99 research outputs found
Can The Delivery Method Influence Lower Urinary Tract Symptoms Triggered By The First Pregnancy
Introduction and Objectives: The increase of the intensity of urinary symptoms in late pregnancy and postpartum has been well documented by several authors, but their causes remain uncertain, partly because of its probable multifactor origin. There are also controversies whether the etiology of lower urinary tract symptoms during pregnancy is the same as postpartum and whether the method of delivery could infl uence the risk of onset of urinary symptoms. This study aimed to evaluate the urinary symptoms triggered during pregnancy and its evolutionin the late puerperium, correlating them with the delivery method. Materials and Methods: A longitudinal study was conducted, which included 75 primigravidae women, classifi ed according to method of delivery as: (VD) vaginal delivery with right mediolateral episiotomy (n = 28); (CS) elective caesarean section (n = 26); and (EC) emergency caesarean section (n = 21). Urinary symptoms were assessed in the last trimester of pregnancy and at 45 days (± 10) of puerperium with validated versions for Portuguese language of the following questionnaires: International Consultation on Incontinence Questionnaire - Urinary Incontinence Short Form (ICIQ-UI SF) and the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB). Results: It was observed that frequency, urgency, nocturia and urge incontinence, triggered during pregnancy, decreased signifi cantly in the postpartum period, regardless of the delivery method (p = 0.0001). However, symptoms related to urinary loss due to stress persisted after vaginal delivery (p = 0.0001). Conclusions: Urgency, frequency and nocturia triggered during pregnancy tend to disappear in the late postpartum period, regardless of the delivery method, but the symptoms related to urinary loss due to stress tend to persist in late postpartum period after vaginal delivery.382267276Abrams, P., Cardozo, L., Fall, M., Griffiths, D., Rosier, P., Ulmsten, U., The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society (2002) Neurourol Urodyn., 21, pp. 167-178Milsom, I., Altman, D., Lapitan, M.C., Nelson, R., SillĂ©n, U., Thom, D., Epidemiology of urinary (UI) and faecal (FI) incontinence and pelvic organ prolapse (POP). In: Abrams P, Cardozo L, Khoury S, Wein A (eds). Incontinence, 4th edn. (2009) Committee 1. 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In: Abrams P, Cardozo L, Khoury, Wein A (ed.), Incontinence. 4th ed. (2009) Plymouth: Health Publication Ltd, pp. 255-330Parente, M.P., Jorge, R.M., Mascarenhas, T., Fernandes, A.A., Martins, J.A., Deformation of the pelvic floor muscles during a vagin l delivery (2008) Int Urogynecol J Pelvic Floor Dysfunct, 19, pp. 65-71Arruda, R.M., Castro, R.A., GirĂo, M.J.B.C., Impacto na qualidade de vida. In: Truzzi JC, Dambros M. Bexiga Hiperativa - AspectosPrĂĄticos (2009) SĂo Paulo, Nome da Rosa, pp. 36-39Tamanini, J.T., Dambros, M., D'Ancona, C.A., Palma, P.C., Rodrigues Netto Jr., N., ValidaçĂo para o portuguĂȘs do International Consultation on Incontinence questionnaire - Short Form (ICIQ-UI SF) (2004) Rev Saude Publica, 38, pp. 438-444Pereira, S.B., Thiel, R.R.C., Riccetto, C., Silva, J.M., Pereria, L.C., Herrmann, V., ValidaçĂo do International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQOAB) para a lĂngua portuguesa (2010) Rev. Bras. Ginecol. 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A cohort study in 232 primiparous women (2008) Am J Obstet Gy ecol, 199, pp. 73.e1-74.e1McLennan, M.T., Melick, C.F., Alten, B., Young, J., Hoehn, M.R., Patients' knowledge of potential pelvic floor changes associated with pregnancy and delivery (2006) Int Urogynecol J Pelvic Floor Dysfunct, 17, pp. 22-26Burgio, K.L., Zyczynski, H., Locher, J.L., Richter, H.E., Redden, D.T., Wright, K.C., Urinary incontinence in the 12-month postpartum eriod (2003) Obstet Gynecol, 102, pp. 1291-1298Bruschini, H., Etiopatogenia e classificaçĂo da incontinĂncia urinĂĄria feminina. In: Amaro JL, Haddad JM, Trindade JCS,Ribeiro RM (ed.), ReabilitaçĂo do assoalho pĂ©lvico nas disfunçÔes urinĂĄrias e anorretais. (2005) SĂo Paulo: Se mento Farma, pp. 41-46Chin, H.Y., Chen, M.C., Liu, Y.H., Wang, K.H., Postpartum urinary incontinence: a comparison of vaginal delivery, elective, and emergent cesarean section (2006) Int Urogynecol J Pelvic Floor Dysfunct, 17, pp. 631-635Dumoulin, C., Hay-Smith, J., Pelvic floor muscle training versus no treatment for urinary incontinence in women (2007) Eura Medicophys, 43, pp. 1-17Hay-Smith, J., Berghmans, B., Burgio, K., Dumoulin, C., Hagen, S., Moore, K., Adult Conservative Management In: Abrams P, Cardozo L, Khoury S, Wein A (ed.), Incontinence. 4th International Consultation on Incontinence, Paris, July 5-8, 2008. (2009) Health Publications Ltd, Portsmouth, pp. 1025-112
Observation of Antineutrinos from Distant Reactors using Pure Water at SNO+
The SNO+ collaboration reports the first observation of reactor antineutrinos
in a Cherenkov detector. The nearest nuclear reactors are located 240 km away
in Ontario, Canada. This analysis used events with energies lower than in any
previous analysis with a large water Cherenkov detector. Two analytical methods
were used to distinguish reactor antineutrinos from background events in 190
days of data and yielded consistent observations of antineutrinos with a
combined significance of 3.5 .Comment: v2: add missing author, add link to supplemental materia
Improved search for invisible modes of nucleon decay in water with the SNO+ detector
This paper reports results from a search for single and multi-nucleon
disappearance from the O nucleus in water within the \snoplus{} detector
using all of the available data. These so-called "invisible" decays do not
directly deposit energy within the detector but are instead detected through
their subsequent nuclear de-excitation and gamma-ray emission. New limits are
given for the partial lifetimes:
years, years, years,
years, and years at 90\% Bayesian
credibility level (with a prior uniform in rate). All but the () results improve on existing limits by a factor of about 3.info:eu-repo/semantics/publishedVersio
Measurement of neutron-proton capture in the SNO+ water phase
The SNO+ experiment collected data as a low-threshold water Cherenkov
detector from September 2017 to July 2019. Measurements of the 2.2-MeV
produced by neutron capture on hydrogen have been made using an Am-Be
calibration source, for which a large fraction of emitted neutrons are produced
simultaneously with a 4.4-MeV . Analysis of the delayed coincidence
between the 4.4-MeV and the 2.2-MeV capture revealed a
neutron detection efficiency that is centered around 50% and varies at the
level of 1% across the inner region of the detector, which to our knowledge is
the highest efficiency achieved among pure water Cherenkov detectors. In
addition, the neutron capture time constant was measured and converted to a
thermal neutron-proton capture cross section of mb
Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis _ state of the art
Fibrosis represents a major global disease burden, yet a potent antifibrotic compound is still not in sight. Part of the explanation for this situation is the difficulties that both academic laboratories and research and development departments in the pharmaceutical industry have been facing in re-enacting the fibrotic process in vitro for screening procedures prior to animal testing. Effective in vitro characterization of antifibrotic compounds has been hampered by cell culture settings that are lacking crucial cofactors or are not holistic representations of the biosynthetic and depositional pathway leading to the formation of an insoluble pericellular collagen matrix. In order to appreciate the task which in vitro screening of antifibrotics is up against, we will first review the fibrotic process by categorizing it into events that are upstream of collagen biosynthesis and the actual biosynthetic and depositional cascade of collagen I. We point out oversights such as the omission of vitamin C, a vital cofactor for the production of stable procollagen molecules, as well as the little known in vitro tardy procollagen processing by collagen C-proteinase/BMP-1, another reason for minimal collagen deposition in cell culture. We review current methods of cell culture and collagen quantitation vis-Ă -vis the high content options and requirements for normalization against cell number for meaningful data retrieval. Only when collagen has formed a fibrillar matrix that becomes cross-linked, invested with ligands, and can be remodelled and resorbed, the complete picture of fibrogenesis can be reflected in vitro. We show here how this can be achieved. A well thought-out in vitro fibrogenesis system represents the missing link between brute force chemical library screens and rational animal experimentation, thus providing both cost-effectiveness and streamlined procedures towards the development of better antifibrotic drugs
Isomer spectroscopy in oddâeven Ti isotopes:Approaching n = 40
Our understanding of the evolution of the shell structure in nuclei far from stability is based on the study of some key nuclei. Nuclei at or next to double shell closures play a special role in this. Presently, a lot of discussion is concentrated on the neutron-rich calcium isotopes, which provide a rich testing ground for various nuclear models with several traditional and new magic numbers. Ca-60 is now almost within reach with the most advanced radioactive beam facilities. In order to investigate the evolution of the shell gap at N = 40, the configuration of states in the odd-even titanium isotopes up to N = 37 (Ti-59) have been studied. In order to experimentally access the shell gap at N = 40, it is nowadays within the reach of the most advanced facility the investigation of neutron hole configuration states in odd-even titanium isotopes up to N = 37, in the Ti-59 nucleus. Such states correspond to relatively simple configurations that constitute a challenging testing ground for effective nuclear interactions. The new data obtained in our experiment allows to place the present predictions concerning the shell closure at N = 40 in the calcium region on a more solid ground
New strategies to improve results of mesh surgeries for vaginal prolapses repair â an update
Isomeric states in neutron-rich nuclei near N=40
Neutron-rich nuclei in the vicinity of the island of inversion are
characterized by shell evolution and exhibit deformed ground states. In several
nuclei isomeric states have been observed and attributed to excitations to the
intruder neutron orbital. In the present study we searched for
isomeric states in nuclei around , produced by projectile
fragmentation at RIBF. Delayed rays were detected by the EURICA
germanium detector array. High statistics data allowed for an updated decay
scheme of V. The lifetime of an isomeric state in V was measured
for the first time in the present experiment. A previously unobserved isomeric
state was discovered in Sc. The measured lifetime suggests a parity
changing transition, originating from an odd number of neutrons in the
orbital. The nature of the isomeric state in Sc is thus
different from isomers in the less exotic V and Sc nuclei.Comment: PRC accepte
First spectroscopy of <sup>61</sup> Ti and the transition to the Island of Inversion at NâŻ=âŻ40
Isomeric states in 59,61Ti have been populated in the projectile fragmentation of a 345 AMeV 238U beam at the Radioactive Isotope Beam Factory. The decay lifetimes and delayed \u3b3-ray transitions were measured with the EURICA array. Besides the known isomeric state in 59Ti, two isomeric states in 61Ti are observed for the first time. Based on the measured lifetimes, transition multipolarities as well as tentative spins and parities are assigned. Large-scale shell model calculations based on the modified LNPS interaction show that both 59Ti and 61Ti belong to the Island of Inversion at with ground state configurations dominated by particle-hole excitations to the and orbits
Gender Differences in COVID-19 Among Liver Transplant Recipients: Results from a Multicenter Brazilian Cohort
Introduction: Existing literature presents varying perspectives on the impact of COVID-19 on liver transplant recipients.However, no research has specifically investigated the role of gender differences in the manifestation of COVID-19 among liver transplant recipients. This study aims to examine the effects of COVID-19 on liver transplant recipients, with a focus on gender differences in disease presentation and progression. Methods: Conducted as a multicenter historical cohort study, this research collected patient records through an online questionnaire. Assessing COVID-related mortality was the main objective. Additionally, demographic, clinical, and laboratory data pertaining to disease presentation and progression werecollected. Results: The study included a total of 283 patients, of whom 76 were female and 206 were male. The median follow-up period for males was 99 days (IQR 38-283), while for females, it was 126 days (IQR 44-291). A higher prevalence of cardiovascular disease was observed in males (p=0.002). Females frequently experienced a loss of smell (p=0.021), whereas males commonly exhibited fever (p=0.031). Levels of ALT and gamma-glutamyl transferase were significantly elevated in males (p=0.008 and 0.004, respectively). Although there was a trend towards increased mortality in males, it did not reach statistical significance. Conclusion: This study is the first attempt to investigate gender differences in COVID-19 among liver transplant recipients. Our findings highlight the need for a comprehensive and personalised approach to treating this patient population and underscore the importance of further elucidating the disease presentation in these individuals
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