Potencialización del emprendedurismo juvenil a través de los activos del desarrollo comunitario en la comarca de San Cayetano del municipio de San Rafael del Sur

Propuesta de intervención social, desarrollada con el fin de contribuir al incremento de opciones de desarrollo humano, potencializando el emprendedurismo juvenil, basado en los activos de desarrollo comunitario de la comarca San Cayetano en el municipio San Rafael del Sur, como una alternativa para la generación de autoempleo

IMPACT OF GLOBALISATION ON TEXTILE INDUSTRIES: A CASE STUDY OF SOME NIGERIAN INDUSTRIES IN KANO METROPOLIS

Using panel data set for 3 selected textile industries in Kano State for the period 1985 – 2005 this study utilized Fixed Effects Regression Model (FEM) and Random Effects Regression Model (REM) to investigate on globalization and textile output in Kano. Results from this research reveal that electricity consumption has significant positive influence on textile output. Another finding of the research is that globalization and exchange rate of naira against United State dollar have negative but significant influence on textile output. The study therefore recommends that Nigerian government should take a second look at her membership of the World Trade Organisation (W.T.O) and selectively engage those policies that will promote her national interest, most especially the imperative need to protect the textile firms. As for the exchange rate, adjustment should be made in the level of the domestic currency based on the interactions of market forces that will facilitate appropriate pricing of the foreign exchange and enhance domestic products which enhance their competitiveness in the export market. Moreover, stable and reliable power supply is necessary to generate optimum production at lower cost so as to enhance utilization of idle resources, expand factor incomes, improve competitiveness and expand overall textile output

Effect of rowing on mobility, functionality, and quality of life in women with and without breast cancer: a 4-month intervention

Purpose: Of the different modalities of rowing, dragon boat training is the most analyzed in breast cancer (BC). However, other types of boats, such as the felucca, use different biomechanical techniques, which have not been studied in the scientific literature. Consequently, in this study, we sought to determine the benefits of felucca rowing on the physical, psychological, and emotional well-being of patients with BC and healthy persons. Methods: A pre- and post-intervention, single-arm study without a control group with a 4-month intervention was carried out in Spain in 2019. The study sample included six women with BC and 15 healthy women. The following questionnaires were administered before and after the intervention: Disabilities of the Arm, Shoulder, and Hand (DASH), Constant-Murley score (CMS), and the European Quality of Life 5 Dimensions (EQ-5D, rate your health today). Differences were determined before and after the intervention using the paired t test. Results: Significant differences (p < 0.05) were found in the results of all the questionnaires for the women with BC and for the healthy women: DASH (- 13.8 BC and - 6.7 healthy), CMS (+ 12.0 BC and 9.2 healthy), and EQ-5D (+ 8.5 BC and 10.5 healthy). Conclusion: Felucca rowing showed benefits in health and quality of life in both women with BC and healthy women. In future studies with controlled design, values regarding clinical relevance, such as effect sizes/confidence intervals, are needed to corroborate our results

Histopatología y bioquímica clínica de ratas expuestas de forma subcrónica al extracto de migración de un material nanocompuesto

Junta de Andalucía AGR5969Ministerio de Ciencia e Innovación AGL2010-2121

Skipped BSCL2 Transcript in Celia’s Encephalopathy (PELD): New Insights on Fatty Acids Involvement, Senescence and Adipogenesis

Objective PELD (Progressive Encephalopathy with or without Lipodystrophy or Celia’s Encephalopathy) is a fatal and rare neurodegenerative syndrome associated with the BSCL2 mutation c.985C>T, that results in an aberrant transcript without the exon 7 (Celia seipin). The aim of this study was to evaluate both the process of cellular senescence and the effect of unsaturated fatty acids on preadipocytes from a homozygous c.985C>T patient. Also, the role of aberrant seipin isoform on adipogenesis was studied in adipose-derived human mesenchymal stem cells. Material and methods Cellular senescence was evaluated using β-galactosidase staining of preadipocytes obtained from a homozygous c.985C>T patient. Moreover, these cells were cultured during 24 hours with Intralipid, a soybean oil-based commercial lipid emulsion. The expression of the different BSCL2 transcripts was measured by qPCR. Adipose-derived human mesenchymal stem cells were differentiated to a fat lineage using StemPRO adipogenesis kit, and the expression of BSCL2 transcripts and several adipogenesis-related genes was measured by qPCR. Results the treatment of preadipocytes with unsaturated fatty acids significantly reduced the expression of the BSCL2 transcript without exon 7 by 34 to 63%. On the other hand, at least in preadipocytes, this mutation does not disturb cellular senescence rate. Finally, during adipocyte differentiation of adipose-derived human mesenchymal stem cells, the expression of adipogenic genes (PPARG, LPIN1, and LPL) increased significantly over 14 days, and noteworthy is that the BSCL2 transcript without exon 7 was differentially expressed by 332 to 723% when compared to day 0, suggesting an underlying role in adipogenesis. Conclusions our results suggest that Celia seipin is probably playing an underestimated role in adipocyte maturation, but not in senescence, and its expression can be modified by exogenous factors as fatty acidsThis work was supported by the Instituto de Salud Carlos III and the European Regional Development Fund, FEDER (grants number PI10/02873 and PI13/00314, http://www.isciii.es/), ISCIII/PI13/00314/Cofinanciado FEDER and by the Consellería de Industria, Xunta de Galicia (grant number 10PXIB208013PR, http://www.xunta.es/). SRG was awarded a Research Fellowship, granted by the Asociación Española de Familiares y Afectados de Lipodistrofias (AELIP, http://www.aelip.org/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptS

Futuro de la minería zacatecana y los retos en capital humano

Se analizan los requerimientos de capital humano del sector minero y programa de formación, con proyección al 2025, en la zona de influencia del clúster minero de Zacatecas; se describe el panorama económico de la minería y los factores que influyen en su evolución, los retos productivos, sociales, ambientales, de seguridad y de certidumbre gubernamental que enfrenta la industria minera zacatecana, así como las tendencias tecnológicas que dominan y predominarán para los próximos diez años a lo largo de la cadena de valor de la minería, destacando aquellas áreas tecnológicas como maquinaria y equipo, tecnologías de la información y la comunicación, y gestión ambiental, que impactarán en la industria minera. Asimismo, se destacan las capacidades técnicas y genéricas de recursos humanos y los perfiles profesionales que requerirán las empresas mineras y proveedoras de servicios especializados, así como las brechas actuales entre la oferta y la demanda de capital humano en el estado de Zacatecas y su zona de influencia. Como parte de las conclusiones se propone una serie de recomendaciones dirigidas al sector minero e instituciones de educación superior y media superior con la finalidad de generar estrategias empresariales y políticas educativas orientadas a incentivar y reforzar la formación de capital humano que demandan las tecnologías del sector minero, de tal manera que la industria minera zacatecana asegure su competitividad en el mediano y largo plazo.Consejo Nacional de Ciencia y TecnologíaConsejo Zacatecano de Ciencia y TecnologíaGobierno del Estado de Zacateca

Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years.

Clonal hematopoiesis, especially that of indeterminate potential (CHIP), has been associated with age-related diseases, such as those contributing to a more severe COVID-19. Four studies have attempted to associate CHIP with COVID-19 severity without conclusive findings. In the present work, we explore the association between CHIP and COVID-19 mortality. Genomic DNA extracted from peripheral blood of COVID-19 patients (n = 241 deceased, n = 239 survivors) was sequenced with the Myeloid Solutions™ panel of SOPHiA Genetics. The association between clonality and age and clonality and mortality was studied using logistic regression models adjusted for sex, ethnicity, and comorbidities. The association with mortality was performed with patients stratified into four groups of age according to the quartiles of the distribution: 60–74 years, 75–84 years, 85–91 years, and 92–101 years. Clonality was found in 38% of the cohort. The presence of CHIP variants, but not the number, significantly increased with age in the entire cohort of COVID-19 patients, as well as in the group of survivors (p < 0.001). When patients were stratified by age and the analysis adjusted, CHIP classified as pathogenic/likely pathogenic was significantly more represented in deceased patients compared with survivors in the group of 75–84 years (34.6% vs 13.7%, p = 0.020). We confirmed the well-established linear relationship between age and clonality in the cohort of COVID-19 patients and found a significant association between pathogenic/likely pathogenic CHIP and mortality in patients from 75 to 84 years that needs to be further validated.post-print1034 K

Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19

Rare variants affecting host defense against pathogens could be involved in COVID-19 severity and may help explain fatal outcomes in young and middle-aged patients. Our aim was to report the presence of rare genetic variants in certain genes, by using whole exome sequencing, in a selected group of COVID-19 patients under 65 years who required intubation or resulting in death (n = 44). To this end, different etiopathogenic mechanisms were explored using gene prioritization-based analysis in which genes involved in immune response, immunodeficiencies or blood coagulation were studied. We detected 44 different variants of interest, in 29 different patients (66%). Some of these variants were previously described as pathogenic and were located in genes mainly involved in immune response. A network analysis, including the 42 genes with candidate variants, showed three main components, consisting of 25 highly interconnected genes related to immune response and two additional networks composed by genes enriched in carbohydrate metabolism and in DNA metabolism and repair processes. In conclusion, we have detected candidate variants that may potentially influence COVID-19 outcome in our cohort of patients. Further studies are needed to confirm the ultimate role of the genetic variants described in the present study on COVID-19 severityTis work was supported by Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation (COVID19 Research Call, COV20/00181) co-fnanced by European Development Regional Fund (FEDER, A way to achieve Europe) and contributions from Estrella de Levante S.A. and Colabora Mujer Association. CIBERer (Centro de Investigación en Red de Enfermedades Raras) is funded by Instituto de Salud Carlos III.R.L-R.and M.dP.V. are sponsored by the project COV20/00181. M.C., P.M. and B.A. are supported by the Miguel Servet (CP17/00006, CP16/00116) and Juan Rodes (JR17/00020) programs, respectively, of the Instituto de Salud Carlos III, co-fnanced by the European Regional Development Fund (FEDER). R.R. is supported by a postdoctoral fellowship of the Comunidad de Madrid (2019-T2/BMD-13714) and G.N.-M. by a contract of the Comunidad de Madrid (PEJ-2020-AI/BMD-18610