281 research outputs found
Clinical anatomy of the anterior meniscofemoral ligament of humphrey : an original MRI study, meta-analysis, and systematic review
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/01/2021
- Field of study
Clinical anatomy of the posterior meniscofemoral ligament of wrisberg : an original MRI study, meta-analysis, and systematic review
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/01/2021
- Field of study
A chemical survey of exoplanets with ARIEL
- Author
- A Broomhall
- A Burrows
- A Burrows
- A Burrows
- A Cassan
- A Fukui
- A Garcia-Munoz
- A Garcia-Piquer
- A LĂ©ger
- A LĂ©ger
- A Maggio
- A Matter
- A Morbidelli
- A Sozzetti
- A Triaud
- A Tsiaras
- A Tsiaras
- A Vanderburg
- A Vazan
- A Vidal-Madjiar
- A Zurlo
- A. Luntzer
- A. Stiepen
- Aikaterini Radioti
- AJ Pickles
- Alan Aylward
- Albert Rosich
- Aldo S. Bonomo
- Alessandro Mura
- Alessandro Sozzetti
- Alexander Medvedev
- Alexandre Santerne
- Allan Hornstrup
- Allan Sacha Brun
- Allona Vazan
- AM Mandell
- Amaury Triaud
- Andrea Moneti
- Andreas Papageorgiou
- Angela Ciaravella
- Angelos Tsiaras
- Anna Maria Di Giorgio
- Anna Wawrzaszek
- Anthony Whitworth
- Antoine Strugarek
- Antonino Petralia
- Antonio GarcĂa Muñoz
- Antonio Maggio
- AP Showman
- AS Eddington
- Astrid Heske
- Athena Coustenis
- AW Mayo
- B Brandl
- B Charnay
- B Gustafsson
- B Macintosh
- B Marty
- B Rackham
- Bart Vandenbussche
- Bastien Duong
- Bejamin Charnay
- Benjamin Drummond
- Benoit Hubert
- Bertrand Bonfond
- Billy Edwards
- BJ Fulton
- BMS Hansen
- BO Demory
- BO Demory
- Bruno BĂ©zard
- Bruno Sicardy
- C Beichman
- C Broeg
- C Danielski
- C Majeau
- C. Tucker
- Caitlin Griffith
- Camilla Danielski
- Carles Sierra
- Carsten Dominik
- Cesare Cecchi Pestellini
- CG Tinney
- Chris Pearson
- Christophe Alard
- Christopher Jarchow
- CJ Grillmair
- Claudio Arena
- CM Sharp
- Cristian Baccani
- D Apai
- D Charbonneau
- D Charbonneau
- D Charbonneau
- D Deming
- D Deming
- D Fabricky
- D Huber
- D Queloz
- D Turrini
- D Turrini
- D Valencia
- D Valencia
- D Valencia
- DA Fisher
- David Pinfield
- David Waltham
- DC Fabrycky
- Deirdre Coffey
- Denis Grodent
- Diana Valencia
- Diego Turrini
- DK Sing
- DL Pollacco
- DM Kipping
- DM Williams
- DP Thorngren
- E Herrero
- E Hertzsprung
- E Miller-Ricci
- E Pascale
- E Rauscher
- EB Ford
- Emanuel Lellouch
- Emanuele Pace
- Emeline Bolmont
- Enric Palle
- Enrique Herrero
- Enzo Pascale
- ER Adams
- ES Kite
- Etienne Renotte
- Ettore Flaccomio
- F Forget
- F Fressin
- Fabrizio Oliva
- Federico Landini
- Francesc Vilardell
- Francesca Altieri
- Franck Selsis
- Frans Zwart
- Franz Kerschbaum
- François Forget
- G Basri
- G Bruno
- G Fu
- G Laughlin
- G Micela
- G Micela
- G Morello
- G Morello
- G Morello
- G Morello
- G Morello
- G Scandariato
- G Tinetti
- G Tinetti
- G Tinetti
- G Tinetti
- GA Bakos
- Gaetano Scandariato
- Gaspar Bakos
- Gautam Vasisht
- Georgia Bishop
- Giampaolo Piotto
- Giampaolo Pisano
- Giancarlo Bellucci
- Gianluca Morgante
- Gillian Wright
- Giorgio Savini
- Giovanna Tinetti
- Giuseppe Leto
- Giuseppe Malaguti
- Giuseppe Morello
- Giuseppe Piccioni
- Giuseppe Sindoni
- Giusi Micela
- GMHJ Habets
- GR Ricker
- Guo Chen
- Göran Pilbratt
- H Kjeldsen
- H Rauer
- H. Gomez
- HA Bethe
- HA Knutson
- HA Knutson
- Hans Ulrik NĂžrgaard-Nielsen
- Hervé Geoffray
- HF Levison
- HN Russell
- Hugh Jones
- I Baraffe
- IAG Snellen
- IAG Snellen
- Ian Bryson
- Ignas Snellen
- Ignasi Ribas
- Ignazio Pillitteri
- IJM Crossfield
- IJM Crossfield
- Ingo Waldmann
- Ioannis Argyriou
- IP Waldmann
- IP Waldmann
- IP Waldmann
- IP Waldmann
- IP Waldmann
- IP Waldmann
- IP Waldmann
- Isabel Escudero Sanz
- Isabella Pagano
- J Fortney
- J Fraine
- J Leconte
- J Leconte
- J Leconte
- J Leconte
- J Lissauer
- J Moses
- J Rowe
- J Tennyson
- J Tennyson
- J Venturini
- J Wit De
- J Wit De
- J-M Lee
- J-P Beaulieu
- J-P Beaulieu
- Jacques Gustin
- Jake Taylor
- James Cho
- JC Morales
- Jean Claude GĂ©rard
- Jean Jaubert
- Jean-Baptiste Marquette
- Jean-Louis AuguĂšres
- Jean-Michel RĂ©ess
- Jean-Philippe Beaulieu
- Jean-Pierre Maillard
- Jerome Amiaux
- Jesus Maldonado
- JG Ingalls
- JJ Bochinski
- JK Barstow
- JK Barstow
- JK Barstow
- JK Barstow
- JL Bean
- JL Birkby
- JL Linsky
- JM Andersen
- JM Matthews
- Joanna Barstow
- John Robert Brucato
- Jonathan Tennyson
- Josep Colomé
- JRA Davenport
- Juan Carlos Morales
- JW Tofflemire
- JY-K Cho
- Jérémy Leconte
- K Tsiganis
- Kate Symonds
- Kay Justtanont
- KB Stevenson
- Keiko Hamano
- Kevin Heng
- Kevin Middleton
- KO Todorov
- Konrad Skup
- L Kreidberg
- L Kreidberg
- L Lindegren
- L Puig
- L Puig
- LA Balona
- Ladislav Rezac
- Lars A. Buchave
- Laura Affer
- Lauriane Soret
- Leen Decin
- Leigh Fletcher
- Lluis Gesa
- Loredana Prisinzano
- LT Elkins-Tanton
- Luca Terenzi
- Ludovic Puig
- M AgĂșndez
- M AgĂșndez
- M Auvergne
- M Brogi
- M Damiano
- M Gillon
- M Gillon
- M Ikoma
- M Rocchetto
- Manuel Guedel
- Manuel Perger
- Marc Ollivier
- Marcell Tessenyi
- Marco Rocchetto
- Marek Banaszkiewicz
- Maria Blecka
- Maria Farina
- Marina Galand
- Marina Lafarga
- Mario Damasso
- Mario Damiano
- Mario Giuseppe Guarcello
- Mark Swain
- Markus FrÀnz
- Martin Crook
- Martin Ferus
- Martin Frericks
- MarĂa Rosa Zapatero Osorio
- Masahiro Ikoma
- Mateusz Sobiecki
- Matt Burleigh
- Matt Griffin
- Matthijs Krijger
- Maurizio Pancrazzi
- Mauro Focardi
- Michael Gillon
- Michel Berthé
- Michiel Min
- Mike Barlow
- Mirek Rataj
- Miriam Rengel
- MJ Holman
- MR Line
- MR Line
- MR Swain
- MR Swain
- MR Swain
- N Batalha
- N Crouzet
- N Crouzet
- N Madhusudhan
- N. Nguyen Tong
- Naidu Bezawada
- NB Cowan
- Neil Bowles
- Nicolas Iro
- Nicole Allard
- Nicoletta Sanna
- Norbert Krupp
- Norio Narita
- O Grasset
- O Venot
- O Venot
- O Venot
- Olivia Venot
- P Ballerini
- P Bodenheimer
- P Eccleston
- P Irwin
- P McCullough
- P MolliĂšre
- P Nutzman
- P Sartoretti
- Patrick Irwin
- Paul Eccleston
- Paul Hartogh
- Paul Palmer
- Paulina Wolkenberg
- Pedro Machado
- Pernelle Bernardi
- Peter Ade
- Peter Hargrave
- Pierre Drossart
- Pierre Kervella
- Pierre Maxted
- Pierre-Elie Crouzet
- Pierre-Olivier Lagage
- Pieter Deroo
- Piotr Wawer
- PL Palle
- PR McCullough
- PW Sullivan
- PW Sullivan
- Q Konopacky
- Queyrel Julien
- R Alonso
- R Bounaceur
- R Helled
- R Varley
- RafaĆ Graczyk
- Ralf Kohley
- Ravit Helled
- Ray Pierrehumbert
- RC Domingos
- RD Wordsworth
- Rens Waters
- René Doyon
- Riccardo Claudi
- Richard Stamper
- RL Gilliland
- Robert Szabo
- Robert Zellem
- Rodolphe Clédassou
- Roland Ottensamer
- Rosaria Bonito
- RT Zellem
- S Chatterjee
- S Sarkar
- S Seager
- Sabrine Vinatier
- Sarah Casewell
- SB Howell
- Serena Benatti
- Serena Viti
- Sergey N. Yurchenko
- Shigeru Ida
- Shingo Kameda
- Simon Doyle
- SJ Kim
- SJ Weidenschilling
- SK Solanki
- SN Raymond
- SN Yurchenko
- SR Cranmer
- Stefano Pezzuto
- Stephane Mathis
- Stephanie Werner
- Stephen Eales
- Steve Fossey
- Subhajit Sarkar
- T Encrenaz
- T Guillot
- T Guillot
- T Guillot
- T Sasaki
- Taro Matsuo
- Theresa Rank-LĂŒftinger
- Therese Encrenaz
- Tiziano Zingales
- TJ Bogdan
- TM Brown
- Tom Hunt
- Tom Ray
- Tommi Koskinen
- TP Greene
- TS Barman
- Urs Mall
- V Parmentier
- V Wakelam
- V Wakelam
- Valerio Nascimbeni
- Vanessa Doublier
- Vania Da Peppo
- Vincent Coudé du Foresto
- Vincent Minier
- Virginie Batista
- Vivien Parmentier
- Vladimiro Noce
- W Kley
- Waldemar Bujwan
- Walter Gear
- William Taylor
- WJ Borucki
- X Dumusque
- Y Miguel
- Y Miguel
- Yamila Miguel
- Yann Hello
- Yuk L. Yung
- Yuka Fujii
- Yves André
- Z Berta
- Ălvaro GarcĂa-Piquer
- Ă Artigau
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planetâs birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25â7.8 ÎŒm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10â100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed â using conservative estimates of mission performance and a full model of all significant noise sources in the measurement â using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL â in line with the stated mission objectives â will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio
Long-range angular correlations on the near and away side in p–Pb collisions at
- Author
- Abdiel Ramirez Reyes
- Adam Ryszard Kisiel
- Adam Tomasz Matyja
- Adam Wlodzimierz Jacholkowski
- Adam Szczepankiewicz
- Adela Kravcakova
- Aditya Nath Mishra
- Adrian Sevcenco
- Adriana Telesca
- Airton Deppman
- Ajay Kumar Dash
- Alberica Toia
- Alberto Baldisseri
- Alberto Collu
- Alberto Gago
- Alberto Masoni
- Alejandro Szanto de Toledo
- Alessandra Maria Mazzoni
- Alessandra Fantoni
- Alessandro De Falco
- Alessandro Feliciello
- Alessandro Grelli
- Alessandro Pesci
- Alexander Philipp Kalweit
- Alexander Akindinov
- Alexander Borissov
- Alexander Hansen
- Alexander Kluge
- Alexander Mamonov
- Alexander Nedosekin
- Alexander Ochirov
- Alexander Vinogradov
- Alexander Vodopianov
- Alexander Wilk
- Alexandr Tumkin
- Alexandre Alarcon do Passo Suaide
- Alexandre Nyanin
- Alexandre Rachevski
- Alexandre Shabetai
- Alexandru Florin Dobrin
- Alexandru Bercuci
- Alexei Kaidalov
- Alexei Khanzadeev
- Alexei Pavlinov
- Alexey Bogdanov
- Alexey Kuryakin
- Alexey Vyushin
- Alexis Jean Michel Mas
- Alfonso Tarazona Martinez
- Alfredo Musso
- Alice Zimmermann
- Alina Gabriela Grigoras
- Alis Rodriguez Manso
- Alla Maevskaya
- Alphonse Rademakers
- Amalia Pop
- Amaya Ofelia Casanova Diaz
- Ana Maria Marin
- Anais Annick Erica Bergognon
- Anand Kumar Dubey
- Anatoly Kolojvari
- Anders Garritt Knospe
- Anders Nils Erik Oskarsson
- Andras Gabor Agocs
- Andre Augustinus
- Andre Mischke
- Andrea Agostinelli
- Andrea Alici
- Andrea Dainese
- Andrea Danu
- Andrea Dubla
- Andrea Festanti
- Andrea Francescon
- Andrea Rossi
- Andreas Arend
- Andreas Morsch
- Andrei Geae Gheata
- Andrei Ionut Herghelegiu
- Andres Sandoval
- Andrew Marshall Adare
- Andrey Ivanov
- Andrey Kazantsev
- Andrey Reshetin
- Andrey Vasiliev
- Andrey Zarochentsev
- Andry Malala Rakotozafindrabe
- Andrzej Deloff
- Andrzej Rybicki
- Andzhey Asryan
- Angela Badala
- Anik Gupta
- Anitha Nyatha
- Anju Bhasin
- Ankita Goswami
- Anna Rita Reolon
- Annalisa De Caro
- Annalisa Mastroserio
- Annika Passfeld
- Anselmo Margotti
- Ante Bilandzic
- Anthony Timmins
- Antoine Xavier Lardeux
- Anton Alkin
- Anton Andronic
- Anton Jusko
- Antonin Maire
- Antonino Zichichi
- Antonio Carlos Oliveira Da Silva
- Antonio Di Mauro
- Antonio Juan Rubio Montero
- Antonio Ortiz Velasquez
- Antonio Uras
- Ara Grigoryan
- Armando Palmeri
- Arnaldi Roberta
- Arnulfo Martinez Davalos
- Arsen Hayrapetyan
- Arshad Ahmad
- Artem Konevskih
- Artur Krzysztof Szostak
- Arturo Alejandro Menchaca Rocha
- Arturo Fernandez Tellez
- Arturo Tauro
- Arvinder Singh Palaha
- Ashok Kumar Bhati
- Astrid Morreale
- Attilio Tarantola Peloni
- Attiq Ur Rehman
- Aurora Diozcora Vargas
- Austin Harton
- Ayben Karasu Uysal
- Baba Potukuchi
- Bae Svane Nielsen
- Barbara Erazmus
- Barbara Guerzoni
- Barthelemy von Haller
- Basanta Kumar Nandi
- Bastian Bathen
- Bedangadas Mohanty
- Benjamin Andreas Hess
- Benjamin Donigus
- Beole&apos
- Beomkyu Kim
- Beomsu Chang
- Bernard Hicks
- Bernd Stefan Windelband
- Bernhard Skaali
- Berzano Dario Carlo Domenico
- Betty Abelev
- Bianchi Livio
- Bikash Sinha
- Biswarup Paul
- Bjarte Kileng
- Bjorn Steven Nilsen
- Blahoslav Pastircak
- Blanco F.
- Bo Fenton Olsen
- Bogdan Theodor Rascanu
- Bogdan Vulpescu
- Boris Batyunya
- Boris Grinyov
- Boris Hippolyte
- Boris Polichtchouk
- Boris Wagner
- Bossu&apos
- Botta Elena
- Branislav Sitar
- Brigitte Cheynis
- Brijesh Kumar Srivastava
- Bruno Alessandro
- Bruno Espagnon
- Bruno Ghidini
- Bufalino Stefania
- Byounghee Han
- Cai Xu
- Camilo Ernesto Lara
- Carlos Albert Salgado
- Carlos Eugenio Perez Lara
- Carlos Pajares
- Carmelo Di Giglio
- Carsten Sogaard
- Casper Nygaard
- Catherine Silvestre
- Catia Petta
- Cenek Zach
- Cesar Ceballos Sanchez
- Chiara Zampolli
- Christelle Sophie Roy
- Christian Claude Kuhn
- Christian Holm Christensen
- Christian Joachim Schmidt
- Christian Klein Bosing
- Christian Lippmann
- Christina Markert
- Christine Nattrass
- Christoph Heinrich Baumann
- Christoph Blume
- Christoph Mayer
- Christophe Pierre Suire
- Christophe Furget
- Christopher Daniel Anson
- Cinzia Luzzi
- Ciprian Mihai Mitu
- Claude Andre Pruneau
- Claudio Geuna
- Claudiu Cornel Schiaua
- Constantinos Loizides
- Corrado Cicalo
- Corrales Morales Yasser
- Costanza Cavicchioli
- Costin Grigoras
- Crispin Williams
- Cristian Geae Ivan
- Cristian Andrei
- Cristina Terrevoli
- Csaba Soos
- Cvetan Cheshkov
- Cynthia Marie Hadjidakis
- Dae Sung Hwang
- Dagmar Adamova
- Daicui Zhou
- Daniel Jesus Tapia Takaki
- Daniel Berenyi
- Daniel Felea
- Daniel Lohner
- Daniela Fabris
- Daniele De Gruttola
- Danilo Vranic
- Danthasinghe Piyarathna
- Dariusz Miskowiec
- David Christopher Truesdale
- David Olle Rickard Silvermyr
- David Philip Emschermann
- David Chinellato
- David Evans
- David Rohr
- David Tlusty
- Davide Caffarri
- Davide Falchieri
- Davide Perrino
- Debasish Das
- Deepa Thomas
- Deepika Rathee
- Deeptanshu Manu Jha
- Denise Aparecida Moreira De Godoy
- Despoina Hatzifotiadou
- Dhevan Raja Gangadharan
- Diego Caballero Orduna
- Diego Perini
- Diego Stocco
- Dieter Rohrich
- Dilan Minthaka Madagodahettige Don
- Dmitri Ivanovich Patalakha
- Dmitri Peresunko
- Dmitry Aleksandrov
- Dmitry Blau
- Dmitry Budnikov
- Dmitry Finogeev
- Dmitry Malʼ
- Do Won Kim
- Domenico Di Bari
- Domenico Colella
- Domenico Elia
- Dominik Fehlker
- Dong Jo Kim
- Dong Wang
- Dosatsu Sakata
- Durga Prasad Mahapatra
- Dutta Majumdar A. K.
- Edith Zinhle Buthelezi
- Edmundo Garcia Solis
- Eleazar Cuautle
- Elena Gonzalez Ferreiro
- Elena Bruna
- Elienos Pereira De Oliveira Filho
- Elisa Incani
- Elisabetta Crescio
- Emanuele Quercigh
- Emilia Cruz Alaniz
- Emmanuel Floratos
- Enrichetta Maria Fiore
- Enrico Fragiacomo
- Erick Jonathan Almaraz Avina
- Ermes Braidot
- Ernesto Belmont Moreno
- Ernesto Calvo Villar
- Ernesto Lopez Torres
- Ervin Denes
- Ester Anna Rita Casula
- Esther Montes
- Eugen Mudnic
- Eugenio Nappi
- Eugenio Scapparone
- Eulogio Serradilla
- Eva Sicking
- Evert Anders Stenlund
- Evgeny Karpechev
- Evgeny Kryshen
- Evgeny Ryabinkin
- Ewa Gladysz Dziadus
- Fabio Colamaria
- Fabrizio Coccetti
- Fatima Padilla
- Federico Antinori
- Federico Carminati
- Federico Cindolo
- Federico Ronchetti
- Fedor Guber
- Felix Vincenz Rettig
- Fengchu Zhou
- Fernando Baltasar Dos Santos Pedrosa
- Fernando Scarlassara
- Ferretti Alessandro
- Filip Krizek
- Filippo Costa
- Fiorella Fionda
- Florian Painke
- Francesca Bellini
- Francesca Soramel
- Francesco Barile
- Francesco Blanco
- Francesco Carena
- Francesco Noferini
- Francesco Prino
- Francesco Riggi
- Franck Manso
- Franco Meddi
- Frederick Kramer
- Gabriel de Barros
- Gagliardi Martino
- Galina Shabratova
- Gallio Mauro
- Gennady Zinovjev
- Gerardo Antonio Herrera Corral
- Gerardus Nooren
- Gergely Gabor Barnafoldi
- Gergoe Hamar
- Giacinto de Cataldo
- Giacomo Vito Margagliotti
- Giacomo Contin
- Giacomo Volpe
- Gianfranco Segato
- Gianluca Aglieri Rinella
- Gianluca Santagati
- Gianluca Usai
- Gideon Francois Steyn
- Gilda Scioli
- Gines Martinez Garcia
- Ginevra Dʼ
- Giovanna Puddu
- Giovanni Cara Romeo
- Giuseppe Eugenio Bruno
- Giuseppe Pappalardo
- Giuseppe Simonetti
- Giuseppe Viesti
- Goran Simatovic
- Graham Richard Lee
- Grazia Luparello
- Greeshma Koyithatta Meethaleveedu
- Grigory Feofilov
- Grzegorz Andrzej Wilk
- Grzegorz Stefanek
- Guido Marie Urciuoli
- Guillaume Batigne
- Guillermo Tejeda Munoz
- Gunnar Lovhoiden
- Gustavo Conesa Balbastre
- Guy Paic
- Gyula Bencedi
- Gyulnara Eyyubova
- Haavard Helstrup
- Haeng Jin Jang
- Haitao Zhang
- Hanna Paulina Zbroszczyk
- Hans Hjersing Dalsgaard
- Hans Martin Ljunggren
- Hans Rudolf Schmidt
- Hans Beck
- Hans Boggild
- Hans Muller
- Harald Appelshauser
- Hege Austrheim Erdal
- Heiko Engel
- Helen Louise Caines
- Helmut Oskar Oeschler
- Henner Buesching
- Henning Kvaerno
- Henrik Qvigstad
- Hermes Leon Vargas
- Hermes Leon
- Herve Borel
- Hideki Hamagaki
- Hiroaki Sakaguchi
- Hisayuki Torii
- Hongsheng Zhu
- Hongyan Yang
- Hrant Gulkanyan
- Hugo Denis Antonio Pereira Da Costa
- Hugues Delagrange
- Hyung Taik Jung
- Hyungsuk Son
- Ian Gardner Bearden
- Igor Altsybeev
- Igor Kulakov
- Igor Lakomov
- Igor Pshenichnov
- Igor Yushmanov
- Ildefonso Leon Monzon
- Ilya Selyuzhenkov
- Imrich Szarka
- In Kwon Yoo
- Indranil Das
- Innocenti Gian Michele
- Ionel Stan
- Ionela Berceanu
- Ionut Cristian Arsene
- Iosif Legrand
- Iouri Belikov
- Irakli Garishvili
- Irakli Martashvili
- Iryna Ilkiv
- Isha Chawla
- Ismael Cortes Maldonado
- Ivan Kisel
- Ivan Kralik
- Ivan Vorobyev
- Ivana Hrivnacova
- Ivonne Alicia Maldonado Cervantes
- Iwona Sputowska
- Jacek Tomasz Otwinowski
- Jae Mercado Perez
- Jaen Lien
- Jai Salzwedel
- Jan de Cuveland
- Jan Fiete Grosse Oetringhaus
- Jan Marian Pluta
- Jan Cepila
- Jan Figiel
- Jan Musinsky
- Jan Rak
- Jana Bielcikova
- Janka Vrlakova
- Janusz Oleniacz
- Jaroslav Adam
- Jaroslav Ban
- Jaroslav Bielcik
- Jason Glyndwr Ulery
- Javier Ernesto Castillo Castellanos
- Jean Luc Fernand Charvet
- Jean Pierre Revol
- Jean Sebastien Real
- Jean Willy Andre Cleymans
- Jean Yves Grossiord
- Jeewon Seo
- Jennifer Lynn Klay
- Jens Joergen Gaardhoje
- Jens Wiechula
- Jerzy Gustaw Bartke
- Jesus Guillermo Contreras
- Jianhui Zhu
- Jianlin Zhu
- Jiebin Luo
- Jihye Song
- Jihyun Bhom
- Jin Sook Kim
- Jiri Kral
- Jiri Mares
- Jitendra Kumar
- Joakim Ingemar Nystrand
- Jocelyn Mlynarz
- Jochen Mathias Thader
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- Joel Mazer
- Joerg Walter Lehnert
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- Jonghyun Kim
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- Krzysztof Redlich
- Kurepin A.
- Kurepin A. B.
- Kushal Das
- Kyoichiro Ozawa
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- Sumit Basu
- Sun Kun Oh
- Sung Chul Lee
- Supriya Das
- Susanta Kumar Pal
- Svein Lindal
- Sven Gotovac
- Svetlana Kushpil
- Sylvain Chapeland
- Tadeusz Antoni Dobrowolski
- Taebong Moon
- Taesoo Kim
- Takafumi Niida
- Taku Gunji
- Tapan Kumar Nayak
- Tatiana Karavicheva
- Tatjana Susa
- Tatsuya Chujo
- Teodor Siemiarczuk
- Terry Awes
- Thanushan Kugathasan
- Theo Alexander Broker
- Thomas Michael Cormier
- Thomas Dietel
- Thomas Humanic
- Thomas Peitzmann
- Thorsten Kollegger
- Tim Schuster
- Timo Gunther Breitner
- Timothy Symons
- Timur Pocheptsov
- Tinku Sinha
- Tiziano Virgili
- Tobias Krawutschke
- Tomas Robert Aronsson
- Tomasz Jan Pawlak
- Tome Anticic
- Tomi Samuli Raiha
- Tomoya Tsuji
- Torsten Alt
- Toru Sugitate
- Trine Spedstad Tveter
- Tuomo Esa Aukusti Kalliokoski
- Tuva Richert
- Tyler Allen Browning
- Udo Wolfgang Kebschull
- Ulrich Michael Frankenfeld
- Ulrich Fuchs
- Uwe Westerhoff
- Valentina Zaccolo
- Valeria Muccifora
- Valerie Barret
- Valerio Altini
- Valery Kondratiev
- Valery Punin
- Vardanush Papikyan
- Vasco Miguel Chibante Barroso
- Vasile Catanescu
- Vasily Kushpil
- Vedran Nikolic
- Venelin Anguelov
- Vera Loggins
- Vercellin Ermanno
- Veronica Canoa Roman
- Victor Trubnikov
- Vikas Singhal
- Vincenzo Paticchio
- Vitaly Loginov
- Vito Lenti
- Vito Manzari
- Vladimir Ivanov
- Vladimir Kaplin
- Vladimir Kovalenko
- Vladimir Nikulin
- Vladimir Peskov
- Vladimir Pospisil
- Vladimir Samsonov
- Vladimir Vechernin
- Vladimir Wagner
- Vladislav Grigoriev
- Vladislav Manko
- Vojtech Petracek
- Volker Lindenstruth
- Weilin Yu
- Werner Riegler
- Wiktor Stanislaw Peryt
- Wisla Carena
- Wladyslaw Henryk Trzaska
- Woo Jin Park
- Xavier Bernard Lopez
- Xianbao Yuan
- Xiangrong Zhu
- Xianguo Lu
- Xiaoming Zhang
- Xitzel Sanchez Castro
- Yaldo Chris G.
- Yannick Denis Zoccarato
- Yaping Wang
- Yaroslav Berdnikov
- Yasuo Miake
- Yasuto Hori
- Yaxian Mao
- Yevgen Martynov
- Yifei Wang
- Yogendra Viyogi
- Yong Wook Baek
- Yorito Yamaguchi
- You Zhou
- Youngil Kwon
- Yury Kharlov
- Yury Kucheriaev
- Yury Pestov
- Yury Sibiriak
- Yury Vinogradov
- Yves Roland Schutz
- Yvonne Chiara Pachmayer
- Zabulon Vilakazi
- Zaida Conesa del Valle
- Zhongbao Yin
- Zubayer Ahammed
- Zuzana Harmanova
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.
- Author
- Abbas Abul K.
- Appel Silke
- Bacchetta Rosa
- Battaglia Manuela
- Berglund David
- Blazar Bruce
- Bluestone Jeffrey A.
- BornhÀuser Martin
- Brusko Todd M.
- Cools Nathalie
- Cuturi Maria Cristina
- Di Ianni Mauro
- Fuchs Anke
- Geissler Edward
- Giannoukakis Nick
- GliwiĆski Mateusz
- GoĆab Karolina
- Grageda Nathali
- Gregori Silvia
- Hafler David A.
- Hester Joanna
- Hilkens Catharien M. U.
- Hippen Keli
- Ilic Natasa
- Isaacs John
- Issa Fadi
- Iwaszkiewicz-GrzeĆ Dorota
- Jaeckel Elmar
- Joosten Irma
- Klatzmann David
- Koenen Hans
- Korsgren Olle
- Kretschmer Karsten
- Levings Megan
- Lombardi Giovanna
- Lord Phillip
- Marek-Trzonkowska Natalia Maria
- Martinez-Caceres Eva M.
- Martinez-Llordella Marc
- MiljkoviÄ ÄorÄe
- Mills Kingston H G
- Miranda Joana P.
- Piccirillo Ciriaco A.
- Putnam Amy L.
- Ritter Thomas
- Roncarolo Maria Grazia
- Sakaguchi Shimon
- Sawitzki Birgit
- Sofronic-Milosavljevic Ljiljana
- Spiering Rachel
- Sykes Megan
- SĂĄnchez-RamĂłn Silvia
- Tang Qizhi
- Ten Brinke Anja
- Trzonkowski Piotr
- van Ham S. Marieke
- van Kooten Cees
- Vives-Pi Marta
- Waldmann Herman
- Witkowski Piotr
- Wood Kathryn J.
- Publication venue
- Publication date
- Field of study
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
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- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
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- Aritomi Naoki
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- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
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- Aubin Florian
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- Badger C.
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- Di Renzo Francesco
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- LIETO ALBERTO. DI.
- LIGO Collaboration
- Lin Chien-Yu
- Lin Chun-Yu
- Lin En-Tzu
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- MORALES ESTER. RUIZ.
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- Ălvarez-LĂłpez S.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 Mâ) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<eâ€0.3 at 0.33 Gpcâ3 yrâ1 at 90\% confidence level
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
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- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
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- Asada Hideki
- Ashton Gregory
- Aso Yoichi
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- Aubin Florian
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- Baier J. G.
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- Ballardin G.
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- GIORGIO CINZIA. DI.
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- LIGO Scientific Collaboration
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- Zhan M.
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- Zhao Yuhang
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- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- çè°š
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
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- Banerjee Biswajit
- Bankar Deepak
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- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta DĂĄniel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger MichaĆ
- Belardinelli Daniele
- Bell Angus
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- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
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- Bhaumik Shubhagata
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- Binetti Alberto
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- Birnholtz Ofek
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- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)BâL gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)BâL gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt JĂŒrgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
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- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
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- Bell Bryan
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- Bender Lewis H
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- Berglund Peter
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- Facciponte John
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- Fraser Kathryn
- Frederix Kim
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- Fridman Leticia
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- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
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- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
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