e-DoX:DEPED Student Grade Records Management System with Implementation of Advanced Encryption Standard and PKI Infrastructure

This study entitled e-DoX: DEPED Student Grade Records Management System with Implementation of Advanced Encryption Standard and PKI Infrastructure for the Department of Education in the Province of Cavite is an online based application designed to aid private and public schools in submission of reports on promotions composed of Form 18-A, Form 18-E1 and Form 18-E2 to the Division Office of the Department of Education in the province of Cavite. The system would also be eliminating factors such as transportation and storage to maximize time allotment for the evaluation of the submitted reports. In this study Advanced Encryption Standard and Public and Private Infrastructure was implemented in e-DoX to secure digital data into an undecipherable format that are sent by the schools in Cavite to DEPED application. This data is typically scrambled by using hashing algorithms, which convert data into a secret scrambled encryption format. This is the reason AES and PKI was implemented because it has the highest defined level for data encryption and security that will secure important data such as the student grade records of the schools in Cavite.The study covers all of the underlying plans and designs that were considered and executed in order to accomplish the research project. This includes collective plans and blueprints right from the conceptualization of the research project, data gathering on the existing system, knowledge requirements on different technologies included in the system, design and development of the system, up to the software evaluation. The researcher used Prototyping as the method for development. This type of approach of developing the software is used for people who are usually not good at specifying their requirements, nor can tell properly about what they expect from the software. This type of System Development Method is employed when it is very difficult to obtain exact requirements from the client. While making the model, user keeps giving feedbacks from time to time and based on it, a prototype is made. The findings of this project based on all of the results gathered during the software evaluation phase were carefully tabulated and analyzed by the proponent to come up with the best possible conclusion and recommendations for the betterment of the research project. The research project during the evaluation phase received an overall strongly acceptable remark from the respondents

Characterization of pharyngeal hypocontractility patterns during deglutition: High Resolution Impedance Manometry findings

Introduction High resolution impedance manometry (HRIM) provides an objective measure of pharyngeal pressurization and bolus flow and can be analysed using pressure flow analysis (PFA). The aim of the study is to investigate different types of pharyngeal hypocontractility and their distribution in patients with pharyngeal dysphagia. Material and Methods A cohort study was conducted on patients with dysphagia referred for HRIM. Inclusion criteria were abnormal (<5th percentile) pharyngeal contractile integral (PhCI) or abnormal regional contractile integrals (velo- or meso- or hypo-pharyngeal integrals). PFA was performed on 10ml liquid swallows using the Swallow GatewayTM open access analysis portal. Patients were classified based on a proposed HRIM scheme. The distribution of PFA metrics was compared between patients with normal and abnormal PhCI using the chi-squared test. Results In total 38 patients were studied and 137 swallows were analysed. Absent pharyngeal contractility was found in 5.3% (2/38) of the patients, ineffective pharyngeal contractility in 68.4% (26/38), and fragmented pharyngeal contractility in 26.3% (10/38). Regional weakness was mainly observed in the mesopharynx (94.7% of the patients), followed by the hypopharynx (50%) and the velopharynx (15.8%). A combined disorder of pharyngeal propulsion and UES restriction was seen in 44.7% (17/38) of the patients. Patients with a normal PhCI (fragmented pharyngeal contractility) were more likely to present an abnormal integrated relaxation pressure at the level of the upper esophageal sphincter (\u3c72=14.56, p=0.001) Conclusion Based on the pharyngeal contractile integrals, two main types of pharyngeal hypocontractility are present in the clinical population of patients: ineffective and fragmented pharyngeal contractility. Totally absent peristalsis in uncommon. In almost half of the patients, pharyngeal propulsion disorders are combined to disorders of UES restriction

Characterization of esophageal motility and esophagogastric junction in preterm infants with bronchopulmonary dysplasia

Background: To characterize esophageal motility and function of the esophagogastric junction (EGJ) in preterm infants with bronchopulmonary dysplasia (BPD). Methods: High-resolution manometry with impedance was used to investigate esophageal motility and EGJ function in 28 tube-fed preterm infants with BPD. Patients with BPD were studied at term age during oral feeding. Thirteen healthy term-aged infants were included as controls. Esophageal analysis derived objective measures to evaluate esophageal contractile vigor, bolus distension pressure, EGJ relaxation, and EGJ barrier function (in rest and during respiration). In addition, we investigated the effect of BPD severity on these measures. Key results: A total of 140 nutritive swallows were analyzed (BPD, n = 92; controls, n = 48). Normal esophageal peristaltic wave patterns were observed in all infants. BPD patients had higher distal contractile esophageal strength compared with controls (Kruskal-Wallis (KW) P =.048), and their deglutitive EGJ relaxation was comparable to controls. Severe BPD patients showed higher bolus distension pressures, higher EGJ resting pressures, and increased EGJ contractile integrals compared with mild BPD patients (Mann-Whitney U P =.009, KW P =.012 and KW P =.028, respectively). Conclusions and Inferences: Preterm infants with BPD consistently present with normal peristaltic esophageal patterns following nutritive liquid swallows. The EGJ barrier tone and relaxation pressure appeared normal. In general, infants with BPD do not have altered esophageal motor function. There is however evidence for increased flow resistance at the EGJ in severe BPD patients possibly related to an increased contractility of the diaphragm

Association of preterm birth with ADHD-like cognitive impairments and additional subtle impairments in attention and arousal malleability

BACKGROUND: Whilst preterm-born individuals have an increased risk of developing attention-deficit/hyperactivity disorder (ADHD), and are reported to have ADHD-like attention and arousal impairments, direct group comparisons are scarce. METHODS: We directly compared preterm-born adolescents (n = 186) to term-born adolescents with ADHD (n = 69), and term-born controls (n = 135), aged 11-23, on cognitive-performance, event-related potential and skin conductance level (SCL) measures associated with attention and arousal. The measures are from baseline and fast-incentive conditions of a four-choice reaction time task, previously shown to discriminate between the individuals with ADHD and controls. We aimed to establish whether preterm-born adolescents show: (a) identical cognitive-neurophysiological impairments to term-born adolescents with ADHD (b) possible additional impairments, and whether (c) the observed impairments correlate with ADHD symptom scores. RESULTS: The preterm group, like the term-born ADHD group, showed increased mean reaction time (MRT) and reaction time variability (RTV) in the baseline condition, and attenuated contingent negative variation (CNV) amplitude (response preparation) in the fast-incentive condition. The preterm group, only, did not show significant within-group adjustments in P3 amplitude (attention allocation) and SCL (peripheral arousal). Dimensional analyses showed that ADHD symptoms scores correlated significantly with MRT, RTV and CNV amplitude only. CONCLUSIONS: We find impairments in cognition and brain function in preterm-born adolescents that are linked to increased ADHD symptoms, as well as further impairments, in lack of malleability in neurophysiological processes. Our findings indicate that such impairments extend at least to adolescence. Future studies should extend these investigations into adulthood

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma. Recently, small-molecule and ATP-competitive PI(3)K inhibitors with a wide range of selectivities have entered clinical development. In order to understand the mechanisms underlying the isoform selectivity of these inhibitors, we developed a new expression strategy that enabled us to determine to our knowledge the first crystal structure of the catalytic subunit of the class IA PI(3)K p110 delta. Structures of this enzyme in complex with a broad panel of isoform- and pan-selective class I PI(3)K inhibitors reveal that selectivity toward p110 delta can be achieved by exploiting its conformational flexibility and the sequence diversity of active site residues that do not contact ATP. We have used these observations to rationalize and synthesize highly selective inhibitors for p110 delta with greatly improved potencies

Impairments in error processing and their association with ADHD symptoms in individuals born preterm

<p>(<b>A</b>) Grand average response-locked event-related potentials (ERPs) of the error-related positivity (Pe) at the Cz electrode between 150 and 450 ms for the preterm group (represented by dotted lines), the ADHD group (attention-deficit/hyperactivity disorder represented by dashed lines) and the control group (shown in solid lines), and (<b>B</b>) topographic maps for each group.</p

SIMBA: a web tool for managing bacterial genome assembly generated by Ion PGM sequencing technology

Background The evolution of Next-Generation Sequencing (NGS) has considerably reduced the cost per sequenced-base, allowing a significant rise of sequencing projects, mainly in prokaryotes. However, the range of available NGS platforms requires different strategies and software to correctly assemble genomes. Different strategies are necessary to properly complete an assembly project, in addition to the installation or modification of various software. This requires users to have significant expertise in these software and command line scripting experience on Unix platforms, besides possessing the basic expertise on methodologies and techniques for genome assembly. These difficulties often delay the complete genome assembly projects. Results In order to overcome this, we developed SIMBA (SImple Manager for Bacterial Assemblies), a freely available web tool that integrates several component tools for assembling and finishing bacterial genomes. SIMBA provides a friendly and intuitive user interface so bioinformaticians, even with low computational expertise, can work under a centralized administrative control system of assemblies managed by the assembly center head. SIMBA guides the users to execute assembly process through simple and interactive pages. SIMBA workflow was divided in three modules: (i) projects: allows a general vision of genome sequencing projects, in addition to data quality analysis and data format conversions; (ii) assemblies: allows de novo assemblies with the software Mira, Minia, Newbler and SPAdes, also assembly quality validations using QUAST software; and (iii) curation: presents methods to finishing assemblies through tools for scaffolding contigs and close gaps. We also presented a case study that validated the efficacy of SIMBA to manage bacterial assemblies projects sequenced using Ion Torrent PGM. Conclusion Besides to be a web tool for genome assembly, SIMBA is a complete genome assemblies project management system, which can be useful for managing of several projects in laboratories. SIMBA source code is available to download and install in local webservers at http://ufmg-simba.sourceforge.net

Is association of preterm birth with cognitive-neurophysiological impairments and ADHD symptoms consistent with a causal inference or due to familial confounds?

BACKGROUND: Preterm birth is associated with an increased risk for cognitive-neurophysiological impairments and attention-deficit/hyperactivity disorder (ADHD). Whether the associations are due to the preterm birth insult per se, or due to other risk factors that characterise families with preterm-born children, is largely unknown. METHODS: We employed a within-sibling comparison design, using cognitive-performance and event-related potential (ERP) measures from 104 preterm-born adolescents and 104 of their term-born siblings. Analyses focused on ADHD symptoms and cognitive and ERP measures from a cued continuous performance test, an arrow flanker task and a reaction time task. RESULTS: Within-sibling analyses showed that preterm birth was significantly associated with increased ADHD symptoms (β = 0.32, p = 0.01, 95% CI 0.05 to 0.58) and specific cognitive-ERP impairments, such as IQ (β = -0.20, p = 0.02, 95% CI -0.40 to -0.01), preparation-vigilance measures and measures of error processing (ranging from β = 0.71, -0.35). There was a negligible within-sibling association between preterm birth with executive control measures of inhibition (NoGo-P3, β = -0.07, p = 0.45, 95% CI -0.33 to 0.15) or verbal working memory (digit span backward, β = -0.05, p = 0.63, 95% CI -0.30 to 0.18). CONCLUSIONS: Our results suggest that the relationship between preterm birth with ADHD symptoms and specific cognitive-neurophysiological impairments (IQ, preparation-vigilance and error processing) is independent of family-level risk and consistent with a causal inference. In contrast, our results suggest that previously observed associations between preterm birth with executive control processes of inhibition and working memory are instead linked to background characteristics of families with a preterm-born child rather than preterm birth insult per se. These findings suggest that interventions need to target both preterm-birth specific and family-level risk factors

Serum Concentrations of Myostatin and Myostatin-Interacting Proteins do not differ between young and Scarcopenic elderly men

Peer reviewedPostprin