-time. Another flexure-bearing convertor was recently manually shutdown after 105,620 hours of operation, then disassembled and inspected. This inspection produced a wealth of information about the effects of this amount of runtime on the technology's components. One of the engineering unit flexure-bearing convertors recently underwent launch simulation vibration test, a static acceleration exposure up to 20 g, and was then placed on extended operation. Amongst the gas-bearing convertors, the longest running unit has accumulated over 70,000 hours of operation. Four high-fidelity gas-bearing convertors from the ASRG project are still operating continuously, for which the longest runtime has reached 28,000 hours

Soft X-ray spectral variations of the narrow line Seyfert l galaxy Markarian 766

The X-ray variability of the narrow-line Seyfert 1 galaxy Markarian 766 is studied using nine ROSAT PSPC data sets. The spectrum is well described by a power law combined with a blackbody (kT ∼ 70 eV) soft excess. Examination of flux ratio changes and variability amplitude in three X-ray bands shows that the power-law component varies continuously on time-scales of ∼ 5000 s and is steeper when it is brighter. In contrast, variability of the soft excess is not detected. Spectral modelling of 31 spectra from different observations and at a range of count rates is also consistent with a picture in which the power law is steeper when it is brighter, and in which the soft-excess component does not vary. The power-law variability can be explained if the power law is produced by variable thermal or non-thermal Comptonization of soft photons. This behaviour is similar to that of Galactic black hole candidates in the low state. The X-ray and multiwavelength properties of Markarian 766 are shown to be very similar to those of other narrow-line Seyfert 1s. This may mean that the rapid X-ray variability seen in other narrow-line Seyfert 1s may also not originate in their strong soft-excess components

XMM-Newton observation of the deep minimum state of PG 2112+059: A spectrum dominated by reflection from the accretion disk?

We analyse a 75ks XMM-Newton observation of PG 2112+059 performed in November 2005 and compare it with a 15ks XMM-Newton observation taken in May 2003. PG 2112+059 was found in a deep minimum state as its 0.2-12 keV flux decreased by a factor of 10 in comparison to the May 2003 observation. During the deep minimum state the spectra show strong emission in excess of the continuum in the 3-6 keV region. The excess emission corresponds to an EW = 26.1 keV whereas its shape resembles that of heavily absorbed objects. The spectra of both observations of PG 2112+059 can be explained statistically by a combination of two absorbers where one shows a high column density, $N_{H} \sim 4.5 \times 10^{23} cm^{-2}$, and the other high ionisation parameters. As the ionisation parameter of the high flux state, $\xi \sim 34 erg cm s^{-1}$, is lower than the value found for the deep minimum state, $\xi \sim 110 erg cm s^{-1}$, either the absorbers are physically different or the absorbing material is moving with respect to the X-ray source. The spectra can also be explained by a continuum plus X-ray ionised reflection on the accretion disk, seen behind a warm absorber. The ionisation parameter of the high state ($\xi \sim 5.6 erg cm s^{-1}$) is higher than the ionisation parameter of the deep minimum state ($\xi \sim 0.2 erg cm s^{-1}$), as expected for a stationary absorber. The values found for the ionisation parameters are in the range typical for AGNs. The spectra observed during the deep minimum state are reflection dominated and show no continuum emission. These can be understood in the context of light bending near the supermassive black hole as predicted by Minutti and Fabian.Comment: 13 pages, 3 figures, A&A latex, accepted for publication in Astronomy & Astrophysic

EPLIN: a fundamental actin regulator in cancer metastasis?

Treatment of malignant disease is of paramount importance in modern medicine. In 2012, it was estimated that 162,000 people died from cancer in the UK which illustrates a fundamental problem. Traditional treatments for cancer have various drawbacks, and this creates a considerable need for specific, molecular targets to overcome cancer spread. Epithelial protein lost in neoplasm (EPLIN) is an actin-associated molecule which has been implicated in the development and progression of various cancers including breast, prostate, oesophageal and lung where EPLIN expression is frequently lost as the cancer progresses. EPLIN is important in the regulation of actin dynamics and has multiple associations at epithelial cells junctions. Thus, EPLIN loss in cancer may have significant effects on cancer cell migration and invasion, increasing metastatic potential. Overexpression of EPLIN has proved to be an effective tool for manipulating cancerous traits such as reducing cell growth and cell motility and rendering cells less invasive illustrating the therapeutic potential of EPLIN. Here, we review the current state of knowledge of EPLIN, highlighting EPLIN involvement in regulating cytoskeletal dynamics, signalling pathways and implications in cancer and metastasis