106 research outputs found
Options for re-establishing river continuity, with an emphasis on the special solution âfish liftâ: examples from Austria.
The European Water Framework Directive (WFD) became a major tool in European water policy. All the member states had to develop River Basin Management Plans (RBMPs). Austriaâs first National Water Resource Management Plan was published in 2009 and describes measures to be set. Depending on the catchment size, ecological targets were defined on water body level, to be reached by 2015, 2021 or 2027. A priority goal is the re-establishment of river continuity. Therefore the Austrian Federal Ministry of Agriculture, Forestry, Environment and Water Management published a âGuideline for the construction of fish passesâ in 2012.We provide an overview on measures to re-establish river continuity that were recently planned or already established at the Inn catchment, a major tributary to the upper Danube River. Planning principles as well as details from the construction phase and monitoring concepts as well as first results are presented.Founded in 1924 TIWAG started its business with the construction of the HPP Achensee, at the time one of Europeâs largest storage facilities. Since then TIWAG expanded its expertise on engineering, constructing and operating hydro power plants in Tyrol. In the first river basin management cycle at three hydropower plants, located in theâpriority river networkâ (HPP Langkampfen, HPP Kirchbichl and HPP Imst - the latter with the weir Runserau and the water intake at Wenns), measures had to be developed to overcome discontinuity. During planning phase it was tried to apply âstandard solutionsâ according to the Austrian guideline. This was possible for three sites, where we planned vertical slot fish passes in combination with natural bypass channels. To enable upstream migration at the weir Runserau, different alternatives were evaluated, but it was not possible to use a âstandard solutionâ. A Â review about existing fish lifts was the basis for a promising solution. The chosen design combines a conventional fish migration facility (vertical slot) with a fish lift. Linked together those facilities are offering new, additional possibilities. The characteristics of this new concept and its advantages are presented.</p
Planung einer aufgelösten, unstrukturierten Blockrampe am Wehr Brunau an der Ătztaler Ache
Aufsatz veröffentlicht in: "Wasserbau-Symposium 2021: Wasserbau in Zeiten von Energiewende, GewÀsserschutz und Klimawandel, Zurich, Switzerland, September 15-17, 2021, Band 2" veröffentlicht unter: https://doi.org/10.3929/ethz-b-00049975
A new paraclinical CSF marker for hypoxiaâlike tissue damage in multiple sclerosis lesions
Recent studies on the immunopathology of multiple sclerosis revealed a heterogeneity in the patterns of demyelination, suggesting interindividual differences in the mechanism responsible for myelin destruction. One of these patterns of demyelination, characterized by oligodendrocyte dystrophy and apoptosis, closely mimics myelin destruction in acute white matter ischaemia. In the course of a systematic screening for virus antigen expression in multiple sclerosis brains, we identified a monoclonal antibody against canine distemper virus, which detects a crossâreactive endogenous brain epitope, highly expressed in this specific subtype of actively demyelinating multiple sclerosis lesions with little or no immunoreactivity in other active multiple sclerosis cases. The respective epitope, which is a phosphorylationâdependent sequence of one or more proteins of 50, 70 and 115kDa, is also expressed in a subset of active lesions of different virusâinduced inflammatory brain diseases, but is present most prominently and consistently in acute lesions of white matter ischaemia. Its presence is significantly associated with nuclear expression of hypoxiaâinducible factorâ1α within the lesions of both inflammatory and ischaemic brain diseases. The respective epitope is liberated into the CSF and, thus, may become a useful diagnostic tool to identify clinically a defined multiple sclerosis subtyp
First-year Sloan Digital Sky Survey-II (SDSS-II) Supernova Results: Hubble Diagram and Cosmological Parameters
We present measurements of the Hubble diagram for 103 Type Ia supernovae
(SNe) with redshifts 0.04 < z < 0.42, discovered during the first season (Fall
2005) of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey. These data
fill in the redshift "desert" between low- and high-redshift SN Ia surveys. We
combine the SDSS-II measurements with new distance estimates for published SN
data from the ESSENCE survey, the Supernova Legacy Survey, the Hubble Space
Telescope, and a compilation of nearby SN Ia measurements. Combining the SN
Hubble diagram with measurements of Baryon Acoustic Oscillations from the SDSS
Luminous Red Galaxy sample and with CMB temperature anisotropy measurements
from WMAP, we estimate the cosmological parameters w and Omega_M, assuming a
spatially flat cosmological model (FwCDM) with constant dark energy equation of
state parameter, w. For the FwCDM model and the combined sample of 288 SNe Ia,
we find w = -0.76 +- 0.07(stat) +- 0.11(syst), Omega_M = 0.306 +- 0.019(stat)
+- 0.023(syst) using MLCS2k2 and w = -0.96 +- 0.06(stat) +- 0.12(syst), Omega_M
= 0.265 +- 0.016(stat) +- 0.025(syst) using the SALT-II fitter. We trace the
discrepancy between these results to a difference in the rest-frame UV model
combined with a different luminosity correction from color variations; these
differences mostly affect the distance estimates for the SNLS and HST
supernovae. We present detailed discussions of systematic errors for both
light-curve methods and find that they both show data-model discrepancies in
rest-frame -band. For the SALT-II approach, we also see strong evidence for
redshift-dependence of the color-luminosity parameter (beta). Restricting the
analysis to the 136 SNe Ia in the Nearby+SDSS-II samples, we find much better
agreement between the two analysis methods but with larger uncertainties.Comment: Accepted for publication by ApJ
Immune profiling in multiple sclerosis: a single-center study of 65 cytokines, chemokines, and related molecules in cerebrospinal fluid and serum
IntroductionThe understanding of the pathophysiology of multiple sclerosis (MS) has evolved alongside the characterization of cytokines and chemokines in cerebrospinal fluid (CSF) and serum. However, the complex interplay of pro- and anti-inflammatory cytokines and chemokines in different body fluids in people with MS (pwMS) and their association with disease progression is still not well understood and needs further investigation. Therefore, the aim of this study was to profile a total of 65 cytokines, chemokines, and related molecules in paired serum and CSF samples of pwMS at disease onset.MethodsMultiplex bead-based assays were performed and baseline routine laboratory diagnostics, magnetic resonance imaging (MRI), and clinical characteristics were assessed. Of 44 participants included, 40 had a relapsingâremitting disease course and four a primary progressive MS.ResultsThere were 29 cytokines and chemokines that were significantly higher in CSF and 15 in serum. Statistically significant associations with moderate effect sizes were found for 34 of 65 analytes with sex, age, CSF, and MRI parameters and disease progression.DiscussionIn conclusion, this study provides data on the distribution of 65 different cytokines, chemokines, and related molecules in CSF and serum in newly diagnosed pwMS
Evidence for Type Ia Supernova Diversity from Ultraviolet Observations with the Hubble Space Telescope
We present ultraviolet (UV) spectroscopy and photometry of four Type Ia
supernovae (SNe 2004dt, 2004ef, 2005M, and 2005cf) obtained with the UV prism
of the Advanced Camera for Surveys on the Hubble Space Telescope. This dataset
provides unique spectral time series down to 2000 Angstrom. Significant
diversity is seen in the near maximum-light spectra (~ 2000--3500 Angstrom) for
this small sample. The corresponding photometric data, together with archival
data from Swift Ultraviolet/Optical Telescope observations, provide further
evidence of increased dispersion in the UV emission with respect to the
optical. The peak luminosities measured in uvw1/F250W are found to correlate
with the B-band light-curve shape parameter dm15(B), but with much larger
scatter relative to the correlation in the broad-band B band (e.g., ~0.4 mag
versus ~0.2 mag for those with 0.8 < dm15 < 1.7 mag). SN 2004dt is found as an
outlier of this correlation (at > 3 sigma), being brighter than normal SNe Ia
such as SN 2005cf by ~0.9 mag and ~2.0 mag in the uvw1/F250W and uvm2/F220W
filters, respectively. We show that different progenitor metallicity or
line-expansion velocities alone cannot explain such a large discrepancy.
Viewing-angle effects, such as due to an asymmetric explosion, may have a
significant influence on the flux emitted in the UV region. Detailed modeling
is needed to disentangle and quantify the above effects.Comment: 17 pages, 13 figures, accepted by Ap
Coherent elastic neutrino-nucleus scattering: Terrestrial and astrophysical applications
Coherent elastic neutrino-nucleus scattering (CENS) is a process in which neutrinos scatter on a nucleus which acts as a single particle. Though the total cross section is large by neutrino standards, CENS has long proven difficult to detect, since the deposited energy into the nucleus is keV. In 2017, the COHERENT collaboration announced the detection of CENS using a stopped-pion source with CsI detectors, followed up the detection of CENS using an Ar target. The detection of CENS has spawned a flurry of activities in high-energy physics, inspiring new constraints on beyond the Standard Model (BSM) physics, and new experimental methods. The CENS process has important implications for not only high-energy physics, but also astrophysics, nuclear physics, and beyond. This whitepaper discusses the scientific importance of CENS, highlighting how present experiments such as COHERENT are informing theory, and also how future experiments will provide a wealth of information across the aforementioned fields of physics
Coherent elastic neutrino-nucleus scattering: Terrestrial and astrophysical applications
Coherent elastic neutrino-nucleus scattering (CENS) is a process inwhich neutrinos scatter on a nucleus which acts as a single particle. Thoughthe total cross section is large by neutrino standards, CENS has longproven difficult to detect, since the deposited energy into the nucleus is keV. In 2017, the COHERENT collaboration announced the detection ofCENS using a stopped-pion source with CsI detectors, followed up thedetection of CENS using an Ar target. The detection of CENS hasspawned a flurry of activities in high-energy physics, inspiring newconstraints on beyond the Standard Model (BSM) physics, and new experimentalmethods. The CENS process has important implications for not onlyhigh-energy physics, but also astrophysics, nuclear physics, and beyond. Thiswhitepaper discusses the scientific importance of CENS, highlighting howpresent experiments such as COHERENT are informing theory, and also how futureexperiments will provide a wealth of information across the aforementionedfields of physics.<br
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