Two-field cosmological models and large-scale cosmic magnetic fields

We consider two different toy cosmological models based on two fields (one normal scalar and one phantom) realizing the same evolution of the Bang-to-Rip type. One of the fields (pseudoscalar) interacts with the magnetic field breaking the conformal invariance of the latter. The effects of the amplification of cosmic magnetic fields are studied and it is shown that the presence of such effects can discriminate between different cosmological models realizing the same global evolution of the universe.Comment: 12 pages, 3 figure

Genotoxic effects of chromium onpolytene chromosomes of Chironomus riparius Meigen 1804 (Diptera, Chironomidae)

Abstract Genotoxic effect as tested of chronic exposure to three different concentrations of Chromium (III) on polytene chromosomes of larvae of Chironomus riparius (syn. Chironomus thummi) from the embryonic stage to the IV larval instar for two successive generations. In chromosomes AB, CD, EF and G significant differences of chromosome aberrations were found between exposed and control larvae as well as changes in functional activity (induction of novel puffs not corresponding to those induced during normal larval development in arms A, B, C and E, telomeric and centromeric decondensations especially at telomeres of chromosome G and arm C.). No significant differences were found between the effects of the three treatments nor between the two generations. In chromosome G the Balbiani Ring system (where some permanently active regions are involved in transcription of salivary proteins) appeared as a model for studying the response of the genome to Cr (III) treatment. In approximately one-third of the cel..

Development and validation of a clinical index to predict survival after cardiac resynchronisation therapy

To develop and validate a prognostic risk index of cardiovascular mortality after cardiac resynchronisation therapy (CRT)

Energetic Ion Moments and Polytropic Index in Saturn’s Magnetosphere using Cassini/MIMI Measurements: A Simple Model Based on κ‐Distribution Functions

Moments of the charged particle distribution function provide a compact way of studying the transport, acceleration, and interactions of plasma and energetic particles in the magnetosphere. We employ κ‐distributions to describe the energy spectra of H+ and O+, based on >20 keV measurements by the three detectors of Cassini’s Magnetospheric Imaging Instrument, covering the time period from DOY 183/2004 to 016/2016, 5 < L < 20. From the analytical spectra we calculate the equatorial distributions of energetic ion moments inside Saturn’s magnetosphere and then focus on the distributions of the characteristic energy (Ec=IE/In), temperature, and κ‐index of these ions. A semiempirical model is utilized to simulate the equatorial ion moments in both local time and L‐shell, allowing the derivation of the polytropic index (Γ) for both H+ and O+. Primary results are as follows: (a) The ∼9 < L < 20 region corresponds to a local equatorial acceleration region, where subadiabatic transport of H+ (Γ∼1.25) and quasi‐isothermal behavior of O+ (Γ∼0.95) dominate the ion energetics; (b) energetic ions are heavily depleted in the inner magnetospheric regions, and their behavior appears to be quasi‐isothermal (Γ<1); (c) the (quasi‐) periodic energetic ion injections in the outer parts of Saturn’s magnetosphere (especially beyond 17–18 RS) produce durable signatures in the energetic ion moments; (d) the plasma sheet does not seem to have a ground thermodynamic state, but the extended neutral gas distribution at Saturn provides an effective cooling mechanism that does not allow the plasma sheet to behave adiabatically.Key PointsDerivation of energetic ion moments, κ‐index, characteristic energy, temperature, and polytropic index in Saturn’s magnetospherePresentation of a semiempirical analytical model for the 20 keV energetic ion Pressure, density, and temperatureThe neutral gas at Saturn provides an effective cooling mechanism and does not allow the plasma sheet to behave adiabaticallyPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146558/1/jgra54546.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146558/2/jgra54546_am.pd

Physical boundary Hilbert space and volume operator in the Lorentzian new spin-foam theory

A covariant spin-foam formulation of quantum gravity has been recently developed, characterized by a kinematics which appears to match well the one of canonical loop quantum gravity. In this paper we reconsider the implementation of the constraints that defines the model. We define in a simple way the boundary Hilbert space of the theory, introducing a slight modification of the embedding of the SU(2) representations into the SL(2,C) ones. We then show directly that all constraints vanish on this space in a weak sense. The vanishing is exact (and not just in the large quantum number limit.) We also generalize the definition of the volume operator in the spinfoam model to the Lorentzian signature, and show that it matches the one of loop quantum gravity, as does in the Euclidean case.Comment: 11 page

Long-term survival in patients undergoing cardiac resynchronization therapy: the importance of performing atrio-ventricular junction ablation in patients with permanent atrial fibrillation

AIMS: To investigate the effects of cardiac resynchronization therapy (CRT) on survival in heart failure (HF) patients with permanent atrial fibrillation (AF) and the role of atrio-ventricular junction (AVJ) ablation in these patients. METHODS AND RESULTS: Data from 1285 consecutive patients implanted with CRT devices are presented: 1042 patients were in sinus rhythm (SR) and 243 (19%) in AF. Rate control in AF was achieved by either ablating the AVJ in 118 patients (AVJ-abl) or prescribing negative chronotropic drugs (AF-Drugs). Compared with SR, patients with AF were significantly older, more likely to be non-ischaemic, with higher ejection fraction, shorter QRS duration, and less often received ICD back-up. During a median follow-up of 34 months, 170/1042 patients in SR and 39/243 in AF died (mortality: 8.4 and 8.9 per 100 person-year, respectively). Adjusted hazard ratios were similar for all-cause and cardiac mortality [0.9 (0.57-1.42), P = 0.64 and 1.00 (0.60-1.66) P = 0.99, respectively]. Among AF patients, only 11/118 AVJ-abl patients died vs. 28/125 AF-Drugs patients (mortality: 4.3 and 15.2 per 100 person-year, respectively, P < 0.001). Adjusted hazard ratios of AVJ-abl vs. AF-Drugs was 0.26 [95% confidence interval (CI) 0.09-0.73, P = 0.010] for all-cause mortality, 0.31 (95% CI 0.10-0.99, P = 0.048) for cardiac mortality, and 0.15 (95% CI 0.03-0.70, P = 0.016) for HF mortality. CONCLUSION: Patients with HF and AF treated with CRT have similar mortality compared with patients in SR. In AF, AVJ ablation in addition to CRT significantly improves overall survival compared with CRT alone, primarily by reducing HF death

Long-lasting effects of chronic exposure to chemical pollution on the hologenome of the Manila clam

Chronic exposure to pollutants affects natural populations, creating specific molecular and biochemical signatures. In the present study, we tested the hypothesis that chronic exposure to pollutants might have substantial effects on the Manila clam hologenome long after removal from contaminated sites. To reach this goal, a highly integrative approach was implemented, combining transcriptome, genetic and microbiota analyses with the evaluation of biochemical and histological profiles of the edible Manila clam Ruditapes philippinarum, as it was transplanted for 6 months from the polluted area of Porto Marghera (PM) to the clean area of Chioggia (Venice lagoon, Italy). One month post‐transplantation, PM clams showed several modifications to its resident microbiota, including an overrepresentation of the opportunistic pathogen Arcobacter spp. This may be related to the upregulation of several immune genes in the PM clams, potentially representing a host response to the increased abundance of deleterious bacteria. Six months after transplantation, PM clams demonstrated a lower ability to respond to environmental/physiological stressors related to the summer season, and the hepatopancreas‐associated microbiota still showed different compositions among PM and CH clams. This study confirms that different stressors have predictable effects in clams at different biological levels and demonstrates that chronic exposure to pollutants leads to long‐lasting effects on the animal hologenome. In addition, no genetic differentiation between samples from the two areas was detected, confirming that PM and CH clams belong to a single population. Overall, the obtained responses were largely reversible and potentially related to phenotypic plasticity rather than genetic adaptation. The results here presented will be functional for the assessment of the environmental risk imposed by chemicals on an economically important bivalve species