428 research outputs found
On unbounded p-summable Fredholm modules
We prove that odd unbounded p-summable Fredholm modules are also bounded
p-summable Fredholm modules (this is the odd counterpart of a result of A.
Connes for the case of even Fredholm modules)
Inverse scattering at fixed energy on surfaces with Euclidean ends
On a fixed Riemann surface with Euclidean ends and genus ,
we show that, under a topological condition, the scattering matrix S_V(\la)
at frequency \la > 0 for the operator determines the potential
if for all
and for some , where denotes the distance
from to a fixed point . The topological condition is given by
for and by if . In \rr^2 this
implies that the operator S_V(\la) determines any potential
such that for all .Comment: 21 page
Neuropsychological constraints to human data production on a global scale
Which are the factors underlying human information production on a global
level? In order to gain an insight into this question we study a corpus of
252-633 Million publicly available data files on the Internet corresponding to
an overall storage volume of 284-675 Terabytes. Analyzing the file size
distribution for several distinct data types we find indications that the
neuropsychological capacity of the human brain to process and record
information may constitute the dominant limiting factor for the overall growth
of globally stored information, with real-world economic constraints having
only a negligible influence. This supposition draws support from the
observation that the files size distributions follow a power law for data
without a time component, like images, and a log-normal distribution for
multimedia files, for which time is a defining qualia.Comment: to be published in: European Physical Journal
Explicit solution of the (quantum) elliptic Calogero-Sutherland model
We derive explicit formulas for the eigenfunctions and eigenvalues of the
elliptic Calogero-Sutherland model as infinite series, to all orders and for
arbitrary particle numbers and coupling parameters. The eigenfunctions obtained
provide an elliptic deformation of the Jack polynomials. We prove in certain
special cases that these series have a finite radius of convergence in the nome
of the elliptic functions, including the two particle (= Lam\'e) case for
non-integer coupling parameters.Comment: v1: 17 pages. The solution is given as series in q but only to low
order. v2: 30 pages. Results significantly extended. v3: 35 pages. Paper
completely revised: the results of v1 and v2 are extended to all order
String-localized Quantum Fields and Modular Localization
We study free, covariant, quantum (Bose) fields that are associated with
irreducible representations of the Poincar\'e group and localized in
semi-infinite strings extending to spacelike infinity. Among these are fields
that generate the irreducible representations of mass zero and infinite spin
that are known to be incompatible with point-like localized fields. For the
massive representation and the massless representations of finite helicity, all
string-localized free fields can be written as an integral, along the string,
of point-localized tensor or spinor fields. As a special case we discuss the
string-localized vector fields associated with the point-like electromagnetic
field and their relation to the axial gauge condition in the usual setting.Comment: minor correction
Theory of spin-polarized bipolar transport in magnetic p-n junctions
The interplay between spin and charge transport in electrically and
magnetically inhomogeneous semiconductor systems is investigated theoretically.
In particular, the theory of spin-polarized bipolar transport in magnetic p-n
junctions is formulated, generalizing the classic Shockley model. The theory
assumes that in the depletion layer the nonequilibrium chemical potentials of
spin up and spin down carriers are constant and carrier recombination and spin
relaxation are inhibited. Under the general conditions of an applied bias and
externally injected (source) spin, the model formulates analytically carrier
and spin transport in magnetic p-n junctions at low bias. The evaluation of the
carrier and spin densities at the depletion layer establishes the necessary
boundary conditions for solving the diffusive transport equations in the bulk
regions separately, thus greatly simplifying the problem. The carrier and spin
density and current profiles in the bulk regions are calculated and the I-V
characteristics of the junction are obtained. It is demonstrated that spin
injection through the depletion layer of a magnetic p-n junction is not
possible unless nonequilibrium spin accumulates in the bulk regions--either by
external spin injection or by the application of a large bias. Implications of
the theory for majority spin injection across the depletion layer, minority
spin pumping and spin amplification, giant magnetoresistance, spin-voltaic
effect, biasing electrode spin injection, and magnetic drift in the bulk
regions are discussed in details, and illustrated using the example of a GaAs
based magnetic p-n junction.Comment: 36 pages, 11 figures, 2 table
Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques.
Improved antigenicity against HIV-1 envelope (Env) protein is needed to elicit vaccine-induced protective immunity in humans. Here we describe the first tests in non-human primates (NHPs) of Env gp140 protein fused to a humanized anti-LOX-1 recombinant antibody for delivering Env directly to LOX-1-bearing antigen presenting cells, especially dendritic cells (DC). LOX-1, or 1ectin-like oxidized low-density lipoprotein (LDL) receptor-1, is expressed on various antigen presenting cells and endothelial cells, and is involved in promoting humoral immune responses. The anti-LOX-1 Env gp140 fusion protein was tested for priming immune responses and boosting responses in animals primed with replication competent NYVAC-KC Env gp140 vaccinia virus. Anti-LOX-1 Env gp140 vaccination elicited robust cellular and humoral responses when used for either priming or boosting immunity. Co-administration with Poly ICLC, a TLR3 agonist, was superior to GLA, a TLR4 agonist. Both CD4+ and CD8+ Env-specific T cell responses were elicited by anti-LOX-1 Env gp140, but in particular the CD4+ T cells were multifunctional and directed to multiple epitopes. Serum IgG and IgA antibody responses induced by anti-LOX-1 Env gp140 against various gp140 domains were cross-reactive across HIV-1 clades; however, the sera neutralized only HIV-1 bearing sequences most similar to the clade C 96ZM651 Env gp140 carried by the anti-LOX-1 vehicle. These data, as well as the safety of this protein vaccine, justify further exploration of this DC-targeting vaccine approach for protective immunity against HIV-1
Sotagliflozin in combination with optimized insulin therapy in adults with type 1 diabetes: The North American in Tandem1 study
OBJECTIVE: Evaluate the efficacy and safety of the dual sodium-glucose cotransporter 1 (SGLT1) and SGLT2 inhibitor sotagliflozin in combination with optimized insulin in type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: The in Tandem1 trial, a double-blind, 52-week phase 3 trial, randomized North American adults with T1D to placebo (n = 268), sotagliflozin 200 mg (n = 263), or sotagliflozin 400mg(n =262) after6 weeks ofinsulin optimization. The primary end point was HbA1c change from baseline at 24 weeks. HbA1c, weight, and safety were also assessed through 52 weeks. RESULTS: From a mean baseline of 7.57%, placebo-adjusted HbA1c reductions were 0.36% and 0.41% with sotagliflozin 200 and 400 mg, respectively, at 24 weeks and 0.25% and 0.31% at 52 weeks (all P < 0.001). Among patients with a baseline HbA1c ≥7.0%, an HbA1c <7% was achieved by 15.7%, 27.2%, and 40.3% of patients receiving placebo, sotagliflozin 200 mg, and sotagliflozin 400 mg, respectively (P ≤ 0.003 vs. placebo) at 24 weeks. At 52 weeks, mean treatment differences between sotagliflozin 400 mg and placebo were 21.08 mmol/L for fasting plasma glucose, 24.32 kg for weight, and 215.63% for bolus insulin dose and 211.87% for basal insulin dose (all P < 0.001). Diabetes Treatment Satisfaction Questionnaire scores increased significantly by 2.5 points with sotagliflozin versus placebo (P < 0.001) at 24 weeks. Genital mycotic infections and diarrhea occurred more frequently with sotagliflozin. Adjudicated diabetic ketoacidosis (DKA) occurred in 9 (3.4%) and 11 (4.2%) patients receiving sotagliflozin 200 and 400 mg, respectively, and in 1 (0.4%) receiving placebo. Severe hypoglycemia occurred in 17 (6.5%) patients from each sotagliflozin group and 26 (9.7%) patients receiving placebo. CONCLUSIONS: In a 1-year T1D study, sotagliflozin combined with optimized insulin therapy was associated with sustained HbA1c reduction, weight loss, lower insulin dose, fewer episodes of severe hypoglycemia, improved patient-reported outcomes, and more DKA relative to placebo (ClinicalTrials.gov, NCT02384941)
Equine Protozoal Myeloencephalitis: An Updated Consensus Statement with a Focus on Parasite Biology, Diagnosis, Treatment, and Prevention
Equine protozoal myeloencephalitis (EPM) remains an important neurologic disease of horses. There are no pathognomonic clinical signs for the disease. Affected horses can have focal or multifocal central nervous system (CNS) disease. EPM can be difficult to diagnose antemortem. It is caused by either of 2 parasites, Sarcocystis neurona and Neospora hughesi, with much less known about N. hughesi. Although risk factors such as transport stress and breed and age correlations have been identified, biologic factors such as genetic predispositions of individual animals, and parasite-specific factors such as strain differences in virulence, remain largely undetermined. This consensus statement update presents current published knowledge of the parasite biology, host immune response, disease pathogenesis, epidemiology, and risk factors. Importantly, the statement provides recommendations for EPM diagnosis, treatment, and prevention
Energy and system size dependence of \phi meson production in Cu+Cu and Au+Au collisions
We study the beam-energy and system-size dependence of \phi meson production
(using the hadronic decay mode \phi -- K+K-) by comparing the new results from
Cu+Cu collisions and previously reported Au+Au collisions at \sqrt{s_NN} = 62.4
and 200 GeV measured in the STAR experiment at RHIC. Data presented are from
mid-rapidity (|y|<0.5) for 0.4 < pT < 5 GeV/c. At a given beam energy, the
transverse momentum distributions for \phi mesons are observed to be similar in
yield and shape for Cu+Cu and Au+Au colliding systems with similar average
numbers of participating nucleons. The \phi meson yields in nucleus-nucleus
collisions, normalised by the average number of participating nucleons, are
found to be enhanced relative to those from p+p collisions with a different
trend compared to strange baryons. The enhancement for \phi mesons is observed
to be higher at \sqrt{s_NN} = 200 GeV compared to 62.4 GeV. These observations
for the produced \phi(s\bar{s}) mesons clearly suggest that, at these collision
energies, the source of enhancement of strange hadrons is related to the
formation of a dense partonic medium in high energy nucleus-nucleus collisions
and cannot be alone due to canonical suppression of their production in smaller
systems.Comment: 20 pages and 5 figure
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