Influence of open and closed river systems on the migrations of two northern New Zealand populations of banded kokopu (Galaxias fasciatus)

Otolith microchemical analysis by laser ablation inductively coupled mass spectrometry (ICP-MS) was used to investigate the migratory life histories of banded kokopu (Galaxias fasciatus) in two streams on the North Island of New Zealand. Known differences in marine and freshwater chemistry were used as a premise to document the migratory life strategies of banded kokopu between these environments. More specifically, temporal trends in high and low strontium/calcium ratios (Sr/Ca) identified in fish otoliths were used to determine evidence of migration between fresh and saltwater environments. Trace element analysis of fish captured above the Whau Valley Reservoir reflected non-migratory life histories and exhibited consistently low Sr/Ca ratios across the entire otolith. However, one fish from above the reservoir indicated unusually high Sr/Ca ratios in early adulthood. These high Sr levels were attributed to localised inputs from mineral-rich seepages associated with past mining practices in the region and low calcium availability within the Pukenui Stream. Otoliths from banded kokopu collected from Komiti Stream were shown to be migratory with a marine larval stage (high Sr/Ca ratio levels at the otolith nucleus), followed by a freshwater adult phase (low Sr/Ca ratio levels towards the edge) indicating their amphidromous origins. The study provides further evidence of non-diadromous recruitment for banded kokopu as a consequence of a large in-stream barrier and will add to the known distribution of landlocked species in New Zealand

An evaluation of three two-dimensional computational fluid dynamics codes including low Reynolds numbers and transonic Mach numbers

Full-potential, Euler, and Navier-Stokes computational fluid dynamics (CFD) codes were evaluated for use in analyzing the flow field about airfoils sections operating at Mach numbers from 0.20 to 0.60 and Reynolds numbers from 500,000 to 2,000,000. The potential code (LBAUER) includes weakly coupled integral boundary layer equations for laminar and turbulent flow with simple transition and separation models. The Navier-Stokes code (ARC2D) uses the thin-layer formulation of the Reynolds-averaged equations with an algebraic turbulence model. The Euler code (ISES) includes strongly coupled integral boundary layer equations and advanced transition and separation calculations with the capability to model laminar separation bubbles and limited zones of turbulent separation. The best experiment/CFD correlation was obtained with the Euler code because its boundary layer equations model the physics of the flow better than the other two codes. An unusual reversal of boundary layer separation with increasing angle of attack, following initial shock formation on the upper surface of the airfoil, was found in the experiment data. This phenomenon was not predicted by the CFD codes evaluated

An experimental study of the turbulent boundary layer on a transport wing in subsonic and transonic flow

The upper surface boundary layer on a transport wing model was extensively surveyed with miniature yaw probes at a subsonic and a transonic cruise condition. Additional data were obtained at a second transonic test condition, for which a separated region was present at mid-semispan, aft of mid-chord. Significant variation in flow direction with distance from the surface was observed near the trailing edge except at the wing root and tip. The data collected at the transonic cruise condition show boundary layer growth associated with shock wave/boundary layer interaction, followed by recovery of the boundary layer downstream of the shock. Measurements of fluctuating surface pressure and wingtip acceleration were also obtained. The influence of flow field unsteadiness on the boundary layer data is discussed. Comparisons among the data and predictions from a variety of computational methods are presented. The computed predictions are in reasonable agreement with the experimental data in the outboard regions where 3-D effects are moderate and adverse pressure gradients are mild. In the more highly loaded mid-span region near the trailing edge, displacement thickness growth was significantly underpredicted, except when unrealistically severe adverse pressure gradients associated with inviscid calculations were used to perform boundary layer calculations

A Method of Reducing Aeroelastic Effects of Highly Swept Wings

The greatest efficiency for a lifting surface at supersonic speeds, according to the theoretical considerations of reference 1, can be attained if the leading edge is swept well behind the Mach cone and the highest aspect ratio which is structurally possible is employed. Such a wing, designed for a Mach number of 3.0, would have 80 deg. of sweepback. Aeroelastic effects have < been shown 3 to be considerable for a wing with 60deg of sweepback and designed for a Mach number of 2.0. The wing shown was found theoretically to have considerable loss in maximum lift-drag ratio attributable to aeroelasticity. This wing has 12-per cent-thick Clark-Y airfoils normal to the wing leading edge. If it were of solid aluminum and flying at a dynamic pressure of 2,400 lbs./sq.ft. (flexibility parameter qb(exp. 4) /El(0) = 7.8), analysis indicates that the wing would deflect so as to reduce the maximum lift-drag ratio about 30 per cent

Investigation of sonic boom for the Space Shuttle: High cross-range orbiter

Recent studies of a proposed low cross-range straight-wing space shuttle orbiter have shown that the sonic boom created during reentry may be objectionable, particularly at low supersonic Mach number. Because of this, additional tests have been conducted to determine the sonic-boom overpressure for a blended wing-body shape proposed for use as a high cross-range shuttle orbiter. Two mission profiles, in which a constant angle of attack was held during the supersonic portion of the flight, were studied. In one case the angle of attack was 60 degrees; in the other 25 degrees. The sonic-boom pressure signatures were measured in a wind tunnel and used to estimate overpressures for both missions. A technique for alleviating the boom is indicated

Trade Policy, Economic Interests and Party Politics in a Developing Country: The Political Economy of CAFTA

Abstract Developing countries have increasingly opened their economies to trade. Research about trade policy in developed countries focuses on a bottom-up process by identifying economic preferences of domestic groups. We know less about developing countries. We analyze how economic and political variables influenced Costa Rican voters in a referendum on CAFTA, an international trade agreement. We find little support for Stolper-Samuelson models of economic preferences, but more support for specific factor models. We also isolate the effects of political parties on the referendum, controlling for many economic factors; we document how at least one party influenced voters and this made the difference for CAFTA passage. Politics, namely parties using their organizational strength to cue and frame messages for voters, influenced this important trade policy decision. Theories about trade policy need to take into account top-down political factors along with economic interests

Sonic boom prediction and minimization using computational fluid dynamics

This paper describes the NASA ARC program in sonic boom prediction methodologies. This activity supports NASA's High Speed Research Program (HSRP). An overview of the program, recent results, conclusions, and current effort will be given. This effort complements research in sonic boom acceptability and validation being conducted at LaRC and ARC. The goals of the sonic boom element are as follows: to establish a predictive capability for sonic booms generated by High-Speed Civil Transport (HSCT) concepts; to establish guidelines of acceptability for supersonic overland flight; and to validate these findings with wind tunnel and flight tests. The cumulative result of these efforts will be an assessment of economic viability for supersonic transportation. This determination will ultimately be made by the aerospace industry

Stephan's Quintet: The X-ray Anatomy of a Multiple Galaxy Collision

Chandra observations of the compact galaxy group known as Stephan's Quintet (SQ) are presented. The major morphological features that were discovered with the ROSAT HRI are now imaged with higher resolution and S/N. The large scale shock (1.5', ~40kpc if at 85 Mpc) is resolved into a narrow NS feature embedded in more extended diffuse emission (D>=3'). The NS structure is somewhat clumpy, more sharply bounded on the W side and prominent only in the soft band (energies below ~2 keV). Its observational properties are best explained as a shock produced by a high velocity encounter between NGC7318b, a ``new intruder'', and the intergalactic medium in SQ. The shock conditions near the high speed intruder suggest that a bow shock is propagating into a pre-existing HI cloud and heating the gas to a temperature of ~0.5 keV. The low temperature in the shock is a problem unless we postulate an oblique shock. One member, NGC7319, hosts a Seyfert 2 nucleus, with an intrinsic luminosity Lx=10^43 erg/s, embedded in a region of more diffuse emission with 10'' radius extent. The nuclear spectrum can be modeled with a strongly absorbed power-law typical of this class of sources. Several additional compact sources are detected including three in foreground NGC7320. Some of these sources are very luminous and could be related to the ultraluminous X-ray sources found in nearby galaxies.Comment: Accepted for publication in Astronomy & Astrophysics Quality of figures has been degraded to fit in the astroph requirements; fig12 could not be inserted in the tex and is given as a jpe

The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence

<p>Abstract</p> <p>Background</p> <p>Over-expression of <it>HER2 </it>in a subset of breast cancers (<it>HER2</it>+) is associated with high histological grade and aggressive clinical course. Despite these distinctive features, the differences in response of <it>HER2</it>+ patients to both adjuvant cytotoxic chemotherapy and targeted therapy (e.g. trastuzumab) suggests that unrecognized biologic and clinical diversity is confounding treatment strategies. Furthermore, the small but established risk of cardiac morbidity with trastuzumab therapy compels efforts towards the identification of biomarkers that might help stratify patients.</p> <p>Methods</p> <p>A single institution tissue array cohort assembled at the Clearview Cancer Institute of Huntsville (CCIH) was screened by immunohistochemistry staining using a large number of novel and commercially available antibodies to identify those with a univariate association with clinical outcome in <it>HER2</it>+ patients. Staining with antibody directed at TRMT2A was found to be strongly associated with outcome in <it>HER2</it>+ patients. This association with outcome was tested in two independent validation cohorts; an existing staining dataset derived from tissue assembled at the Cleveland Clinic Foundation (CCF), and in a new retrospective study performed by staining archived paraffin blocks available at the Roswell Park Cancer Institute (RPCI).</p> <p>Results</p> <p>TRMT2A staining showed a strong correlation with likelihood of recurrence at five years in 67 <it>HER2</it>+ patients from the CCIH discovery cohort (HR 7.0; 95% CI 2.4 to 20.1, p < 0.0004). This association with outcome was confirmed using 75 <it>HER2</it>+ patients from the CCF cohort (HR 3.6; 95% CI 1.3 to 10.2, p < 0.02) and 64 patients from the RPCI cohort (HR 3.4; 95% CI 1.3-8.9, p < 0.02). In bivariable analysis the association with outcome was independent of grade, tumor size, nodal status and the administration of conventional adjuvant chemotherapy in the CCIH and RPCI cohorts.</p> <p>Conclusions</p> <p>Studies from three independent single institution cohorts support TRMT2A protein expression as a biomarker of increased risk of recurrence in <it>HER2+ </it>breast cancer patients. These results suggest that TRMT2A expression should be further studied in the clinical trial setting to explore its predictive power for response to adjuvant cytotoxic chemotherapy in combination with <it>HER2 </it>targeted therapy.</p

Information Visualisation for Project Management: Case Study of Bath Formula Student Project

This paper contributes to a better understanding and design of dashboards for monitoring of engineering projects based on the projects’ digital footprint and user-centered design approach. The paper presents an explicit insight-based framework for the evaluation of dashboard visualisations and compares the performance of two groups of student engineering project managers against the framework: a group with the dashboard visualisations and a group without the dashboard. The results of our exploratory study demonstrate that student project managers who used the dashboard generated more useful information and exhibited more complex reasoning on the project progress, thus informing knowledge of the provision of information to engineers in support of their project understanding