Interactions entre composition fonctionnelle de communautés végétales et formation des sols sans des lits de ravines en cours de restauration écologique

L activité érosive des badlands marneux des Alpes du Sud présente des conséquences négatives pour l homme qui a ainsi cherché à restaurer ces terrains dès le XIXème siècle. Depuis une dizaine d années, une stratégie d ingénierie écologique y est développée et se concentre sur les lits de ravines, pierres angulaires de leur restauration. La question appliquée à la base de ce travail de thèse est d identifier comment l implantation d ouvrages de génie écologique dans lelit de ravines marneuses érodées favorise leur restauration écologique sur le long terme.L objectif de recherche associé à cette question est de mieux comprendre comment des communautés végétales interagissent avec la restauration des sols de lits de ravines érodées sur le long terme. Nous avons fait l hypothèse que les traits végétaux des plantes à l échelle de communautés constituent un point d entrée pertinent pour étudier ces interactions. Dans la première partie, nous avons utilisé les traits comme un outil de compréhension de l effet mécanique des plantes sur les dynamiques géomorphologiques des lits de ravines en cours de restauration. Nous avons notamment montré que les traits permettent d expliquer la capacité de communautés végétales implantées à favoriser la formation d amas sédimentaires dans le lit des ravines durant la première décennie post-travaux. Dans la deuxième partie, nous nous sommes intéressés à l évolution potentielle sur le long terme (centaine d années) des propriétés de ces amas, constituant des sols en devenir. Nous avons montré que la diversité ainsi que les valeurs dominantes des traits végétaux influencent les propriétés de ces sols, notamment la stabilité des agrégats et la fertilité des sols. En plus d être un outil de compréhension, nous montrons que cette utilisation des traits constitue un outil pour guider les actions de restauration de badlands via l implantation d ouvrages de génie écologique, en apportant des éléments sur le devenir géomorphologique et écologique post-travaux des systèmes sol-plante de lits de ravines.In the French Southern Alps, severe erosion in marly badlands shows negative consequencesfor human populations, who worked to restore these terrains since the XIXth century. For adecade, an ecological engineering strategy is developed and focuses on gully beds, cornerstonesof their restoration. The operational question at the root of this PhD project is to identify towhat extent ecological engineering structures implanted in marly gully beds can foster theirlong-term ecological restoration. The scientific objective related to this question is to betterunderstand how plant communities interact in the long-term with the restoration of soils ingully beds. We hypothesized that plant traits at the community scale is a relevant entry point tostudy these interactions. In the first part, we used traits as a tool to study the mechanical effectof plants on geomorphological dynamics in gully beds under restoration. In particular, weshowed that traits enable us to explain the capacity of plant communities to favor theaccumulation of sediment mounds in gully beds during the first decade after ecologicalengineering works. In the second part, we concentrated on the potential long-term (century)evolution of the properties of these sediment mounds, in the process of becoming real soils. Weshowed that both trait diversity and dominant values of traits interacted with the properties ofthese soils, such as soil aggregate stability and soil fertility. With a strong multidisciplinaryapproach, this work provides results and insights on the interactions between plant traits andecosystem functioning in the specific case of highly eroded semi-natural ecosystems. It alsocontribute to set tools to restore badlands via ecological engineering works, by providinginformation about the long-term geomorphological and ecological evolution of soil-plantsystems in restored gully beds.SAVOIE-SCD - Bib.électronique (730659901) / SudocGRENOBLE1/INP-Bib.électronique (384210012) / SudocGRENOBLE2/3-Bib.électronique (384219901) / SudocSudocFranceF

Visual and auditory perceptual strength norms for 3,596 French nouns and their relationship with other psycholinguistic variables

Perceptual experience plays a critical role in the conceptual representation of words. Higher levels of semantic variables such as imageability, concreteness, and sensory experience are generally associated with faster and more accurate word processing. Nevertheless, these variables tend to be assessed mostly on the basis of visual experience. This underestimates the potential contributions of other perceptual modalities. Accordingly, recent evidence has stressed the importance of providing modality-specific perceptual strength norms. In the present study, we developed French Canadian norms of visual and auditory perceptual strength (i.e., the modalities that have major impact on word processing) for 3,596 nouns. We then explored the relationship between these newly developed variables and other lexical, orthographic, and semantic variables. Finally, we demonstrated the contributions of visual and auditory perceptual strength ratings to visual word processing beyond those of other semantic variables related to perceptual experience (e.g., concreteness, imageability, and sensory experience ratings). The ratings developed in this study are a meaningful contribution toward the implementation of new studies that will shed further light on the interaction between linguistic, semantic, and perceptual systems

Reciprocal regulation between the molecular clock and kidney injury

Tubulointerstitial fibrosis is the common pathological substrate for many etiologies leading to chronic kidney disease. Although perturbations in the circadian rhythm have been associated with renal disease, the role of the molecular clock in the pathogenesis of fibrosis remains incompletely understood. We investigated the relationship between the molecular clock and renal damage in experimental models of injury and fibrosis (unilateral ureteral obstruction, folic acid, and adenine nephrotoxicity), using genetically modified mice with selective deficiencies of the clock components Bmal1, Clock, and Cry. We found that the molecular clock pathway was enriched in damaged tubular epithelial cells with marked metabolic alterations. In human tubular epithelial cells, TGFβ significantly altered the expression of clock components. Although Clock played a role in the macrophage-mediated inflammatory response, the combined absence of Cry1 and Cry2 was critical for the recruitment of neutrophils, correlating with a worsening of fibrosis and with a major shift in the expression of metabolism-related genes. These results support that renal damage disrupts the kidney peripheral molecular clock, which in turn promotes metabolic derangement linked to inflammatory and fibrotic responses.This work was supported by grants from the Ministerio de Ciencia e Innovación PID2019-104233RB-100/AEI/10.13039/501100011033 (S Lamas), Instituto de Salud Carlos III REDinREN RD12/0021/0009 and RD16/0009/0016 (S Lamas), Comunidad de Madrid “NOVELREN” B2017/BMD-3751 and INNOREN P2022/BMD-7221 (S Lamas and C Barbas), and Fundación Renal “Iñigo Alvarez de Toledo” (S Lamas), all from Spain. C Rey-Serra has been the recipient of an FPI research training contract from the Spanish Research State Agency (BES-2016-076735). The CBMSO receives institutional support from Fundación “Ramón Areces.

Pour une démocratie socio-environnementale : cadre pour une plate-forme participative « transition écologique »

Contribution publiée in Penser une démocratie alimentaire Volume II – Proposition Lascaux entre ressources naturelles et besoins fondamentaux, F. Collart Dutilleul et T. Bréger (dir), Inida, San José, 2014, pp. 87-111.International audienceL’anthropocène triomphant actuel, avec ses forçages environnementaux et sociaux, est à l’origine de l’accélération des dégradations des milieux de vie sur Terre et de l’accentuation des tensions sociales et géopolitiques. Passer à un anthropocène de gestion équitable, informé et sobre vis-à-vis de toutes les ressources et dans tous les secteurs d’activité (slow anthropocene), impose une analyse préalable sur l’ensemble des activités et des rapports humains. Cette transition dite « écologique », mais en réalité à la fois sociétale et écologique, est tout sauf un ajustement technique de secteurs dits prioritaires et technocratiques. Elle est avant tout culturelle, politique et philosophique au sens propre du terme. Elle est un horizon pour des trajectoires de développement humain, pour des constructions sociales et économiques, censées redéfinir socialement richesse, bien-être, travail etc. La dénomination « transition écologique » est largement véhiculée, mais ses bases conceptuelles ne sont pas entièrement acquises ni même élaborées. Dans ce contexte, les étudiants en première année de Master BioSciences à l’Ecole Normale Supérieure (ENS) de Lyon ont préparé une première étude analytique de ce changement radical et global de société pour mieux comprendre dans quelle société ils souhaitent vivre, en donnant du sens aux activités humaines présentes et à venir. Une trentaine de dossiers sur divers secteurs d’activités et acteurs de la société ont été produits et ont servis de support à cette synthèse. Plus largement, le but est de construire un socle conceptuel et une plate-forme de travail sur lesquels les questions de fond, mais aussi opérationnelles, peuvent être posées et étudiées en permanence. Cette démarche participative est ouverte à la collectivité sur le site http://institutmichelserres.ens-lyon.fr/

The future of road transport

A perfect storm of new technologies and new business models is transforming not only our vehicles, but everything about how we get around, and how we live our lives. The JRC report “The future of road transport - Implications of automated, connected, low-carbon and shared mobility” looks at some main enablers of the transformation of road transport, such as data governance, infrastructures, communication technologies and cybersecurity, and legislation. It discusses the potential impacts on the economy, employment and skills, energy use and emissions, the sustainability of raw materials, democracy, privacy and social fairness, as well as on the urban context. It shows how the massive changes on the horizon represent an opportunity to move towards a transport system that is more efficient, safer, less polluting and more accessible to larger parts of society than the current one centred on car ownership. However, new transport technologies, on their own, won't spontaneously make our lives better without upgrading our transport systems and policies to the 21st century. The improvement of governance and the development of innovative mobility solutions will be crucial to ensure that the future of transport is cleaner and more equitable than its car-centred present.JRC.C.4-Sustainable Transpor

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Links between memory and perception : towards common mechanisms

Dans notre vie quotidienne, nous recueillons et intégrons constamment un grand nombre d’informations sensorielles (Calvert & Thesen, 2004). Tout au long de nos activités perceptives, les connaissances que nous avons sur l’environnement sont continuellement "récupérées" en mémoire. Le cadre de la cognition incarnée et située proposent que les processus cognitifs (i.e. processus mnésiques, processus langagiers) sont ancrés dans les mêmes systèmes sensorimoteurs que ceux engagés dans les processus perceptivo-moteurs (Glenberg, 1997 ; Slotnick, 2004 ; Pecher & Zwaan, 2005).La mémoire contient des traces sensori-motrices encodées lors des multiples expériences de l’individu dans son environnement (Versace, Labeye, Badard, & Rose, 2009). De nombreux travaux en psychologie cognitive et en neurosciences démontrent que les connaissances sont construites et (re)émergent à partir de l’activation des systèmes neuronaux typiquement associés aux mécanismes perceptivo-moteurs. Le contenu et le fonctionnement de notre mémoire sont intrinsèquement liés à nos activités sensori-motrices passées et présentes. Pour être efficace, les connaissances impliquées dans nos activités cognitives doivent être étroitement liées à la situation présente. Cette capacité à s’adapter à des situations spécifiques ne serait pas possible à moins que les connaissances, y compris les connaissances conceptuelles, soientissues de la réactivation de traces mnésiques d’expériences passées (Barsalou, 2008 ; Versace et al., 2014). Réciproquement, les activités sensori-motrices sont totalement dépendantes des traces mnésiques d’expériences sensori-motrices passées. Ainsi, la différence entre perception et mémoire réside dans le fait que, dans le premier cas, les propriétés sont perceptivement présentes, tandis que, dans le deuxième cas, celles-ci sont absentes mais réactivées.Ce travail de thèse avait pour objectif d’étudier les liens entre mémoire et perception et, plus précisément, d’apporter des arguments en faveur de la similarité entre les processus mnésiques et perceptifs qui résultent de l’activation de composants de même nature sensorimotrice.Nous avons testé l’hypothèse selon laquelle des effets perceptifs devraient pouvoir être obtenus avec des composants réactivés en mémoire. Pour cela, nous avons utilisé des effets perceptifs - tels que l’effet de masquage ou les biais de jugement perceptif - afin d’explorer la possibilité de répliquer ce type d’effets avec l’intervention des dimensions mnésiques.In everyday life, each of us is constantly processing perceptual input from the environment, we collect and then integrate numerous items of sensory information (Calvert & Thesen, 2004). Alongside these perceptual activities, knowledge related to our environment is continually "recovered" from memory. Embodied cognition and grounded cognition theories suggest that cognitive processes (e.g., memory processes, language processes) are grounded in the same sensory-motor systems as those used in perceptual and motor processes (Glenberg, 1997 ; Slotnick, 2004 ; Pecher & Zwaan, 2005).Memory is composed of sensorimotor traces encoded during the several experiences of an individual in his environment (Versace et al., 2009). A large number of studies in cognitive psychology and neurosciences demonstrated that knowledge is constructed and (re)emerged from the activation of neural systems typically associated with perceptual-motor mechanisms. The contents and the functioning of our memory are intrinsically linked to our past and present sensorimotor activities. To be effective, knowledge involved in our cognitive activities must be closely linked to the actual situation. This ability to adapt to specific situations would not be possible unless knowledge, including conceptual knowledge, is derived from the reactivation of memory traces of past experiences (Barsalou, 2008 ; Versace et al., 2014). Conversely, sensorimotor activities are totally dependent on memory traces of past sensorimotor experiences. Thus, the difference between perception and memory is that, in the former, properties are perceptually present, whereas, in the latter, they are absent but reactivated. This PhD research focused on the link between memory and perception and, more precisely, aims to provide arguments in favor of the similarity of memory and perceptual processes that result from the activation of components of same sensorimotor nature. We tested the hypothesis that perceptual effects should be observed with reactivated components in memory. We used well-known perceptual effects (such as masking effect or perceptual bias invisual illusion) to investigate the possibility to replicate these effects by replacing the sensorial present components by reactivated components in memory

When a Reactivated Visual Mask Disrupts Serial Recall

Abstract. To prevent forgetting in working memory, the attentional refreshing is supposed to increase the level of activation of memory traces by focusing attention. However, the involvement of memory traces reactivation in refreshing relies in the majority on indirect evidence. The aim of this study was to show that refreshing relies on the reactivation of memory traces by investigating how the reactivation of an irrelevant trace prevents the attentional refreshing to take place, and (2) the memory traces reactivated are sensorial in nature. We used a reactivated visual mask presented during the encoding (Experiment 1) and the refreshing (Experiment 2) of pictures in a complex span task. Results showed impaired serial recall performance in both experiments when the mask was reactivated compared to a control stimulus. Experiment 3 confirmed the refreshing account of these results. We proposed that refreshing relies on the reactivation of sensory memory traces

A comprehensive literature review of chronic pain and memory

International audienceChronic pain patients often complain of their "poor memory" and numerous studies objectively confirmed such difficulties in reporting working memory (WM) and long-term memory (LTM) dysfunctions. This paper provides a comprehensive review of the literature on memory impairment in chronic pain (CP) patients. Twenty-four observational studies evaluating WM or/and LTM in a chronic pain group and a control group were included in this review. Results showed that studies consistently reported a moderate decline, in both WM and LTM performances in CP patients. Even if CP patients complained about forgetfulness, objective measurements did not permit to conclude to a long-term storage impairment. CP patients exhibited more specifically encoding or retrieving difficulties compared to controls. Results showed that chronic pain selectively impacted the most attention-demanding memory processes, such as working memory and recollection in long-term memory. Results also demonstrated that CP patients exhibited a memory bias directed towards painful events compared to control subjects. Several authors have suggested that CP could be a maladaptive consequence of memory mechanisms. The long-lasting presence of pain continuously reinforces aversive emotional associations with incidental events. The inability to extinguish this painful memory trace could explain the chronic persistence of pain even when the original injury has disappeared. A major concern is the need to extricate pain-related cognitive effects from those resulting from all the co-morbidities associated with CP which both have a deleterious effect on cognitive function