Correlación Entre Las Variables Meteorológicas Y Concentración De Los Contaminantes Atmosféricos, En El Distrito De Villa María Del Triunfo, En Mayo De 2018

La investigación desarrolló un análisis temporal de las variables meteorológicas (temperatura horaria del aire, humedad relativa horaria, velocidad y dirección del viento) y concentración de los contaminantes atmosféricos (PM 10 , PM 2.5 , CO, SO 2 , NO 2 y O 3 ) a través de series de tiempo, medidas de tendencia central (media, mediana, desviación estándar, coeficiente de variación), la comparación con el D.S Nº 003-2017 MINAM - Estándares de Calidad Ambiental y finalmente se determinó la correlación entre las variables meteorológicas y los contaminantes atmosféricos usando el coeficiente de correlación Pearson, teniendo resultados significativos donde la correlación de la temperatura horaria del aire y el PM 10 tiene una correlación significativa y una relación positiva baja. Para la correlación de temperatura del aire y el monóxido de carbono existe una correlación significativa y una relación inversa. La correlación de temperatura del aire y el ozono troposférico (O 3 ) existe una correlación significativa directamente proporcional fuerte. La correlación de humedad relativa y el PM 10 existe una correlación significativa inversamente proporcional baja. La correlación de la humedad relativa y monóxido de carbono es significativa y tiene una relación inversamente proporcional. La correlación de humedad relativa y el dióxido de nitrógeno (NO 2 ) es significativa inversamente proporcional baja. La correlación de humedad relativa y el ozono troposférico (O 3 ) existe una correlación significativa inversamente proporcional media. La correlación de la velocidad del viento y el monóxido de carbono (CO) es significativa e inversamente proporcional baja. La correlación de la velocidad del viento y el dióxido de azufre es inversamente proporcional baja. La correlación de la velocidad del viento y el ozono troposférico es directamente proporcional media. Estos datos han sido medidos y analizados por SENAMHI, a través de la red de monitoreo de calidad de aire de la estación de Villa María del Triunfo.Trabajo de suficiencia profesiona

Gestión de la producción en pequeñas y medianas empresas del sector de pinturas, barnices y lacas

En el presente artículo se presentan los resultados arrojados por la investigación Gestión de la producción en pequeñas y medianas empresas del sector de pinturas, barnices y lacas, en el cual se caracterizó la gestión de la producción de dicho sector, basado en información secundaria y principalmente en datos recolectados en la fuente mediante entrevistas y encuestas elegidas con un muestreo basado en estadística. Por consiguiente, se muestran los principales factores encontrados en dicha investigación los cuales son: inventarios, pronósticos, instalaciones, nivel tecnológico, capacidades, producción, programación, control, investigación y desarrollo, recurso humano; desglosándolos en las diferentes áreas que abarca la gestión de la producción, analizando las características generales que fueron identificadas

CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes.

Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D, they must first traffic to the islets and extravasate through the islet vasculature. Understanding the cues that lead to T cell entry into inflamed islets is important because diagnosed T1D patients already have established immune infiltration of their islets. Here we show that CD11

Study of the rehydration kinetics of nixtamalized corn by using two nixtamalization methods

The present work aimed to study the rehydration kinetics of previously nixtamalized and dried corn. Nixtamalization was carried out by two methods: using wood ash (classical method) and using calcium hydroxide (Ca(OH)2) (traditional method), after the samples were sun-dried. The rehydration kinetics was described using six mathematical models (Fick, Peleg, Weibull, Page, Ibarz et al. and first-order model) in which the possible interpretation of its parameters and the goodness of fit was evaluated. As results, it was obtained that the nixtamalization with wood ash obtained better rehydration properties. The kinetic parameters values of all the used models showed that the rehydration in this treatment was the fastest. In addition, this treatment also reached a high moisture content (49.22 ± 2.10% w.b.) compared to other treatments (Control and Ca(OH)2). The evaluation of the models fit suggests that the firstorder model is not adequate to describe the rehydration in any treatment here evaluated, while Fick is suitable to describe the rehydration of Control samples (without treatment), and the models such as Page, Peleg or Weibull are suitable for describing rehydration in samples processed by nixtamalization, especially with ash

Economic evaluation of a novel community-based diabetes care model in rural Mexico: a cost and cost-effectiveness study.

OBJECTIVES: Diabetes is the leading cause of disability-adjusted life years in Mexico, and cost-effective care models are needed to address the epidemic. We sought to evaluate the cost and cost-effectiveness of a novel community-based model of diabetes care in rural Mexico, compared with usual care. DESIGN: We performed time-driven activity-based costing to estimate annualised costs associated with typical diabetes care in Chiapas, Mexico, as well as a novel diabetes care model known as Compañeros En Salud Programa de Enfermedades Crónicas (CESPEC). We conducted Markov chain analysis to estimate the cost-effectiveness of CESPEC compared with usual care from a societal perspective. We used patient outcomes from CESPEC in 2016, as well as secondary data from existing literature. SETTING: Rural primary care clinics in Chiapas, Mexico. PARTICIPANTS: Adults with diabetes. INTERVENTIONS: CESPEC is a novel, comprehensive, diabetes care model that integrates community health workers, provider education, supply chain management and active case finding. OUTCOME MEASURE: The primary outcome was the incremental cost-effectiveness of CESPEC compared with care as usual, per quality-adjusted life year (QALY) gained, expressed in 2016 US dollars. RESULTS: The economic cost of the CESPEC diabetes model was US$144 per patient per year, compared with US$125 for diabetes care as usual. However, CESPEC care was associated with 0.13 additional years of health-adjusted life expectancy compared with usual care and 0.02 additional years in the first 5 years of treatment. This translated to an incremental cost-effectiveness ratio (ICER) of US$2981 per QALY gained over a patient's lifetime and an ICER of US$10 444 over the first 5 years. Findings were robust to multiple sensitivity analyses. CONCLUSIONS: CESPEC is a cost-effective, community-based model of diabetes care for patients in rural Mexico. Given the high prevalence and significant morbidity associated with diabetes in Mexico and other countries in Central America, this model should be considered for broader scale up and evaluation

CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes

Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D, they must first traffic to the islets and extravasate through the islet vasculature. Understanding the cues that lead to T cell entry into inflamed islets is important because diagnosed T1D patients already have established immune infiltration of their islets. Here we show that CD11c+ cells are a key mediator of T cell trafficking to infiltrated islets in non-obese diabetic (NOD) mice. Using intravital 2-photon islet imaging we show that T cell extravasation into the islets is an extended process, with T cells arresting in the islet vasculature in close proximity to perivascular CD11c+ cells. Antigen is not required for T cell trafficking to infiltrated islets, but T cell chemokine receptor signaling is necessary. Using RNAseq, we show that islet CD11c+ cells express over 20 different chemokines that bind chemokine receptors expressed on islet T cells. One highly expressed chemokine-receptor pair is CXCL16-CXCR6. However, NOD. CXCR6−/− mice progressed normally to T1D and CXCR6 deficient T cells trafficked normally to the islets. Even with CXCR3 and CXCR6 dual deficiency, T cells trafficked to infiltrated islets. These data reinforce that chemokine receptor signaling is highly redundant for T cell trafficking to inflamed islets. Importantly, depletion of CD11c+ cells strongly inhibited T cell trafficking to infiltrated islets of NOD mice. We suggest that targeted depletion of CD11c+ cells associated with the islet vasculature may yield a therapeutic target to inhibit T cell trafficking to inflamed islets to prevent progression of T1D

Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics

A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance of b-tagging and the trigger. The physics potential for a variety of interesting physics processes, within the Standard Model and beyond, is examined. The study comprises a series of notes based on simulations of the detector and physics processes, with particular emphasis given to the data expected from the first years of operation of the LHC at CERN

Plant Antimicrobial Agents and Their Effects on Plant and Human Pathogens

To protect themselves, plants accumulate an armoury of antimicrobial secondary metabolites. Some metabolites represent constitutive chemical barriers to microbial attack (phytoanticipins) and others inducible antimicrobials (phytoalexins). They are extensively studied as promising plant and human disease-controlling agents. This review discusses the bioactivity of several phytoalexins and phytoanticipins defending plants against fungal and bacterial aggressors and those with antibacterial activities against pathogens affecting humans such as Pseudomonas aeruginosa and Staphylococcus aureus involved in respiratory infections of cystic fibrosis patients. The utility of plant products as “antibiotic potentiators” and “virulence attenuators” is also described as well as some biotechnological applications in phytoprotection

Bromophenols in Marine Algae and Their Bioactivities

Marine algae contain various bromophenols that have been shown to possess a variety of biological activities, including antioxidant, antimicrobial, anticancer, anti-diabetic, and anti-thrombotic effects. Here, we briefly review the recent progress of these marine algal biomaterials, with respect to structure, bioactivities, and their potential application as pharmaceuticals

Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice

Gedunin, a family of natural products from the Indian neem tree, possess a variety of biological activities. Here we report the discovery of deoxygedunin, which activates the mouse TrkB receptor and its downstream signaling cascades. Deoxygedunin is orally available and activates TrkB in mouse brain in a BDNF-independent way. Strikingly, it prevents the degeneration of vestibular ganglion in BDNF −/− pups. Moreover, deoxygedunin robustly protects rat neurons from cell death in a TrkB-dependent manner. Further, administration of deoxygedunin into mice displays potent neuroprotective, anti-depressant and learning enhancement effects, all of which are mediated by the TrkB receptor. Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases