A. DeVries

A. Joyson

A. M. Tommasi

A. Ratkevicius

Amin

Baumgartner

C. A. Greig

C. Grierson

Carlson

Clark

D. Crowther

D. M. Reid

F. Gilbert

Gonzalez-Cadavid

GREIG

H. Wackerhage

Hameed

I. Selmer

J. Brady

K. C. H. Fearon

Lakshman

Lauretani

Lexell

Moreland

Newman

P. Rauchhaus

P. Yaworsky

Pahor

Payette

Rantanen

Rommel

Rosenberg

S. Alesci

Schuelke

Siriett

Streckis

T. Dhanani

T. W. Redpath

Wagner

Wolfe

Zimmers

The Journals of Gerontology Series A

English

Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm(2)) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm(2)) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm(2)), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor α, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p &lt; .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG

Ratkevicius, Aivaras

Joyson, A

Selmer, I

Dhanani, T

Grierson, C

Tommasi, AM

DeVries, Annick

Rauchhaus, P

Crowther, D

Alesci, S

Gilbert, F

Redpath, TW

Brady, J

Fearon, KCH

Reid, D

Greig, Carolyn

Wackerhage, H

University of Birmingham Research Portal

Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men

Crossref

Serum Concentrations of Myostatin and Myostatin-Interacting Proteins Do Not Differ Between Young and Sarcopenic Elderly Men

Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm2) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm2) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm2), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor a, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p &lt; .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.</p

Ratkevicius, A.

Joyson, A.

Selmer, I.

Dhanani, T.

Grierson, C.

Tommasi, A. M.

DeVries, A.

Rauchhaus, P.

Crowther, D.

Alesci, S.

Yaworsky, P.

Gilbert, F.

W. Redpath, T.

Brady, J.

Fearon, K. C.H.

Reid, D. M.

Greig, C. A.

Wackerhage, H.

Discovery Research Portal

Joyson, Amanda Jayne

Tommasi, A.M

DeVries, A

Yaworsky, P

Gilbert, Fiona Jane

Redpath, Thomas William

Fearon, K.C.H

Reid, D.M

Greig, C.A

Wackerhage, Henning

Aberdeen University Research

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Serum Concentrations of Myostatin and Myostatin-Interacting Proteins do not differ between young and Scarcopenic elderly men

Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm(2)) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm(2)) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm(2)), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor α, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.status: publishe

Ratkevicius, A

de Vries, Annick

Reid, DM

Greig, CA

Lirias

https://aura.abdn.ac.uk/bitstream/2164/2372/1/Wackerhage_Serum_concentrations_of_myostatin_and_myostatin_interacting_proteins.pdf

Serum Concentrations of Myostatin and Myostatin-Interacting Proteins do not differ between young and Scarcopenic elderly men

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