Documentación arqueológica de la iglesia de la Anunciación de Javier

La intervención arqueológica llevada a cabo durante los trabajos de reforma de la iglesia de la Anunciación de Javier (Navarra) ha permitido recuperar una interesante información sobre la evolución histórica del lugar de Javier, las vicisitudes históricas de su iglesia parroquial y las costumbres funerarias empleadas en la zona en los siglos XVIII y XIX

Un asentamiento de la Edad del Hierro en la cueva de Mendukilo (Astitz-Valle de Larraun- Navarra)

Se da a conocer el resultado de la intervención arqueológica en la cueva de Mendukilo, de la Edad del Hierro.----------The result of the archaeological intervention is announced in the cave of Mendukilo, of the Iron age

La cerámica de estilo Cogotas I y los ciclos culturales en las postrimerías de la Edad del Bronce en Navarra

En el presente artículo se analizan los yacimientos conocidos en Navarra con cerámica decorada de estilo Cogotas I, situándolos en su contexto cronológico y cultural. Se analiza la división del territorio en dos grupos con importantes diferencias culturales

Electromagnetic Assessment of UHF-RFID Devices in Healthcare Environment

In this work, the evaluation of electromagnetic effect of Ultra High Frequency Radio Frequency Identification (UHF-RFID) passive tags used in the healthcare environment is presented. In order to evaluate exposure levels caused by EM field (865–868 MHz) of UHF-RFID readers, EM measurements in an anechoic chamber and in a real medical environment (Hospital Universitario de Canarias), as well as simulations by 3D Ray Launching algorithm, and of biophysical exposure effects in human models are presented. The results obtained show that the EM exposure is localized, in close vicinity of RFID reader and inversely proportional to its reading range. The EM exposure levels detected are sufficient to cause EM immunity effects in electronic devices (malfunctions in medical equipment or implants). Moreover, more than negligible direct effects in humans (exceeding relevant SAR values) were found only next to the reader, up to approximately 30% of the reading range. As a consequence, the EM risk could be firstly evaluated based on RFID parameters, but should include an in situ exposure assessment. It requires attention and additional studies, as increased applications of monitoring systems are observed in the healthcare sector—specifically when any system is located close to the workplace that is permanently occupied.This work was supported by Instituto de Salud Carlos III project “Electromagnetic “Characterization in Smart Environments of Healthcare, and their involvement in Personal, Occupational, and Environmental Health” (PI14CIII/00056) https://portalfis.isciii.es/es/Paginas/DetalleProyecto. aspx?idProyecto=PI14CIII%2f00056 (accessed on 24 July 2022), and project “ (PI19CIII/00033) TMPY 508/19 “ Metrics development for electromagnetic safety assessment in healthcare centers in the context of 5G“ https://portalfis.isciii.es/es/Paginas/DetalleProyecto.aspx?idProyecto=PI19 CIII%2f00033, (accessed on 24 July 2022) from Sub-Directorate-General for Research Assessment and Promotion. The results of a research task (II.PB.15) carried out within the National Programme “Improvement of safety and working conditions” partly supported in Poland in 2020-2022-within the scope of research and development-by the National Centre for Research and Development were also included.S

Exploring genetic factors involved in huntington disease age of onset. E2F2 as a new potential modifier gene

Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although the mechanism by which it could affect AO is presently unknown. The aim of this study is to explore the contribution of candidate genetic factors to HD AO in order to gain insight into the pathogenic mechanisms underlying this disorder. For that purpose, two AO definitions were used: the earliest age with unequivocal signs of HD (earliest AO or eAO), and the first motor symptoms age (motor AO or mAO). Multiple linear regression analyses were performed between genetic variation within 20 candidate genes and eAO or mAO, using DNA and clinical information of 253 HD patients from REGISTRY project. Gene expression analyses were carried out by RT-qPCR with an independent sample of 35 HD patients from Basque Country Hospitals. We found suggestive association signals between HD eAO and/or mAO and genetic variation within the E2F2, ATF7IP, GRIN2A, GRIN2B, LINC01559, HIP1 and GRIK2 genes. Among them, the most significant was the association between eAO and rs2742976, mapping to the promoter region of E2F2 transcription factor. Furthermore, rs2742976 T allele patient carriers exhibited significantly lower lymphocyte E2F2 gene expression, suggesting a possible implication of E2F2-dependent transcriptional activity in HD pathogenesis. Thus, E2F2 emerges as a new potential HD AO modifier factor

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Documentación arqueológica de la iglesia de la Anunciación de Javier

La intervención arqueológica llevada a cabo durante los trabajos de reforma de la iglesia de la Anunciación de Javier (Navarra) ha permitido recuperar una interesante información sobre la evolución histórica del lugar de Javier, las vicisitudes históricas de su iglesia parroquial y las costumbres funerarias empleadas en la zona en los siglos XVIII y XIX

La cerámica de estilo Cogotas I y los ciclos culturales en las postrimerías de la Edad del Bronce en Navarra

En el presente artículo se analizan los yacimientos conocidos en Navarra con cerámica decorada de estilo Cogotas I, situándolos en su contexto cronológico y cultural. Se analiza la división del territorio en dos grupos con importantes diferencias culturales

Electromagnetic characterization of uhf-rfid fixed reader in healthcare centers related to the personal and labor health

Hospitals and healthcare centers are experiencing a remarkable implementation of new systems based on wireless communications technologies. Many of these systems provide location services and identification of materials, instrumentation and even patients, which promotes the increase of the quality and the efficiency of healthcare. A tracking system based on short-range radio frequency, UHF-RFID is evaluated. This system helps with location of orthopedic prosthesis according to the criteria and requirements of a specific hospital environment. It is characterized the influence of UHF-RFID system in the electromagnetic environment by measuring the parameters and characteristics of the emission levels. The results of the assessment are represented through 2D contour maps and simulations have been performed by means of an in-house 3D-RL algorithm. The proposed graph aims to provide a methodology of studying the electromagnetic environments and the evaluation of the safety conditions of workers, patients, and people in general. E field exposure levels due to the RFID localization system were analyzed in order to verify regulations concerning the safety of patients and the general public in the labor and healthcare fields. Localized electromagnetic field exposure at levels which may cause electromagnetic hazards in the specific healthcare environment have been found and potentially excessive exposure to EMF emitted by UHF RFID devices may apply to patients or bystanders. In all cases, insufficient electromagnetic immunity of electronic devices (including AIMD and other medical devices) should be considered and the electromagnetic hazards may be limited also by relevant preventive measures, as also shown in this paper, together with the principles of an in-situ evaluation of electromagnetic hazards near the UHF-RFID devices.This work was supported in part by the Instituto de Salud Carlos III Project 'Electromagnetic Characterization in Smart Environments of Healthcare, and Their Involvement in Personal, Occupational, and Environmental Health' under Grant PI14CIII/00056, and in part by the Sub-Directorate-General for Research Assessment and Promotion through the Project 'Metrics Development for Electromagnetic Safety Assessment in Healthcare Centers in the Context of 5G [(PI19CIII/00033) TMPY 508/19].

Exploring Genetic Factors Involved in Huntington Disease Age of Onset: <i>E2F2</i> as a New Potential Modifier Gene

Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although the mechanism by which it could affect AO is presently unknown. The aim of this study is to explore the contribution of candidate genetic factors to HD AO in order to gain insight into the pathogenic mechanisms underlying this disorder. For that purpose, two AO definitions were used: the earliest age with unequivocal signs of HD (earliest AO or eAO), and the first motor symptoms age (motor AO or mAO). Multiple linear regression analyses were performed between genetic variation within 20 candidate genes and eAO or mAO, using DNA and clinical information of 253 HD patients from REGISTRY project. Gene expression analyses were carried out by RT-qPCR with an independent sample of 35 HD patients from Basque Country Hospitals. We found suggestive association signals between HD eAO and/or mAO and genetic variation within the E2F2, ATF7IP, GRIN2A, GRIN2B, LINC01559, HIP1 and GRIK2 genes. Among them, the most significant was the association between eAO and rs2742976, mapping to the promoter region of E2F2 transcription factor. Furthermore, rs2742976 T allele patient carriers exhibited significantly lower lymphocyte E2F2 gene expression, suggesting a possible implication of E2F2-dependent transcriptional activity in HD pathogenesis. Thus, E2F2 emerges as a new potential HD AO modifier factor