The Influence of Heat Transfer on Peristaltic Transport of MHD Second Grade Fluid through Porous Medium in a Vertical Asymmetric Channel

In this paper, we study the influence of heat transfer on the peristaltic transport of an incompressible magnetohydrodynamic second grade fluid in vertical symmetric and asymmetric channels. The channel asymmetry is produced by choosing the peristaltic wave train on the walls to have different amplitudes and phase. The flow is investigated in the wave frame of reference moving with velocity of the wave. Perturbation solutions are obtained for the stream function, temperature and pressure gradient under long wave length assumption. Pressure difference and frictional force are discussed through numerical integration. The influence of various parameters of interest on the flow are discussed and also the graphical results are obtained for different wave forms

SB-Router: A Swapped Buffer Activated Low Latency Network-on-Chip Router

Switch Allocation (SA) holds a critical stage in Network-on-Chip (NoC) routers, its performance gets affected adversely due to Head-of-Line (HoL) blocking. In traditionally used Input-Queued Routers (IQR), packets are arranged in a particular order in each Virtual Channel (VC). This implementation is vulnerable to HoL blocking, as the switch allocator can allocate only those packets which are available at the head in a VC. In this paper, Swapped Buffer (SB) Router architecture is proposed to schedule packets in input buffers by using SB registers. The VCs are designed as SBs, this allows the packets stored in SB registers along with the head packet of VC to participate in SA. The concept of the SB register minimizes the conflicts in SA and thus reduces HoL blocking, therefore improves the performance of NoC. This paper proposes a priority mechanism to prioritize the non-head packets as compared to head packets in case of conflict between them. Two methods have been proposed in this paper, to enhance the performance of the NoC router. First, a VC allocation technique is proposed to optimize the order of packets in the input buffer. Next, SB-Router is combined with the Fill VC allocation technique to further enhance the performance of NoC routers. The performance of the proposed router is evaluated and the experimental results indicate that our design achieves latency improvement of 68.75% over (Time-Series) TS-Router for uniform traffic at the injection rate of 0.42 flits/cycle for a 64 node mesh network with moderate power consumption and area usage. The performance improvement in packet latency for traces from Princeton Application Repository for Shared-Memory Computers (PARSEC) has also been evaluated. With the achieved reduction in latency, the proposed method has the potential to serve high-speed operations while mapping different applications on multiple core architectures.</p

Regression Based Performance Analysis and Fault Detection in Induction Motors by Using Deep Learning Technique

The recent improvements related to the area of electric locomotive, power electronics, assembly processes and manufacturing of machines have increased the robustness and reliability of induction motors. Regardless of the increased availability, the application of induction motors in many fields alleges the need for operating state supervision and condition monitoring. In other words, fault identification at the initial stage helps make appropriate control decisions, influencing product quality as well as providing safety. Inspired by these demands, this work proposes a regression based modeling for the analysis of performance in induction motors. In this approach, the feature extraction process is combined with classification for efficient fault detection. Deep Belief Network (DBN) stacked with multiple Restricted Boltzmann Machine (RBM) is exploited for the robust diagnosis of faults with the adoption of training process. The influences of harmonics over induction motors are identified and the losses are mitigated. The simulation of the suggested approach and its comparison with traditional approaches are executed. An overall accuracy of 99.5% is obtained which in turn proves the efficiency of DBN in detecting faults

Heat Transfer Attributes of Gold–Silver–Blood Hybrid Nanomaterial Flow in an EMHD Peristaltic Channel with Activation Energy

The heat enhancement in hybrid nanofluid flow through the peristaltic mechanism has received great attention due to its occurrence in many engineering and biomedical systems, such as flow through canals, the cavity flow model and biomedicine. Therefore, the aim of the current study was to discuss the hybrid nanofluid flow in a symmetric peristaltic channel with diverse effects, such as electromagnetohydrodynamics (EMHD), activation energy, gyrotactic microorganisms and solar radiation. The equations governing this motion were simplified under the approximations of a low Reynolds number (LRN), a long wavelength (LWL) and Debye–Hückel linearization (DHL). The numerical solutions for the non-dimensional system of equations were tackled using the com-putational software Mathematica. The influences of diverse physical parameters on the flow and thermal characteristics were computed through pictorial interpretations. It was concluded from the results that the thermophoresis parameter and Grashof number increased the hybrid nanofluid velocity near the right wall. The nanoparticle temperature decreased with the radiation parameter and Schmidt number. The activation energy and radiation enhanced the nanoparticle volume fraction, and motile microorganisms decreased with an increase in the Peclet number and Schmidt number. The applications of the current investigation include chyme flow in the gastrointestinal tract, the control of blood flow during surgery by altering the magnetic field and novel drug delivery systems in pharmacological engineering.This work was supported by the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia (Project No. AN00052)

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Improved risk stratification of patients with atrial fibrillation: an integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation.

OBJECTIVES: To provide an accurate, web-based tool for stratifying patients with atrial fibrillation to facilitate decisions on the potential benefits/risks of anticoagulation, based on mortality, stroke and bleeding risks. DESIGN: The new tool was developed, using stepwise regression, for all and then applied to lower risk patients. C-statistics were compared with CHA2DS2-VASc using 30-fold cross-validation to control for overfitting. External validation was undertaken in an independent dataset, Outcome Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). PARTICIPANTS: Data from 39 898 patients enrolled in the prospective GARFIELD-AF registry provided the basis for deriving and validating an integrated risk tool to predict stroke risk, mortality and bleeding risk. RESULTS: The discriminatory value of the GARFIELD-AF risk model was superior to CHA2DS2-VASc for patients with or without anticoagulation. C-statistics (95% CI) for all-cause mortality, ischaemic stroke/systemic embolism and haemorrhagic stroke/major bleeding (treated patients) were: 0.77 (0.76 to 0.78), 0.69 (0.67 to 0.71) and 0.66 (0.62 to 0.69), respectively, for the GARFIELD-AF risk models, and 0.66 (0.64-0.67), 0.64 (0.61-0.66) and 0.64 (0.61-0.68), respectively, for CHA2DS2-VASc (or HAS-BLED for bleeding). In very low to low risk patients (CHA2DS2-VASc 0 or 1 (men) and 1 or 2 (women)), the CHA2DS2-VASc and HAS-BLED (for bleeding) scores offered weak discriminatory value for mortality, stroke/systemic embolism and major bleeding. C-statistics for the GARFIELD-AF risk tool were 0.69 (0.64 to 0.75), 0.65 (0.56 to 0.73) and 0.60 (0.47 to 0.73) for each end point, respectively, versus 0.50 (0.45 to 0.55), 0.59 (0.50 to 0.67) and 0.55 (0.53 to 0.56) for CHA2DS2-VASc (or HAS-BLED for bleeding). Upon validation in the ORBIT-AF population, C-statistics showed that the GARFIELD-AF risk tool was effective for predicting 1-year all-cause mortality using the full and simplified model for all-cause mortality: C-statistics 0.75 (0.73 to 0.77) and 0.75 (0.73 to 0.77), respectively, and for predicting for any stroke or systemic embolism over 1 year, C-statistics 0.68 (0.62 to 0.74). CONCLUSIONS: Performance of the GARFIELD-AF risk tool was superior to CHA2DS2-VASc in predicting stroke and mortality and superior to HAS-BLED for bleeding, overall and in lower risk patients. The GARFIELD-AF tool has the potential for incorporation in routine electronic systems, and for the first time, permits simultaneous evaluation of ischaemic stroke, mortality and bleeding risks. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier for GARFIELD-AF (NCT01090362) and for ORBIT-AF (NCT01165710)

Two-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF.

AIMS: The relationship between outcomes and time after diagnosis for patients with non-valvular atrial fibrillation (NVAF) is poorly defined, especially beyond the first year. METHODS AND RESULTS: GARFIELD-AF is an ongoing, global observational study of adults with newly diagnosed NVAF. Two-year outcomes of 17 162 patients prospectively enrolled in GARFIELD-AF were analysed in light of baseline characteristics, risk profiles for stroke/systemic embolism (SE), and antithrombotic therapy. The mean (standard deviation) age was 69.8 (11.4) years, 43.8% were women, and the mean CHA2DS2-VASc score was 3.3 (1.6); 60.8% of patients were prescribed anticoagulant therapy with/without antiplatelet (AP) therapy, 27.4% AP monotherapy, and 11.8% no antithrombotic therapy. At 2-year follow-up, all-cause mortality, stroke/SE, and major bleeding had occurred at a rate (95% confidence interval) of 3.83 (3.62; 4.05), 1.25 (1.13; 1.38), and 0.70 (0.62; 0.81) per 100 person-years, respectively. Rates for all three major events were highest during the first 4 months. Congestive heart failure, acute coronary syndromes, sudden/unwitnessed death, malignancy, respiratory failure, and infection/sepsis accounted for 65% of all known causes of death and strokes for <10%. Anticoagulant treatment was associated with a 35% lower risk of death. CONCLUSION: The most frequent of the three major outcome measures was death, whose most common causes are not known to be significantly influenced by anticoagulation. This suggests that a more comprehensive approach to the management of NVAF may be needed to improve outcome. This could include, in addition to anticoagulation, interventions targeting modifiable, cause-specific risk factors for death. CLINICAL TRIAL REGISTRATION: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Numerical Scrutinization of Ternary Nanofluid Flow over an Exponentially Stretching Sheet with Gyrotactic Microorganisms

In the modern age, the study of nanofluids over the stretching sheet has received much attention from researchers due to its significant role in the polymer industry, for instance in the production of fibre sheets and the extrusion of molten polymers through a slit die. Due to these affordable applications, the current study focusses on the motion of metallic ternary nanofluids (Ag-Au-Cu/H2O) past an exponential stretching sheet, taking diverse effects such as gyrotactic microorganisms, activation energy, buoyancy forces and thermal radiation into consideration. The model was created with the complex system of partial differential equations. Suitable similarity transformations and non-dimensional quantities were utilized to transform the complex system of partial differential equations to a set of ordinary differential equations. The resultant system is solved with the help of Matlab software. The computational outcomes are presented through the tables and pictorial notations. It is observed from the current analysis that the nanoparticle temperature of the ternary nanofluid enhances with the enhancement of activation energy and Brownian motion parameters. For the rising values of Lewis and thermophoresis numbers there is a declination in the nanoparticle concentration distribution. The Brownian motion and radiation effects increase the microorganism profile

Indian railway employees' job satisfaction at the Guntakal division

For me, employee satisfaction at the Guntakal Railway Division is a fascinating issue. The vast majority of workers are pleased with the company's performance. The majority of workers are aware of the company's strategy and have faith in its leadership. The majority of employees get enough appreciation for their contributions. Railways that pay their workers a decent wage will continue to function. Employees must share tasks and work in line with the organization's goals, just as they would in a family. People are constantly given opportunities to demonstrate their abilities and be acknowledged. The upper management is quite accessible