Le marais doux endigué de Bourgneuf-Machecoul (Pays de Loire) Premier éléments de connaissance du peuplement piscicole. Relation ichtyofaune-habitat et problèmes majeurs de gestion (Maroc)

Le peuplement ichtyologique d'un marais littoral endigué, géré en eau douce, a été étudié sur une zone de 2 700 ha, située au nord du marais Breton-Vendéen (Loire-Atlantique, France). Le réseau hydraulique, qui représente près de 16 % de cette surface, se compose, d'environ 91 m de linéaire de fossés par ha (en tout 234 km) et de bassins présents uniquement dans la partie d'origine salicole du marais. Les hauteurs d'eau, l'envasement et le recouvrement par la végétation aquatique dépendent de la gestion humaine et sont très variables (moyennes respectives : 42 cm; 43 cm; 70 %). Cela se traduit par un morcellement spatial de l'habitat pour les poissons. La stratégie d'échantillonnage adoptée, qui tient compte de cette hétérogénéité, a permis de décrire un peuplement comportant 21 espèces. Dominé par les poissons-chats et par les anguilles, ce dernier est caractéristique de la zone à brèmes des cours d'eau. Les abondances sont relativement élevées (en moyenne 315 kg/ha et 11 460 poissons/ha), mais elles sont très hétérogènes. L'évolution qualitative et quantitative de la répartition spatio-temporelle est décrite à l'aide d'une analyse factorielle des correspondances portant sur 74 échantillons prélevés par pêche électrique entre 1987 et 1989. Bien que l'approche de ce milieu soit complexe et les références bibliographiques relativement rares, l'analyse des premières données permet d'ores et déjà d'identifier quelques problèmes de gestion ayant des répercussions directes sur le peuplement piscicole de cette zone.The dammed up marshes of the French Atlantic coast cover about 200 000 ha between River Vilaine and the « Bassin d'Arcachon ». Eighty eight % are managed with freshwater. They constitute original environments initially created for agriculture or for salt production, and they are now threatened by land abandonment within the next decade. Concurrently to aquaculture (in created or existing ponds), exploitation of the fish stocks in the ditchweb is likely to encourage a diversification of agricultural activities. Unfortunately, bibliographic analysis reveals the relative scarceness of research about sampling methods and qualitative or quantitative characteristics of these fish communities. This is quite surprising considering the importance of the ditchwed of this kind of environment outlined by several authors. In the Netherlands, BELTMANN (1984) assessed that there is a total of 400 000 km of ditches. In France, the littoral dyked marshes of the Atlantic coast couid comprise 20 000 km of ditches and about 24 000 ha of open water. The present work provides for the first data on the fish community of Bourgneuf marsh.The northern part of the marsh of Bourgneuf, 2 700 ha provided whith f reshwater, contains nearly every kind of landscapes found throughout the whole Breton-Vendéen marsh. The pattern of the ditch network strongly changes from a zone to another (fig.1) : presence of former salt pans in the western part, regular geometric shapes in the recently created polders next to the River Falleron, irregular ditchweb pattern in the eastern part. The average density of the ditch network is 91 m of ditches per ha, totalizing 234 km in the study area. The total surface of open water, composed of ditches and basins (former salt pans), covers 411 ha (over 15 % of the study site). Diversity of ditch types occurs at fine scales (<1 000 m2), they vary according to their widths (0,3 to 7 m), depths (average, 42 cm; SD, 20,4), thickness of silt layer (average, 43 cm; SD, 42) and their hydrophyte vegetation cover (average, 70 %; SD, 60 %). As a consequence of this heterogeneity, available habitats are scattered over the marsh (mosaïc distribution). A nested sampling (FRONTIER, 1983) was carried out to take into account this high heterogeneity : 5 sampling areas were selected randomly. In each one, 3 to 5 ditches were chosen according to their characteristics (see above). Sampling stations were delimited by 2 stop nets (5 mm mesh) settled 30 m apart, in order to avoid fish migration. Field work was conducted using « Heron » electric fishing material (see LAMARQUE et al., 1978). In each ditch-section, we carried out as many successive catches as necessary to apply the maximum likelihood weighted estimation method of CARLE and STRUB (1978). Nine to 19 stations were sampled at 5 periods, between 1987 and 1989. A total of 74 samples were collected.The fish community was composed of 21 species (table 1) and corresponded to the bream zone of Verneaux's classification (1977). The densities and biomass were quite high (on average 315 kg/ha and 11 460 fishes/ha) but very variable (0 to 2 120 kg/ ha and 0 to 39 300 fishes/ha). The catfish, Ictalurus nebulosus (170 kg/ha), the eel, Anguilla anguilla (47 kg/ha) and the tench, Tinca tinca (28 kg/ha), represented on average 77,5 % of the standing crop, but their spatial distribution was very irregular. These estimates are assumed to be reliable considering that the data used for the calculations were provided by a sampling design which permits to respect the basic assumptions of the removal method. (f) The population size could only change because of the fishings (no migration because of the stop nets; no recruitment/death because of the short duration of the fishing sequences). (ii) The standard sampling design permitted to reduce the variations of the catch probabilities between the successive removals. Several studies have shown that this removal method under-estimates by about 20 % the true size of the fish populations (e. g. BOHLIN and SUNDSTROM, 1977; MAHON, 1980). But they were based on Zippin's method, and the estimator of CARLE and STRUB (1978), that we used, was shown to be more robust (COWX, 1983; GERDEAUX, 1987). Nevertheless, we assume that the values presented in this paper provide for an approached information on the sizes of the studied fish populations.To assess the fish-habitat relationship, a correspondence analysis (fig. 2) was performed on the 74 samples X 17 species matrix (excluding the sticklebacks, Gaslerosteus aculeatus and Pungitius pungitius, which population size estimations failed because of their low catchabilities). Four groups of samples were ordinated according to their specific richness and the species they contained. Several habitat parameters were projected on F1-F2 factorial map (fig. 3). Hydrophyte cover, thickness of silt layer, water depth (fig. 3 and 4), which are directly controlled by human maintenance, appeared to be the major structuring habitat parameters for the fish community. In the deepest and less silted stations, the communities were rich (on average 11 species; group 4, fig. 2). Predators such as pike-perch, Stizostedion lucioperca, and perch, Perca fluviatilis, occurred, and cold water species were found, such as minnow, Phoxinus phoxinus, or chub, Leuciscus cephalus. When the silt layer was thicker and the water level was intermediate, the specific richness decreased (average, 6,2 species) and the community was either dominated by the cattish (group 2, fig. 2) or by the rudd, Scardinius erythrophtalmus (group 3, fig. 2), according to the importance of the aquatic vegetation cover. Habitats with thickest silt layers, shallowest waters and maximum aquatic vegetation cover contained the poorest communities (average 3,9 species) dominated by eel (group 1, fig. 2). There is also evidence that the diversity of the community has progressively decreased since 1987 (fig. 5). The most stenothermous species disappeared, and the importance of the catfish increased : it doubled between May 1987 and September 1989 (fig. 6). Although the eel is the species most adapted to this environment, we emphasize the diminution of its biomass (fig. 7). These phenomena could be partly due to the climate (cold winter in 1987, important swelling in January 1988 and 2 droughts in summers 1988 and 1989). But they are mainly caused by the water management policy which is intended to favour agriculture by keeping stable water levels (evacuation of swellings) and by preventing the freshwater part from the marine influence (collective sluice gates). This does mot permit an optimal breeding of the species that have to spawn on flooded meadows, neither a proper colonisation of the marsh by elvers

Subgraph spotting in graph representations of comic book images

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record Graph-based representations are the most powerful data structures for extracting, representing and preserving the structural information of underlying data. Subgraph spotting is an interesting research problem, especially for studying and investigating the structural information based content-based image retrieval (CBIR) and query by example (QBE) in image databases. In this paper we address the problem of lack of freely available ground-truthed datasets for subgraph spotting and present a new dataset for subgraph spotting in graph representations of comic book images (SSGCI) with its ground-truth and evaluation protocol. Experimental results of two state-of-the-art methods of subgraph spotting are presented on the new SSGCI dataset.University of La Rochelle (France

Le mouflon de Corse

Synthèse des études disponibles sur le mouflon de Corse en France (Génétique population, répartition, particularités morphologiques, particularités physiologiques, pathologie, utilisation de l'espace, utilisation du temps, alimentation, vie sociale, comportement reproducteur, relations interspécifiques, dynamique et structure des populations

Active Membrane Fluctuations Studied by Micropipet Aspiration

We present a detailed analysis of the micropipet experiments recently reported in J-B. Manneville et al., Phys. Rev. Lett. 82, 4356--4359 (1999), including a derivation of the expected behaviour of the membrane tension as a function of the areal strain in the case of an active membrane, i.e., containing a nonequilibrium noise source. We give a general expression, which takes into account the effect of active centers both directly on the membrane, and on the embedding fluid dynamics, keeping track of the coupling between the density of active centers and the membrane curvature. The data of the micropipet experiments are well reproduced by the new expressions. In particular, we show that a natural choice of the parameters quantifying the strength of the active noise explains both the large amplitude of the observed effects and its remarkable insensitivity to the active-center density in the investigated range. [Submitted to Phys Rev E, 22 March 2001]Comment: 14 pages, 5 encapsulated Postscript figure

The ANTARES Optical Beacon System

ANTARES is a neutrino telescope being deployed in the Mediterranean Sea. It consists of a three dimensional array of photomultiplier tubes that can detect the Cherenkov light induced by charged particles produced in the interactions of neutrinos with the surrounding medium. High angular resolution can be achieved, in particular when a muon is produced, provided that the Cherenkov photons are detected with sufficient timing precision. Considerations of the intrinsic time uncertainties stemming from the transit time spread in the photomultiplier tubes and the mechanism of transmission of light in sea water lead to the conclusion that a relative time accuracy of the order of 0.5 ns is desirable. Accordingly, different time calibration systems have been developed for the ANTARES telescope. In this article, a system based on Optical Beacons, a set of external and well-controlled pulsed light sources located throughout the detector, is described. This calibration system takes into account the optical properties of sea water, which is used as the detection volume of the ANTARES telescope. The design, tests, construction and first results of the two types of beacons, LED and laser-based, are presented.Comment: 21 pages, 18 figures, submitted to Nucl. Instr. and Meth. Phys. Res.

Long-term safety in patients with recurrent ovarian cancer treated with niraparib versus placebo: Results from the phase III ENGOT-OV16/NOVA trial

OBJECTIVE: Niraparib is a poly(ADP-ribose) polymerase (PARP) inhibitor approved for use in heavily pretreated patients and as maintenance treatment in patients with newly-diagnosed or recurrent ovarian cancer following a response to platinum-based chemotherapy. We present long-term safety data for niraparib from the ENGOT-OV16/NOVA trial. METHODS: This multicenter, double-blind, randomized, controlled phase III trial evaluated the efficacy and safety of niraparib for the treatment of recurrent ovarian cancer. Patients were randomly assigned 2:1 to receive either once-daily niraparib 300 mg or placebo. Two independent cohorts were enrolled based on germline BRCA mutation status. The primary endpoint was progression-free survival, reported previously. Long-term safety data were from the most recent data cutoff (September 2017). RESULTS: Overall, 367 patients received niraparib 300 mg once daily. Dose reductions due to TEAEs were highest in month 1 (34%) and declined every month thereafter. Incidence of any-grade and grade ≥ 3 hematologic and symptomatic TEAEs was also highest in month 1 and subsequently declined. Incidence of grade ≥ 3 thrombocytopenia decreased from 28% (month 1) to 9% and 5% (months 2 and 3, respectively), with protocol-directed dose interruptions and/or reductions. Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) were reported in 2 and 6 niraparib-treated patients, respectively, and in 1 placebo patient each. Treatment discontinuations due to TEAEs were <5% in each month and time interval measured. CONCLUSION: These data demonstrate the importance of appropriate dose reduction according to toxicity criteria and support the safe long-term use of niraparib for maintenance treatment in patients with recurrent ovarian cancer. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01847274

Wolbachia Mediate Variation of Host Immunocompetence

BACKGROUND: After decades during which endosymbionts were considered as silent in their hosts, in particular concerning the immune system, recent studies have revealed the contrary. In the present paper, we addressed the effect of Wolbachia, the most prevalent endosymbiont in arthropods, on host immunocompetence. To this end, we chose the A. vulgare-Wolbachia symbiosis as a model system because it leads to compare consequences of two Wolbachia strains (wVulC and wVulM) on hosts from the same population. Moreover, A. vulgare is the only host-species in which Wolbachia have been directly observed within haemocytes which are responsible for both humoral and cellular immune responses. METHODOLOGY/PRINCIPAL FINDINGS: We sampled gravid females from the same population that were either asymbiotic, infected with wVulC, or infected with wVulM. The offspring from these females were tested and it was revealed that individuals harbouring wVulC exhibited: (i) lower haemocyte densities, (ii) more intense septicaemia in their haemolymph and (iii) a reduced lifespan as compared to individuals habouring wVulM or asymbiotic ones. Therefore, individuals in this population of A. vulgare appeared to suffer more from wVulC than from wVulM. Symbiotic titer and location in the haemocytes did not differ for the two Wolbachia strains showing that these two parameters were not responsible for differences observed in their extended phenotypes in A. vulgare. CONCLUSION/SIGNIFICANCE: The two Wolbachia strains infecting A. vulgare in the same population induced variation in immunocompetence and survival of their hosts. Such variation should highly influence the dynamics of this host-symbiont system. We propose in accordance with previous population genetic works, that wVulM is a local strain that has attenuated its virulence through a long term adaptation process towards local A. vulgare genotypes whereas wVulC, which is a widespread and invasive strain, is not locally adapted