Gestión del Conocimiento para Mejorar la Calidad de la Educación Superior y su Aporte al Desarrollo Regional

This research analyzes the context of knowledge management in higher education institutions in Latin America, taking as a case study Ecuador and Colombia, and proposes a strategic model, based on the administration of human talent and quality management, for that the management of knowledge in these institutions contributes effectively, efficiently and effectively to improving the quality of higher education and thus its contribution to regional development.Esta investigación analiza el contexto de la gestión del conocimiento en las instituciones de educación superior (IES) en América Latina, tomando como caso de estudio a Ecuador y Colombia, y propone un modelo estratégico, basado en la administración del talento humano y la gestión de calidad, para que la gestión del conocimiento (GC) en estas instituciones contribuya de manera eficaz, eficiente y efectiva a mejorar la calidad de la educación superior y con ello su aporte al desarrollo regional

Hestenes' Tetrad and Spin Connections

Defining a spin connection is necessary for formulating Dirac's bispinor equation in a curved space-time. Hestenes has shown that a bispinor field is equivalent to an orthonormal tetrad of vector fields together with a complex scalar field. In this paper, we show that using Hestenes' tetrad for the spin connection in a Riemannian space-time leads to a Yang-Mills formulation of the Dirac Lagrangian in which the bispinor field is mapped to a set of Yang-Mills gauge potentials and a complex scalar field. This result was previously proved for a Minkowski space-time using Fierz identities. As an application we derive several different non-Riemannian spin connections found in the literature directly from an arbitrary linear connection acting on Hestenes' tetrad and scalar fields. We also derive spin connections for which Dirac's bispinor equation is form invariant. Previous work has not considered form invariance of the Dirac equation as a criterion for defining a general spin connection

DISEÑO Y CONSTRUCCIÓN DE UN SISTEMA DE ELECTRÓLISIS PARA SÍNTESIS DE NANOPARTÍCULAS DE PLATA UTILIZANDO INSTRUMENTACIÓN VIRTUAL CON LABVIEW (DESIGN AND CONSTRUCTION OF AN ELECTROLISIS SYSTEM FOR SILVER NANOPARTICLES SYNTHESIS BY VIRTUAL INSTRUMENTATION)

ResumenActualmente, la nanotecnología está presente en muchos productos que se encuentran en el mercado y cada vez tiene mayor uso en la solución de problemáticas, al ser un área interdisciplinaria, es necesario el trabajo en conjunto de científicos e ingenieros para el desarrollo de tecnologías. Los materiales en una escala nanométrica requieren de sistemas especializados y complejos, dando como resultado variedad de estructuras tales como nanovarillas, nanoalambres, nanocolumnas y nanopartículas, por mencionar algunas. En este trabajo, se presenta un sistema de síntesis de nanopartículas de plata utilizando un multímetro Fluke de doble pantalla (dual display) para medición de corriente, una fuente de voltaje de la marca BK Precision, una tarjeta Arduino como interface e instrumentación virtual con LabVIEW para control de los tiempos de reacción y el tiempo de conmutación de polaridad de los electrodos. En conjunto es un sistema que puede realizar las tareas de adquisición, procesamiento y presentación de datos. Se realizaron dos experimentos de síntesis de NPs, con un tiempo de proceso de 30 minutos, tiempo de conmutación de la polaridad de 5 minutos a 60 °C variando el voltaje aplicado de 5 y 10 V. La obtención de las NPs en los experimentos es demostrada analizando los espectros de absorción UV-Vis de la solución coloidal obtenida. Se obtuvieron NPs con un tamaño promedio de 122 nm para el voltaje de aplicación de 5 V y 106 nm para las NPs sintetizadas con un voltaje de 10 V. La distribución de tamaño fue obtenida utilizando la técnica de Dispersión de Luz Dinámica (DLS, Dynamic Light Scattering). En futuras investigaciones se pretende utilizar las NPs obtenidas con este sistema automático para realizar la síntesis de óxido de zinc dopado con plata (ZnO tipo p), el cual, será utilizado para la fabricación de dispositivos electrónicos como LEDs y celdas solares.Palabras Claves: Nanopartículas, Plata, Electrolisis, Automatizado.                                       AbstractCurrently, nanotechnology is present in many products that are in the market and is increasingly used to solve problems, being an interdisciplinary area, it is necessary the joint work of scientists and engineers for the development of technologies. Materials on a nanometric scale require specialized and complex systems, resulting in a variety of structures such as nanowires, nanowires, nanocolumns and nanoparticles, to name a few. In this work, a system for the synthesis of silver nanoparticles is presented using a dual display Fluke multimeter (dual display) for current measurement, a voltage source of the BK Precision brand, an Arduino card as an interface and virtual instrumentation with LabVIEW for control of reaction times and electrode polarity switching time. Together it is a system that can perform the tasks of acquisition, processing and presentation of data. Two experiments of synthesis of NPs were carried out, with a process time of 30 minutes, polarity switching time of 5 minutes at 60 ° C varying the applied voltage of 5 and 10 V. The formation of NPs in the experiments is demonstrated by analyzing the UV-Vis absorption spectra of the colloidal solution obtained. NPs with an average size of 122 nm were obtained for the application voltage of 5 V and 106 nm for NPs synthesized with a voltage of 10 V. The size distribution was obtained using Dynamic Light scattering. In future research it is intended to use the NPs obtained with this automatic system to perform the synthesis of zinc oxide doped with silver (ZnO type p), which will be used for the manufacture of electronic devices such as LEDs and solar cells.Keywords: Nanoparticles, Silver, Electrolysis, Automated

Cerebral activations related to ballistic, stepwise interrupted and gradually modulated movements in parkinson patients

Patients with Parkinson's disease (PD) experience impaired initiation and inhibition of movements such as difficulty to start/stop walking. At single-joint level this is accompanied by reduced inhibition of antagonist muscle activity. While normal basal ganglia (BG) contributions to motor control include selecting appropriate muscles by inhibiting others, it is unclear how PD-related changes in BG function cause impaired movement initiation and inhibition at single-joint level. To further elucidate these changes we studied 4 right-hand movement tasks with fMRI, by dissociating activations related to abrupt movement initiation, inhibition and gradual movement modulation. Initiation and inhibition were inferred from ballistic and stepwise interrupted movement, respectively, while smooth wrist circumduction enabled the assessment of gradually modulated movement. Task-related activations were compared between PD patients (N = 12) and healthy subjects (N = 18). In healthy subjects, movement initiation was characterized by antero-ventral striatum, substantia nigra (SN) and premotor activations while inhibition was dominated by subthalamic nucleus (STN) and pallidal activations, in line with the known role of these areas in simple movement. Gradual movement mainly involved antero-dorsal putamen and pallidum. Compared to healthy subjects, patients showed reduced striatal/SN and increased pallidal activation for initiation, whereas for inhibition STN activation was reduced and striatal-thalamo-cortical activation increased. For gradual movement patients showed reduced pallidal and increased thalamo-cortical activation. We conclude that PD-related changes during movement initiation fit the (rather static) model of alterations in direct and indirect BG pathways. Reduced STN activation and regional cortical increased activation in PD during inhibition and gradual movement modulation are better explained by a dynamic model that also takes into account enhanced responsiveness to external stimuli in this disease and the effects of hyper-fluctuating cortical inputs to the striatum and STN in particular

At What Stage of Neural Processing Does Cocaine Act to Boost Pursuit of Rewards?

Dopamine-containing neurons have been implicated in reward and decision making. One element of the supporting evidence is that cocaine, like other drugs that increase dopaminergic neurotransmission, powerfully potentiates reward seeking. We analyze this phenomenon from a novel perspective, introducing a new conceptual framework and new methodology for determining the stage(s) of neural processing at which drugs, lesions and physiological manipulations act to influence reward-seeking behavior. Cocaine strongly boosts the proclivity of rats to work for rewarding electrical brain stimulation. We show that the conventional conceptual framework and methods do not distinguish between three conflicting accounts of how the drug produces this effect: increased sensitivity of brain reward circuitry, increased gain, or decreased subjective reward costs. Sensitivity determines the stimulation strength required to produce a reward of a given intensity (a measure analogous to the KM of an enzyme) whereas gain determines the maximum intensity attainable (a measure analogous to the vmax of an enzyme-catalyzed reaction). To distinguish sensitivity changes from the other determinants, we measured and modeled reward seeking as a function of both stimulation strength and opportunity cost. The principal effect of cocaine was a two-fourfold increase in willingness to pay for the electrical reward, an effect consistent with increased gain or decreased subjective cost. This finding challenges the long-standing view that cocaine increases the sensitivity of brain reward circuitry. We discuss the implications of the results and the analytic approach for theories of how dopaminergic neurons and other diffuse modulatory brain systems contribute to reward pursuit, and we explore the implications of the conceptual framework for the study of natural rewards, drug reward, and mood

Phylogeny and evolution of life-history strategies in the Sycophaginae non-pollinating fig wasps (Hymenoptera, Chalcidoidea)

<p>Abstract</p> <p>Background</p> <p>Non-pollinating Sycophaginae (Hymenoptera, Chalcidoidea) form small communities within <it>Urostigma </it>and <it>Sycomorus </it>fig trees. The species show differences in galling habits and exhibit apterous, winged or dimorphic males. The large gall inducers oviposit early in syconium development and lay few eggs; the small gall inducers lay more eggs soon after pollination; the ostiolar gall-inducers enter the syconium to oviposit and the cleptoparasites oviposit in galls induced by other fig wasps. The systematics of the group remains unclear and only one phylogeny based on limited sampling has been published to date. Here we present an expanded phylogeny for sycophagine fig wasps including about 1.5 times the number of described species. We sequenced mitochondrial and nuclear markers (4.2 kb) on 73 species and 145 individuals and conducted maximum likelihood and Bayesian phylogenetic analyses. We then used this phylogeny to reconstruct the evolution of Sycophaginae life-history strategies and test if the presence of winged males and small brood size may be correlated.</p> <p>Results</p> <p>The resulting trees are well resolved and strongly supported. With the exception of <it>Apocrytophagus</it>, which is paraphyletic with respect to <it>Sycophaga</it>, all genera are monophyletic. The Sycophaginae are divided into three clades: (i) <it>Eukoebelea</it>; (ii) <it>Pseudidarnes</it>, <it>Anidarnes </it>and <it>Conidarnes </it>and (iii) <it>Apocryptophagus</it>, <it>Sycophaga </it>and <it>Idarnes</it>. The ancestral states for galling habits and male morphology remain ambiguous and our reconstructions show that the two traits are evolutionary labile.</p> <p>Conclusions</p> <p>The three main clades could be considered as tribes and we list some morphological characters that define them. The same biologies re-evolved several times independently, which make Sycophaginae an interesting model to test predictions on what factors will canalize the evolution of a particular biology. The ostiolar gall-inducers are the only monophyletic group. In 15 Myr, they evolved several morphological adaptations to enter the syconia that make them strongly divergent from their sister taxa. Sycophaginae appears to be another example where sexual selection on male mating opportunities favored winged males in species with small broods and wingless males in species with large broods. However, some species are exceptional in that they lay few eggs but exhibit apterous males, which we hypothesize could be due to other selective pressures selecting against the re-appearance of winged morphs.</p

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362