First Report of Ventriculoperitoneal Shunt Infection due to Cyberlindnera fabianii.

Fungal infections in the central nervous system (CNS) are associated with significant morbidity and death. Transient fungemia in immunocompetent patients without any other risk factors for fungemia has been suggested as a possible mechanism that may lead to serious fungal ventriculoperitoneal (VP) shunt infections, but evidence is lacking. The clinical spectrum, diagnosis, and optimal therapy of Cyberlindnera fabianii infections remain to be determined. We describe the first case of CNS infection due to C. fabianii that occurred in an immunocompetent adult with a VP shunt. Spontaneous translocation with yeast that is not part of the normal gastrointestinal flora in the setting of ingestion of multiple servings of a fermentation product was the likely source from which Cyberlindnera fabianii gained entrance into the VP shunt system, causing meningitis in this patient. The authors conclude that, in view of the high morbidity associated with yeast infection of the CNS, long-term antifungal therapy should be strongly considered in cases where the VP shunt cannot be completely removed. Transient fungemia may lead to invasive disease in an immunocompetent host with VP shunt, even in the absence of any other risk factors for fungemia and even after remote placement of the VP shunt

Sensitive VLBI Continuum and H I Absorption Observations of NGC 7674: First Scientific Observations with the Combined Array VLBA, VLA & Arecibo

We present phase-referenced VLBI observations of the radio continuum emission from, and the H I 21 cm absorption toward, the Luminous Infrared Galaxy NGC 7674. The observations were carried out at 1380 MHz using the VLBA, the phased VLA, and theArecibo radio telescope. These observations constitute the first scientific use of the Arecibo telescope in a VLBI observation with the VLBA. The high- and low-resolution radio continuum images reveal several new continuum structures in the nuclear region of this galaxy. At ~100 mas resolution, we distinguish six continuum structures extending over 1.4 arcsec, with a total flux density of 138 mJy. Only three of these structures were known previously. All these structures seem to be related to AGN activity. At the full resolution of the array, we only detect two of the six continuum structures. Both are composed of several compact components with brightness temperatures on the order of $10^{7}$ K. While it is possible that one of these compact structures could host an AGN, they could also be shock-like features formed by the interaction of the jet with compact interstellar clouds in the nuclear region of this galaxy. Complex H I absorption is detected with our VLBI array at both high and low angular resolution. Assuming that the widest H I feature is associated with a rotating H I disk or torus feeding a central AGN, we estimate an enclosed dynamical mass of ~7 x 10^7 M_sun, comparable to the value derived from the hidden broad H$\beta$ emission in this galaxy. The narrower H I lines could represent clumpy neutral hydrogen structures in the H I torus. The detection of H I absorption toward some of the continuum components, and its absence toward others, suggest an inclined H I disk or torus in the central region of NGC 7674.Comment: 37 pages, 11 figures. ApJ accepted. To appear in the Nov. 10, 2003 issue of ApJ. Please use the PDF version if the postscript doesn't show the figure

First Report of Ventriculoperitoneal Shunt Infection due to Cyberlindnera fabianii

Fungal infections in the central nervous system (CNS) are associated with significant morbidity and death. Transient fungemia in immunocompetent patients without any other risk factors for fungemia has been suggested as a possible mechanism that may lead to serious fungal ventriculoperitoneal (VP) shunt infections, but evidence is lacking. The clinical spectrum, diagnosis, and optimal therapy of Cyberlindnera fabianii infections remain to be determined. We describe the first case of CNS infection due to C. fabianii that occurred in an immunocompetent adult with a VP shunt. Spontaneous translocation with yeast that is not part of the normal gastrointestinal flora in the setting of ingestion of multiple servings of a fermentation product was the likely source from which Cyberlindnera fabianii gained entrance into the VP shunt system, causing meningitis in this patient. The authors conclude that, in view of the high morbidity associated with yeast infection of the CNS, long-term antifungal therapy should be strongly considered in cases where the VP shunt cannot be completely removed. Transient fungemia may lead to invasive disease in an immunocompetent host with VP shunt, even in the absence of any other risk factors for fungemia and even after remote placement of the VP shunt

VLBA Continuum and H I Absorption Observations of the Ultra-Luminous Infrared Galaxy IRAS 17208-0014

We present phase-referenced VLBI observations of the radio continuum emission from, and the neutral hydrogen 21 cm absorption toward, the Ultra-Luminous Infrared Galaxy IRAS 17208-0014. The observations were carried out at 1362 MHz using the Very Long Baseline Array, including the phased Very Large Array as an element. The high-resolution radio continuum images reveal a nuclear starburst region in this galaxy, which is composed of diffuse emission approximately 670 x 340 pc on the plane of the sky, and a number of compact sources. These sources are most likely to be clustered supernova remnants and/or luminous radio supernovae. Their brightness temperatures range over (2.2-6.6) x 10^{5} K, with radio spectral luminosities between (1-10) x 10^{21} W Hz^{-1}. The total VLBI flux density of the starburst region is ~52 mJy, which is about 50% of the total flux density detected with the VLA at arcsecond resolution. For this galaxy, we derive a massive star formation rate of ~84pm13 M{_\odot} yr^{-1}, and a supernova rate of ~4pm1 yr^{-1}. H I absorption is detected in multiple components with optical depths ranging between 0.3 and 2.5, and velocity widths between 58 and 232 km s^{-1}. The derived column densities, assuming T_{s}=100 K, range over (10-26) x 10^{21} cm^{-2}. The H I absorption shows a strong velocity gradient of 453 km s^{-1} across 0.36 arcsec (274 pc). Assuming Keplerian motion, the enclosed dynamical mass is about 2.3 x 10^9 sin^{-2}i M{_\odot}, comparable to the enclosed dynamical mass estimated from CO observations.Comment: 26 pages total, 6 figures. ApJ accepted. To appear in the April 1, 2003 issue of ApJ. For a version with better images, see http://www.aoc.nrao.edu/~emomjian/IRAS.p

A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.

Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions induced by disease-associated T helper 17 (Th17) polarizing conditions. We observed 15 metabolites with CD4+ T-cell bioactivity, 3 previously reported, and 12 unprecedented. A deeper investigation of the microbe-derived metabolite, ascorbate, revealed its selective inhibition on activated human CD4+ effector T cells, including IL-17A-, IL-4-, and IFNγ-producing cells. Mechanistic assessment suggested the apoptosis of activated human CD4+ T cells associated with selective inhibition of energy metabolism. These findings suggest a substantial rate of relevant T-cell bioactivity among Crohn's disease-associated microbial metabolites, and evidence for novel modes of bioactivity, including targeting of T-cell energy metabolism

Radio Interferometric Observation of an Asteroid Occultation

The occultation of the radio galaxy 0141+268 by the asteroid (372) Palma on 2017 May 15 was observed using six antennas of the Very Long Baseline Array (VLBA). The shadow of Palma crossed the VLBA station at Brewster, Washington. Owing to the wavelength used, and the size and the distance of the asteroid, a diffraction pattern in the Fraunhofer regime was observed. The measurement retrieves both the amplitude and the phase of the diffracted electromagnetic wave. This is the first astronomical measurement of the phase shift caused by diffraction. The maximum phase shift is sensitive to the effective diameter of the asteroid. The bright spot at the shadow's center, the so called Arago-Poisson spot, is clearly detected in the amplitude time-series, and its strength is a good indicator of the closest angular distance between the center of the asteroid and the radio source. A sample of random shapes constructed using a Markov chain Monte Carlo algorithm suggests that the silhouette of Palma deviates from a perfect circle by 26 +/- 13%. The best-fitting random shapes resemble each other, and we suggest their average approximates the shape of the silhouette at the time of the occultation. The effective diameter obtained for Palma, 192.1 +/- 4.8 km, is in excellent agreement with recent estimates from thermal modeling of mid-infrared photometry. Finally, our computations show that because of the high positional accuracy, a single radio interferometric occultation measurement can reduce the long-term ephemeris uncertainty by an order of magnitude

Lipopolysaccharide Renders Transgenic Mice Expressing Human Serum Amyloid P Component Sensitive to Shiga Toxin 2

Transgenic C57BL/6 mice expressing human serum amyloid P component (HuSAP) are resistant to Shiga toxin 2 (Stx2) at dosages that are lethal in HuSAP-negative wild-type mice. However, it is well established that Stx2 initiates extra-intestinal complications such as the haemolytic-uremic syndrome despite the presence of HuSAP in human sera. We now demonstrate that co-administering purified Escherichia coli O55 lipopolysaccharide (LPS), at a dosage of 300 ng/g body weight, to HuSAP-transgenic mice increases their susceptibility to the lethal effects of Stx2. The enhanced susceptibility to Stx2 correlated with an increased expression of genes encoding the pro-inflammatory cytokine TNFα and chemokines of the CXC and CC families in the kidneys of LPS-treated mice, 48 hours after the Stx2/LPS challenge. Co-administering the glucocorticoid dexamethasone, but not the LPS neutralizing cationic peptide LL-37, protected LPS-sensitized HuSAP-transgenic mice from lethal doses of Stx2. Dexamethasone protection was specifically associated with decreased expression of the same inflammatory mediators (CXC and CC-type chemokines and TNFα) linked to enhanced susceptibility caused by LPS. The studies reveal further details about the complex cascade of host-related events that are initiated by Stx2 as well as establish a new animal model system in which to investigate strategies for diminishing serious Stx2-mediated complications in humans infected with enterohemorrhagic E. coli strains

Overview of the coordinated ground-based observations of Titan during the Huygens mission

Coordinated ground-based observations of Titan were performed around or during the Huygens atmospheric probe mission at Titan on 14 January 2005, connecting the momentary in situ observations by the probe with the synoptic coverage provided by continuing ground-based programs. These observations consisted of three different categories: (1) radio telescope tracking of the Huygens signal at 2040 MHz, (2) observations of the atmosphere and surface of Titan, and (3) attempts to observe radiation emitted during the Huygens Probe entry into Titan's atmosphere. The Probe radio signal was successfully acquired by a network of terrestrial telescopes, recovering a vertical profile of wind speed in Titan's atmosphere from 140 km altitude down to the surface. Ground-based observations brought new information on atmosphere and surface properties of the largest Satumian moon. No positive detection of phenomena associated with the Probe entry was reported. This paper reviews all these measurements and highlights the achieved results. The ground-based observations, both radio and optical, are of fundamental imnortance for the interpretatinn of results from the Huygens mission