Accurate Internal Proper Motions of Globular Clusters

We have undertaken a long term program to measure high precision proper motions of nearby Galactic globular cluster (GC) stars using multi-epoch observations with the WFPC2 and the ACS cameras on-board the Hubble Space Telescope. The proper motions are used to study the internal cluster kinematics, and to obtain accurate cluster distances. In this paper, we also show how the proper motions of the field stars projected in the direction of the studied clusters can be used to set constraints on the Galaxy kinematics.Comment: 4 pages, 2 figures, A.S.P. Conf. Ser., in press in Vol. 296, 200

How to detect an anti-spacetime

Is it possible, in principle, to measure the sign of the Lapse? We show that fermion dynamics distinguishes spacetimes having the same metric but different tetrads, for instance a Lapse with opposite sign. This sign might be a physical quantity not captured by the metric. We discuss its possible role in quantum gravity.Comment: Article awarded with an "Honorable Mention" from the 2012 Gravity Foundation Award. 6 pages, 8 (pretty) figure

HST color-magnitude diagrams of 74 galactic globular clusters in the HST F439W and F555W bands

We present the complete photometric database and the color-magnitude diagrams for 74 Galactic globular clusters observed with the HST/WFPC2 camera in the F439W and F555W bands. A detailed discussion of the various reduction steps is also presented, and of the procedures to transform instrumental magnitudes into both the HST F439W and F555W flight system and the standard Johnson B and V systems. We also describe the artificial star experiments which have been performed to derive the star count completeness in all the relevant branches of the color magnitude diagram. The entire photometric database and the completeness function will be made available on the Web immediately after the publication of the present paper.Comment: 21 pages, 77 figures. High resolution version of this paper can be retrived at http://dipastro.pd.astro.it/globular

Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones

Today, polymeric drug delivery systems (DDS) appear as an interesting solution against bacterial resistance, having great advantages such as low toxicity, biocompatibility, and biodegradability. In this work, two polyketones (PK) have been post-functionalized with sodium taurinate (PKT) or potassium sulfanilate (PKSK) and employed as carriers for Vancomycin against bacterial infections. Modified PKs were easily prepared by the Paal-Knorr reaction and loaded with Vancomycin at a variable pH. All polymers were characterized by FT-IR, DSC, TGA, SEM, and elemental analysis. Antimicrobial activity was tested against Gram-positive Staphylococcus aureus ATCC 25923 and correlated to the different pHs used for its loading (between 2.3 and 8.8). In particular, the minimum inhibitory concentrations achieved with PKT and PKSK loaded with Vancomycin were similar, at 0.23 mu g/mL and 0.24 mu g/mL, respectively, i.e., six times lower than that with Vancomycin alone. The use of post-functionalized aliphatic polyketones has thus been demonstrated to be a promising way to obtain very efficient polymeric DDS

The Red Giant Branch in Near-Infrared Colour-Magnitude Diagrams. II: The luminosity of the Bump and the Tip

We present new empirical calibrations of the Red Giant Branch (RGB) Bump and Tip based on a homogeneous near-Infrared database of 24 Galactic Globular Clusters. The luminosities of the RGB Bump and Tip in the J, H and K bands and their dependence on the cluster metallicity have been studied, yielding empirical relationships. By using recent transformations between the observational and theoretical planes, we also derived similar calibrations in terms of bolometric luminosity. Direct comparison between updated theoretical models and observations show an excellent agreement. The empirical calibration of the RGB Tip luminosity in the near-Infrared passbands presented here is a fundamental tool to derive distances to far galaxies beyond the Local Group, in view of using the new ground-based adaptive optics facilities and, in the next future, the James Webb Space Telescope.Comment: 7 pages, 7 figures, accepted for publication in MNRA

Effect of the crystal structure on the optical properties and Ag sensitization of Tb3+/Yb3+ ions in silica-zirconia glasses and glass-ceramics

The role of the material structure in the energy transfer between Ag and Tb3+/Yb3+ ions is studied in silica-soda-zirconia sol-gel glasses and glass-ceramics. The preparation of Tb3+ and Yb3+ doped silica-soda-zirconia layers was carried out by sol-gel and dip-coating, followed by thermal annealing. The precipitation of zirconia nanocrystals was obtained by controlling the annealing temperature: from a full amorphous glass at 700 °C into a glass-ceramic at 1000 °C. A different crystalline structure of zirconia nanocrystals, tetragonal or cubic, was controlled by the rare-earth doping and investigated in relation to the Tb3+/Yb3+ optical properties. Moreover, Ag codoping was introduced by ion-exchange, obtaining a significant photoluminescence enhancement, both in the intensity and in the broadness of the excitation band, covering the whole UV region and part of the violet-blue region. Ag-sensitized Tb3+/Yb3+ doped silica-soda-zirconia glass-ceramics were attested to be potential candidates for energy-related applications, such as spectral conversion layers for solar cells, lasers and light-emitting devices (LEDs) in the visible and NIR spectral regions

Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials.

Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. However, they do not address the symptoms of heart failure that result from reductions in cardiac output and reserve. Over the last few decades, numerous attempts have been made to develop and test positive cardiac inotropes that improve cardiac haemodynamics. However, definitive clinical trials have failed to show a survival benefit. As a result, no positive inotrope is currently approved for long-term use in heart failure. The focus of this state-of-the-art review is to revisit prior clinical trials and to understand the causes for their findings. Using the learnings from those experiences, we propose a framework for future trials of such agents that maximizes their potential for success. This includes enriching the trials with patients who are most likely to derive benefit, using biomarkers and imaging in trial design and execution, evaluating efficacy based on a wider range of intermediate phenotypes, and collecting detailed data on functional status and quality of life. With a rapidly growing population of patients with advanced heart failure, the epidemiologic insignificance of heart transplantation as a therapeutic intervention, and both the cost and morbidity associated with ventricular assist devices, there is an enormous potential for positive inotropic therapies to impact the outcomes that matter most to patients

A Spectroscopic Study of Type Ibc Supernova Host Galaxies from Untargeted Surveys

We present the largest spectroscopic study of the host environments of Type Ibc supernovae (SN Ibc) discovered exclusively by untargeted SN searches. Past studies of SN Ibc host environments have been biased towards high-mass, high-metallicity galaxies by focusing on SNe discovered in galaxy-targeted SN searches. Our new observations more than double the total number of spectroscopic stellar population age and metallicity measurements published for untargeted SN Ibc host environments, and extend to a median redshift about twice as large as previous statistical studies (z = 0.04). For the 12 SNe Ib and 21 SNe Ic in our metallicity sample, we find median metallicities of log(O/H)+12 = 8.48 and 8.61, respectively, but determine that the discrepancy in the full distribution of metallicities is not statistically significant. This median difference would correspond to only a small difference in the mass loss via metal-line driven winds (<30%), suggesting this does not play the dominant role in distinguishing SN Ib and Ic progenitors. However, the median metallicity of the 7 broad-lined SN Ic (SN Ic-BL) in our sample is significantly lower, log(O/H)+12 = 8.34. The age of the young stellar population of SN Ic-BL host environments also seems to be lower than for SN Ib and Ic, but our age sample is small. A synthesis of SN Ibc host environment spectroscopy to date does not reveal a significant difference in SN Ib and Ic metallicities, but reinforces the significance of the lower metallicities for SN Ic-BL. This combined sample demonstrates that galaxy-targeted SN searches introduce a significant bias for studies seeking to infer the metallicity distribution of SN progenitors, and we identify and discuss other systematic effects that play smaller roles. We discuss the path forward for making progress on SN Ibc progenitor studies in the LSST era.Comment: 27 pages, 12 Figures, V2 as accepted by ApJ, more information at http://www.cfa.harvard.edu/~nsanders/papers/Ibchosts/summary.htm

Stealth silica nanoparticles for theranostic applications

Silica nanoparticles (SNPs) are a promising carrier system for medical applications. They can be conveniently tailored with different moieties in order to obtain peculiar capabilities. SNPs surface is successfully modified in order to obtain a specific targeting ability through Boletus Edulis Lectin (BEL) bioconjugation, a lectin that specifically recognize overexpressed tumor markers. Moreover, stealthing abilities are imparted with a one-step cocondensation of silanated poly(ethylene) glycol monomethyl ether. Herein we present the preliminary results of these studies