Incrimination of Dog Vector of Cystic Echinococcosis and Impact of the Appropriate Dogs’ Treatment

Dogs are involved in the transmission of several parasitic zoonosis. Among these, hydatidosis is very endemic in many countries of the world. Dog populations are very variable from one region to another, which increases the infestation risks across human populations especially in the developing countries such as in Morocco. Moreover, the risk of exposure is higher in dogs with access to rural slaughterhouses than in owned dogs. As for preventive measures, this calls for effective implementation of the appropriate dogs’ treatment against hydatidosis. Thus, the following chapter updates the most relevant information on the impact of hydatidosis upon human populations and livestock animals, as to stretch understanding on the vector contribution of dogs

Community perception and knowledge of cystic echinococcosis in the High Atlas Mountains, Morocco

Cystic echinococcosis (CE), a neglected zoonosis caused by the larval stage of the tapeworm Echinococcus granulosus, remains a public health issue in many developing countries that practice extensive sheep breeding. Control of CE is difficult and requires a community-based integrated approach. We assessed the communities' knowledge and perception of CE, its animal hosts, and its control in a CE endemic area of the High Atlas Mountains, Morocco. We conducted twenty focus group discussions (FGDs) stratified by gender with villagers, butchers and students in ten Berber villages that were purposefully selected for their CE prevalence. This community considers CE to be a severe and relatively common disease in humans and animals but has a poor understanding of the parasite's life cycle. Risk behaviour and disabling factors for disease control are mainly related to cultural practices in sheep breeding and home slaughtering, dog keeping, and offal disposal at home, as well as in slaughterhouses. Participants in our focus group discussions were supportive of control measures as management of canine populations, waste disposal, and monitoring of slaughterhouses. The uncontrolled stray dog population and dogs having access to offal (both at village dumps and slaughterhouses) suggest that authorities should be more closely involved in CE control. This study also highlights the need for improved knowledge about the transmission cycle of the parasite among communities and health professionals. Inter-sectoral collaboration between health staff, veterinarians, and social scientists appears to be crucial for sustainable control of this parasitic zoonosis

Parasitoses caprines dans la région de Chefchaouen: épidémiologie et prophylaxie

Cette étude épidémiologique des parasitoses caprines a été effectuée, de septembre 1993 à août 1994, dans la région de Chefchaouen (Rif). Les caprins conduits en élevage extensif sont exposés à un polyparasitisme interne et externe très diversifié. La population des strongles gastro-intestinaux, constituée de sept espèces, est maximale en décembre et en avril. Les strongles respiratoires composés principalement de protostrongylidés montrent une forte charge parasitaire en septembre, décembre et mai. Au niveau hépatique, le trématode Fasciola hepatica manifeste un pic bicuspidal automno-hivernal. Les parasitoses de moindre importance sont la monieziose et l'oestrose. Parmi les parasitoses transmises au caprin par le chien, la cysticercose hépato-péritonéale prédomine l'hydatidose. Les ectoparasites dominants sont les mallophages en hiver et les ixodidés en été. Un programme de traitement anthelminthique est proposé

Les Intoxications Accidentelles Par Les Pesticides Au Maroc Entre 2008-2014: Evolution Et Facteurs De Risque

The aim of this study was to determine the epidemiological profile of accidental poisoning by pesticides. A retrospective study of poisoning cases, declared between January 2008 to December 2014 at the Moroccan Anti poisoning and Pharmacovigilance Center (MAPPC), was conducted. During the study period, 4 110 acute accidental poisoning by pesticides cases were collected. The average age was of patients 19, 24±0,25 years. The sex-ratio (female/male) was 0.95. Poisoning mainly concerned adults between the ages of 20 and 74 (about 43%). The pesticide poisoning occurs more often in urban zones with 54.1%. These were mainly poisonings that occurred at home in 70.5% of cases. Patients were mostly symptomatic (about 65%), these poisonings occurred mainly during the spring mostly in the spring (32%) and summer (29%). Insecticides were the most commonly incriminated in 64, 13% of cases, followed by rats, pesticides, and herbicides with respectively 29%, 3.42% and 0.85%. The declarations came from all regions of Morocco, the highest incidence was recorded in the Tadla-Azilal region (4.04 per 100 000 inhabitants). The Fes Boulemane region showed a significant lethality of 6.43%. Among the 3,077 patients for whom the evolution was known, 98.1% had progressed favorably. 47 cases of death were recorded with a lethality of 1.2%

The socio-economic burden of cystic echinococcosis in morocco:A combination of estimation method

Cystic echinococcosis (CE) is a major zoonosis in Morocco despite the launch of a national control programme in 2005. As its economic consequences have not been studied yet in Morocco, this study estimated CE impact in terms of monetary losses, disability-adjusted life years (DALY), and DALY for zoonotic diseases (zDALY) in the entire country and in specific regions for the 2011 to 2014 period. The direct monetary losses were related to organ seizure from infected animal in slaughterhouses, and to healthcare expenses as well as lost wages for infected humans. Animal production losses concerned milk yield, fertility, carcass weight, and wool production. Losses due to human infection were also composed of disability and productivity losses at work. Monte Carlo simulations were used to estimate monetary losses and zDALY values. Nationwide, the estimated DALY was 0.5 years per 100,000 persons per year, and the zDALY was 55 years per 100,000 persons per year. Total yearly losses were estimated at 73 million USD (54-92 million USD). However, losses differed significantly among regions. Most of the economic losses consisted of unperceived consequences, i.e. decreased animal production and reduced productivity of asymptomatic individuals. Future studies should determine the socioeconomic and epidemiological factors underlying the differences in economic losses among regions to develop better adapted control programmes. Author summary Cystic echinococcosis (CE) is a major neglected zoonosis in Morocco, despite the launch of a national control programme in 2005. The first study on CE in Morocco dates back to 1924. However, no evaluation of economic losses was made until now. The present study estimated the economic losses caused by CE in Morocco, at the national and regional scale, by combining financial and non-financial methods. Estimation of the direct and indirect losses caused by CE infection in humans and livestock (sheep, cattle, goats and camels) highlighted the important disease burden nationwide, amounting to 0.07% of Morocco Gross Domestic Product. The combination of methods brought information on the different CE-linked economic losses, including the unperceived consequences. These results indicate that the national CE control strategy did not result in a decrease of the disease burden, which calls for its evaluation and improvement

Evaluation of rK39 rapid diagnostic tests for canine visceral leishmaniasis : longitudinal study and meta-analysis

Canine visceral leishmaniasis is a vector-borne disease caused by the intracellular parasite Leishmania infantum. It is an important veterinary disease, and dogs are also the main animal reservoir for human infection. The disease is widespread in the Mediterranean area, and parts of Asia and South and Central America, and is potentially fatal in both dogs and humans unless treated. Diagnosis of canine infections requires serological or molecular tests. Detection of infection in dogs is important prior to treatment, and in epidemiological studies and control programmes, and a sensitive and specific rapid diagnostic test would be very useful. Rapid diagnostic tests (RDTs) have been developed, but their diagnostic performance has been reported to be variable. We evaluated the sensitivity of a RDT based on serological detection of the rK39 antigen in a cohort of naturally infected Brazilian dogs. The sensitivity of the test to detect infection was relatively low, but increased with time since infection and the severity of infection. We then carried out a meta-analysis of published studies of rK39 RDTs, evaluating the sensitivity to detect disease and infection. The results suggest that rK39 RDTs may be useful in a veterinary clinical setting, but the sensitivity to detect infection is too low for operational control programmes

Biomarkers Associated with Leishmania infantum Exposure, Infection, and Disease in Dogs

Canine leishmaniosis (CanL) is a vector-borne disease caused by the protozoan Leishmania (Leishmania) infantum species [syn. L. (L.) infantum chagasi species in the Americas] which is transmitted by the bite of a female phlebotomine sand fly. This parasitosis is endemic and affect millions of dogs in Asia, the Americas and the Mediterranean basin. Domestic dogs are the main hosts and the main reservoir hosts for human zoonotic leishmaniosis. The outcome of infection is a consequence of intricate interactions between the protozoan and the immunological and genetic background of the host. Clinical manifestations can range from subclinical infection to very severe disease. Early detection of infected dogs, their close surveillance and treatment are essential to control the dissemination of the parasite among other dogs, being also a pivotal element for the control of human zoonotic leishmaniosis. Hence, the identification of biomarkers for the confirmation of Leishmania infection, disease and determination of an appropriate treatment would represent an important tool to assist clinicians in diagnosis, monitoring and in giving a realistic prognosis to subclinical infected and sick dogs. Here, we review the recent advances in the identification of Leishmania infantum biomarkers, focusing on those related to parasite exposure, susceptibility to infection and disease development. Markers related to the pathogenesis of the disease and to monitoring the evolution of leishmaniosis and treatment outcome are also summarized. Data emphasizes the complexity of parasite-host interactions and that a single biomarker cannot be used alone for CanL diagnosis or prognosis. Nevertheless, results are encouraging and future research to explore the potential clinical application of biomarkers is warranted.publishersversionpublishe