A CONSTITUIÇÃO DO SER PROFESSORA NA EDUCAÇÃO ESPECIAL DURANTE O PRIMEIRO ANO DE CARREIRA

O trabalho apresenta considerações sobre uma pesquisa em que buscamos compreender a constituição do ser professora no campo da Educação Especial a partir de narrativas de uma docente principiante. Nesse sentido, recorremos a um referencial teórico que aborda a formação de professores na perspectiva da inclusão, bem como os desafios decorrentes da fase de entrada na carreira. O eixo metodológico tem caráter qualitativo de cunho descritivo-analítico e foram utilizados dados obtidos por meio de um roteiro de narrativa em que as vivências da prática pedagógica em relação ao contexto da inclusão são discutidas. Os resultados indicam a necessidade uma formação na perspectiva do trabalho com a realidade dos alunos que possuem alguma necessidade educativa especial, uma vez que os sentimentos decorrentes do início da docência podem se constituir como meio de reflexão para um modelo formativo que contemple esse segmento de atuação do profissional da educação

Photobiomodulation Therapy Restores IL-10 Secretion in a Murine Model of Chronic Asthma: Relevance to the Population of CD4+CD25+Foxp3+ Cells in Lung.

It is largely known that photobiomodulation (PBM) has beneficial effects on allergic pulmonary inflammation. Our previous study showed an anti-inflammatory effect of the PBM in an acute experimental model of asthma, and we see that this mechanism is partly dependent on IL-10. However, it remains unclear whether the activation of regulatory T cells is mediated by PBM in a chronic experimental model of asthma. In this sense, the objective of this study was to verify the anti-inflammatory role of the PBM in the pulmonary inflammatory response in a chronic experimental asthma model. The protocol used for asthma induction was the administration of OVA subcutaneously (days 0 and 14) and intranasally (3 times/week, for 5 weeks). On day 50, the animals were sacrificed for the evaluation of the different parameters. The PBM used was the diode, with a wavelength of 660 nm, a power of 100 mW, and 5 J for 50 s/point, in three different application points. Our results showed that PBM decreases macrophages, neutrophils, and lymphocytes in the bronchoalveolar lavage fluid (BALF). Moreover, PBM decreased the release of cytokines by the lung, mucus, and collagen in the airways and pulmonary mechanics. When we analyzed the percentage of Treg cells in the group irradiated with laser, we verified an increase in these cells, as well as the release of IL-10 in the BALF. Therefore, we conclude that the use of PBM therapy in chronic airway inflammation attenuated the inflammatory process, as well as the pulmonary functional and structural parameters, probably due to an increase in Treg cells.post-print1951 K

Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells

Acute respiratory distress syndrome (ARDS) is defined as hypoxemic respiratory failure with intense pulmonary inflammation, involving hyperactivation of endothelial cells and neutrophils. Given the anti-inflammatory effects of aerobic exercise (AE), this study investigated whether AE performed daily for 5 weeks would inhibit extra-pulmonary LPS-induced ARDS. C57Bl/6 mice were distributed into Control, Exercise, LPS and Exercise+ LPS groups. AE was performed on a treadmill for 5x/week for four weeks before LPS administration. 24hours after the final AE physical test, animals received 100ug of LPS intra-peritoneally. In addition, whole blood cell culture, neutrophils and human endothelial cells were pre-incubated with IL-10, an anti-inflammatory cytokine induced by exercise. AE reduced total protein levels (p<0.01) and neutrophil accumulation in bronchoalveolar lavage (BAL) (p<0.01) and lung parenchyma (p<0.01). AE reduced BAL inflammatory cytokines IL-1 beta, IL-6 and GM-CSF (p<0.001), CXCL1/KC, IL-17, TNF-alpha and IGF-1 (p<0.01). Systemically, AE reduced IL-1 beta, IL-6 and IFN-gamma (p<0.001), CXCL1/KC (p<0.01) and TNF-alpha (p<0.05). AE increased IL-10 levels in serum (p<0.001) and BAL (p<0.001). Furthermore, AE increased superoxide dismutase SOD (p<0.01) and decreased superoxide anion accumulation in the lungs (p<0.01). Lastly, pre-incubation with IL-10 significantly reduced LPS-induced activation of whole blood cells, neutrophils and HUVECs, as observed by reduced production of IL-1 beta, IL-6, IL-8 and TNF-alpha. Our data suggest that AE inhibited LPS-induced lung inflammation by attenuating inflammatory cytokines and oxidative stress markers in mice and human cell culture via enhanced IL-10 production.Sao Paulo Research Foundation (FAPESP) [2012/15165-2]Conselho Nacional de Pesquisa e Desenvolvimento (CNPq) [311335-2015-2]Comissao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [12804/13-4, 1303/13-9]FAPESP [2013/24076-6, 2014/23196-0, 2012/14604-8, 2012/25435-7, 2012/24880-7]CAPESNove Julho Univ, Sao Paulo, SP, BrazilBrazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, SP, BrazilFed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP, BrazilUniv Brasil, Sao Paulo, SP, BrazilUniv Sao Paulo, Sch Med, Dept Pathol LIM 59, Sao Paulo, SP, BrazilUniv Fed Lavras UFLA, Sci Dept Hlth, Lavras, MG, BrazilFed Univ Sao Paulo UNIFESP, Campus Sao Paulo, Sao Paulo, SP, BrazilHarbor UCLA Med Ctr, Div Resp & Crit Care Physiol & Med, Los Angeles Biomed Res Inst, Torrance, CA 90509 USAUniv Tubingen, Inst Clin & Expt Transfus Med IKET, Tubingen, GermanyFed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP, BrazilFed Univ Sao Paulo UNIFESP, Campus Sao Paulo, Sao Paulo, SP, BrazilFAPESP [2012/15165-2]CNPq [311335-2015-2]CAPES [12804/13-4, 1303/13-9]FAPESP [2013/24076-6, 2014/23196-0, 2012/14604-8, 2012/25435-7, 2012/24880-7]Web of Scienc

Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor

Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces. COPD is in the top five leading causes of deaths worldwide and presents a high economic cost. However, there are some preventive measures to lower the risk of developing COPD. Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects. So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD. C57BL/6 mice were submitted to cigarette smoke for 75 days (2x/day). After 60 days to smoke exposure, the treated group was submitted to LLLT (diode laser, 660 nm, 30 mW, and 3 J/cm(2)) for 15 days and euthanized for morphologic and functional analysis of the lungs. Our results showed that LLLT significantly reduced the number of inflammatory cells and the proinflammatory cytokine secretion such as IL-1 beta, IL-6, and TNF-alpha in bronchoalveolar lavage fluid (BALF). We also observed that LLLT decreased collagen deposition as well as the expression of purinergic P2X7 receptor. On the other hand, LLLT increased the IL-10 release. Thus, LLLT can be pointed as a promising therapeutic approach for lung inflammatory diseases as COPD.Sao Paulo Research Foundation (FAPESP) [2012/16498-5, 2012/15165-2]FAPESP [2015/23152-6, 2014/14604-8, 2015/13486-4]Univ Nove Julho UNINOVE, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo, SP, BrazilBrazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, SP, BrazilUniv Nove Julho UNINOVE, Masters Degree & PhD Program Rehabil Sci, Expt Cardioresp Physiol Lab, Sao Paulo, SP, BrazilUniv Calif San Diego UCSD Hlth Sci, Div Trauma Surg Crit Care Burns & Acute Care Surg, Dept Surg, San Diego, CA USAFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Sao Jose Dos Campos, SP, BrazilUniv Brasil, Postgrad Program Bioengn, Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP, BrazilFed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Sao Jose Dos Campos, SP, BrazilFed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP, BrazilFAPESP [2012/16498-5, 2012/15165-2]FAPESP [2015/23152-6, 2014/14604-8, 2015/13486-4]Web of Scienc

Benefícios da posição verticalizada no parto normal / Benefits of the upright position in normal childbirth

A Organização Mundial de Saúde (OMS), desde a década de 90, emitiu resoluções a respeito das práticas adotadas no trabalho de parto que favorecem o binômio. Dessa forma, nos últimos anos no Brasil, principalmente após a instituição da Política Nacional de Humanização do Parto, de 2011, a humanização do trabalho de parto tem sido defendida, a fim de proporcionar a melhor experiência para a parturiente.  No que concerne aos benefícios para mãe e feto, inúmeros estudos demonstram como a autonomia da mulher no momento do parto é saudável, tanto no âmbito físico como psicológico, para um momento menos doloroso e traumático, além da recuperação mais eficaz e a melhor conexão entre os pacientes e a equipe de multiprofissional de saúde.Assim, esse procedimento de parto humanizado foi analisado, neste trabalho, através de uma Revisão Integrativa da Literatura respaldada pela busca nas bases de dados, nas quais elencou-se 15 artigos científicos para esta produção textual que contemplavam todos os critérios estabelecidos. Após a leitura minuciosa dos artigos científicos, constatou-se que a posição verticalizada no parto normal deve ser defendida e estimulada, por proporcionar maior qualidade para mulher no momento de parir e diminuir as taxas de intercorrências no momento do parto e no pós-parto

Light-based technologies for management of COVID-19 pandemic crisis.

The global dissemination of the novel coronavirus disease (COVID-19) has accelerated the need for the implementation of effective antimicrobial strategies to target the causative agent SARS-CoV-2. Light-based technologies have a demonstrable broad range of activity over standard chemotherapeutic antimicrobials and conventional disinfectants, negligible emergence of resistance, and the capability to modulate the host immune response. This perspective article identifies the benefits, challenges, and pitfalls of repurposing light-based strategies to combat the emergence of COVID-19 pandemic

Docência na educação especial: narrativas de uma professora principiante

This paper presents considerations about a research in which we have sought to understand the constitution of being a female teacher in the field of Special Education based on the accounts of a beginning teacher. Thus, we have recurred to a theoretical framework that deals with teacher education in the perspective of inclusion, as well as the challenges arising from the moment one starts their career. The methodological toolkit has a qualitative nature with a descriptive/analytical approach. Data were collect by means of a script of narration in which the experiences of pedagogical practice in relation to the context of inclusion are discussed. The results indicate the need for  basic training in the perspective of how a professional will handle the reality of students who have some kind of special educational need, since the feelings that emerge in the start of a career may become a means of reflection for a formative model which includes this segment of professional education workers. O trabalho apresenta considerações sobre uma pesquisa em que buscamos compreender a constituição do ser professora no campo da Educação Especial a partir de narrativas de uma docente principiante. Nesse sentido, recorremos a um referencial teórico que aborda a formação de professores na perspectiva da inclusão, bem como os desafios decorrentes da fase de entrada na carreira. O eixo metodológico tem caráter qualitativo de cunho descritivo-analítico e foram utilizados dados obtidos por meio de um roteiro de narrativa em que as vivências da prática pedagógica em relação ao contexto da inclusão são discutidas. Os resultados indicam a necessidade uma formação na perspectiva do trabalho com a realidade dos alunos que possuem alguma necessidade educativa especial, uma vez que os sentimentos decorrentes do início da docência podem se constituir como meio de reflexão para um modelo formativo que contemple esse segmento de atuação do profissional da educação