Pion and Kaon box contribution to aμHLbL

The authors acknowledge support from CONACYT and Cátedras Marcos Moshinsky (Fundación Marcos Moshinsky). This research was also supported by CONACYT grant ‘Paradigmas y Controversias de la Ciencia 2022’ (Project No. 319395) and by Coordinación de la Investigación Científica (CIC) of the University of Michoacán, M´exico, through Grant No. 4.10.We present an evaluation of the π ± and K ± box contributions to the hadronic light-by-light piece of the muon’s anomalous magnetic moment, a μ . The calculation of the corresponding electromagnetic form factors (EFFs) is performed within a Dyson-Schwinger equations (DSE) approach to quantum chromodynamics. These form factors are calculated in the so-called rainbow-ladder (RL) truncation, following two different evaluation methods and, subsequently, in a further improved approximation scheme which incorporates meson cloud effects. The results are mutually consistent, indicating that in the domain of relevance for a μ the obtained EFFs are practically equivalent. Our analysis yields the combined estimates of a π ± − box μ = − ( 15.6 ± 0.2 ) × 10 − 11 and a K ± − box μ = − ( 0.48 ± 0.02 ) × 10 − 11 , in full agreement with results previously obtained within the DSE formalism and other contemporary estimates.CONACYT and Cátedras Marcos Moshinsky (Fundación Marcos Moshinsky)CONACYT (Project No. 319395)Coordinación de la Investigación Científica Grant No. 4.10

Inborn errors of metabolism: Lessons from iPSC models

The possibility of reprogramming human somatic cells to pluripotency has opened unprecedented opportunities for creating genuinely human experimental models of disease. Inborn errors of metabolism (IEMs) constitute a greatly heterogeneous class of diseases that appear, in principle, especially suited to be modeled by iPSC-based technology. Indeed, dozens of IEMs have already been modeled to some extent using patient-specific iPSCs. Here, we review the advantages and disadvantages of iPSC-based disease modeling in the context of IEMs, as well as particular challenges associated to this approach, together with solutions researchers have proposed to tackle them. We have structured this review around six lessons that we have learnt from those previous modeling efforts, and that we believe should be carefully considered by researchers wishing to embark in future iPSC-based models of IEMs

El trabajo colaborativo en un aula multicultural de 2.º de Bachillerato

A través del presente Trabajo Fin de Máster (TFM), se analizan los resultados obtenidos mediante el diseño y la aplicación de una propuesta de intervención basada en una metodología operativa-participativa en un aula de segundo de bachillerato en la asignatura de Economía de la Empresa. El objetivo principal de la investigación consiste en determinar si dicha metodología, basada en la técnica del aprendizaje colaborativo, influye en el rendimiento de los alumnos, además de determinar si la diversidad cultural puede considerarse más que un problema una gran oportunidad como intercambio y enriquecimiento en las aulas. Se establecen otros objetivos específicos como la mejora la autoestima, la cooperación, cohesión, empatía y por consiguiente, eliminación de barreras culturales y sociales como estereotipos o segregación hacia otras culturas o etnias. Para ello se ha aplicado una metodología eminentemente práctica centrada en el alumno como principal protagonista del proceso de enseñanza-aprendizaje. El planteamiento del problema surgió de la observación, donde se detectó dos aspectos claves como son el desfase entre la metodología aplicada en el aula -eminentemente teórica e individual- y los malos resultados obtenidos por el grupo y las peculiaridades actuales de los centros educativos como son las aulas multiétnicas y multiculturales A lo largo del presente trabajo de investigación se incluye una introducción teórica sobre el aprendizaje colaborativo, la legislación vigente y la propuesta de intervención que se ha realizado. También se incluyen los resultados de un cuestionario y un examen tipo test realizados por los alumnos para evaluar y analizar sus resultados. De este estudio se concluye que el aprendizaje colaborativo basado en la metodología práctica mejora el rendimiento de los alumnos de 2º de bachillerato en la asignatura de Economía de la Empresa, además de otros aspectos personales, sociales y culturales.The Final Master Thesis (TFM) analyzes the obtained results whether the design and implementation of a proposed intervention based in an operational-participatory methodology in the last year of high school in the subject of Business Economics. The main goal of the research is to determine whether this methodology, based in collaborative learning, improve the performance of the student. It has been applied to an eminently practical methodology focused on the students as the main character of their learning process, in addition to determine if cultural diversity can be considered a great opportunity for classroom interchange and enrichment istead of a problem. Other objectives are established such as better estimate, cooperation, cohesion, empathy and therefore, elimination of cultural and social barriers and also refusal towards different ethnic groups. The approach of the problem become as a result of the observation period, where a significant gap was detected between the methodology used in the classroom-too theoretical and individual- and the weak academic results obtained by the group and real necessities of the educational centers such as multiethnic and multicultural classrooms. Throughout this research work it is included a theoretical introduction on collaborative learning, the actual legislation and the proposed intervention which it has been done. Moreover, there are included the obtained results of a questioner and a test examination done by the students examination done by the students in order to evaluate and analyze their results. From this study we have concluded that collaborative learning based in practical methodology improve the performance of the students in the last year of high school in the subject of Business Economics, in addition to other personal, cultural and social aspects.Universidad de Granada. Máster Universitario en Diversidad Cultural. Un enfoque multidisciplinar y transfronterizo. Curso académico 2016-201

El cine en terapia

In this article the cinema is considered as a vicar learning tool. There are different kind of films: some ones are biographical, explaining vital process of a particular person, others are thematic films, which focus on a specific subject and show a particular view about it, others are «change» films, in which narrates the process of adaptation of a person after living a critical event causing a new identity construction and vital; there as also films focused «in therapy», which assists the process of therapy of the protagonist or the daily life of the therapist.En este artículo el cine se considera como una herramienta de aprendizaje vicario. Algunas películas que son biográficas, que explican el proceso vital de una persona determinada, otras son películas temáticas, que se centran en un tema concreto y muestran una visión particular sobre él, otras son películas «de cambio», en las que se narra el proceso de adaptación de una persona después de vivir un acontecimiento crítico que provoca una nueva construcción identitaria y vital, como también hay películas propiamente «de terapia», donde se asiste al proceso de terapia del protagonista o a la cotidianidad del terapeuta

Analysing the performance of radiological monitoring network during nuclear accidents

JRODOS was used to simulate the dispersion of airborne radioactive material from a point source over the period 2012–2015. In total, 1331 radioactive plumes were simulated with the objective to investigate the influence of changes in meteorological conditions in the performance of the monitoring network. For this purpose, the existing set of 84 monitoring stations included in the EUropean Radiological Data Exchange Platform (EURDEP) system in an area of 200 km around the source point is taken as reference. A methodology is presented for quantitative evaluation of the variability of the number of stations affected, the time of the first detection, the maximum registered and differences between the maximum values match in the network and in the simulated plumes. The results show seasonal differences in all of these parameters according to changes in the size and shape of the affected area due to meteorological conditions. There are large differences in the number of monitoring stations affected by the plumes, from 2 to 74; in the timing and location of the first alert given by the network, from 1 to more than 5 h and faster along the west-east axis from the source; and in level of maximum gamma dose rate detected by the monitoring stations, from 0.17 nSv/h in summer to 0.22 nSv/h in autumn. These results show the need to consider this type of analysis over the years in the design of monitoring networks and in the development of nuclear emergency preparedness and response (EP&R) plans

Cèl·lules mare embrionàries i medicina regenerativa

Embryonary stem cells and Regenerative Medicine.Embryonary stem cells have represented a scientific revolution in recent years given their potential capacity to turn into any cell type in the organism. Their therapeutic importance lies in the fact that they can be useful for treating diseases caused by a deficit in cell functioning. Numerous research groups world-wide are working to find out the differentiation mechanisms, as well as alternative techniques to using preembryos, in order to discover a safe and efficient therapy for these types of illness

Engineering and Assessing Cardiac Tissue Complexity

Cardiac tissue engineering is very much in a current focus of regenerative medicine research as it represents a promising strategy for cardiac disease modelling, cardiotoxicity testing and cardiovascular repair. Advances in this field over the last two decades have enabled the generation of human engineered cardiac tissue constructs with progressively increased functional capabilities. However, reproducing tissue-like properties is still a pending issue, as constructs generated to date remain immature relative to native adult heart. Moreover, there is a high degree of heterogeneity in the methodologies used to assess the functionality and cardiac maturation state of engineered cardiac tissue constructs, which further complicates the comparison of constructs generated in different ways. Here, we present an overview of the general approaches developed to generate functional cardiac tissues, discussing the different cell sources, biomaterials, and types of engineering strategies utilized to date. Moreover, we discuss the main functional assays used to evaluate the cardiac maturation state of the constructs, both at the cellular and the tissue levels. We trust that researchers interested in developing engineered cardiac tissue constructs will find the information reviewed here useful. Furthermore, we believe that providing a unified framework for comparison will further the development of human engineered cardiac tissue constructs displaying the specific properties best suited for each particular application

Life-history traits of the giant squid Architeuthis dux revealed from stable isotope signatures recorded in beaks

Peer reviewedPreprin

Using iPS Cells toward the Understanding of Parkinson's Disease

Cellular reprogramming of somatic cells to human pluripotent stem cells (iPSC) represents an efficient tool for in vitro modeling of human brain diseases and provides an innovative opportunity in the identification of new therapeutic drugs. Patient-specific iPSC can be differentiated into disease-relevant cell types, including neurons, carrying the genetic background of the donor and enabling de novo generation of human models of genetically complex disorders. Parkinson's disease (PD) is the second most common age-related progressive neurodegenerative disease, which is mainly characterized by nigrostriatal dopaminergic (DA) neuron degeneration and synaptic dysfunction. Recently, the generation of disease-specific iPSC from patients suffering from PD has unveiled a recapitulation of disease-related cell phenotypes, such as abnormal α-synuclein accumulation and alterations in autophagy machinery. The use of patient-specific iPSC has a remarkable potential to uncover novel insights of the disease pathogenesis, which in turn will open new avenues for clinical intervention. This review explores the current Parkinson's disease iPSC-based models highlighting their role in the discovery of new drugs, as well as discussing the most challenging limitations iPSC-models face today